Okufanele Ukwazi Ngezivivinyo Zemitholampilo Ye-Mantle Cell Lymphoma

-Delile

• Yini isivivinyo somtholampilo?
• Imithi ihlolwa kanjani ukuphepha ngaphambi kokuhlolwa komtholampilo?
• Yiziphi izinzuzo ezingaba khona zokubamba iqhaza esivivinyweni somtholampilo?
• Yiziphi izingcuphe ezingaba khona zokubamba iqhaza esivivinyweni somtholampilo?
• Ngingafunda kuphi ngezivivinyo zomtholampilo zamanje nezizayo?
• Yini okufanele ngiyibuze udokotela wami ngaphambi kokujoyina isilingo somtholampilo?
• Ukuthatha

Eminyakeni yamuva nje, ukwelashwa okusha kwe-mantle cell lymphoma (MCL) kusize ekuthuthukiseni isikhathi sokuphila kanye nekhwalithi yempilo kubantu abaningi abanalesi sifo. Kodwa-ke, i-MCL isabhekwa njengengelapheki.

Ekufuneni kwabo okuqhubekayo ikhambi, abacwaningi emhlabeni jikelele bayaqhubeka nokwakha nokuhlola izindlela ezintsha zokwelashwa ze-MCL.

Ukuthola leyo mithi yokwelapha, i-American Cancer Society iphakamisa ukuthi abantu abane-MCL bangafuna ukubamba iqhaza esivivinyweni somtholampilo.

Funda ukuze ufunde kabanzi mayelana nezinzuzo nezingozi ezingaba khona ngokwenza kanjalo.

Yini isivivinyo somtholampilo?

Isivivinyo somtholampilo uhlobo locwaningo lapho abahlanganyeli bathola ukwelashwa, basebenzise idivayisi, noma bahlolwa noma enye inqubo efundwayo.

Abaphenyi basebenzisa izivivinyo zomtholampilo ukuze bafunde ukuthi imishanguzo emisha nezinye izindlela zokwelapha ziphephile yini futhi ziyasebenza ekwelapheni izifo ezithile, kufaka phakathi i-MCL. Basebenzisa nokuhlolwa kwemitholampilo ukuqhathanisa izindlela ezintsha nezikhona zokwelashwa ukuze kufundwe okufanele amaqembu athile eziguli.

Ngesikhathi sokuhlolwa komtholampilo ekwelashweni kwe-MCL, abacwaningi baqoqa imininingwane ngemiphumela emibi abahlanganyeli ababa nayo ngenkathi belashwa. Futhi baqoqa imininingwane mayelana nemiphumela ebonakalayo yokwelashwa ekusindeni kwabahlanganyeli, izimpawu, neminye imiphumela yezempilo.

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuvuma kuphela ukwelashwa okusha ngemuva kokuthi kutholakale ukuthi kuphephile futhi kusebenza ngempumelelo ekuhlolweni kwemitholampilo.

Imithi ihlolwa kanjani ukuphepha ngaphambi kokuhlolwa komtholampilo?

Ngaphambi kokuhlolwa komdlavuza omusha esivivinyweni somtholampilo, kudlula ezigabeni eziningi zokuhlolwa kwelabhorethri.

Ngesikhathi sokuhlolwa kwelabhorethri, ososayensi bangahlola ukwelashwa kumaseli omdlavuza akhule ezitsheni ze-petri noma kumashubhu wokuhlola. Uma imiphumela yalolo vivinyo ithembisa, bangahlola ukwelashwa ezilwaneni eziphilayo njengamagundane elebhu.

Uma ukwelashwa kutholakala kuphephile futhi kusebenza ngempumelelo ezifundweni zezilwane, ososayensi bangabe sebesungula inqubo yokuhlolwa komtholampilo ukuyifundela kubantu.

Iphaneli lochwepheshe libuyekeza inqubo ngayinye yokuhlolwa komtholampilo ukusiza ukuqinisekisa ukuthi ucwaningo lwenziwa ngendlela ephephile nenesimilo.

Yiziphi izinzuzo ezingaba khona zokubamba iqhaza esivivinyweni somtholampilo?

Ukubamba iqhaza esivivinyweni somtholampilo kungakunika ukufinyelela kunqubo yokwelashwa yokuhlola engakavunyelwa noma enziwe yatholakalela okwamanje, njenge:

• uhlobo olusha lwe-immunotherapy, ukwelashwa okuhlosiwe, noma ukwelashwa kofuzo
• isu elisha lokusebenzisa izindlela zokwelapha ezikhona ngezigaba ezahlukene ze-MCL
• indlela entsha yokuhlanganisa izindlela zokwelapha ezikhona ekwelashweni okuhlanganisiwe

Asikho isiqinisekiso sokuthi indlela yokwelashwa yokulinga izosebenza. Kodwa-ke, kungakunika inketho yokwelashwa lapho ukwelashwa okujwayelekile kungatholakali noma kungakusebenzelanga kahle.

Uma uthatha isinqumo sokubamba iqhaza esivivinyweni somtholampilo, uzophinda usize abacwaningi ukuthi bafunde kabanzi nge-MCL. Lokhu kungabasiza bathuthukise izindlela zokwelashwa zeziguli ngokuzayo.

Kwezinye izimo, kungabiza kakhulu kuwe ukuthola ukwelashwa esivivinyweni somtholampilo. Abaxhasi bokufunda kwesinye isikhathi bahlanganisa ezinye noma zonke izindleko zokwelashwa kwabahlanganyeli.

