Umlobi: Randy Alexander
Usuku Lokudalwa: 1 Epreli 2021
Ukuvuselela Usuku: 25 Hamba 2025
Anonim
All About Empliciti (Elotuzumab)
Ividiyo: All About Empliciti (Elotuzumab)

-Delile

Yini i-Empliciti?

I-Empliciti iyisidakamizwa somuthi esinegama lomuthi. Isetshenziselwa ukwelapha uhlobo lomdlavuza wegazi obizwa nge-multiple myeloma kubantu abadala.

I-Empliciti inqunyelwe abantu abangena kwesinye sezimo ezimbili zokwelashwa:

  • Abantu abadala abake bathola ukwelashwa okukodwa kuya kwezintathu esikhathini esidlule nge-myeloma yabo eminingi. Kulaba bantu, i-Empliciti isetshenziswa ngokuhlangana ne-lenalidomide (Revlimid) ne-dexamethasone.
  • Abantu abadala asebeke bathola okungenani imishanguzo emibili edlule ye-myeloma ebandakanya i-lenalidomide (Revlimid) ne-proteasome inhibitor, efana ne-bortezomib (Velcade) noma i-carfilzomib (i-Kyprolis). Kulaba bantu, i-Empliciti isetshenziswa ngokuhlangana ne-pomalidomide (Pomalyst) ne-dexamethasone.

I-Empliciti ingeyesigaba semithi ebizwa ngama-antibody monoclonal. Le mithi yenziwa elebhu kusuka kumaseli omzimba. IMpliciti isebenza ngokwenza amasosha akho omzimba asebenze nokwenza amaseli omzimba wakho aqine. Isidakamizwa futhi sisiza ukukhombisa amasosha omzimba wakho lapho amaseli amaningi e-myeloma asemzimbeni wakho ukuze la maseli abhujiswe.


I-Empliciti itholakala ngamandla amabili: 300 mg kanye no-400 mg. Kuza njengempuphu eyenziwe isisombululo soketshezi futhi unikezwe ngomjovo we-intravenous (IV) (umjovo emthanjeni wakho isikhathi esithile). Ama-infusions anikezwa esikhungweni sokunakekelwa kwezempilo futhi ahlala cishe ihora noma ngaphezulu.

Ukusebenza ngempumelelo

Ucwaningo lwezokwelapha luye lwabonisa ukuthi i-Empliciti iyasebenza ekunqandeni ukuqhubekela phambili (okuba kubi kakhulu) kwe-myeloma eminingi. Imiphumela yezinye zalezi zifundo ichazwe ngezansi.

I-Empliciti ene-lenalidomide (i-Revlimid) ne-dexamethasone

Ekuvivinyweni komtholampilo, abantu abane-myeloma eminingi banikezwe i-Empliciti ene-lenalidomide ne-dexamethasone, noma i-lenalidomide ne-dexamethasone kuphela.

Izifundo zikhombise ukuthi abantu abathatha inhlanganisela ye-Empliciti babenobungozi obuphansi bokuthi izifo zabo ziqhubeke. Okungenani okungenani iminyaka emibili, labo abathatha i-Empliciti nge-lenalidomide ne-dexamethasone babenobungozi obuphansi ngama-30% kunabantu ababephuza lezo zidakamizwa ngaphandle kwe-Empliciti.


Kwesinye isifundo esathatha iminyaka emihlanu, abantu abathatha inhlanganisela ye-Empliciti babenengozi ephansi engama-27% yesifo sabo esiba sibi kunabantu abathatha i-lenalidomide ne-dexamethasone bodwa.

I-Empliciti ene-pomalidomide (i-Pomalyst) ne-dexamethasone

Ekuvivinyweni komtholampilo, abantu abane-myeloma eminingi banikezwa i-Empliciti nge-pomalidomide ne-dexamethasone, noma i-pomalidomide ne-dexamethasone kuphela.

Abantu abathatha inhlanganisela ye-Empliciti babenobungozi obuphansi ngama-46% besifo sabo ukuba sibi kakhulu ngemuva kwezinyanga okungenani eziyisishiyagalolunye zokwelashwa, uma kuqhathaniswa nabantu abathatha i-pomalidomide ne-dexamethasone bodwa.

I-Empliciti ejwayelekile

I-Empliciti itholakala kuphela njengomuthi wegama lomkhiqizo. Okwamanje ayitholakali ngendlela ejwayelekile.

I-Empliciti iqukethe umuthi osebenzayo elotuzumab.

Imiphumela emibi ye-Empliciti

I-Empliciti ingadala imiphumela emibi noma emibi. Uhlu olulandelayo luqukethe eminye yemiphumela emibi engase ivele ngenkathi uthatha i-Empliciti. Lolu hlu alufaki yonke imiphumela emibi engaba khona.


Imiphumela yakho emibi ingahluka ngokuya ngokuthi uthatha i-Empliciti ne-dexamethasone nge-lenalidomide (i-Revlimid) noma i-pomalidomide (i-Pomalyst).

Ngeminye imininingwane ngemiphumela engemihle ye-Empliciti, khuluma nodokotela wakho noma usokhemisi. Bangakunika amathiphu okuthi ungabhekana kanjani nanoma yimiphi imiphumela emibi engase ikukhathaze.

Imiphumela emibi ejwayelekile

Imiphumela emibi ejwayelekile ye-Empliciti lapho ithathwa nge-lenalidomide ne-dexamethasone ingafaka:

  • ukukhathala (ukungabi namandla)
  • isifo sohudo
  • imfiva
  • ukuqunjelwa
  • ukukhwehlela
  • izifo, njengokutheleleka kwesinus noma inyumoniya
  • ukuncipha kokudla noma ukunciphisa umzimba
  • isifo semizwa esiyindilinga (ukulimala kwezinye izinzwa zakho)
  • ubuhlungu ezingalweni noma emilenzeni
  • ikhanda
  • ukuhlanza
  • inkalakatha yobuso (ukusibilika efeni lens yeso lakho)
  • ubuhlungu emlonyeni nasemphinjeni
  • izinguquko emazingeni athile ekuhlolweni kwegazi lakho

Imiphumela emibi ejwayelekile ye-Empliciti lapho ithathwa nge-pomalidomide ne-dexamethasone ingafaka:

  • ukuqunjelwa
  • ukwanda kwezinga likashukela egazini
  • izifo, njenge-pneumonia noma i-sinus izifo
  • isifo sohudo
  • ubuhlungu bamathambo
  • inkinga yokuphefumula
  • ukuphazamiseka kwemisipha
  • ukuvuvukala ezingalweni noma emilenzeni
  • izinguquko emazingeni athile ekuhlolweni kwegazi lakho

Iningi lalemiphumela emibi ingahle ihambe ezinsukwini ezimbalwa noma emasontweni ambalwa. Uma zinzima kakhulu noma zingahambi, khuluma nodokotela wakho noma usokhemisi.

Imiphumela emibi kakhulu

Imiphumela emibi kakhulu ingenzeka nge-Empliciti. Shayela udokotela wakho ngokushesha uma unemiphumela emibi kakhulu. Shayela u-911 uma izimpawu zakho zizizwa zisongela impilo noma uma ucabanga ukuthi unezimo eziphuthumayo zezokwelapha.

Imiphumela emibi kanye nezimpawu zayo zingafaka okulandelayo:

  • Ezinye izinhlobo zomdlavuza, njengomdlavuza wesikhumba. Izimpawu zingafaka:
    • ubuthakathaka
    • ngizizwe ngikhathele
    • izinguquko ekubukeni kwesikhumba sakho nezimvukuzane
    • ama-lymph node avuvukile
  • Izinkinga zesibindi. Izimpawu zingafaka:
    • ngizizwe ngikhathele
    • ubuthakathaka
    • ukuphuzi kwabamhlophe bamehlo akho noma isikhumba sakho
    • ukuncipha kokudla
    • ukuvuvukala esiswini sakho
    • ngizizwe ngididekile

Eminye imiphumela emibi emibi, okuxoxwa ngayo ngokuningiliziwe ngezansi, ingafaka okulandelayo:

  • ukumnika ukumnika (kungadalwa ngokuba nokufakwa emthanjeni ngemithi)
  • ukusabela okweqile komzimba
  • izifo

Imininingwane yomphumela oseceleni

Ungase uzibuze ukuthi kaningi kangakanani imiphumela emibi ethile eba khona ngalo muthi. Nayi imininingwane ngeminye imiphumela emibi engadalwa yilesi sidakamizwa.

