Konke Owafuna Ukwazi Nge-SGLT2 Inhibitors

-Delile

• Yiziphi izinhlobo ezahlukahlukene ze-SGLT2 inhibitors?
• Uthathwa kanjani lo muthi?
• Ziyini izinzuzo ezingaba khona zokuthatha i-SGLT2 inhibitor?
• Ziyini izingozi ezingaba khona kanye nemiphumela emibi yokuthatha lo muthi?
• Kuphephile ukuhlanganisa lolu hlobo lomuthi nezinye izidakamizwa?
• Ukuthatha

Ukubuka konke

Ama-inhibitors e-SGLT2 ayisigaba semithi esetshenziselwa ukwelapha uhlobo lwesifo sikashukela sohlobo 2. Babizwa nangokuthi i-sodium-glucose transport protein 2 inhibitors noma ama-gliflozins.

Ama-inhibitors e-SGLT2 avimbela ukubuyiswa kabusha kwe-glucose egazini elihlungwe ngezinso zakho, ngakho-ke kusiza ukukhishwa kwe-glucose emchameni. Lokhu kusiza ukunciphisa amazinga kashukela egazini lakho.

Funda ukuze ufunde kabanzi mayelana nezinhlobo ezahlukahlukene ze-SGLT2 inhibitors, kanye nezinzuzo ezingaba khona nezingozi zokwengeza lolu hlobo lomuthi ohlelweni lwakho lokwelashwa.

Yiziphi izinhlobo ezahlukahlukene ze-SGLT2 inhibitors?

Kuze kube manje, i-U.S. Food and Drug Administration (FDA) ivume izinhlobo ezine ze-SGLT2 inhibitors ukwelapha uhlobo lwesifo sikashukela sohlobo 2:

• i-canagliflozin (i-Invokana)
• dapagliflozin (Farxiga)
• empagliflozin (Jardiance)
• i-ertugliflozin (Steglatro)

Ezinye izinhlobo ze-SGLT2 inhibitors ziyakhiwa futhi zihlolwe ekuhlolweni kwemitholampilo.

Uthathwa kanjani lo muthi?

Ama-SGLT2 inhibitors yimithi yokwelapha ngomlomo. Atholakala efomini lamaphilisi.

Uma udokotela wakho engeza i-SGLT2 inhibitor ohlelweni lwakho lokwelashwa, bazokweluleka ukuthi uyithathe kanye noma kabili ngosuku.

Kwezinye izimo, udokotela wakho angahle anikeze i-SGLT2 inhibitor kanye neminye imithi yesifo sikashukela. Isibonelo, lesi sigaba semithi singahlanganiswa ne-metformin.

Inhlanganisela yemithi yesifo sikashukela ingakusiza ugcine izinga likashukela egazini lakho ku-target range. Kubalulekile ukuthatha umthamo ofanele womuthi ngamunye ukuze unqande izinga likashukela egazini lakho ukuba lehle kakhulu.

Ziyini izinzuzo ezingaba khona zokuthatha i-SGLT2 inhibitor?

Uma uthathwe wedwa noma ngeminye imithi yesifo sikashukela, ama-SGLT2 inhibitors angasiza ukwehlisa amazinga kashukela egazini lakho. Lokhu kunciphisa amathuba akho okuba nezinkinga ezivela kuhlobo 2 sikashukela.

Ngokuya ngocwaningo lwango-2018 olushicilelwe ephephabhukwini iDiabetes Care, ososayensi babika ukuthi ama-SGLT2 inhibitors nawo angakhuthaza ukwehla kwesisindo nokuthuthuka okuncane kumfutho wegazi kanye namazinga egazi egazini.

Ukubuyekezwa kwango-2019 kutholakale ukuthi ama-SGLT2 inhibitors axhumene nengozi ephansi yokushaywa unhlangothi, isifo senhliziyo, nokufa okubangelwa yisifo senhliziyo kubantu abanesifo sikashukela sohlobo 2 kanye nemithambo eqinile.

Ukubuyekezwa okufanayo kuthole ukuthi ama-SGLT2 inhibitors anganciphisa ukukhula kwesifo sezinso.

