I-Lobular Carcinoma ehlaselayo: Izimpawu, Ukwelashwa, nokuningi

-Delile

• Yini i-invasive lobular carcinoma (ILC)?
• Izimpawu zomdlavuza webele we-lobular
• Izimbangela zomdlavuza webele we-lobular
• Izici zobungozi
• I-Lobular carcinoma in situ (LCIS)
• Utholakala kanjani umdlavuza webele we-lobular?
• AmaMammograms
• Isiteji ILC
• Uphathwa kanjani umdlavuza webele we-lobular?
• Imithi ehambisanayo neyenye indlela
• Ngingawuvikela kanjani umdlavuza webele we-lobular?
• I-LCIS
• Ngingawatholaphi amaqembu ezokuxhaswa?
• Umbono

Yini i-invasive lobular carcinoma (ILC)?

I-Invasive lobular carcinoma (ILC) umdlavuza ezingqimbeni ezikhiqiza ubisi. Abantu abane-ILC mancane amathuba okuthi bazizwe izigaxa ze-telltale. Kuyaziwa nangokuthi ngokungenisa i-lobular carcinoma noma umdlavuza webele we-lobular.

I-ILC iyakhula futhi isakazeke ngokwehlukile kunamanye umdlavuza webele onjenge-invasive ductal carcinoma (IDC), noma umdlavuza wamapayipi obisi.

Lapho umdlavuza usakazeka, ubizwa ngokuthi yi-metastatic. E-ILC, umdlavuza uqala kuma-lobules webele bese udlulela ezicutshini zamabele ezizungezile. Ingahamba futhi iye kuma-lymph node nakwezinye izitho emzimbeni.

Abesifazane abangaphezu kwe-180,000 e-United States unyaka ngamunye bazothola ukuxilongwa komdlavuza webele webele. I-ILC yakha cishe amaphesenti ayishumi alabo abaxilongwa.

Izimpawu zomdlavuza webele we-lobular

I-ILC ikhula ngokwehlukile kunezinhlobo ezejwayelekile zomdlavuza webele. Mancane amathuba okuba kube nezigaxa ezisobala. Ezigabeni zokuqala, bekungeke kube khona zimpawu noma zimpawu. Kepha njengoba umdlavuza ukhula, ungaqaphela amabele akho:

• ukuqina noma ukuqina endaweni ethile
• ukuvuvukala noma ukuzizwa ugcwele endaweni ethile
• ukushintsha ekubunjweni noma ekubukeni kwesikhumba, njengokuncipha
• ukuthuthukisa ingono esanda kuguqulwa
• ukushintsha ngosayizi noma ukuma

Ezinye izimpawu zingafaka:

• ubuhlungu besifuba
• ubuhlungu bezingono
• ukukhipha ngaphandle kobisi lwebele
• isigaxa esizungeze indawo engaphansi

Lezi zivame ukuba yizimpawu zokuqala zomdlavuza webele, kufaka phakathi i-ILC. Bheka udokotela wakho uma ubona lezi zimpawu noma lezi zimpawu.

Izimbangela zomdlavuza webele we-lobular

Okudala i-ILC akucaci. Kodwa lolu hlobo lomdlavuza luqala lapho amangqamuzana asezindlala zakho ezikhiqiza ubisi akha ushintsho lwe-DNA ngokuvamile olulawula ukukhula kwamaseli nokufa.

Amaseli womdlavuza aqala ukuhlukana nokusakazeka njengamagatsha, yingakho ungeke uzizwe uyisigaxa.

Izici zobungozi

Amathuba okuthola i-ILC ayanda uma:

• owesifazane
• lapho usumdala, ngaphezu kwezinye izinhlobo zomdlavuza webele
• owesifazane osebenzisa i-hormone replacement therapy (HRT), imvamisa ngemuva kokunqamuka kokuya esikhathini
• ethwele izakhi zofuzo zomdlavuza

I-Lobular carcinoma in situ (LCIS)

Ingozi yakho yokuthuthukisa i-ILC ingakhuphuka uma ngabe uphethwe yi-LCIS. I-LCIS ilapho kutholakala amaseli angajwayelekile noma angajwayelekile, kepha lawa maseli agcinwa kuma-lobules futhi awazange ahlasele izicubu zamabele ezizungezile.

I-LCIS ayiwona umdlavuza futhi ibhekwa njengesimo esingajwayelekile.

Utholakala kanjani umdlavuza webele we-lobular?