Ukusabela okweqile

Njengezidakamizwa eziningi, abanye abantu bangaba ne-allergen reaction ngemuva kokuthatha i-Empliciti. Izimpawu zokuphendula okuncane komzimba zingabandakanya:

  • ukuqubuka kwesikhumba
  • ukulunywa
  • ukuqhuma (ukufudumala nokubomvu esikhunjeni sakho)

Ukusabela okweqile okwedlulele akuvamile kodwa kungenzeka. Izimpawu zokuphendula okweqile kakhulu zingabandakanya:

  • ukuvuvukala ngaphansi kwesikhumba sakho, imvamisa ezinkalweni zakho, izindebe, izandla, noma izinyawo
  • ukuvuvukala kolimi lwakho, umlomo, noma umphimbo
  • inkinga yokuphefumula

Shayela udokotela wakho khona manjalo uma une-allergic reaction enamandla ku-Empliciti. Shayela u-911 uma izimpawu zakho zizizwa zisongela impilo noma uma ucabanga ukuthi unezimo eziphuthumayo zezokwelapha.

Ukumnika ukusabela

Ungaba nokuphendula kokumnika ngemuva kokuthola i-Empliciti. Lokhu kungukusabela okungenzeka kuze kufike emahoreni angama-24 ngemuva kokuthola umuthi ngokumfakelwa ngomjovo (IV).

Ekuvivinyweni komtholampilo, i-10% yabantu abathatha i-Empliciti nge-lenalidomide ne-dexamethasone babenempendulo yokumnika. Iningi lalaba bantu babenokuphendula kokumnika ngesikhathi sokufakwa kwabo kokuqala kwe-Empliciti. Kodwa-ke, bangu-1% kuphela abantu abathatha le nhlanganisela yokwelashwa obekufanele bayeke ukwelashwa ngenxa yokusabela okunzima kokufakwa.

Futhi ezivivinyweni zomtholampilo, 3.3% wabantu abathatha i-Empliciti nge-pomalidomide ne-dexamethasone babe nokusabela kokumnika. Okuwukuphela kwesibonakaliso sokuphendula kwabo ukumnika ubuhlungu besifuba.

Izimpawu zokuphendula ukumnika zingabandakanya:

  • imfiva
  • Ukugodola
  • ukunyusa noma ukwehlisa umfutho wegazi
  • kwehle izinga lokushaya kwenhliziyo
  • inkinga yokuphefumula
  • isiyezi
  • ukuqubuka kwesikhumba
  • ubuhlungu besifuba

Ngaphambi kokufakwa kwakho kwe-IV kwe-Empliciti, udokotela wakho noma umhlengikazi uzokunika imithi ethile yokusiza ukuvimbela ukuminyelwa kokungenzeki kungenzeki.

Uma unezimpawu zokuphendula kokumnika ngenkathi uthola i-Empliciti, noma kufika emahoreni angama-24 ngemuva kokufakwa kwakho, tshela udokotela wakho khona manjalo. Ezimweni ezimbi kakhulu, udokotela wakho angancoma ukuthi uyeke ukwelashwa kwe-Empliciti.

Kwesinye isikhathi, ukwelashwa kwe-Empliciti kungaqalwa kabusha ngemuva kokuphendula ukumnika. Kepha kwezinye izimo, ukukhetha umuthi ohlukile kungaba yindlela engcono kuwe.

Izifo

Ungaba nengozi eyengeziwe yokutheleleka ngenkathi uthatha i-Empliciti. Lokhu kufaka phakathi ukutheleleka kwamagciwane, igciwane kanye nefungal. Kwesinye isikhathi, lezi zifo zingaba zimbi kakhulu uma zingelashwa. Kwezinye izimo, kungaholela ekuguleni okukhulu noma ngisho nasekufeni.

Ekuvivinyweni komtholampilo, ukutheleleka kwenzeka kubantu abangama-81% abathatha i-Empliciti nge-lenalidomide ne-dexamethasone. Kubantu abathatha i-lenalidomide ne-dexamethasone kuphela, ama-74% abe nezifo.

Futhi ezivivinyweni zokwelashwa, ukutheleleka kwenzeke kubantu abangama-65% abathatha i-Empliciti nge-pomalidomide ne-dexamethasone. Ukutheleleka kwenzeke ngamaphesenti afanayo abantu abathatha i-pomalidomide ne-dexamethasone kuphela.

Izimpawu zokutheleleka zingahluka ngokuya ngohlobo lokutheleleka onalo. Izibonelo zezimpawu ezingenzeka zifaka:

  • imfiva
  • inkinga yokuphefumula
  • izimpawu ezinjengomkhuhlane, njengokuqaqamba komzimba nokugodola
  • ukukhwehlela
  • ukuqubuka kwesikhumba
  • umuzwa ovuthayo lapho uchama

Uma unezimpawu zokutheleleka, khuluma nodokotela wakho ngokushesha. Bangancoma ukuthi uyeke ukuthatha i-Empliciti kuze kube yilapho ukutheleleka kwakho kuphela. Bazophinda bancome uma ukutheleleka kwakho kudinga ukwelashwa.

Isifo sezinzwa zomngcele

Ungaba nokulimala kwemizwa uma uthatha i-Empliciti. Ukulimala kwemizwa kungabizwa nangokuthi isifo sezinzwa zomzimba. Lesi simo singadala ubuthakathaka nobuhlungu okuvame ukwenzeka ezandleni noma ezinyaweni zakho. Isifo sezinzwa zomngcele ngokuvamile asipheli, kepha singelashwa ngemithi ethile.

Ekuvivinyweni komtholampilo, isifo semizwa esiyindilinga senzeke kubantu abangama-27% abathatha i-Empliciti ngeleneralomide ne-dexamethasone. Lesi simo senzeke kubantu abangu-21% abathatha i-lenalidomide ne-dexamethasone kuphela.

Khuluma nodokotela wakho uma unezimpawu zesifo semizwa esiyindilinga. Bangancoma ukwelashwa uma ukudinga.

Ukukhathala

Ungaba nokukhathala (ukungabi namandla) ngenkathi usebenzisa i-Empliciti. Lokhu bekungumphumela ojwayelekile ojwayelekile obonwe ngesikhathi kwenziwa izifundo kubantu abathatha i-Empliciti nge-lenalidomide ne-dexamethasone.

Ezifundweni, ukukhathala kwenzeke kubantu abangama-62% abathatha i-Empliciti nge-lenalidomide ne-dexamethasone. Kubantu abathatha i-lenalidomide ne-dexamethasone kuphela, ama-52% ayekhathele.

Khuluma nodokotela wakho uma uzizwa ukhathele ngesikhathi sokwelashwa kwakho kwe-Empliciti.Bangancoma ukwelashwa uma udinga noma yini futhi basikisele izindlela zokwehlisa izimpawu zakho.

Uhudo

Ungahle ube nohudo ngenkathi uthatha i-Empliciti. Ekuvivinyweni komtholampilo, isifo sohudo senzeke kubantu abangama-47% abathatha i-Empliciti nge-lenalidomide ne-dexamethasone. Kubantu abathatha i-lenalidomide ne-dexamethasone kuphela, ama-36% abe nohudo.

Uhudo futhi lube nomphumela oseceleni obonwa kubantu abathatha i-Empliciti nge-pomalidomide ne-dexamethasone. Ezivivinyweni zokwelashwa, isifo sohudo senzeke kubantu abangu-18% abathatha le nhlanganisela yezidakamizwa. Kubantu abathatha i-pomalidomide ne-dexamethasone bodwa, u-9% ubenesifo sohudo.

Khuluma nodokotela wakho uma unesifo sohudo ngesikhathi ukwelashwa kwakho kwe-Empliciti. Bangancoma ukwelashwa uma udinga noma yini futhi basikisele izindlela zokwehlisa izimpawu zakho.

Izinguquko kumanani welebhu noma izivivinyo

Ungaba nezinguquko emazingeni athile okuhlolwa kwegazi ngenkathi uthatha i-Empliciti. Izibonelo zifaka izinguquko ku:

  • ukubalwa kwamangqamuzana egazi
  • ukuhlolwa kwesibindi noma izinso
  • amazinga kashukela, i-calcium, i-potassium, noma i-sodium

Udokotela wakho angahlola ukuhlolwa kwegazi kaningi kunokujwayelekile ngenkathi uthatha i-Empliciti. Lokhu kuvumela udokotela wakho ukuthi abone ukuthi ngabe kukhona yini ushintsho emazingeni okuhlolwa kwegazi lakho. Uma izinguquko ezinjalo zenzeka, udokotela wakho angaqapha ukuhlolwa kwegazi kwakho kaningi noma ancoma ukuthi uyeke ukwelashwa kwe-Empliciti.

