Ukuhlolwa Kwezinguquko ze-MTHFR

-Delile

• Kuyini ukuhlolwa kwe-MTHFR mutation?
• Kusetshenziselwa ini?
• Kungani ngidinga isivivinyo sokuguqula isimo se-MTHFR?
• Kwenzekani ngesikhathi sokuhlolwa kokuguqulwa kwesifo se-MTHFR?
• Ngabe kukhona engizodinga ukukwenza ukulungiselela isivivinyo?
• Ingabe zikhona izingozi esivivinyweni?
• Isho ukuthini imiphumela?
• Ngabe kukhona okunye engidinga ukukwazi mayelana nokuhlolwa kokuguquka kwesimo se-MTHFR?
• Izinkomba

Kuyini ukuhlolwa kwe-MTHFR mutation?

Lokhu kuhlolwa kubheka ukuguqulwa (izinguquko) kuhlobo olubizwa nge-MTHFR. Izakhi zofuzo yizingxenye eziyisisekelo zofuzo ezedluliswa zivela kumama nobaba wakho.

Wonke umuntu unezakhi zofuzo ze-MTHFR ezimbili, esisodwa sizuzwe ngonyoko nesinye esivela kubaba wakho. Ukuguquka kwezakhi zofuzo kungenzeka kuhlobo olulodwa noma zombili ze-MTHFR. Kunezinhlobo ezahlukahlukene zokuguqulwa kweMTHFR. Isivivinyo se-MTHFR sibheka ezimbili zalezi zinguquko, ezaziwa nangokuthi okuhlukile. Izinhlobonhlobo ze-MTHFR zibizwa nge-C677T ne-A1298C.

Uhlobo lwe-MTHFR lusiza umzimba wakho ukudiliza into ebizwa nge-homocysteine. I-Homocysteine ​​uhlobo lwe-amino acid, ikhemikhali elisetshenziswa umzimba wakho ukwenza amaprotheni. Imvamisa, i-folic acid namanye amavithamini B aphula i-homocysteine ​​ayishintshe ibe ezinye izinto ezidingwa ngumzimba wakho. Kufanele-ke kube khona i-homocysteine ​​encane kakhulu esele egazini.

Uma une-MTHFR mutation, uhlobo lwakho lwe-MTHFR kungenzeka lungasebenzi kahle. Lokhu kungadala ukuthi i-homocysteine ​​eningi yande egazini, okuholele ezinkingeni zezempilo ezahlukahlukene, kufaka phakathi:

• I-Homocystinuria, ukuphazamiseka okuthinta amehlo, amalunga, namakhono okuqonda. Imvamisa iqala ebuntwaneni.
• Ingozi eyengeziwe yesifo senhliziyo, isifo sohlangothi, umfutho wegazi ophakeme kanye namahlule egazi

Ngaphezu kwalokho, abesifazane abanezinguquko ze-MTHFR banengozi enkulu yokuba nengane enezinkinga ezilandelayo zokuzalwa:

• I-Spina bifida, eyaziwa njenge-neural tube defect. Lesi yisimo lapho amathambo omgogodla engavali ngokuphelele eduze komgogodla.
• I-Anencephaly, olunye uhlobo lwe-neural tube defect. Kulesi sifo, izingxenye zobuchopho kanye / noma ugebhezi kungenzeka zilahlekile noma zikhubazeke.

Unganciphisa amazinga akho e-homocysteine ​​ngokuthatha i-folic acid noma amanye amavithamini e-B Lokhu kungathathwa njengezengezo noma kungezwe ngokushintsha kokudla. Uma udinga ukuthatha i-folic acid noma amanye amavithamini e-B, umhlinzeki wakho wokunakekelwa kwezempilo uzoncoma ukuthi iyiphi inketho ekufanele kakhulu.

Amanye amagama: i-plasma total homocysteine, methylenetetrahydrofolate reductase DNA mutation analysis

Kusetshenziselwa ini?

Lokhu kuhlolwa kusetshenziselwa ukuthola ukuthi ngabe unokukodwa kokuguqulwa kwezinguquko okungu-MTHFR: C677T no-A1298C. Kuvame ukusetshenziselwa ngemuva kokuthi ezinye izivivinyo zikhombise ukuthi unamazinga aphezulu kunejwayelekile we-homocysteine ​​egazini. Izimo ezinjenge-cholesterol ephezulu, isifo se-thyroid, nokuntuleka kokudla nakho kungakhuphula amazinga e-homocysteine. Ukuhlolwa kwe-MTHFR kuzoqinisekisa ukuthi amazinga aphakanyisiwe abangelwa yini ukuguquka kwezakhi zofuzo.

Ngisho noma ukuguqulwa kwe-MTHFR kuletha ubungozi obukhulu bokukhubazeka kokuzalwa, ukuhlolwa akuvame ukunconywa kwabesifazane abakhulelwe. Ukuthatha izengezo ze-folic acid ngesikhathi sokukhulelwa kunganciphisa kakhulu ingozi yokukhubazeka kokuzalwa kwe-neural tube. Ngakho-ke iningi labesifazane abakhulelwe bayakhuthazwa ukuthi bathathe i-folic acid, noma ngabe bane-MTHFR mutation.

