Izinkinga ze-Myelofibrosis nezindlela zokunciphisa ubungozi bakho

-Delile

• Ubende obukhulisiwe
• Amathumba (ukukhula okungadli umdlavuza) kwezinye izingxenye zomzimba wakho
• Umfutho wegazi ophezulu we-portal
• Ukubalwa kweplatelet ephansi
• Ubuhlungu bamathambo namalunga
• Gout
• I-anemia enamandla
• I-acute myeloid leukemia (AML)
• Ukwelapha izinkinga ze-MF
• Ukunciphisa ubungozi bezinkinga ze-MF
• Ukuthatha

I-Myelofibrosis (MF) iyindlela engapheli yomdlavuza wegazi lapho izicubu ezibomvu emnkantsheni we-bone zinciphisa ukukhiqizwa kwamaseli egazi aphilile. Ukushoda kwamaseli egazi kudala izimpawu nezinkinga eziningi ze-MF, njengokukhathala, ukulimazeka okulula, umkhuhlane, nobuhlungu bamathambo noma obuhlangene.

Abantu abaningi abazitholi izimpawu ezinkathini zokuqala zesifo. Njengoba lesi sifo siqhubeka, izimpawu nezinkinga eziboshelwe ekubalweni kwamaseli egazi ngokungajwayelekile zingaqala ukuvela.

Kubalulekile ukusebenza nodokotela wakho ukuze welaphe i-MF, ikakhulukazi lapho uqala ukuhlangabezana nezimpawu. Ukwelashwa kungasiza ekunciphiseni ubungozi bezinkinga futhi kwandise ukusinda.

Nakhu ukubhekisisa izinkinga ezingaba khona ze-MF nokuthi ungabunciphisa kanjani ubungozi bakho.

Ubende obukhulisiwe

Ubende lwakho lusiza ukulwa nezifo futhi luhlunge amaseli egazi amadala noma alimele. Iphinde igcine amangqamuzana abomvu egazi nama-platelets asiza igazi lakho lijiye.

Uma une-MF, umnkantsha wakho awukwazi ukwenza amangqamuzana egazi anele ngenxa yesibazi. Amaseli egazi ekugcineni akhiqizwa ngaphandle komnkantsha wethambo kwezinye izingxenye zomzimba wakho, njengobende bakho.

Lokhu kubizwa ngokuthi yi-extramedullary hematopoiesis. Ubende kwesinye isikhathi buba bukhulu ngokungajwayelekile njengoba kusebenza kanzima ukwenza la maseli.

Ubende obukhulisiwe (splenomegaly) bungadala izimpawu ezingathandeki. Kungadala izinhlungu zesisu lapho sidudulela kwezinye izitho futhi kukwenze uzizwe ugcwele ngisho noma ungadlanga kakhulu.

Amathumba (ukukhula okungadli umdlavuza) kwezinye izingxenye zomzimba wakho

Lapho amangqamuzana egazi ekhiqizwa ngaphandle komnkantsha wethambo, izicubu ezingenasifo somdlavuza zamangqamuzana egazi akhulayo kwesinye isikhathi ziyakheka kwezinye izindawo zomzimba.

Lezi zicubu zingadala ukopha ngaphakathi kohlelo lwakho lwesisu. Lokhu kungakwenza ukhwehlele noma ukhafule igazi. Izicubu zingaphinda zicindezele intambo yakho yomgogodla noma zibangele ukuquleka.

Umfutho wegazi ophezulu we-portal

Igazi ligeleza lisuka ebunzimeni liye esibindini ngomthambo we-portal. Ukwanda kokugeleza kwegazi esikhaleni esikhulisiwe ku-MF kubanga umfutho wegazi ophezulu emthanjeni we-portal.

Ukwanda kwengcindezi yegazi kwesinye isikhathi kuphoqa igazi eliningi ukuba lingene esiswini kanye nomphimbo. Lokhu kungahle kuqhume imithambo emincane kubangele ukopha. Mayelana nabantu abane-MF bahlangabezana nale nkinga.

Ukubalwa kweplatelet ephansi

Ama-platelet egazini asiza igazi lakho ukuba limile ngemuva kokulimala. Isibalo sePlatelet singawela ngaphansi kokujwayelekile njengoba i-MF iqhubeka. Inani eliphansi lama-platelet laziwa njenge-thrombocytopenia.

Ngaphandle kwama-platelet anele, igazi lakho alikwazi ukujiya kahle. Lokhu kungakwenza wophe kalula.

Ubuhlungu bamathambo namalunga

I-MF ingaluqinisa umnkantsha wakho. Kungadala nokuvuvukala kwezicubu ezixhumene namathambo. Lokhu kuholela ebuhlungwini bamathambo namalunga.

