Ukushoda kwe-G6PD

-Delile

• Ziyini izimpawu zokushoda kwe-G6PD?
• Yini ebangela ukuntuleka kwe-G6PD?
• Yiziphi izinto ezinobungozi bokushoda kwe-G6PD?
• Kutholakala kanjani ukuthi kushoda i-G6PD?
• Kuphathwa kanjani ukushoda kwe-G6PD?
• Uyini umbono womuntu onenkinga ye-G6PD?

Kuyini ukushoda kwe-G6PD?

Ukushoda kwe-G6PD ukungajwayelekile kofuzo okuholela kwinani elinganele le-glucose-6-phosphate dehydrogenase (G6PD) egazini. Le yi-enzyme ebaluleke kakhulu (noma amaprotheni) elawula ukusabela okuhlukahlukene kwamakhemikhali emzimbeni.

I-G6PD futhi inesibopho sokugcina amaseli abomvu egazi enempilo ukuze akwazi ukusebenza kahle futhi aphile isikhathi esijwayelekile sokuphila. Ngaphandle kwawo, amaseli abomvu abola ngaphambi kwesikhathi. Lokhu kubhujiswa kokuqala kwamangqamuzana egazi abomvu kwaziwa njenge i-hemolysis, futhi ekugcineni kungaholela ku- i-hemolytic anemia.

I-hemolytic anemia iyakhula lapho amangqamuzana abomvu egazi ebhujiswa ngokushesha kunokuba umzimba ungawabeka esikhundleni sawo, okuholela ekwehliseni ukugeleza komoya-mpilo ezithweni nakwizicubu. Lokhu kungadala ukukhathala, ukuphuzi kwesikhumba namehlo, nokuphefumula okuncane.

Kubantu abanokushoda kwe-G6PD, i-hemolytic anemia ingenzeka ngemuva kokudla ubhontshisi we-fava noma imidumba ethile. Kungabangelwa futhi ukutheleleka noma izidakamizwa ezithile, njenge:

• imishanguzo, uhlobo lomuthi osetshenziselwa ukuvimbela nokwelapha umalaleveva
• i-sulfonamides, umuthi osetshenziselwa ukwelapha izifo ezahlukahlukene
• i-aspirin, umuthi osetshenziselwa ukuqeda umkhuhlane, ubuhlungu nokuvuvukala
• eminye imishanguzo yokulwa nokuvuvukala (ama-NSAID)

Ukushoda kwe-G6PD kudlange kakhulu e-Afrika, lapho kungathinta khona amaphesenti angama-20 wabantu. Lesi simo sesivame kakhulu kwabesilisa kunabesifazane.

Iningi labantu abanokushoda kwe-G6PD imvamisa abanazo izimpawu. Kodwa-ke, abanye bangaba nezimpawu lapho bevezwa umuthi, ukudla, noma ukutheleleka okubangela ukubhujiswa kokuqala kwamaseli abomvu egazi. Lapho imbangela eyisisekelo iphethwe noma ixazululwa, izimpawu zokushoda kwe-G6PD zivame ukunyamalala emasontweni ambalwa.

Ziyini izimpawu zokushoda kwe-G6PD?

Izimpawu zokushoda kwe-G6PD zingafaka:

• ukushaya kwenhliziyo okusheshayo
• ukuphelelwa umoya
• umchamo omnyama noma ophuzi-orange
• imfiva
• ukukhathala
• isiyezi
• ukuphaphatheka
• i-jaundice, noma ukuphuzi kwesikhumba nabamhlophe bamehlo

Yini ebangela ukuntuleka kwe-G6PD?

Ukushoda kwe-G6PD yisimo sezakhi zofuzo esidluliswa sisuka komunye noma bobabili abazali siye enganeni yabo. Isakhi sofuzo esingalungile esidala lokhu kushoda sise-X chromosome, okungenye yama-chromosomes amabili ocansi. Abesilisa bane-X chromosome eyodwa kuphela, kuyilapho abesifazane benama-X chromosomes amabili. Kwabesilisa, ikhophi eyodwa eshintshiwe yofuzo yanele ukudala ukushoda kwe-G6PD.