Kungani ngidinga isivivinyo sokuguqula isimo se-MTHFR?

Ungadinga lokhu kuhlolwa uma:

• Ube nokuhlolwa kwegazi okukhombise ukuphakama kunamazinga ajwayelekile we-homocysteine
• Isihlobo esiseduze sitholwe ukuthi sinoshintsho ku-MTHFR
• Wena kanye / noma amalungu omndeni asondelene unomlando wesifo senhliziyo ngaphambi kwesikhathi noma ukuphazamiseka kwemithambo yegazi

Ingane yakho entsha ingathola nokuhlolwa kwe-MTHFR njengengxenye yokuhlolwa okuvamile kwezinsana. Ukuhlolwa okusanda kuzalwa ukuhlolwa kwegazi okulula okuhlola izifo ezinhlobonhlobo ezibucayi.

Kwenzekani ngesikhathi sokuhlolwa kokuguqulwa kwesifo se-MTHFR?

Uchwepheshe wezempilo uzothatha isampula yegazi emthanjeni osengalweni yakho, esebenzisa inaliti encane. Ngemuva kokuthi kufakwe inaliti, kuzoqoqwa inani elincane legazi kufakwe ithubhu yokuhlola noma isitsha. Ungase uzizwe uluma kancane lapho inaliti ingena noma iphuma. Lokhu ngokuvamile kuthatha imizuzu engaphansi kwemihlanu.

Ukuze kuhlolwe usana olusanda kuzalwa, uchwepheshe wezokunakekelwa kwempilo uzohlanza isithende sengane yakho ngotshwala bese ephoqa isithende ngenaliti encane. Uzoqoqa amaconsi egazi ambalwa bese efaka ibhandishi kusayithi.

Ukuhlolwa kuvame ukwenziwa lapho ingane inosuku olungu-1 kuya kwezi-2 ubudala, imvamisa isesibhedlela lapho yazalelwa khona. Uma ingane yakho ingazalwanga esibhedlela noma ngabe uphume esibhedlela ngaphambi kokuba ingane ihlolwe, khuluma nomhlinzeki wakho wezokunakekelwa kwezempilo mayelana nokuhlela ukuhlolwa ngokushesha okukhulu.

Ngabe kukhona engizodinga ukukwenza ukulungiselela isivivinyo?

Awudingi noma yimaphi amalungiselelo akhethekile esivivinyo sokuguqula isimo se-MTHFR.

Ingabe zikhona izingozi esivivinyweni?

Kunengozi encane kakhulu kuwe noma enganeni yakho ngokuhlolwa kwe-MTHFR. Ungaba nobuhlungu obuncane noma ukulimaza lapho kufakwe khona inaliti, kepha izimpawu eziningi ziyaphela ngokushesha.

Ingane yakho ingazizwa incanyana lapho isithende sibhakwa, futhi umhuzuko omncane ungakheka esizeni. Lokhu kufanele kudlule ngokushesha.

Isho ukuthini imiphumela?

Imiphumela yakho izokhombisa ukuthi ingabe uvumile noma awunalo igalelo le-MTHFR. Uma uvumile, umphumela uzokhombisa ukuthi yikuphi okuguqukayo okubili onakho, nokuthi unekhophi elilodwa noma amabili wesakhi sofuzo esiguqukile. Uma imiphumela yakho ibingeyinhle, kepha unamazinga aphezulu e-homocysteine, umhlinzeki wakho wezokunakekelwa kwempilo anga-oda izivivinyo eziningi ukuthola imbangela.

Ngaphandle kwesizathu samazinga aphezulu e-homocysteine, umhlinzeki wakho wezokunakekelwa kwempilo angancoma ukuthatha i-folic acid kanye / noma ezinye izengezo zikavithamini B, kanye / noma ukushintsha indlela odla ngayo. Amavithamini B angasiza ekubuyiseleni amazinga akho e-homocysteine ​​abuyele kokujwayelekile.

Uma unemibuzo ngemiphumela yakho, khuluma nomhlinzeki wakho wezokunakekelwa kwempilo.

Funda kabanzi mayelana nokuhlolwa kwelabhorethri, ububanzi bezinkomba, nemiphumela yokuqonda.

Ngabe kukhona okunye engidinga ukukwazi mayelana nokuhlolwa kokuguquka kwesimo se-MTHFR?

Abanye abahlinzeki bezempilo bakhetha ukuhlola kuphela amazinga e-homocysteine, kunokuba benze ukuhlolwa kofuzo lwe-MTHFR. Lokho kungenxa yokuthi ukwelashwa kuvame ukufana, noma ngabe amazinga aphezulu e-homocysteine ​​abangelwa ukuguquka kwesimo.

Izinkomba

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