Odokotela bakho bazosebenzisa izivivinyo eziningi ezahlukahlukene zokusiza ekuhloleni umdlavuza webele we-lobular. Lezi zivivinyo zifaka:

• i-ultrasound
• I-MRI
• mammogram
• ukucubungula amabele

I-ILC inezinhlayiya ezimbalwa, ezisuselwa ekubukekeni kwamaseli angaphansi kwesibonakhulu. Kuhlobo lwe-ILC lwakudala, amaseli afola kufayela elilodwa.

Ezinye izinhlobo ezingavamile kakhulu zokukhula zifaka okulandelayo:

• okuqinile: zikhule ngamashidi amakhulu
• i-alveolar: zikhula ngamaqembu amaseli angama-20 noma ngaphezulu
• i-tubulolobular: amanye amaseli ukwakheka kwefayela elilodwa futhi amanye enza izakhiwo ezifana nezhubhu
• i-pleomorphic: inkulu kune-ILC yakudala ene-nuclei ebukeka yehlukile komunye nomunye
• iseli lendandatho lophawu: amaseli agcwele amafinyila

AmaMammograms

AmaMammograms anganikeza imiphumela engeyinhle yomdlavuza we-lobular. Lokhu kungenxa yokuthi, ku-X-ray, umdlavuza we-lobular ubukeka ufana nezicubu ezijwayelekile.

I-ILC ibuye isabalale ngezicubu zamabele ngokuhlukile kwe-IDC.

Izicubu ezakhiwe kahle kanye nokufakwa kwe-calcium akuvamile, okwenza kube nzima kudokotela we-radiologist ukuhlukanisa i-ILC nezicubu zebele ezijwayelekile ku-mammogram.

Kungenzeka futhi ukuthi kuthuthuke endaweni engaphezu kweyodwa yebele noma kuwo womabili amabele. Uma ibonwa ku-mammogram, ingahle ibonakale incane kunalokho eyiyo.

Isiteji ILC

Ukubeka amabele kulapho udokotela wakho enquma ukuthi umdlavuza usuthuthuke kangakanani noma ususabalale kangakanani ukusuka ebeleni.

Isiteji sisuselwa ku:

• ubukhulu besimila
• mangaki ama-lymph node athintekile
• ngabe umdlavuza ususabalele nakwezinye izingxenye zomzimba

Kunezigaba ezine ze-ILC, kusuka ku-1 kuye ku-4.

Njenge-IDC, uma i-ILC isakazeka, ijwayele ukuvela ku:

• ama-lymph node
• amathambo
• isibindi
• amaphaphu
• ubuchopho

Ngokungafani ne-IDC, i-ILC kungenzeka isabalale iye ezindaweni ezingavamile ezifana nalezi:

• isisu namathumbu
• ulwelwesi lwesisu
• izitho zokuzala

Ukuze unqume ukuthi ngabe amaseli womdlavuza asakazekile yini, udokotela wakho angalawula ukuhlolwa ukuze ahlole ama-lymph node, igazi nesibindi sakho.

Uphathwa kanjani umdlavuza webele we-lobular?

Ukhetho lwakho olungcono kakhulu lokwelashwa luzoya ngesigaba sakho somdlavuza, ubudala, nempilo ejwayelekile. Ukwelapha i-ILC kuvame ukufaka ukuhlinzwa nokwelashwa okwengeziwe.

Ukukhetha udokotela ohlinzayo ngokucophelela kubaluleke kakhulu ngenxa yephethini yokukhula engajwayelekile ye-ILC. Udokotela ohlinzayo onolwazi ekwelapheni iziguli ezine-ILC kubalulekile.

Ukuhlinzwa okuncane okunolaka okufana ne-lumpectomy kunemiphumela efanayo ekwelashweni okunolaka njenge-mastectomy.

I-lumpectomy ingaba yindlela enhle uma kuphela ingxenye encane yesifuba inomdlavuza (kulokhu kuhlinzwa, udokotela ohlinzayo ususa kuphela izicubu zomdlavuza).

Uma kuhileleke izicubu zamabele eziningi, udokotela wakho angancoma i-mastectomy (ukususwa ngokuphelele kwebele).

Ezinye izinketho zifaka ukususa ama-lymph node eduze kwesifuba sakho, inqubo ebizwa nge-sentinel lymph node biopsy, ne-armpit, ebizwa nge-axillary lymph node dissection.

