Ukuhlolwa kwe-LDH (Lactic Dehydrogenase): kuyini nokuthi kusho ukuthini umphumela

-Delile

• Yini isivivinyo se-
• Kusho ukuthini i-LDH ephezulu?
• Yini engaba yi-LDH ephansi?

I-LDH, ebizwa nangokuthi i-lactic dehydrogenase noma i-lactate dehydrogenase, iyi-enzyme ekhona ngaphakathi kwamaseli abhekene nokwakheka kwe-glucose emzimbeni. Le enzyme ingatholakala ezithweni nakwizicubu eziningana, ngakho-ke, ukuphakama kwayo akucacisiwe, futhi okunye ukuhlolwa kunconywa ukuze kufinyelele ekuxilongweni.

Endabeni yomphumela we-LDH oshintshiwe, ngaphezu kokunye ukuhlolwa, udokotela angakhombisa isilinganiso se-isoenzymes ye-LDH, ukuphakama kwayo okungakhombisa izinguquko ezithile:

• I-LDH-1, ekhona enhliziyweni, amangqamuzana abomvu egazi nezinso;
• I-LDH-2, engatholakala enhliziyweni, ngezinga elincane, nakuma-leukocyte;
• LDH-3, ekhona emaphashini;
• LDH-4, etholakala ku-placenta nakumanyikwe;
• LDH-5, etholakala esibindini nasemisipha yamathambo.

Amanani ajwayelekile e-lactate dehydrogenase angahluka ngokuya ngelebhu, ngokujwayelekile kucatshangelwa phakathi kuka-120 no-246 IU / L kubantu abadala.

Yini isivivinyo se-

Ukuhlolwa kwe-LDH kungalawulwa ngudokotela njengokuhlolwa okujwayelekile, kanye nokunye ukuhlolwa kwelabhorethri. Kodwa-ke, lolu vivinyo lukhonjiswa kakhulu uma kwenzeka kuphenywa izinkinga zenhliziyo, kucelwa kanye ne-Creatinophosphokinase (CK) ne-troponin, noma yezinguquko ze-hepatic, kucelwa nomthamo we-TGO / AST (Oxalacetic Transaminase / Aspartate Aminotransferase), TGP / I-ALT (Glutamic Pyruvic Transaminase / Alanine Aminotransferase) kanye ne-GGT (gamma glutamyl transferase). Yazi ezinye izivivinyo ezihlola isibindi.

Ukuze wenze ukuhlolwa isikhathi esiningi akudingeki ukuzila ukudla noma olunye uhlobo lokulungiselela, kepha amanye amalabhorethri akhombisa ukuthi kuyadingeka ukuthi umuntu okungenani azile ukudla amahora ama-4. Ngakho-ke, ngaphambi kokwenza isivivinyo, kubalulekile ukwazisa ilabhorethri ngenqubo efanele, ngaphezu kokwazisa ukusetshenziswa kwemithi.

Kusho ukuthini i-LDH ephezulu?

Ukwanda kwe-LDH kuvamise ukukhombisa ukulimala kwezitho noma izicubu. Lokhu kungenxa yokuthi njengomphumela wokulimala kwamaselula, i-LDH equkethwe ngaphakathi kwamaseli iyadedelwa futhi ijikeleze egazini, futhi ukugxilwa kwayo kuhlolwe ngokuhlolwa kwegazi. Izimo eziyinhloko lapho ukwanda kwe-LDH kungabonakala khona yilezi:

• I-megaloblastic anemia;
• I-Carcinoma;
• Ukushaqeka kwe-septic;
• Isifinyezo;
• I-hemolytic anemia;
• Umdlavuza wegazi;
• Mononucleosis;
• I-hepatitis;
• I-jaundice evimbelayo;
• Isifo sokuqina kwesibindi.

Ezinye izimo zingakhuphula amazinga e-LDH, angakhombisi izifo, ikakhulukazi uma eminye imingcele yelabhorethri eceliwe ingokwemvelo. Ezinye zezimo ezingashintsha amazinga e-LDH egazini umsebenzi omkhulu womzimba, ukusetshenziswa kwemithi ethile nokukhulelwa.

Yini engaba yi-LDH ephansi?

Ukwehla kwenani le-lactic dehydrogenase egazini imvamisa akusiyona imbangela yokukhathazeka futhi akuhlobene nezifo futhi akusona isizathu sokuphenywa. Kwezinye izimo, ukwehla kwe-LDH kungahle kuhlobene nokudlulela kukavithamini C, futhi kunganconywa ushintsho endleleni umuntu adla ngayo.