Gout

I-MF ibangela ukuthi umzimba ukhiqize i-uric acid eningi kunokujwayelekile. Uma i-uric acid ikhazimula, kwesinye isikhathi ihlala ezinhlangothini. Lokhu kubizwa ngokuthi yi-gout. I-Gout ingadala amalunga okuvuvukala futhi abuhlungu.

I-anemia enamandla

Isibalo samaseli abomvu aphansi esaziwa njenge-anemia yisifo esijwayelekile se-MF. Kwesinye isikhathi i-anemia iba nzima futhi idale ukukhathala okuqeda amandla, ukulimaza, nezinye izimpawu.

I-acute myeloid leukemia (AML)

Cishe kubantu abangamaphesenti ayi-15 kuye kwangama-20, i-MF idlulela ohlotsheni lomdlavuza olubi kakhulu olwaziwa ngokuthi i-acute myeloid leukemia (AML). I-AML ingumdlavuza oqhubeka ngokushesha wegazi nomnkantsha.

Ukwelapha izinkinga ze-MF

Udokotela wakho angakunikeza izindlela zokwelashwa ezahlukahlukene ukubhekana nezinkinga ze-MF. Lokhu kufaka phakathi:

• Ama-JAK inhibitors, kufaka phakathi i-ruxolitinib (Jakafi) ne-fedratinib (Inrebic)
• izidakamizwa zomzimba, ezifana ne-thalidomide (Thalomid), lenalidomide (Revlimid), i-interferon, ne-pomalidomide (i-Pomalyst)
• ama-corticosteroids, njenge-prednisone
• ukususwa kokuhlinzwa kobende (splenectomy)
• ukwelashwa kwe-androgen
• izidakamizwa ze-chemotherapy, njenge-hydroxyurea

Ukunciphisa ubungozi bezinkinga ze-MF

Kubalulekile ukusebenza nodokotela wakho ukuphatha i-MF. Ukuqapha njalo kuyisihluthulelo sokunciphisa ubungozi bezinkinga ze-MF. Udokotela wakho angacela ukuthi ungene ukubalwa kwegazi nokuhlolwa komzimba kanye noma kabili ngonyaka noma kaningi kanye ngesonto.

Uma njengamanje ungenazo izimpawu kanye ne-MF enobungozi obuphansi, abukho ubufakazi bokuthi uzohlomula ngokungenelela kwangaphambilini. Udokotela wakho angalinda ukuqala ukwelashwa kuze kube yilapho isimo sakho siqhubeka.

Uma unezimpawu noma i-MF ephakathi noma engcupheni enkulu, udokotela wakho angakunikeza ukwelashwa.

I-JAK inhibitors i-ruxolitinib ne-fedratinib ibhekise ukusayina kwendlela okungavamile okubangelwa ukuguquka kwezakhi zofuzo okuvamile kwe-MF. Le mithi ikhonjiswe ukuthi inciphisa kakhulu usayizi wobende futhi ibhekane nezinye izimpawu eziqeda amandla kubandakanya nobuhlungu bethambo nobulunga. Ucwaningo lunganciphisa kakhulu ubungozi bezinkinga futhi lwenyuse ukusinda.

Ukufakelwa komnkantsha wukuphela kokwelapha okungaphulukisa i-MF. Kufaka phakathi ukwamukelwa kwamaseli ama-stem kumnikeli ophilile, okufaka esikhundleni samaseli we-stem angalungile abangela izimpawu ze-MF.

Le nqubo inezingozi ezibalulekile nezingasongela impilo. Ngokuvamile kunconywa kuphela kubantu abasha ngaphandle kwezinye izimo zempilo esezikhona.

Izindlela ezintsha zokwelapha ze-MF zenziwa njalo. Zama ukuhlala usesikhathini ngocwaningo lwamuva ku-MF, bese ubuza udokotela wakho ukuthi ngabe kufanele ucabangele ukubhalisa esivivinyweni somtholampilo.

Ukuthatha

I-Myelofibrosis ngumdlavuza ongajwayelekile lapho izibazi zigcina umnkantsha wakho ungakhiqizi amaseli wegazi anele. Uma une-MF ephakathi noma engcupheni enkulu, izindlela zokwelashwa eziningana zingabhekana nezimpawu, zinciphise ubungozi bezinkinga, futhi zikhulise ukusinda.

Izilingo eziningi eziqhubekayo ziyaqhubeka nokuhlola ukwelashwa okusha. Hlala uthintana nodokotela wakho futhi nixoxe ngokuthi iziphi izindlela zokwelashwa ezingakulungela.