Izindleko ze-Empliciti

Njengayo yonke imithi, izindleko ze-Empliciti zingahluka. Lesi sidakamizwa sinikezwa ukumnika okufakwa emthanjeni (IV) emitholampilo yezempilo.

Intengo yangempela ozoyikhokha incike ohlelweni lwakho lomshuwalense, indawo okuyo, nasendaweni yezokwelapha lapho uthola khona ukwelashwa kwakho.

Usizo lwezezimali nolomshuwalense

Uma udinga ukwesekwa kwezezimali ukukhokhela i-Empliciti, noma uma udinga usizo lokuqonda umshuwalense wakho, usizo luyatholakala.

IBristol-Myers Squibb, umkhiqizi we-Empliciti, unikela ngohlelo olubizwa nge-BMS Access Support. Ukuthola eminye imininingwane nokuthola ukuthi ukulungele yini ukwesekwa, shayela ku-800-861-0048 noma uvakashele iwebhusayithi yohlelo.

Umthamo we-Empliciti

Isilinganiso se-Empliciti udokotela wakho asinqumayo sizoxhomeka ezicini ezimbalwa. Lokhu kufaka phakathi:

  • imiphi imishanguzo oyiphuzayo ne-Empliciti
  • isisindo somzimba wakho

Umthamo wakho ungalungiswa ngokuhamba kwesikhathi ukuze ufinyelele inani elifanele wena. Udokotela wakho ekugcineni uzonikeza isilinganiso esincane kunazo zonke esihlinzeka ngomphumela oyifunayo.

Imininingwane elandelayo ichaza imithamo esetshenziswa kakhulu noma enconywayo. Kodwa-ke, qiniseka ukuthatha isilinganiso udokotela wakho akubekela sona. Udokotela wakho uzonquma isilinganiso esihle kakhulu ukuhlangabezana nezidingo zakho.

Amafomu wezidakamizwa namandla

IMpliciti iza njengempuphu exutshwe namanzi oyinyumba futhi yenziwa isisombululo. Inikezwa njengokufakwa ngomjovo (IV) (umjovo emthanjeni wakho isikhathi esithile). Isixazululo senziwa futhi ukumnika kwe-IV kunikezwa wena esikhungweni sokunakekelwa kwezempilo.

I-Empliciti itholakala ngamandla amabili: 300 mg kanye no-400 mg.

Isilinganiso se-myeloma eminingi

Umthamo we-Empliciti owutholayo uncike esisindweni somzimba wakho nokuthi imiphi imithi oyiphuzayo ne-Empliciti.

Uma uthatha i-Empliciti nge-lenalidomide (Revlimid) ne-dexamethasone:

  • isilinganiso esijwayelekile singu-10 mg we-Empliciti kwikhilogremu ngalinye (cishe amakhilogremu angu-2.2) wesisindo somzimba wakho
  • uzothola imithamo yamasonto onke ye-Empliciti emasontweni ayisishiyagalombili okuqala, okubhekwa njengemijikelezo emibili, yokwelashwa
  • ngemuva kwemijikelezo yakho yokuqala yokwelashwa, i-Empliciti inikezwa kanye njalo emavikini amabili

Uma uthatha i-Empliciti nge-pomalidomide (Pomalyst) ne-dexamethasone:

  • isilinganiso esijwayelekile singu-10 mg we-Empliciti kwikhilogremu ngalinye (cishe amakhilogremu angu-2.2) wesisindo somzimba wakho
  • uzothola imithamo yamasonto onke ye-Empliciti emasontweni ayisishiyagalombili okuqala, okubhekwa njengemijikelezo emibili, yokwelashwa
  • ngemuva kwemijikelezo yakho emibili yokwelashwa, umthamo ukhuphukela ku-20 mg we-Empliciti kuwo wonke amakhilogremu wesisindo somzimba wakho, unikezwa kanye njalo emavikini amane

Njengesibonelo sokubala umthamo, umuntu omdala onesisindo esingamakhilogremu angama-70 (cishe amakhilogremu ayi-154) uzothola isilinganiso esingu-700 mg se-Empliciti. Lokhu kubalwa njengamakhilogremu angama-70 ephindaphindwe ngo-10 mg womuthi, olingana no-700 mg we-Empliciti.

Ngenketho yomthamo, uvamise ukuqhubeka nokuthatha i-Empliciti kuze kube yilapho i-myeloma yakho eminingi iba yimbi noma unemiphumela emibi ekhathazayo evela ku-Empliciti.

Kuthiwani uma ngiphuthelwa umthamo?

Uma uphuthelwa i-aphoyintimenti yokufakwa kwakho kwe-Empliciti, hlela enye i-aphoyintimenti ngokushesha okukhulu. Khuluma nodokotela wakho mayelana nendlela engcono yokuhlela amanani akho esikhathi esizayo ukuze ukwazi ukukwenza kube yimizwa yakho.

Qinisekisa ukuthatha umthamo wakho we-dexamethasone njengoba uqondiswe udokotela wakho. Uma uphuthelwa umthamo we-dexamethasone, tshela udokotela wakho ukuthi ukhohliwe ukuwuthatha. Ukukhohlwa umthamo walesi sidakamizwa kungadala ukuthi uphendule ku-Empliciti. Lokhu kwesinye isikhathi kungaba kubi kakhulu.

Ngabe kuzodingeka ngisebenzise lesi sidakamizwa isikhathi eside?

Kwesinye isikhathi ukusebenzisa imishanguzo kungagcina i-myeloma yakho ezinzile (ingabi kubi) isikhathi eside. Uma uthatha i-Empliciti futhi i-myeloma yakho eminingi ayibi kubi, udokotela wakho angancoma ukuthi uhlale ekwelashweni kwe-Empliciti isikhathi eside.

Ezivivinyweni zomtholampilo, ngaphezu kwesigamu sabantu abathatha i-Empliciti babengenakho ukwanda kwe-myeloma yabo eningi ngaphezu kwezinyanga eziyishumi. Isikhathi ozosithatha i-Empliciti sincike ekutheni umzimba wakho uphendula kanjani emithini.

Ezinye izindlela zokusebenzisa i-Empliciti

Ezinye izidakamizwa noma izindlela zokwelapha ziyatholakala ezingelapha i-myeloma eminingi. Ezinye zingakulungela kangcono kunabanye. Uma unentshisekelo yokuthola enye indlela ye-Empliciti, khuluma nodokotela wakho. Bangakutshela ngeminye imithi noma izindlela zokwelashwa ezingakusebenzela kahle.

Izibonelo zezinye izidakamizwa ezingasetshenziswa ukwelapha i-myeloma eminingi zifaka:

  • i-bortezomib (Velcade)
  • i-carfilzomib (Kyprolis)
  • ixazomib (Ninlaro)
  • i-daratumumab (Darzalex)
  • thalidomide (Thalomid)
  • lenalidomide (Revlimid)
  • pomalidomide (Pomalyst)
  • ama-steroids athile, njenge-prednisone noma i-dexamethasone

Ezinye izindlela zokwelashwa ezingasetshenziswa ukwelapha i-myeloma eminingi zifaka:

  • imisebe (isebenzisa imishayo yamandla ukubulala amangqamuzana omdlavuza)
  • ukufakelwa kwe-stem cell

I-Empliciti (elotuzumab) vs. Darzalex (daratumumab)

Ungase uzibuze ukuthi i-Empliciti iqhathanisa kanjani neminye imithi enqunyelwe ukusetshenziswa okufanayo. Lapha sibheka ukuthi i-Empliciti neDarzalex zifana kanjani futhi zehlukile.

Isebenzisa

Kokubili i-Empliciti neDarzalex zivunyelwe yi-Food and Drug Administration (FDA) ukwelapha i-myeloma eminingi kubantu abadala abenza lokhu:

  • Sengizame okungenani izindlela ezimbili zokwelashwa ezedlule ezibandakanya i-lenalidomide (Revlimid) kanye ne-proteasome inhibitor, efana ne-bortezomib (Velcade) noma i-carfilzomib (i-Kyprolis). Kulaba bantu, i-Empliciti noma i-Darzalex isetshenziswa ne-pomalidomide (Pomalyst) ne-dexamethasone.

