Ukwelashwa kwe-RA: Ama-DMARD kanye ne-TNF-Alpha Inhibitors

-Delile

• Isingeniso
• Ama-DMARD: Okubalulekile ekwelashweni kokuqala
• Ama-DMARD anamaphilisi ezinhlungu
• Ama-Corticosteroids
• Ama-NSAID angaphezu kwama-counter
• Ama-NSAID kadokotela
• Ama-DMARD nezifo
• I-TNF-alpha inhibitors
• Khuluma nodokotela wakho
• Q:
• A:

Isingeniso

I-rheumatoid arthritis (RA) yisifo esingapheliyo se-autoimmune. Kubangela ukuthi amasosha omzimba wakho ahlasele izicubu ezinempilo emajoyintini akho, okuholela ebuhlungu, ukuvuvukala nokuqina. Ngokungafani ne-osteoarthritis, ebangelwa ukuguga okuvamile njengoba ukhula, i-RA ingathinta noma ngubani kunoma yimuphi ubudala. Akekho owazi kahle ukuthi kubangelwa yini.

I-RA ayinawo umuthi, kepha imithi ingasiza ekunciphiseni izimpawu. Le mithi ifaka phakathi izidakamizwa ezilwa nokuvuvukala, ama-corticosteroids, nezidakamizwa ezicindezela amasosha omzimba. Ezinye zezindlela zokwelapha eziphumelela kakhulu ukuguqula izifo ezithinta i-rheumatic (DMARDs), okubandakanya i-TNF-alpha inhibitors.

Ama-DMARD: Okubalulekile ekwelashweni kokuqala

Ama-DMARD yimithi i-rheumatologists evame ukuyinikeza ngemuva nje kokutholakala kwe-RA. Ukulimala okuhlala njalo okuhlangene okuvela ku-RA kwenzeka eminyakeni emibili yokuqala, ngakho-ke le mithi ingenza umthelela omkhulu ekuqaleni kwesifo.

Ama-DMARD asebenza ngokwenza buthaka amasosha akho omzimba. Lesi senzo sinciphisa ukuhlaselwa kwe-RA kumajoyini akho ukunciphisa ukulimala okuphelele.

Izibonelo zama-DMARD zifaka:

• i-methotrexate (Otrexup)
• i-hydroxychloroquine (i-Plaquenil)
• leflunomide (Arava)

Ama-DMARD anamaphilisi ezinhlungu

Okubi kakhulu ekusebenziseni ama-DMARD ukuthi bayaphuza ukwenza. Kungathatha izinyanga ezimbalwa ukuzwa ukukhululeka kobuhlungu kusuka ku-DMARD. Ngalesi sizathu, odokotela be-rheumatologists bavamise ukunikela ngamaphilisi ezinhlungu asebenza ngokushesha njenge-corticosteroids noma ama-nonsteroidal anti-inflammatory (NSAIDs) okumele athathwe ngasikhathi sinye. Le mithi ingasiza ekunciphiseni ubuhlungu ngenkathi ulinde i-DMARD ukuthi iqale ukusebenza.

Izibonelo zama-corticosteroids noma ama-NSAID angasetshenziswa nama-DMARD afaka:

Ama-Corticosteroids

• i-prednisone (iRayos)
• i-methylprednisolone (iDepo-Medrol)
• i-triamcinolone (i-Aristospan)

Ama-NSAID angaphezu kwama-counter

• i-aspirin
• ibuprofen
• i-naproxen sodium

Ama-NSAID kadokotela

• nabumetone
• celecoxib (Celebrex)
• i-piroxicam (Feldene)

Ama-DMARD nezifo

Ama-DMARD athinta wonke amasosha omzimba wakho. Lokhu kusho ukuthi bakubeka engcupheni enkulu yokutheleleka.

Izifo ezivame kakhulu eziba nazo iziguli ze-RA yilezi:

• izifo zesikhumba
• izifo eziphezulu zokuphefumula
• inyumoniya
• izifo zomgudu womchamo

Ukusiza ukuvikela ukutheleleka, kufanele usebenzise inhlanzeko enhle, kufaka phakathi ukugeza izandla njalo nokugeza nsuku zonke noma ngalo lonke olunye usuku. Kufanele futhi uhlale kude nabantu abagulayo.

I-TNF-alpha inhibitors

I-alphor necrosis factor alpha, noma i-alpha ye-TNF, yinto eyenzeka ngokwemvelo emzimbeni wakho. Ku-RA, amaseli omzimba ahlasela amalunga enza amazinga aphezulu we-alpha ye-TNF. La mazinga aphezulu abangela ubuhlungu nokuvuvukala. Ngenkathi ezinye izinto eziningana zengeza ekulimaleni kweRA emajoyinini, i-TNF alpha ingumdlali omkhulu kule nqubo.

Ngoba i-alpha ye-TNF iyinkinga enkulu kangako ku-RA, i-TNF-alpha inhibitors zingenye yezinhlobo ezibaluleke kakhulu zama-DMARD emakethe njengamanje.

Kunezinhlobo ezinhlanu ze-TNF-alpha inhibitors:

• i-adalimumab (Humira)
• i-etanercept (Enbrel)
• isitifiketi se-certolizumab (Cimzia)
• golimumab (Simponi)
• infliximab (i-Remicade)

Le mithi ibizwa nangokuthi i-TNF-alpha blocker ngoba ivimba umsebenzi we-TNF alpha. Zinciphisa amazinga we-TNF alpha emzimbeni wakho ukusiza ukwehlisa izimpawu ze-RA. Baqala futhi ukusebenza ngokushesha kunamanye ama-DMARD. Zingaqala ukusebenza kungakapheli amasonto amabili kuya enyangeni.

Khuluma nodokotela wakho

Iningi labantu abane-RA liphendula kahle kuma-inhibitors e-TNF-alpha nakwamanye ama-DMARD, kepha kwabanye abantu, lezi zinketho kungenzeka zingasebenzi nhlobo. Uma zingakusebenzeli, tshela i-rheumatologist yakho. Kungenzeka banikeze i-TNF-alpha inhibitor ehlukile njengesinyathelo esilandelayo, noma bangaphakamisa uhlobo oluhlukile lwe-DMARD ngokuphelele.

Qiniseka ukuthi uvuselela i-rheumatologist yakho ukuthi uzizwa kanjani nokuthi ucabanga ukuthi umuthi wakho usebenza kahle kangakanani. Ngokubambisana, wena nodokotela wakho ningathola uhlelo lokwelashwa lwe-RA oluzonisebenzela.

Q:

Ingabe engikudlayo kungayithinta i-RA yami?

A:

Yebo. Kunokudla okuningi okungasiza ukunciphisa ukuvuvukala emzimbeni wakho. Uma ufuna ukuzama izinguquko zokudla ukuze uthuthukise izimpawu zakho ze-RA, qala ngokudla ukudla okuningi okuqukethe i-omega-3 fatty acids, ama-antioxidants, ne-fiber, njengamantongomane, inhlanzi, amajikijolo, imifino, netiye eluhlaza. Enye indlela enhle yokuletha lokhu kudla enkambisweni yakho yansuku zonke ukulandela ukudla kwaseMedithera. Ngemininingwane engaphezulu ngalokhu kudla nokunye ukudla okungasiza ekunciphiseni izimpawu ze-RA, hlola ukudla okulwa nokuvuvukala kwe-RA.