Khumbula, izinzuzo ezingaba khona ze-SGLT2 inhibitors ziyahlukahluka kuye ngomuntu, kuya ngomlando wazo wezokwelapha.

Ukuze ufunde kabanzi ngalolu hlobo lwemithi, nokuthi ngabe ilulungele yini uhlelo lwakho lokwelashwa, khuluma nodokotela wakho.

Ziyini izingozi ezingaba khona kanye nemiphumela emibi yokuthatha lo muthi?

Ama-inhibitors e-SGLT2 ngokuvamile abhekwa njengaphephile, kepha kwezinye izimo, angadala imiphumela emibi.

Isibonelo, ukuthatha lolu hlobo lomuthi kungakhuphula ubungozi bokuthuthuka:

• izifo zomgudu womchamo
• izifo ezithathelwana ngocansi ezingekho ocansini, njengezifo zemvubelo
• i-ketoacidosis yesifo sikashukela, edala ukuthi igazi lakho libe ne-asidi
• i-hypoglycemia, noma ushukela wegazi ophansi

Ezimweni ezingavamile, ukutheleleka okungathí sina ngokobulili kuye kwaba kubantu abathatha i-SGLT2 inhibitors. Lolu hlobo lokutheleleka lwaziwa njenge-necrotizing fasciitis noma i-Fournier's gangrene.

Olunye ucwaningo luphakamisa nokuthi i-canagliflozin ingakhuphula ubungozi bokuphuka kwamathambo. Le miphumela emibi ayixhunywanga kwamanye ama-SGLT2 inhibitors.

Udokotela wakho angakwazisa kabanzi ngobungozi obungaba khona bokuthatha i-SGLT2 inhibitors. Futhi zingakusiza ufunde ukuthi ungabona kanjani futhi uphathe noma yimiphi imiphumela emibi engaba khona.

Uma ucabanga ukuthi kungenzeka ukuthi uhlangabezana nemiphumela emibi evela emithini, xhumana nodokotela wakho ngokushesha.

Kuphephile ukuhlanganisa lolu hlobo lomuthi nezinye izidakamizwa?

Noma nini lapho ufaka umuthi omusha ohlelweni lwakho lokwelashwa, kubalulekile ukuthi ucabangele ukuthi ungahlangana kanjani nemithi osuvele uyiphuzile.

Uma uthatha eminye imithi yesifo sikashukela ukwehlisa amazinga kashukela egazini lakho, ukwengeza i-SGLT2 inhibitor kwandisa ingozi yokuba neshukela egazini eliphansi.

Ngaphezu kwalokho, uma uthatha izinhlobo ezithile ze-diuretics, i-SGLT2 inhibitors ingakhuphula umthelela wokukhishwa kwaleyo mithi, ikwenze uchame kaningi. Lokho kungakhuphula ingozi yakho yokuphelelwa amandla kwamanzi nomfutho wegazi ophansi.

Ngaphambi kokuba uqale ukuthatha umuthi omusha noma isengezo, buza udokotela wakho ukuthi angasebenzisana yini nanoma yini ohlelweni lwakho lokwelashwa olukhona.

Kwezinye izimo, udokotela wakho angenza ushintsho ekwelashweni kwakho okunqunyiwe ukuze anciphise ubungozi bokuhlangana kwezidakamizwa ezingezinhle.

Ukuthatha

Ama-SGLT2 inhibitors aklanyelwe ukusiza ukuphatha ushukela wegazi kubantu abaphila nohlobo 2 lwesifo sikashukela.

Ngaphezu kokwehlisa amazinga kashukela egazini, lesi sigaba semithi sitholakale sinezinzuzo zenhliziyo nemithambo yezinso. Yize ngokuvamile kubhekwa njengokuphephile, i-SGLT2 inhibitors kwesinye isikhathi ibangela imiphumela emibi noma ukuxhumana okungekuhle nezidakamizwa ezithile.

Udokotela wakho angakutshela kabanzi mayelana nezinzuzo nezingozi ezingaba khona zokwengeza lolu hlobo lwemithi kuhlelo lwakho lokwelashwa.