I-bilirubin eqondile nengaqondile: iyini nokuthi kungani ingaba phezulu

-Delile

• Amanani esithenjwa seBilirubin
• Kuthathwa nini ukuhlolwa kwe-bilirubin
• Yini engaba yi-bilirubin ephezulu
• Ukwandiswa kwe-bilirubin engaqondile
• Ukwandiswa kwe-bilirubin eqondile

Ukuhlolwa kwe-bilirubin kusiza ukuxilonga izinkinga zesibindi, amapayipi e-bile noma i-hemolytic anemia, ngokwesibonelo, njengoba i-bilirubin ingumkhiqizo wokubhujiswa kwamaseli abomvu egazi futhi ukuze isuswe ngumzimba idinga ukuhlanganiswa noshukela esesibindi futhi ihlupheke isenzo se-bile.

Kunezinhlobo ezimbili eziyinhloko ze-bilirubin ezingalinganiswa nalesi sivivinyo:

• I-bilirubin engaqondile noma ayihlanganisiwe: yinto eyakheka ngesikhathi sokucekelwa phansi kwamangqamuzana egazi abomvu egazini abese eyiswa esibindini. Ngalesi sizathu, ukugxila kwayo kuphakeme egazini futhi kungashintshwa lapho kunesimo esihilela amangqamuzana abomvu egazi, njenge-hemolytic anemia, ngokwesibonelo;
• Qondisa uBilirubin noma i-conjugate: ihambelana nokuhlangana phakathi kwe-bilirubin ne-glucuronic acid, ushukela, esibindini. I-bilirubin eqondile yenza isenzo se-bile emathunjini, isuswe ngendlela ye-urobilinogen noma i-stereobilinogen. Ngakho-ke, ukuhlushwa kwe-bilirubin eqondile kuyashintshwa lapho kukhona ukulimala kwesibindi noma ukuvinjelwa kwe-biliary.

Ukuhlolwa kweBilirubin kuyacelwa ngenhloso yokuhlola ukusebenza kwesibindi, ukuqapha ukwelashwa kwezinsana ezisanda kuzalwa kanye nokuhlola izifo ezingaphazamisa ukukhiqizwa kwe-bilirubin, ukugcinwa, imetabolism noma ukuphuma. Imvamisa udokotela u-oda inani eliphelele le-bilirubin, kepha ama-laboratories nawo avame ukukhipha imithamo ye-bilirubin eqondile nengaqondile, ngoba le mithamo emibili ibhekele inani eliphelele le-bilirubin. Bona ukuthi yiziphi ezinye izivivinyo ezisiza ukukhomba izinkinga zesibindi.

Ukuhlolwa kwe-bilirubin akudingi ukulungiswa futhi kwenziwa ngegazi elincane. Kodwa-ke, umphumela walokhu kuhlolwa ungaphazanyiswa lapho isampula selisuswe i-hemolyzed, okungukuthi, lapho inani lamaseli abomvu elibhujisiwe likhulu kakhulu, okuvame ukwenzeka lapho iqoqo lingenziwanga kahle. Kungakho kubalulekile ukuthi ukuqoqwa kwenziwe kwilabhorethri ethembekile futhi kube nochwepheshe abaqeqeshiwe.

Amanani esithenjwa seBilirubin

Amanani ayisethenjwa e-bilirubin egazini yile:

Ezinye izingane ezisanda kuzalwa zingaba namazinga aphezulu kakhulu e-bilirubin, okungaba ngenxa yokungavuthwa kwezitho ezihlobene ne-bilirubin metabolism noma ukucindezelwa kwabasebenzi. Amanani ayizethenjwa e-bilirubin ezinganeni ayahluka ngokuya ngempilo yawo, ngokuba:

• Kuze kube ngamahora angama-24 ngemuva kokuzalwa: 1.4 - 8.7 mg / dL;
• Kuze kube ngamahora angama-48 ngemuva kokuzalwa: 3.4 - 11.5 mg / dL;
• Phakathi kwezinsuku ezi-3 kuya kwezi-5 emva kokuzalwa: 1.5 - 12 mg / dL.

Ngemuva kosuku lwesithupha, amanani ayizethenjwa ayafana nalawo womuntu omdala. Amanani angaphezu kwenani lesethenjwa akhombisa ukuthi ingane ine-jaundice, engesinye sezifo ezivame kakhulu enganeni esanda kuzalwa futhi engelashwa kalula nge-phototherapy, ehlose ukunciphisa ukugxila kwe-bilirubin emzimbeni wengane. Funda kabanzi mayelana ne-jaundice ye-neonatal, izimbangela nokuthi kwenziwa kanjani ukwelashwa.

Kuthathwa nini ukuhlolwa kwe-bilirubin

Ukuhlolwa kwe-bilirubin kuvame uku-oda udokotela lapho kunezimpawu zezinkinga zesibindi, njengokukhathala ngokweqile, isicanucanu njalo, ukuhlanza, ubuhlungu obungapheli esiswini, umchamo omnyama noma isikhumba esiphuzi, ngokwesibonelo.

Kodwa-ke, lokhu kuhlolwa kungasetshenziswa futhi lapho kusolwa khona i-cirrhosis, hepatitis kanye ne-hemolytic anemia, ngokwesibonelo, okudala izimpawu ezifana ne-pallor, ukulala kaningi, isikhumba esomile, izinwele ezinciphile noma izinzipho ezibuthakathaka. Bona ezinye izimpawu ze-hemolytic anemia.

Ukwehla kwamazinga e-bilirubin ngokuvamile kubangelwa ukusetshenziswa kwemithi ethile, noma kunjalo, amazinga aphakanyisiwe e-bilirubin ngokuvamile akhombisa izinkinga zempilo ezingaba zimbi uma zingalashwa.

Yini engaba yi-bilirubin ephezulu

Imbangela yokwanda kwe-bilirubin egazini iyahlukahluka ngohlobo lwe-bilirubin eyandisiwe:

Ukwandiswa kwe-bilirubin engaqondile

Kulezi zimo, ushintsho emazingeni e-bilirubin cishe njalo lubangelwa ushintsho egazini, kepha izimbangela ezinkulu zifaka:

• I-hemolytic anemia;
• I-anemia enamandla;
• Ama-hemoglobinopathies;
• Ukumpontshelwa igazi.

Ngaphezu kwalokho, kukhona nezimo lapho i-bilirubin engaqondile inyuka khona ngenxa yesifo, esaziwa njenge-Gilbert's syndrome, lapho kukhona khona ukuguqulwa kwezakhi zofuzo okuvimbela isibindi ekuqedeni kahle i-bilirubin. Funda kabanzi nge-Gilbert's syndrome.

Ukwandiswa kwe-bilirubin eqondile

Lapho kunokwanda kwe-bilirubin eqondile imvamisa kuyisibonakaliso sokuthi kunenkinga esibindini noma emibhobho yenyongo. Ngakho-ke, ezinye zezimbangela eziyinhloko zifaka:

• I-hepatitis yegciwane;
• Isifo sesibindi sokuphuza utshwala;
• Itshe emibhobho yenyongo;
• Izimila esibindini noma emithanjeni yenyongo.

Ukusetshenziswa ngokweqile kwezidakamizwa ezithinta isibindi, njengeParacetamol, nakho kungaholela ekwandeni kwalolu hlobo lwe-bilirubin egazini. Qonda kangcono ukuthi yini ebangela ukwanda kwe-bilirubin ne-jaundice kubantu abadala.