Yiziphi izingcuphe ezingaba khona zokubamba iqhaza esivivinyweni somtholampilo?

Uma uthola ukwelashwa kokuhlola esivivinyweni somtholampilo, kungenzeka ukuthi ukwelashwa:

• kungenzeka ingasebenzi kanye nokwelashwa okujwayelekile
• kungenzeka ingasebenzi kangcono kunokwelapha okujwayelekile
• kungadala imiphumela emibi engalindelekile futhi engaba yingozi kakhulu

Kokunye ukuhlolwa komtholampilo, abacwaningi baqhathanisa ukwelashwa kokuhlola nokwelashwa okujwayelekile. Uma isilingo "singaboni," ababambiqhaza abazi ukuthi bathola luphi unyango. Ungathola ukwelashwa okujwayelekile - bese kamuva uthole ukuthi ukwelashwa kokuhlola kusebenza kangcono.

Kwesinye isikhathi, izivivinyo zokwelashwa ziqhathanisa ukwelashwa kokuhlola ne-placebo. I-placebo ukwelashwa okungafaki izinto ezisebenzayo zokulwa nomdlavuza. Kodwa-ke, ama-placebos akuvamile ukuthi asetshenziswe yedwa ekuhlolweni kwemitholampilo ngomdlavuza.

Ungakuthola kukuphazamisa ukubamba iqhaza esivivinyweni somtholampilo, ikakhulukazi uma kufanele uye emihlanganweni njalo noma uhambe amabanga amade ukuze uthole ukwelashwa noma ukuhlolwa.

Ngingafunda kuphi ngezivivinyo zomtholampilo zamanje nezizayo?

Ukuthola izivivinyo zomtholampilo zamanje nezizayo zabantu abane-MCL, kungasiza uku:

• buza udokotela wakho uma bazi nganoma yiziphi izivivinyo zomtholampilo ongahle ufaneleke kuzo
• sesha izivivinyo zomtholampilo ezifanele usebenzisa imininingwane eqhutshwa yi-US National Library of Medicine, noma iCentreWatch
• hlola amawebhusayithi abakhiqizi bemithi ukuthola ulwazi mayelana nokuhlolwa kwemitholampilo abakwenzayo manje noma abahlelela ikusasa

Ezinye izinhlangano ziphinde zinikeze ngezinsizakalo ezihambisana nokuhlolwa kwezilingo ukusiza abantu bathole izivivinyo ezihambelana nezidingo zabo nezimo zabo.

Yini okufanele ngiyibuze udokotela wami ngaphambi kokujoyina isilingo somtholampilo?

Ngaphambi kokuthi uthathe isinqumo sokubamba iqhaza esivivinyweni somtholampilo, kufanele ukhulume nodokotela wakho namalungu ethimba locwaningo lokuhlolwa komtholampilo ukuze ufunde ngezinzuzo ezingaba khona, ubungozi, nezindleko zokubamba iqhaza.

Nalu uhlu lwemibuzo ongathola ilusizo ukuyibuza:

• Ngabe ngiyahlangabezana nemibandela yalesi silingo somtholampilo?
• Ngabe abacwaningi bazosebenzisana nethimba lami lokwelashwa?
• Ngabe abacwaningi bazonikeza abahlanganyeli i-placebo, ukwelashwa okujwayelekile, noma ukwelashwa kokuhlola? Ngabe ngizokwazi ukuthi yiluphi ukwelashwa engikutholayo?
• Yini esivele isaziwa mayelana nokwelashwa okufundwayo kuleli cala?
• Iyini imiphumela emibi engaba khona, ubungozi, noma izinzuzo zokwelashwa?
• Yikuphi ukuhlolwa engizodinga ukubhekana nakho ngesikhathi sesivivinyo?
• Ngikuthola kangaki futhi kuphi ukwelashwa nokuhlolwa?
• Ngabe kuzofanele ngikhokhe ephaketheni izindleko zokwelashwa nokuhlolwa?
• Ngabe umhlinzeki wami womshuwalense noma umxhasi wesifundo uzokhokhela noma yiziphi izindleko?
• Kufanele ngithinte bani uma nginemibuzo noma ngikhathazeka?
• Kwenzekani uma ngithatha isinqumo sokuthi angisafuni ukubamba iqhaza?
• Ucwaningo luhlelelwe ukuthi luphele nini? Kuzokwenzekani uma ucwaningo luphela?

Udokotela wakho angakusiza ukuthi ulinganise izinzuzo nezingozi ezingaba khona zokubamba iqhaza esivivinyweni somtholampilo. Futhi zingakusiza uqonde ezinye izinketho zakho zokwelashwa.

Ukuthatha

Uma izinketho zokwelashwa ezijwayelekile zingenakwenzeka ukuhlangabezana nezidingo zakho zokwelashwa noma imigomo nge-MCL, udokotela wakho angakukhuthaza ukuthi ucabangele ukubamba iqhaza esivivinyweni somtholampilo.

Udokotela wakho angakusiza uqonde izinzuzo nezingozi ezingaba khona zokubamba iqhaza esivivinyweni somtholampilo. Zingakusiza nokuthi ufunde kabanzi mayelana nezinye izinketho zakho zokwelashwa uma uthatha isinqumo sokungabambi iqhaza esivivinyweni somtholampilo noma uma ungafaneleki kunoma yiziphi izivivinyo zomtholampilo.

Khuluma nodokotela wakho ukuze ufunde ukuthi ukubamba iqhaza esivivinyweni somtholampilo kungaba yisinqumo esihle kuwe.