I-Spironolactone (Aldactone)

-Delile

• Yenzelwe ini
• Ungathatha kanjani
• 1. Umfutho wegazi ophezulu obalulekile
• 2. Ukwehluleka Kwenhliziyo Yesibopho
• 3. Isibindi sokuqina kwesibindi
• 4. I-Nephrotic Syndrome
• 5. I-Edema
• 6. I-Hypokalemia / hypomagnesaemia
• 7. Ukwelashwa kokuhlinzwa kwe-Primary Hyperaldosteronism
• 8.Umfutho wegazi ophezulu obulalayo
• Indlela yokusebenza
• Imiphumela emibi engaba khona
• Izimo

I-Spironolactone, eyaziwa ngokuthengisa njenge-Aldactone, isebenza njenge-diuretic, ikhulisa ukuqedwa kwamanzi ngomchamo, futhi njenge-antihypertensive, futhi ingasetshenziswa ekwelapheni umfutho wegazi ophakeme, ukuvuvukala okuhlobene nezinkinga ekusebenzeni kwenhliziyo noma izifo kwesibindi nezinso, i-hypokalemia noma ekwelapheni i-hyperaldosteronism, isibonelo.

Kwezinye izimo, leli khambi lingabekwa ekwelapheni induna nokuvimbela ukulahleka kwezinwele, kepha lezi zinhlelo zokusebenza aziyona ingxenye yezinkomba eziyinhloko ze-spironolactone, futhi azikhulunywa kufakwa iphakheji.

I-Spironolactone ingathengwa emakhemisi, ngentengo engama-reais ayi-14 kuye kwangama-45, kuya ngokuthi umuntu ukhetha uphawu noma uhlobo olujwayelekile, oludinga ukwethulwa kwencwadi kadokotela.

Yenzelwe ini

I-Spironolactone ikhonjisiwe:

• Umfutho wegazi ophezulu obalulekile;
• I-Edema ebangelwa izinkinga zenhliziyo, izinso noma isibindi;
• I-ediopathic edema;
• Ukwelashwa okusizayo ku-hypertension ebulalayo;
• I-Hypokalemia lapho ezinye izinyathelo zithathwa njengezingalungile noma ezinganele;
• Ukuvimbela i-hypokalemia ne-hypomagnesaemia kubantu abathatha isisu;
• Ukuxilongwa nokwelashwa kwe-hyperaldosteronism.

Funda ngezinye izinhlobo ze-diuretics futhi ufunde ukuthi zisebenza kanjani.

Ungathatha kanjani

Umthamo uncike enkingeni ezolashwa:

1. Umfutho wegazi ophezulu obalulekile

Umthamo ojwayelekile ungama-50 mg / ngosuku uye ku-100 mg / ngosuku, okungathi ezimweni eziphikisayo noma ezinzima zingakhuphuka kancane kancane, ngezikhathi zamasonto amabili, kuze kufike ku-200 mg / ngosuku. Ukwelashwa kufanele kuqhutshwe okungenani amasonto amabili ukuqinisekisa impendulo eyanele ekwelashweni. Umthamo kufanele ulungiswe lapho kudingeka.

2. Ukwehluleka Kwenhliziyo Yesibopho

Umthamo wansuku zonke onconywayo ungu-100 mg kumthamo owodwa noma ohlukanisiwe, ongahluka phakathi kuka-25 mg no-200 mg nsuku zonke. Umthamo ojwayelekile wesondlo kufanele unqunyelwe umuntu ngamunye.

3. Isibindi sokuqina kwesibindi

Uma isilinganiso se-potassium sodium / urinary pottery sikhulu kune-1, isilinganiso esivamile singu-100 mg / ngosuku. Uma lesi silinganiso singaphansi kuka-1, umthamo onconyiwe ungama-200 mg / ngosuku kuya ku-400 mg / ngosuku. Umthamo ojwayelekile wesondlo kufanele unqunyelwe umuntu ngamunye.

4. I-Nephrotic Syndrome

Umthamo ojwayelekile kubantu abadala yi-100 mg / ngosuku kuya ku-200 mg / ngosuku.

5. I-Edema

Umthamo ojwayelekile ungu-100 mg ngosuku kubantu abadala futhi cishe u-3.3 mg ngekhilogremu ngayinye yesisindo esilawulwa kumthamo we-fractional. Umthamo kufanele ulungiswe ngokuya ngempendulo nokubekezelela komuntu ngamunye.

6. I-Hypokalemia / hypomagnesaemia

Kunconywa umthamo ka-25 mg / ngosuku kuya ku-100 mg / ngosuku ekwelapheni i-hypopotassemia kanye / noma i-hypomagnesemia eyenziwe ngama-diuretics, lapho izithako zomlomo ze-potassium kanye / noma i-magnesium zinganele.

7. Ukwelashwa kokuhlinzwa kwe-Primary Hyperaldosteronism

Lapho ukuxilongwa kwe-hyperaldosteronism kusungulwe kahle ngokuhlolwa okucacile, i-spironolactone ingalawulwa ngemithamo yansuku zonke ka-100 mg kuye ku-400 mg ukulungiselela ukuhlinzwa.

8.Umfutho wegazi ophezulu obulalayo

Kufanele isetshenziswe kuphela njengokwelashwa okusizayo futhi lapho kukhona uketshezi oluningi lwe-aldosterone, i-hypokalemia kanye ne-metabolic alkalosis. Umthamo wokuqala ngu-100 mg / ngosuku, ongakhuphuka, uma kunesidingo, ngezikhathi zamasonto amabili, kuze kufike ku-400 mg / ngosuku.

Indlela yokusebenza

I-Spironolactone ingumphikisi othile we-aldosterone, osebenza kakhulu endaweni yokushintshana ye-aldosterone ne-potassium ion exchange, etholakala kwishubhu esichazwe kude leso, okuholela ekwandisweni kokuqedwa kwe-sodium namanzi nokwanda kokugcinwa kwe-potassium.

Imiphumela emibi engaba khona

Eminye imiphumela emibi ye-spironolactone ingabandakanya i-benign breast neoplasm, i-leukopenia, i-thrombocytopenia, ukuphazamiseka kwe-electrolyte, izinguquko ku-libido, ukudideka, isiyezi, ukuphazamiseka kwamathumbu kanye nesicanucanu, ukusebenza kwesibindi okungavamile, i-Steve-Johnson syndrome, i-epidermal necrolysis enobuthi, ukuqubuka kwezidakamizwa, izinwele ukulahlekelwa, i-hypertrichosis, ukulunywa, isifuba, amajaqamba emilenzeni, ukwehluleka okukhulu kwezinso, ubuhlungu besifuba, ukuphazamiseka kokuya esikhathini, i-gynecomastia ne-malaise.

Izimo

I-Spironolactone akufanele isetshenziswe ngabantu abazwela ngokweqile ezingxenyeni zefomula, abantu abanokwehluleka okukhulu kwezinso, ukukhubazeka okukhulu kokusebenza kwezinso, i-anuria, isifo se-Addison, i-hyperkalaemia noma abasebenzisa umuthi obizwa nge-eplerenone.