I-Empliciti nayo ibekelwe abantu abadala:

  • bake bathola ukwelashwa okukodwa kuya kwezintathu esikhathini esidlule ngenxa ye-myeloma yabo eminingi. Kulaba bantu, i-Empliciti isetshenziswa ngokuhlangana ne-lenalidomide (Revlimid) ne-dexamethasone.

I-Darzalex nayo ivunyelwe yi-FDA ukwelapha i-myeloma eminingi kubantu abadala abathathe umuthi owodwa noma ngaphezulu esikhathini esedlule. Kunconywa ukuthi kusetshenziswe ngokwakho futhi kuhlanganiswe nezinye izindlela zokwelapha, ngokuya ngomlando wokwelashwa komuntu ngamunye.

Amafomu wezidakamizwa nokuphathwa

IMpliciti iza njengempuphu. Yenziwe yaba yisixazululo futhi yanikezwa wena njengokufakwa ngomjovo (IV) (umjovo emthanjeni wakho isikhathi esithile). I-Empliciti itholakala ngamandla amabili: 300 mg kanye no-400 mg.

Umthamo wakho we-Empliciti uyehluka ngokuya ngesisindo somzimba wakho kanye neminye imithi oyiphuzayo ne-Empliciti. Ngeminye imininingwane ngemithamo, bheka isigaba esithi “Empliciti dosage” ngenhla.

I-Empliciti ivame ukunikezwa isonto ngalinye ngemijikelezo emibili yokuqala (isamba samasonto ayisishiyagalombili) yokwelashwa. Ngemuva kwalokhu, uzothola i-Empliciti njalo emavikini amabili kuya kwamane, kuya ngokuthi iyiphi imishanguzo oyisebenzisayo ne-Empliciti. Ngeminye imininingwane, sicela ubheke isigaba “Isikali se-Empliciti” ngenhla.

I-Darzalex iza njengesisombululo soketshezi. Iphinde inikezwe njengokufakwa emthanjeni (IV). IDarzalex itholakala ngamandla amabili: 100 mg / 5 mL kanye no-400 mg / 20 mL.

Umthamo wakho weDarzalex nawo uncike esisindweni somzimba wakho. Kodwa-ke, uhlelo lokulinganisa luzohluka ngokuya ngemithi oyisebenzisayo neDarzalex.

I-Darzalex ivame ukunikezwa masonto onke amasonto ayisithupha kuya kwayisishiyagalolunye. Ngemuva kwalokhu, uzothola iDarzalex kanye njalo emavikini amabili kuya kwamane, kuya ngokuthi usisebenzise isikhathi esingakanani.

Imiphumela emibi kanye nezingozi

I-Empliciti ne-Darzalex zombili ziqukethe imishanguzo ekhomba i-myeloma eminingi. Ngakho-ke, yomibili le mithi ingadala imiphumela emibi efanayo. Ngezansi kunezibonelo zale miphumela emibi.

Imiphumela yakho emibi ingahluka ngokuya ngemiphi imishanguzo oyiphuzayo ne-Empliciti noma iDarzalex. Udokotela wakho angachaza imiphumela emibi ejwayelekile ongayithola kuye ngokuthi iyiphi imishanguzo oyiphuzayo.

Imiphumela emibi ejwayelekile

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi ejwayelekile engenzeka nge-Empliciti, neDarzalex, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

  • Kungenzeka nge-Empliciti:
    • inkalakatha yobuso (ukusibilika efeni lens yeso lakho)
    • ubuhlungu emlonyeni noma emphinjeni
    • ubuhlungu bamathambo
  • Kungenzeka ngeDarzalex:
    • ubuthakathaka
    • isicanucanu
    • ukuhlungu obusemhlane
    • isiyezi
    • ukuqwasha (kunzima ukulala)
    • ukwanda komfutho wegazi
    • ubuhlungu obuhlangene
  • Kungenzeka nge-Empliciti ne-Darzalex:
    • ukukhathala (ukungabi namandla)
    • isifo sohudo
    • ukuqunjelwa
    • ukuncipha kokudla
    • imfiva
    • ukukhwehlela
    • ukuhlanza
    • inkinga yokuphefumula
    • ukuphazamiseka kwemisipha
    • ukuvuvukala ezingalweni noma emilenzeni
    • ukwanda kwezinga likashukela egazini
    • ikhanda

Imiphumela emibi kakhulu

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi engaba khona ne-Empliciti, neDarzalex, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

  • Kungenzeka nge-Empliciti:
    • izinkinga zesibindi
    • ukuthuthukisa ezinye izinhlobo zomdlavuza, njengomdlavuza wesikhumba
  • Kungenzeka ngeDarzalex:
    • i-neutropenia (izinga eliphansi lamaseli amhlophe egazi)
    • i-thrombocytopenia (izinga eliphansi leplatelet)
  • Kungenzeka nge-Empliciti ne-Darzalex:
    • ukumnika ukusabela
    • isifo semizwa esiyindilinga (ukulimala kwezinye izinzwa zakho)
    • izifo, njenge-pneumonia

Ukusebenza ngempumelelo

I-Empliciti neDarzalex zombili zivunyelwe ukwelapha i-myeloma eminingi kubantu abadala.

Le mithi ayikaze iqhathaniswe ngqo ezifundweni zokwelashwa. Kepha izifundo ezihlukile zithole ukuthi i-Empliciti neDarzalex iyasebenza ekwelapheni i-myeloma eminingi.

Izindleko

I-Empliciti neDarzalex zombili izidakamizwa zomuthi. Okwamanje azikho izinhlobo ezijwayelekile zomuthi. Imithi enegama lomkhiqizo ivame ukubiza ngaphezu kwama-generic.

Kokubili i-Empliciti neDarzalex zinikezwa njengemithambo yegazi (IV) esikhungweni sokunakekelwa kwezempilo. Inani langempela ozolikhokhela noma imuphi umuthi lizoncika kumshwalense wakho, indawo okuyo, nomtholampilo noma isibhedlela lapho uthola khona ukwelashwa kwakho.

IMpliciti vs. Ninlaro

Ungase uzibuze ukuthi i-Empliciti iqhathanisa kanjani neminye imithi enqunyelwe ukusetshenziswa okufanayo. Lapha sibheka ukuthi i-Empliciti neNinlaro zifana kanjani futhi zehlukile.

Isebenzisa

Kokubili i-Empliciti neNinlaro zivunyelwe yi-Food and Drug Administration (FDA) ukwelapha i-myeloma eminingi.

I-Empliciti inqunyelwe abantu abangena kwesinye sezimo ezimbili zokwelashwa:

  • Abantu abadala abake bathola ukwelashwa okukodwa kuya kwezintathu esikhathini esidlule nge-myeloma yabo eminingi. Kulaba bantu, i-Empliciti isetshenziswa ngokuhlangana ne-lenalidomide (Revlimid) ne-dexamethasone.
  • Abantu abadala asebeke bathola okungenani imishanguzo emibili edlule ye-myeloma ebandakanya i-lenalidomide (Revlimid) ne-proteasome inhibitor, efana ne-bortezomib (Velcade) noma i-carfilzomib (i-Kyprolis). Kulaba bantu, i-Empliciti isetshenziswa ngokuhlangana ne-pomalidomide (Pomalyst) ne-dexamethasone.

UNinlaro uvunyelwe ukwelapha i-myeloma eminingi kubantu abadala abazame okungenani enye indlela yokwelapha esikhathini esedlule. INinlaro ivunyelwe ukusetshenziswa ngokuhlanganiswa ne-lenalidomide (Revlimid) ne-dexamethasone.

Amafomu wezidakamizwa nokuphathwa

IMpliciti iza njengempuphu.Yenziwe yaba yisixazululo futhi yanikezwa wena njengokufakwa ngomjovo (IV) (umjovo emthanjeni wakho isikhathi esithile). I-Empliciti itholakala ngamandla amabili: 300 mg kanye no-400 mg.

Umthamo wakho we-Empliciti uyehluka ngokuya ngesisindo somzimba wakho kanye neminye imithi oyiphuzayo ne-Empliciti. Ngeminye imininingwane ngemithamo, bheka isigaba esithi “Empliciti dosage” ngenhla.

I-Empliciti ivame ukunikezwa masonto onke ngemijikelezo emibili yokuqala (isamba samasonto ayisishiyagalombili) yokwelashwa. Ngemuva kwalokhu, uzothola i-Empliciti njalo emavikini amabili kuya kwamane, kuya ngokuthi iyiphi imishanguzo oyisebenzisayo ne-Empliciti. Ngeminye imininingwane, sicela ubheke isigaba “Isikali se-Empliciti” ngenhla.