Kwabesifazane, noma kunjalo, ushintsho kuzodingeka lube khona kuwo womabili amakhophi wesakhi. Njengoba mancane amathuba okuthi abesifazane babe namakhophi amabili aguquliwe alolu hlobo, abesilisa bathinteka ukushoda kwe-G6PD kaningi kakhulu kunabesifazane.

Yiziphi izinto ezinobungozi bokushoda kwe-G6PD?

Ungaba nengozi enkulu yokuba nokushoda kwe-G6PD uma:

• ngabesilisa
• angama-Afrika-aseMelika
• bangabokudabuka eMpumalanga Ephakathi
• ube nomlando womndeni waleso simo

Ukuba nesici esisodwa noma eziningi zalezi zingcuphe akusho ukuthi uzoba nokushoda kwe-G6PD. Khuluma nodokotela wakho uma ukhathazekile ngengozi yakho yalesi simo.

Kutholakala kanjani ukuthi kushoda i-G6PD?

Udokotela wakho angaxilonga ukuntula kwe-G6PD ngokwenza ukuhlolwa kwegazi okulula ukuze abheke amazinga e-G6PD enzyme.

Ezinye izivivinyo zokuxilonga ezingenziwa zifaka ukubalwa kwegazi okuphelele, ukuhlolwa kwe-serum hemoglobin, kanye nokubala kwe-reticulocyte. Konke lokhu kuhlolwa kunikeza imininingwane ngamangqamuzana abomvu egazi emzimbeni. Futhi zingasiza udokotela wakho ukuthola i-hemolytic anemia.

Ngesikhathi sokuqokwa kwakho, kubalulekile ukutshela udokotela wakho mayelana nokudla kwakho kanye nanoma yimiphi imithi oyiphuzayo njengamanje. Le mininingwane ingasiza udokotela wakho ngokuxilongwa.

Kuphathwa kanjani ukushoda kwe-G6PD?

Ukwelashwa kokushoda kwe-G6PD kubandakanya ukususa i-trigger ebangela izimpawu.

Uma isimo sidalwe ukutheleleka, khona-ke ukutheleleka okuyisisekelo kuphathwa ngokufanele. Noma imiphi imishanguzo yamanje engase ibhubhise amangqamuzana abomvu egazi nayo iyanqanyulwa. Kulezi zimo, abantu abaningi bangalulama esiqeshini bebodwa.

Lapho ukuntuleka kwe-G6PD sekuthuthuke kwaba yi-hemolytic anemia, noma kunjalo, ukwelashwa okunolaka kakhulu kungadingeka. Lokhu kwesinye isikhathi kubandakanya ukwelashwa komoya-mpilo kanye nokumpontshelwa igazi ukugcwalisa amazinga e-oxygen namangqamuzana abomvu egazi.

Uzodinga ukuhlala esibhedlela ngenkathi uthola lezi zindlela zokwelashwa, njengoba ukuqapha okusondele kakhulu kwe-hemolytic anemia kubalulekile ekuqinisekiseni ukululama okugcwele ngaphandle kwezinkinga.

Uyini umbono womuntu onenkinga ye-G6PD?

Abantu abaningi abanenkinga ye-G6PD abakaze babe nazimpawu. Labo abalulama ngokuphelele kwizimpawu zabo uma ukwelashwa sekutholakele okuyimbangela yesimo. Kodwa-ke, kubalulekile ukuthi ufunde ukuthi ungasiphatha kanjani lesi simo futhi uvimbele izimpawu ekuthuthukiseni.

Ukuphatha ukushoda kwe-G6PD kubandakanya ukugwema ukudla nemithi engadala isimo. Ukunciphisa amazinga okucindezeleka kungasiza nasekulawuleni izimpawu. Buza udokotela wakho uhlu oluprintiwe lwemithi nokudla okufanele ukugweme.