I-Herceptin - Ikhambi Lomdlavuza Webele

-Delile

• Yenzelwe ini
• Isetshenziswa kanjani
• 1. Umdlavuza webele
• 2. Umdlavuza wesisu
• Imiphumela emibi engaba khona

IHerceptin umuthi osuselwa kuma-antibody monoclonal, avela elabhorethri yaseRoche, esebenza ngqo engqamuzaneni lomdlavuza futhi isebenza kahle kakhulu kunezinhlobo ezithile zomdlavuza.

Lo muthi unenani elicishe libe yizinkulungwane eziyishumi ze-reais futhi uyatholakala kwa-SUS - Sistema Único de Saúde.

Yenzelwe ini

I-Herceptin ikhonjisiwe ekwelapheni abantu abanomdlavuza webele we-metastatic, umdlavuza wokuqala webele nomdlavuza wesisu othuthukile.

Isetshenziswa kanjani

I-Herceptin kufanele ilawulwe uchwepheshe wezokunakekelwa kwezempilo:

1. Umdlavuza webele

Uma isetshenziswa masonto onke, umthamo wokuqala wokulayisha we-4 mg / kg wesisindo somzimba kufanele unikezwe njengokufakwa okufakwa emthanjeni ngaphezu kwemizuzu engama-90. Ukweqiwa kwamasonto onke okulandelayo kufanele kube yi-2 mg / kg yesisindo somzimba, engalawulwa ekungenisweni kwemizuzu engu-30.

Uma isetshenziswa njalo emavikini amathathu, umthamo wokuqala wokulayisha uyisisindo somzimba esingu-8 mg / kg, kulandelwe isisindo somzimba esingu-6 mg / kg, njalo emavikini amathathu, emithanjeni ehlala cishe imizuzu engama-90. Uma le dose ibekezeleleka kahle, isikhathi sokumnika singancishiswa sibe imizuzu engama-30.

Lo muthi ungasetshenziswa ngokuhlanganyela ne-paclitaxel noma i-docetaxel.

2. Umdlavuza wesisu

Lo muthi kufanele usetshenziswe njalo emavikini ama-3 kanti umthamo wokuqala wokuhlasela ungu-8 mg / kg wesisindo somzimba, ulandelwe ngu-6 mg / kg wesisindo somzimba, okumele uphindwe njalo emavikini amathathu, emithanjeni ehlala cishe imizuzu engama-90. Uma ngabe le dose ibekezeleleke kahle, isikhathi sokufakwa singancishiswa sibe imizuzu engama-30.

Imiphumela emibi engaba khona

Imiphumela emibi kakhulu engahle yenzeke ngesikhathi sokwelashwa ne-Herceptin yi-nasopharyngitis, ukutheleleka, i-anemia, i-thrombocytopenia, i-febrile neutropenia, ukunciphisa isibalo samaseli amhlophe egazi, kwehle noma kwanda isisindo, kwehlisa isifiso sokudla, ukuqwasha, isiyezi, ikhanda, i-paresthesia, i-hypoesthesia, ukunciphisa ukunambitheka , ukudabuka, i-conjunctivitis, i-lymphedema, ukushisa okushisayo, ukuphefumula okuncane, i-epistaxis, ukukhwehlela, ikhala eligijimayo nobuhlungu emlonyeni nasemphinjeni.

Ngaphezu kwalokho, isifo sohudo, ukuhlanza, isicanucanu, ubuhlungu besisu, ukugaya ukudla okungafanele, ukuqunjelwa, i-stomatitis, i-erythema,ukuqubuka, ukulahleka kwezinwele, ukuphazamiseka kwezipikili nobuhlungu bemisipha.

Ngubani ongafanele asebenzise

Leli thuluzi akumele lisetshenziswe kubantu abangenwe igciwane kunoma yiziphi izingxenye zefomula, abesifazane abakhulelwe nabancelisayo.

Lo muthi awuvivinywanga ezinganeni, ebusheni, kwabadala nasebantwini abanokukhubazeka kwezinso noma kwe-hepatic, futhi kufanele usetshenziswe ngokuqapha.