UNinlaro uza njengamaphilisi athathwa ngomlomo kanye ngesonto. INinlaro itholakala ngamandla amathathu:

  • 2.3 mg
  • 3 mg
  • 4 mg

Imiphumela emibi kanye nezingozi

I-Empliciti neNinlaro zombili ziqukethe imishanguzo esiza ukuqeda amaseli amaningi e-myeloma. Ngakho-ke, yomibili le mithi ingadala imiphumela emibi efanayo. Ngezansi kunezibonelo zale miphumela emibi.

INinlaro ivunyelwe kuphela ukusetshenziswa ne-lenalidomide (Revlimid) ne-dexamethasone. Kulesi sigaba, siqhathanisa imiphumela emibi yenhlanganisela yokwelashwa kweNinlaro nemiphumela emibi ye-Empliciti nayo ihlanganiswe ne-lenalidomide (Revlimid) ne-dexamethasone.

Imiphumela yakho emibi ingahluka ngokuya ngemiphi imishanguzo oyiphuzayo ne-Empliciti noma i-Ninlaro. Udokotela wakho angachaza imiphumela emibi ejwayelekile ongayithola kuye ngokuthi iyiphi imishanguzo oyiphuzayo.

Imiphumela emibi ejwayelekile

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi ejwayelekile engenzeka nge-Empliciti, neNinlaro, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

  • Kungenzeka ngenhlanganisela yokwelashwa kwe-Empliciti:
    • ukukhathala (ukungabi namandla)
    • imfiva
    • ukukhwehlela
    • ukuncipha kokudla
    • ikhanda
    • inkalakatha yobuso (ukusibilika efeni lens yeso lakho)
    • ubuhlungu emlonyeni wakho
  • Kungenzeka ngenhlanganisela yokwelashwa kukaNinlaro:
    • isicanucanu
    • ukugcinwa koketshezi, okungadala ukuvuvukala
    • ukuhlungu obusemhlane
  • Kungenzeka ngezinhlanganisela zokwelashwa ze-Empliciti ne-Ninlaro:
    • isifo sohudo
    • ukuqunjelwa
    • ukuhlanza

Imiphumela emibi kakhulu

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi engaba khona ne-Empliciti, neNinlaro, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

  • Kungenzeka ngenhlanganisela yokwelashwa kwe-Empliciti:
    • ukumnika ukusabela
    • izifo ezinzima
    • ukuthuthukisa ezinye izinhlobo zomdlavuza
  • Kungenzeka ngenhlanganisela yokwelashwa kukaNinlaro:
    • i-thrombocytopenia (izinga eliphansi leplatelet)
    • ukuqhuma okukhulu kwesikhumba
  • Kungenzeka ngezinhlanganisela zokwelashwa ze-Empliciti ne-Ninlaro:
    • isifo semizwa esiyindilinga (ukulimala kwezinye izinzwa zakho)
    • izinkinga zesibindi

Ukusebenza ngempumelelo

I-Empliciti neNinlaro bobabili bavunyelwe ukwelapha i-myeloma eminingi kubantu abadala.

Le mithi ayikaze iqhathaniswe ngqo ezifundweni zokwelashwa. Kepha izifundo ezihlukile zithole ukuthi i-Empliciti neNinlaro iyasebenza ekwelapheni i-myeloma eminingi.

Izindleko

I-Empliciti neNinlaro yizidakamizwa ezibizwa ngamagama. Okwamanje azikho izinhlobo ezijwayelekile zomuthi. Imithi enegama lomkhiqizo ivame ukubiza ngaphezu kwama-generic.

I-Empliciti inikezwa njenge-infravenous (IV) ukumnika esikhungweni sezempilo. Amaphilisi we-Ninlaro akhishwa ngamakhemisi akhethekile. Inani langempela ozolikhokhela noma imuphi umuthi lincike kumshuwalense wakho, indawo okuyo, nokuthi uthola imishanguzo yakho emtholampilo noma esibhedlela.

I-Empliciti ye-myeloma eminingi

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuvumela imishanguzo kadokotela efana ne-Empliciti ukwelapha i-myeloma eminingi. Lesi simo uhlobo lomdlavuza oluthinta amangqamuzana akho e-plasma. Lawa maseli awuhlobo lwamaseli amhlophe egazi asiza umzimba wakho ukulwa namagciwane nezifo.

Nge-myeloma eminingi, umzimba wakho wenza amangqamuzana e-plasma angavamile. Amaseli e-plasma angajwayelekile, abizwa ngokuthi ama-myeloma cells, aminyanisa amangqamuzana akho e-plasma anempilo. Lokhu kusho ukuthi unamaseli e-plasma ambalwa aphilile angalwa namagciwane. Amaseli we-Myeloma nawo enza iphrotheni ebizwa nge-M protein. Le phrotheni ingakha emzimbeni wakho futhi ilimaze ezinye izitho zakho.

I-Empliciti inqunyelwe abantu abangena kwesinye sezimo ezimbili zokwelashwa:

  • Abantu abadala abake bathola ukwelashwa okukodwa kuya kwezintathu esikhathini esidlule nge-myeloma yabo eminingi. Kulaba bantu, i-Empliciti isetshenziswa ngokuhlangana ne-lenalidomide (Revlimid) ne-dexamethasone.
  • Abantu abadala asebeke bathola okungenani imishanguzo emibili edlule ye-myeloma ebandakanya i-lenalidomide (Revlimid) ne-proteasome inhibitor, efana ne-bortezomib (Velcade) noma i-carfilzomib (i-Kyprolis). Kulaba bantu, i-Empliciti isetshenziswa ngokuhlangana ne-pomalidomide (Pomalyst) ne-dexamethasone.

Ukuphumelela ukwelapha i-myeloma eminingi

Ucwaningo lwezokwelapha luye lwabonisa ukuthi i-Empliciti iyasebenza ekunqandeni ukuqhubekela phambili (okuba kubi kakhulu) kwe-myeloma eminingi. Imiphumela yezinye zalezi zifundo ichazwe ngezansi.

I-Empliciti ene-lenalidomide (i-Revlimid) ne-dexamethasone

Ekuvivinyweni komtholampilo, abantu abane-myeloma eminingi banikezwe i-Empliciti ene-lenalidomide ne-dexamethasone, noma i-lenalidomide ne-dexamethasone kuphela.

Izifundo zikhombise ukuthi abantu abathatha inhlanganisela ye-Empliciti babenobungozi obuphansi bokuthi izifo zabo ziqhubeke. Okungenani okungenani iminyaka emibili, labo abathatha i-Empliciti nge-lenalidomide ne-dexamethasone babenobungozi obuphansi ngama-30% kunabantu ababephuza lezo zidakamizwa ngaphandle kwe-Empliciti.

Kwesinye isifundo esathatha iminyaka emihlanu, abantu abathatha inhlanganisela ye-Empliciti babenengozi ephansi engama-27% yesifo sabo esiba sibi kunabantu abathatha i-lenalidomide ne-dexamethasone bodwa.

I-Empliciti ene-pomalidomide (i-Pomalyst) ne-dexamethasone

Ekuvivinyweni komtholampilo, abantu abane-myeloma eminingi banikezwa i-Empliciti nge-pomalidomide ne-dexamethasone, noma i-pomalidomide ne-dexamethasone kuphela.

Abantu abathatha inhlanganisela ye-Empliciti babenobungozi obuphansi ngama-46% besifo sabo ukuba sibi kakhulu ngemuva kwezinyanga okungenani eziyisishiyagalolunye zokwelashwa, uma kuqhathaniswa nabantu abathatha i-pomalidomide ne-dexamethasone bodwa.

Ukusetshenziswa kwe-Empliciti nezinye izidakamizwa

I-Empliciti inikezwa neminye imithi lapho isetshenziselwa ukwelapha i-myeloma eminingi.

Imithi eminingi ye-myeloma esetshenziswa ne-Empliciti

I-Empliciti isetshenziswa njalo ngokuhlangana ne-steroid ebizwa nge-dexamethasone. Ibuye isetshenziswe njalo ngokuhlanganiswa ne-lenalidomide (Revlimid) noma i-pomalidomide (i-Pomalyst). Ukusebenzisa le mithi nge-Empliciti kusiza umuthi ukuthi uphumelele kakhulu ekwelapheni i-myeloma eminingi.

Imishanguzo yangaphambi kokumnika esetshenziswa ne-Empliciti

Ngaphambi kokuthola ukumnika kwakho okufakwa emthanjeni (IV) kwe-Empliciti, uzothatha ezinye izidakamizwa ezibizwa ngemithi yokwelapha ngaphambi kokufakwa. Le mithi isetshenziselwa ukuvikela imiphumela engemihle (kufaka phakathi ukusabela kokumnika) okubangelwa ukwelashwa kwe-Empliciti.

