Yini i-sclerosteosis nokuthi kungani kwenzeka

-Delile

• Izimpawu eziyinhloko
• Kungani kwenzeka
• Yelashwa kanjani

I-Sclerosis, eyaziwa nangokuthi isifo se-granite bone, ukuguquka kwezakhi zofuzo okungajwayelekile okubangela ukwanda kwamathambo. Lokhu kuguquka kubangela ukuthi amathambo, esikhundleni sokuncipha kobuningi eminyakeni edlule, akhule aqine futhi abe namandla, abe namandla kune-granite.

Ngakho-ke, i-sclerosteosis ivimbela ukuqala kwezifo zamathambo ezifana ne-osteoporosis, kodwa ibangela ezinye izinguquko, njengokukhuphuka kwengcindezi ngaphakathi kogebhezi, okuthi uma lungelashwa lungasongela impilo.

Izimpawu eziyinhloko

Uphawu oluyinhloko lwe-sclerosteosis ukukhula kwamathambo, noma kunjalo, kunezimpawu ezithile ezingakuxwayisa ngalesi sifo, njenge:

• Ukuhlangana kweminwe emi-2 noma emi-3 ezandleni;
• Izinguquko kusayizi nobukhulu bekhala;
• Ukukhula okweqile kogebhezi nethambo lobuso;
• Kunzima ukuhambisa imisipha ethile yobuso;
• Umunwe wawugobile ubheke phansi;
• Ukungabikho kwezipikili eminwe;
• Ukuphakama okungaphezu kwesilinganiso somzimba.

Njengoba kuyisifo esingajwayelekile neze, ukuxilongwa kwaso kuyinkimbinkimbi ngakho-ke, udokotela kungadingeka ukuthi ahlole zonke izimpawu nomlando womtholampilo, futhi enze izivivinyo eziningana, ezinjenge-bone densimetry, ngaphambi kokuphakamisa ukuxilongwa kwe-sclerosteosis.

Kwezinye izimo, kungahlolwa nokuhlolwa kofuzo okuzohlola i-DNA nokuguquka kwezakhi zofuzo okungenzeka, futhi kungasiza ekuboneni ushintsho kuhlobo lwe-SOST, olubangela lesi sifo.

Kungani kwenzeka

Isizathu esiyinhloko se-sclerosteosis ukuguqulwa okwenzeka kuhlobo lwe-SOST futhi okwehlisa isenzo se-sclerostin, iphrotheni elibhekele ukwehla kwamathambo futhi okwandisa impilo yonke.

Imvamisa, lesi sifo sivela kuphela uma kunamakhophi amabili aguqukile esakhiweni, kepha abantu abanekhophi eyodwa bangaba namathambo aqinile ngokwedlulele kanye nengozi ephansi yezifo zamathambo ezifana ne-osteoporosis noma i-osteopenia.

Yelashwa kanjani

Alikho ikhambi le-sclerosteosis, ngakho-ke, ukwelashwa kwalo kwenziwa kuphela ukukhulula ezinye izimpawu nokukhubazeka okungavela ekukhuleni kwamathambo ngokweqile.

Enye yezindlela zokwelashwa ezisetshenziswa kakhulu ukuhlinzwa, okungasiza ekunciphiseni imizwa yobuso futhi kutholakale ukunyakaza kwemisipha yobuso, noma ukususa ithambo eleqile ukwehlisa ingcindezi ngaphakathi kogebhezi, ngokwesibonelo.

Ngakho-ke, ukwelashwa kufanele kuxoxwe ngakho njalo nodokotela ukuze abheke ukuthi ngabe kukhona yini ushintsho olungaba yingozi empilweni noma olwehla kwekhwalithi yempilo, futhi olungalungiswa.