Ungadinga ukwelashwa okwengeziwe, okufana nemisebe, i-hormonal therapy, noma i-chemotherapy, ukunciphisa ubungozi bokuthi umdlavuza ukhule emuva kokuhlinzwa.

Imithi ehambisanayo neyenye indlela

Ngenkathi ukwelashwa okuhambisanayo nokunye okuhlukile (i-CAM) kungaziwa ukwelapha umdlavuza webele, kungasiza ukukhulula ezinye zezimpawu nemiphumela emibi yomdlavuza kanye nokwelashwa kwawo.

Isibonelo, abantu abathatha ukwelashwa kwama-hormone ngomdlavuza webele bangathola ukushisa okushisayo, noma ukufudumala okungazelelwe, okukhulu nokujuluka.

Ungathola ukukhululeka ngokusebenzisa:

• ukuzindla
• amavithamini
• ukuzivocavoca umzimba
• i-yoga

Njalo khuluma nodokotela wakho ngaphambi kokuzama umuthi omusha noma isengezo. Zingahle zihlanganyele nokwelashwa kwakho kwamanje futhi zidale imiphumela emibi engahlosiwe.

Ukwelashwa kweHormone (HT) kunganconywa uma amaseli akho omdlavuza ezwela kumahomoni afana ne-estrogen ne-progesterone.

Lokhu kuvame ukwenzeka kumdlavuza webele we-lobular. I-HT ingavimba ama-hormone omzimba wakho ekusayineni amangqamuzana omdlavuza ukuthi akhule.

Ngingawuvikela kanjani umdlavuza webele we-lobular?

I-Lobular carcinoma, njengamanye umdlavuza webele, ingakhula ibe ngabantu abaphilile ngenye indlela. Unganciphisa ubungozi bakho ngoku:

• ukuphuza utshwala ngokulinganisela, uma kunjalo
• ukwenza izivivinyo zakho
• ukuthola ukuhlolwa kwaminyaka yonke, kufaka phakathi ama-mammograms
• ukugcina isisindo esinempilo
• ukudla ukudla okunomsoco nokuzivocavoca umzimba njalo

Uma ucabangela i-HRT, xoxa nodokotela wakho ngezingozi nezinzuzo zalolu lwazi. I-HRT ingakhuphula ubungozi be-lobular carcinoma nezinye izinhlobo zomdlavuza webele.

Uma ukhetha ukuthatha i-HRT, kufanele uthathe umthamo ophansi kakhulu osebenza ngesikhathi esifushane kakhulu.

I-LCIS

Ngingawatholaphi amaqembu ezokuxhaswa?

Ukuthola ukuxilongwa komdlavuza webele kwanoma yiluphi uhlobo kungaba nzima kakhulu. Ukufunda ngomdlavuza webele kanye nezinketho zokwelashwa kungakusiza uzizwe ukhululekile njengoba uhamba ohambweni lwakho.

Izindawo ongaphendukela kuzo ukuze uthole ukusekelwa uma kutholakala ukuthi unomdlavuza webele we-lobular zifaka:

• iqembu lakho lezempilo
• abangane nomndeni
• imiphakathi eku-inthanethi
• amaqembu okweseka wendawo

Kunobungozi obandayo bokuhlaselwa ngumdlavuza webele ongafuneki uma kutholakala ukuthi une-LCIS. Ungaphuza imithi, njenge-tamoxifen, ukwehlisa ubungozi bakho.

Udokotela wakho futhi angaphakamisa i-mastectomy uma unomlando womndeni womdlavuza webele.

Umphakathi womdlavuza webele ubonakala futhi unezwi. Amaqembu osizo endawo angasiza ekuxhumaneni nabanye abadlula kokuhlangenwe nakho okufanayo.

Umbono

Ukuxilongwa kusenesikhathi kanye nentuthuko ekwelashweni kusiza ekwandiseni amathuba akho okuphila impilo ende nenempilo. Umbono wesikhathi eside we-ILC uncike ezintweni eziningi, njenge:

• isigaba somdlavuza
• grade kanye subtype
• amama okuhlinzwa, noma ukuthi amangqamuzana omdlavuza asondele kangakanani ezicutshini ezisuswe ebeleni
• iminyaka yakho
• impilo yakho yonke
• uphendula kahle kangakanani ekwelashweni

Esinye isici esithinta imiphumela ku-ILC ukuthi ngabe i-estrogen, i-progesterone, noma i-HER2 (i-human epidermal growth factor receptor 2) ama-receptors atholakala ebusweni bamaseli womdlavuza.