Uzothola le mithi elandelayo yokufakwa ngaphakathi cishe imizuzu engama-45 kuye kwengu-90 ngaphambi kokwelapha kwakho kwe-Empliciti:

  • I-Dexamethasone. Uzothola u-8 mg we-dexamethasone ngomjovo we-IV.
  • I-Diphenhydramine (iBenadryl). Uzothatha u-25 mg uye ku-50 mg we-diphenhydramine ngaphambi kokufakwa kwakho kwe-Empliciti. I-Diphenhydramine inganikezwa ngomjovo we-intravenous (IV) noma njengethebhulethi ethathwa ngomlomo.
  • I-Acetaminophen (iTylenol). Uzothatha futhi u-650 mg uye ku-1,000 mg we-acetaminophen ngomlomo.

Isebenza kanjani i-Empliciti

I-Multiple myeloma wuhlobo lomdlavuza oluthinta amaseli athile amhlophe egazi abizwa ngamaseli e-plasma. La maseli asiza umzimba wakho ukulwa namagciwane nezifo. Amaseli e-Plasma athinteka yi-myeloma eminingi aba nomdlavuza futhi abizwa ngokuthi amaseli e-myeloma.

I-Empliciti isebenza ohlotsheni oluhlukile lweseli elimhlophe elibizwa nge-natural killer (NK) cell. Amaseli e-NK asebenza emzimbeni wakho ukubulala amaseli angajwayelekile, njengamaseli womdlavuza noma amaseli atheleleke ngamagciwane.

I-Empliciti isebenza ngokwenza (ukuvula) amaseli akho e-NK. Lokhu kusiza amangqamuzana akho e-NK ukuthola amangqamuzana e-plasma angajwayelekile athinteka yi-myeloma eminingi. Amaseli we-NK abese ecekela phansi lawo maseli angajwayelekile. I-Empliciti nayo isebenza ngokuthola amaseli we-myeloma amangqamuzana akho e-NK.

I-Empliciti ibizwa ngomuthi we-immunotherapy. Le mithi isebenza namasosha akho omzimba ukusiza umzimba wakho ukulwa nezimo ezithile.

Kuthatha isikhathi esingakanani ukusebenza?

I-Empliciti iqala ukusebenza emzimbeni wakho ngemuva kokuthola ukumnika kwakho kokuqala. Kodwa-ke, ungahle ungaboni lapho i-Empliciti iqala ukusebenza. Udokotela wakho uzokwazi ukuhlola ukuthi kuyasebenza yini ngokwenza izivivinyo ezithile. Uma unemibuzo mayelana nokuthi i-Empliciti ikusebenzela kanjani, khuluma nodokotela wakho.

IMpliciti notshwala

Akukho ukuxhumana okwaziwayo phakathi kwe-Empliciti notshwala. Noma kunjalo, i-Empliciti ingadala izinkinga zesibindi. Ukuphuza utshwala kungaphazamisa ukusebenza kwesibindi sakho.

Khuluma nodokotela wakho ngaphambi kokuphuza utshwala ngenkathi uthatha i-Empliciti. Bangakweluleka ukuthi ngabe kuphephile yini ukuthi uphuze utshwala ngenkathi usebenzisa lo muthi.

Ukusebenzisana kwe-Empliciti

I-Empliciti ayihlangani ngokuvamile neminye imithi. Kodwa-ke, imithi esetshenziswa ne-Empliciti yaziwa ngokuxhumana nezinye izidakamizwa.

Ukuxhumana okuhlukile kungadala imiphumela ehlukile. Isibonelo, ukuxhumana okuthile kungaphazamisa ukusebenza kwesidakamizwa. Okunye ukuxhumana kungakhuphula imiphumela emibi noma kuyenze ibe nzima kakhulu.

Ukwelashwa kwe-Empliciti nakho kungathinta imiphumela yokuhlolwa okuthile kwelebhu.

Ukuhlolwa kwe-Empliciti nelebhu

I-Empliciti ingathinta imiphumela yokuhlolwa okuthile okusetshenziselwa ukuhlola amaprotheni e-M emzimbeni wakho. Amaprotheni akhiqizwa ngamaseli amaningi e-myeloma. Izinga eliphakeme le-M protein lisho ukuthi umdlavuza wakho usuthuthuke kakhulu.

Udokotela wakho uzo-oda ukuhlolwa ukuze ahlole iprotheni engu-M emzimbeni wakho ngesikhathi sokwelashwa kwe-Empliciti. Lokhu kuvumela udokotela wakho ukuthi abone ukuthi umzimba wakho uphendula kahle kanjani kulowo muthi.

Kodwa-ke, i-Empliciti ingaguqula imiphumela yokuhlolwa kwegazi lakho kwamaprotheni M. Lokhu kungenza kube nzima ngodokotela wakho ukwazi ukuthi i-myeloma yakho eminingi iyathuthuka noma cha. I-Empliciti ingenza kubonakale sengathi unamaprotheni amaningi we-M kunalokho okwenzayo. Ukuze usebenze kulokhu, udokotela wakho anga-oda izivivinyo zelebhu ezingathintwa yi-Empliciti ukuqapha ukwelashwa kwakho.

Okunye ukuxhumana kwezidakamizwa

I-Empliciti ihlala ithathwa nge-dexamethasone futhi kungaba ne-pomalidomide (i-Pomalyst) noma i-lenalidomide (i-Revlimid). Ngenkathi kungekho noma yikuphi ukuxhumana kwezidakamizwa okwaziwayo ne-Empliciti, kunokuxhumana okwaziwayo kwemithi esetshenziswa nayo.

Qiniseka ukuthi uxoxa nodokotela wakho noma usokhemisi nganoma ikuphi ukuxhumana okungenzeka ngokuhlanganiswa kwezidakamizwa ozithathayo.

Inikezwa kanjani i-Empliciti

Kufanele uthathe i-Empliciti ngokuya ngemiyalo kadokotela wakho noma yomhlinzeki wezokunakekelwa kwempilo. I-Empliciti inikezwa ngomjovo we-intravenous (IV), imvamisa ngomthambo osengalweni yakho. Izidakamizwa ezinikezwa ukumnika kwe-IV zinikezwa kancane kancane esikhathini esithile. Kungathatha ihora noma ngaphezulu ukuthola umthamo wakho ogcwele we-Empliciti.

I-Empliciti inikezwa kuphela ehhovisi likadokotela noma emtholampilo wezempilo. Ngenkathi uthola ukumnika kwakho, uzobhekelwa ukusabela okweqile noma ukusabela kokumnika.

Ukuthatha nini

I-Empliciti inikezwa ngomjikelezo wokwelashwa wezinsuku ezingama-28. Uwuphuza kaningi kangakanani umuthi kuya ngeminye imithi oyiphuzayo ne-Empliciti. Uhlelo olujwayelekile lokuthi uzothatha nini i-Empliciti lumi kanje:

  • Uma uthatha i-Empliciti nge-lenalidomide (Revlimid) ne-dexamethasone, uzothola i-Empliciti kanye ngesonto ngemijikelezo emibili yokuqala (isamba samasonto ayisishiyagalombili) yokwelashwa. Ngemuva kwalokho, uzothola i-Empliciti kanye njalo ngesonto.
  • Uma uthatha i-Empliciti nge-pomalidomide (Pomalyst) ne-dexamethasone, uzophinda uthole i-Empliciti kanye ngesonto ngemijikelezo emibili yokuqala (amasonto ayisishiyagalombili esewonke) okwelashwa. Ngemuva kwalokho, uzothola i-Empliciti kanye njalo emjikelezweni, okungumthamo owodwa njalo emavikini amane.

Udokotela wakho uzoqapha ukwelashwa kwakho futhi anqume ukuthi mingaki imijikelezo ephelele ye-Empliciti oyodinga.

I-Empliciti nokukhulelwa

Akuzange kube khona noma yiziphi izifundo ze-Empliciti kwabesifazane abakhulelwe. Izifundo zezilwane ekukhulelweni nazo azikenziwa ngalesi sidakamizwa.

Kodwa-ke, i-lenalidomide (i-Revlimid) ne-pomalidomide (i-Pomalyst), ngayinye esetshenziswa ne-Empliciti, ingadala ingozi enkulu kumbungu okhulayo. Le mithi akufanele isetshenziswe ngesikhathi sokukhulelwa. Ukusebenzisa le mithi ngesikhathi sokukhulelwa kungadala ukukhubazeka okukhulu kokuzalwa noma ukukhulelwa kwesisu.

Ngoba i-Empliciti ivunyelwe kuphela ukusetshenziswa ne-lenalidomide (i-Revlimid) noma i-pomalidomide (i-Pomalyst), i-Empliciti nayo kufanele igwenywe ngesikhathi sokukhulelwa. Abantu abathatha i-Empliciti kufanele basebenzise ukulawulwa kokuzalwa uma kudingeka. Bheka isigaba esilandelayo esithi, “Empliciti and birth control,” ukuthola eminye imininingwane.

Uma unemibuzo mayelana nokusebenzisa i-Empliciti ngesikhathi sokukhulelwa, khuluma nodokotela wakho.

I-Empliciti nokulawulwa kokuzalwa

Akwaziwa ukuthi i-Empliciti iphephile yini ukuyithatha ngesikhathi sokukhulelwa.

Kodwa-ke, i-lenalidomide (i-Revlimid) ne-pomalidomide (i-Pomalyst), ngayinye esetshenziswa ne-Empliciti, ingadala ingozi enkulu kumbungu okhulayo. Le mithi akufanele isetshenziswe ngesikhathi sokukhulelwa. Ngoba i-Empliciti ivunyelwe kuphela ukusetshenziswa ne-lenalidomide noma i-pomalidomide, i-Empliciti nayo kufanele igwenywe ngesikhathi sokukhulelwa.

Ngenxa yalokhu, kuye kwenziwa uhlelo olukhethekile lokusiza ukuvimbela ukukhulelwa kubantu abasebenzisa le mithi. Lolu hlelo lubizwa ngohlelo lweRisk Evaluation and Mitigation Strategy (REMS).

Bobabili abesifazane nabesilisa abasebenzisa i-Empliciti kumele bavume futhi balandele imiyalo ye-Revlimid REMS noma i-Pomalyst REMS. Uzolandela uhlelo lwe-REMS nganoma imiphi imithi oyiphuzayo ne-Empliciti. Uhlelo ngalunye lunezidingo ezithile okufanele zilandelwe ukuze uqhubeke nokuthatha i-lenalidomide noma i-pomalidomide.

Ngaphezu kokudinga abantu abathatha i-Empliciti ukuthi basebenzise ukulawulwa kokuzalwa, uhlelo lwe-REMS ludinga nokuthi:

  • ukuhlolwa njalo kokukhulelwa, uma ungowesifazane usebenzisa umuthi
  • vuma ukunganikeli nganoma yiliphi igazi noma isidoda ngenkathi usebenzisa umuthi

Ukulawulwa kokuzalwa kwabesifazane

Uma ungabesifazane abakwaziyo ukukhulelwa, kuzodingeka ukuthi ube nokuhlolwa kokukhulelwa okungabili ngaphambi kokuqala ukusebenzisa i-lenalidomide noma i-pomalidomide.

Ngenkathi uthatha noma imuphi wale mithi, kuzodingeka usebenzise izindlela ezimbili zokulawula ukubeletha noma uyeke ukuya ocansini ngesikhathi sokwelashwa. Kufanele uqhubeke usebenzisa ukulawulwa kokuzalwa noma ugweme ukuya ocansini okungenani amasonto amane ngemuva kokuyeka ukwelashwa.

Ukulawulwa kokuzalwa kwabesilisa

Uma uyindoda ethatha i-Empliciti nge-lenalidomide noma i-pomalidomide, futhi wenza ucansi nabesifazane abakwaziyo ukukhulelwa, kuzodingeka usebenzise izilawuli zokubeletha (njengamakhondomu) ngesikhathi sokwelashwa. Lokhu kubalulekile ukukwenza noma ngabe umlingani wakho esebenzisa ukuvikela inzalo. Kufanele uqhubeke usebenzisa ukulawulwa kokubeletha okungenani amasonto amane ngemuva kokuyeka ukwelashwa.

I-Empliciti nokuncelisa ibele

Azikho izifundo ezibonisa ukuthi ngabe i-Empliciti idlulela obisini lwebele lomuntu noma uma ibanga noma yimuphi umphumela enganeni encelayo.

Futhi akwaziwa ukuthi i-lenalidomide (Revlimid) ne-pomalidomide (i-Pomalyst) ingadala noma imiphi imiphumela ezinganeni. Kodwa-ke, ngenxa yengozi yemiphumela emibi ezinganeni, ukuncelisa ibele kufanele kugwenywe ngenkathi uthatha i-Empliciti.

Imibuzo ejwayelekile mayelana ne-Empliciti

Nazi izimpendulo zemibuzo ebuzwa njalo mayelana ne-Empliciti.

Ingabe i-Empliciti chemotherapy?

Cha, i-Empliciti ayithathwa njenge-chemotherapy (imithi yendabuko esetshenziselwa ukwelapha umdlavuza). I-Chemotherapy isebenza ngokubulala amaseli emzimbeni wakho aphindaphindiwe ngokushesha (enza amaseli amaningi). Yize lokhu kubulala amangqamuzana omdlavuza, kungabulala namanye amaseli aphilile.

Ngokungafani ne-chemotherapy ejwayelekile, i-Empliciti iyindlela yokwelashwa ehlosiwe. Lolu hlobo lomuthi lusebenza kumaseli athile (abizwa ngokuthi amaseli wemvelo abulala), ukukhomba amangqamuzana omdlavuza. Ngoba i-Empliciti ihlose iqembu elikhethekile lamaseli, alithinti amaseli akho enempilo kakhulu. Lokhu kusho ukuthi kungadala imiphumela emibi embalwa kune-chemotherapy ejwayelekile.

Kuzokwenzekani ekwelashweni kwami ​​kwe-Empliciti?

I-Empliciti inikezwa njenge-infravenous (IV) ukumnika (umjovo emthanjeni wakho isikhathi esithile). IV ivame ukufakwa engalweni yakho.

Ngokuvamile uzothola umthamo owodwa we-Empliciti isonto ngalinye kumijikelezo emibili yokuqala yokwelashwa. (Umjikelezo ngamunye izinsuku ezingama-28.) Ngemuva kwalokho, ungathola ukumnika kanye njalo emavikini amabili noma kanye njalo emavikini amane. Le ngxenye yesheduli yakho yokuncipha incike ekutheni imiphi imithi oyiphuzayo ne-Empliciti.

Ubude besikhathi ukumenyezelwa ngakunye kuthatha kuye ngesisindo somzimba wakho nokuthi mingaki imithamo ye-Empliciti osuyitholile.

Ngemuva komthamo wakho wesibili we-Empliciti, ukumnika kwakho akufanele kuthathe isikhathi esingaphezu kwehora elilodwa. Kungaba usizo ukuletha okuthile okufanele ukwenze ngesikhathi sokumunyelwa kwakho ukwenza isikhathi sidlule ngokushesha okukhulu. Isibonelo, ungaletha nencwadi noma umagazini ozowufunda noma umculo ozowulalela.

Ngaphambi kokuthola ukumnika kwakho i-Empliciti, uzothola ezinye izidakamizwa ezizosiza ukuvimbela imiphumela ethile emibi, efaka ukusabela kokumnika. Le mithi ibizwa ngemithi yangaphambi kokufakwa.

Imithi yokwelashwa ngaphambi kokumnika oyonikezwa ngaphambi kokufakwa kwakho kwe-Empliciti yile:

  • i-diphenhydramine (iBenadryl)
  • dexamethasone
  • i-acetaminophen (iTylenol)

Ngizokwazi kanjani ukuthi i-Empliciti iyangisebenzela?

I-Empliciti isebenza ngokusiza amasosha akho omzimba ukulwa namaseli amaningi e-myeloma. Udokotela wakho angabheka ukuthi amasosha omzimba wakho asabela kahle kanjani ekwelashweni ngoku-oda ukuhlolwa ukuhlola amaprotheni akwa-M.

Amaprotheni akhiqizwa ngamaseli amaningi we-myeloma. Lawa maprotheni angakha emzimbeni wakho futhi abangele ukulimala kwezinye izitho zakho. Izinga eliphakeme le-M protein liyabonakala kubantu abane-myeloma eminingi ethuthukile.

Udokotela wakho angahlola amazinga akho amaprotheni M ukubona ukuthi uphendula kahle kangakanani ekwelashweni. Amazinga wamaprotheni M angahlolwa ngokubheka isampula yegazi noma umchamo.

Udokotela wakho futhi angaqapha impendulo yakho ekwelashweni ngoku-oda ukuskena kwamathambo. Lokhu kuskena kuzokhombisa uma unezinguquko ezithile zamathambo ezibangelwa i-myeloma eminingi.

Ingabe ukusebenzisa i-Empliciti kungangenza ngibe nezinye izinhlobo zomdlavuza?

Kungenzeka. Ukusebenzisa i-Empliciti ukwelapha i-myeloma eminingi kungandisa ingozi yokuba nezinye izinhlobo zomdlavuza.

Ezivivinyweni zokwelashwa, u-9% wabantu abathatha i-Empliciti nge-lenalidomide (Revlimid) ne-dexamethasone bahlakulela olunye uhlobo lomdlavuza. Kubantu abathatha i-lenalidomide ne-dexamethasone kuphela, ama-6% abe nomphumela ofanayo. Izinhlobo zomdlavuza ezavela kwaba ngumdlavuza wesikhumba kanye nezicubu eziqinile, njengomdlavuza webele noma wendlala.

Futhi ezivivinyweni zokwelashwa, u-1.8% wabantu abathatha i-Empliciti nge-pomalidomide (i-Pomalyst) ne-dexamethasone bathuthukisa olunye uhlobo lomdlavuza. Kubantu abathatha i-pomalidomide ne-dexamethasone kuphela, akekho noyedwa owathola olunye uhlobo lomdlavuza.

Ngesikhathi sokwelashwa ne-Empliciti, udokotela wakho angalawula ukuhlolwa kwegazi okwengeziwe noma amaskeni wokukuqapha nganoma yimiphi imidlavuza emisha ekhulayo.

Izinyathelo zokuqapha ze-Empliciti

Ngaphambi kokuthatha i-Empliciti, khuluma nodokotela wakho ngomlando wakho wezempilo. I-Empliciti kungenzeka ingakulungeli uma unezimo ezithile zezempilo. Lokhu kufaka phakathi:

  • Ukukhulelwa. Akwaziwa ukuthi i-Empliciti iyingozi kumbungu okhulayo. Kodwa-ke, i-Empliciti isetshenziswa neleneralomide (Revlimid) noma pomalidomide (Pomalyst). Yomibili le mithi yaziwa ngokudala ukukhubazeka kokuzalwa. Ngenxa yalokhu, abantu abathatha i-lenalidomide noma i-pomalidomide kufanele basebenzise ukulawulwa kokuzalwa ukuvimbela ukukhulelwa ngenkathi besebenzisa le mithi. Ngeminye imininingwane, sicela ubheke isigaba “Empliciti and pregnancy” ngenhla.
  • Ukuncelisa ibele. Akwaziwa ukuthi ngabe i-Empliciti idlulela ebeleni lomuntu. Kodwa-ke, ngenxa yengozi yemiphumela emibi ezinganeni, ukuncelisa ibele kufanele kugwenywe ngenkathi uthatha i-Empliciti. Ngeminye imininingwane, sicela ubheke isigaba “Empliciti kanye nokuncelisa ibele” ngenhla.
  • Ukutheleleka kwamanje. Akufanele uqale ukuthatha i-Empliciti uma unesifo esisebenzayo. Lokhu kufaka umkhuhlane ovamile, umkhuhlane, noma okunye ukutheleleka kwamagciwane kanye negciwane. Udokotela wakho angancoma ukuthi uqale i-Empliciti ngemuva kokuthi welashelwe noma yikuphi ukutheleleka. Lokhu kungenxa yokuthi i-Empliciti ingawenza buthaka amasosha akho omzimba, okwenza kube nzima ukulwa nokutheleleka.

Qaphela: Ukuthola eminye imininingwane ngemiphumela emibi engaba khona ye-Empliciti, bheka isigaba "se-Empliciti side effects" ngenhla.

Imininingwane yobuchwepheshe ye-Empliciti

Imininingwane elandelayo inikezwa odokotela nabanye ochwepheshe bezempilo.

Izinkomba

I-Empliciti ikhonjisiwe ukwelapha i-myeloma eminingi kubantu abangena kwesinye salezi zimo ezimbili zokwelashwa:

  • Abantu abadala abake bathola ukwelashwa okukodwa kuya kokuthathu. Kulaba bantu, i-Empliciti isetshenziswa ne-lenalidomide (Revlimid) ne-dexamethasone.
  • Abantu abadala asebethole okungenani izindlela zokwelashwa ezimbili ezibandakanya i-lenalidomide (Revlimid) kanye nanoma iyiphi i-proteasome inhibitor. Kulaba bantu, i-Empliciti isetshenziswa ne-pomalidomide (Pomalyst) ne-dexamethasone.

I-Empliciti ayikhonjisiwe ukuthi ingasetshenziswa kubantu abangaphansi kweminyaka engu-18 ubudala.

Indlela yokusebenza

I-Empliciti iyi-antibody ye-IgG1 monoclonal eyi-immunostimulatory. IMpliciti isebenza ngokukhomba ilunga lomndeni we-Signaling Lymphocytic Activation Molecule Family (SLAMF7).

I-SLAMF7 ayivezwa kuphela kumaseli we-killer wemvelo (NK) namaseli e-plasma egazini, kepha futhi nakumaseli amaningi e-myeloma. I-Empliciti isebenza ngokwenza lula ukubhujiswa kwamangqamuzana e-myeloma ngokusebenzisa i-cytotoxicity yeselula ethembele ku-antibody (ADCC). Le ndlela isebenza ngenxa yokuxhumana phakathi kwamaseli e-NK namaseli atheleleke nge-myeloma. Olunye ucwaningo lukhombisa ukuthi i-Empliciti nayo ingasiza ekuvuseleleni amaseli we-NK, bese efuna futhi aqede amaseli we-myeloma.

I-Pharmacokinetics ne-metabolism

Ukususwa kwe-Empliciti kuyanda njengoba isisindo somzimba sikhuphuka. I-Empliciti ikhombise i-non-linear pharmacokinetics, lapho ukwanda komthamo kubangele ukuvezwa okukhulu komuthi kunalokho obekubikezelwe.

Izimo

I-Empliciti ayinakho ukuphikisana okuthile. Kodwa-ke, kufanele kugwenywe kwabesifazane abakhulelwe lapho bethathwa njengoba kukhonjisiwe, okubandakanya ukusetshenziswa kwe-pomalidomide noma i-lenalidomide.

Isitoreji

I-Empliciti iyatholakala njenge-300 mg noma i-400 mg ye-powder e-lyophilized in a single-use vial. Impuphu kumele yenziwe kabusha futhi ihlanjululwe ngaphambi kokuba inikezwe.

I-Empliciti powder kufanele igcinwe esiqandisini (ezingeni lokushisa lika-36 ° F kuye ku-46 ° F / 2 ° C kuye ku-8 ° C) futhi ivikelwe ekukhanyeni. Ungafrizi noma unyakazise izitsha.

Lapho i-powder isakhiwe kabusha, isixazululo kufanele sifakwe kungakapheli amahora angama-24. Ngemuva kokuxuba, uma ukumnika kungasetshenziswanga khona manjalo, kufanele futhi kufakwe esiqandisini okuvikelwe ekukhanyeni. Isixazululo se-Empliciti kufanele sigcinwe amahora angama-8 (wamahora angama-24 esewonke) ekamelweni lokushisa nasekamelweni lokukhanya.

Ukuzikhulula: IMedical News Namuhla yenze yonke imizamo yokuqinisekisa ukuthi yonke imininingwane iyiqiniso, iphelele futhi ihambisana nesikhathi. Kodwa-ke, le ndatshana akufanele isetshenziswe njengokungena esikhundleni solwazi nobungoti bochwepheshe bezokunakekelwa kwezempilo onelayisense. Kufanele uhlale uthintana nodokotela wakho noma omunye uchwepheshe wezokunakekelwa kwempilo ngaphambi kokuthatha noma imuphi umuthi. Imininingwane yezidakamizwa equkethwe lapha ingashintsha futhi ayihloselwe ukumboza konke ukusetshenziswa okungaba khona, izinkomba, izixwayiso, izexwayiso, ukuxhumana kwezidakamizwa, ukungezwani komzimba, noma imiphumela emibi. Ukungabikho kwezixwayiso noma olunye ulwazi lomuthi othile awukhombisi ukuthi inhlanganisela yezidakamizwa noma yezidakamizwa iphephile, iyasebenza, noma ilungele zonke iziguli noma konke ukusetshenziswa okuthile.

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