Ukulawulwa Kwekholesterol: PCSK9 Inhibitors vs. Statins

-Delile

• Mayelana nezitatimende
• Basebenza kanjani
• Izinhlobo
• Mayelana ne-PCSK9 inhibitors
• Lapho kunqunywa
• Basebenza kanjani
• Okuqhamuka uma udla imishanguzo
• Ukusebenza ngempumelelo
• Izindleko
• Khuluma nodokotela wakho
• Khuluma nodokotela wakho

Isingeniso

Cishe abantu baseMelika abayizigidi ezingama-74 bane-cholesterol ephezulu, ngokusho kwe. Kodwa-ke, bangaphansi kwesigamu abathola ukwelashwa ngalo. Lokhu kubabeka engcupheni ephezulu yokuhlaselwa yisifo senhliziyo nokushaywa unhlangothi. Ngenkathi ukuzivocavoca umzimba kanye nokudla okunempilo kungasiza ukuphatha amazinga e-cholesterol, kwesinye isikhathi imithi iyadingeka.

Izinhlobo ezimbili zemithi ezinikezwe ukwelapha i-cholesterol ephezulu zifaka ama-statins kanye ne-PCSK9 inhibitors. Izitatimende zingumuthi wokwelashwa odumile obelokhu utholakala kusukela ngawo-1980. I-PCSK9 inhibitors, ngakolunye uhlangothi, uhlobo olusha lomuthi we-cholesterol. Zamukelwa yi-Food and Drug Administration ngo-2015.

Lapho wena nodokotela wakho ninqumela umuthi we-cholesterol, ningahle nicabange ngezinto ezinjengemiphumela engemihle, izindleko, nokusebenza kahle. Funda ukuze ufunde kabanzi ngalezi zidakamizwa nokuthi lezi zinhlobo ezimbili ziqhathanisa kanjani.

Mayelana nezitatimende

Izitatimende zingenye yezinhlobo ezivame kakhulu zemithi esetshenziselwa ukusiza ukwehlisa i-cholesterol. Uma une-cholesterol ephezulu noma ezinye izingozi zenhliziyo, udokotela wakho angasikisela ukuthi uqale ukuthatha i-statin. Zivame ukusetshenziswa njengokwelashwa komugqa wokuqala kwe-cholesterol ephezulu. Lokhu kusho ukuthi ukwelashwa kokuqala udokotela wakho angakusikisela.

Basebenza kanjani

Izitatimende zisebenza ngokuvimba into ebizwa nge-HMG-CoA reductase. Lokhu kuyinhlanganisela yesibindi sakho okudingeka yenze i-cholesterol. Ukuvimba le nto kunciphisa inani le-cholesterol elenziwa yisibindi sakho. Izitatimende zisebenza futhi ngokusiza umzimba wakho ukuthi uphinde uvuselele noma iyiphi i-cholesterol eqoqene ezindongeni zemithambo yegazi lakho. Ukuze ufunde kabanzi, funda ngokuthi ama-statins asebenza kanjani.

Izinhlobo

Izitatimende ziza ngendlela yamaphilisi noma amaphilisi owathatha ngomlomo. Kunezinhlobo eziningi ze-statins ezitholakala e-United States namuhla. Kubandakanya:

• i-atorvastatin (Lipitor)
• i-fluvastatin (Lescol)
• i-lovastatin (Altoprev)
• i-pravastatin (Pravachol)
• i-rosuvastatin (Crestor)
• i-simvastatin (Zocor)
• i-pitavastatin (Livalo)

Mayelana ne-PCSK9 inhibitors

Izitatimende zingabekelwa abantu abaningi abane-cholesterol ephezulu, kepha ama-PCSK9 inhibitors ajwayele ukunikezwa izinhlobo ezithile zabantu kuphela. Ngoba ama-statin abekhona isikhathi eside, siyazi kabanzi ukuthi asebenza kanjani. Ama-PCSK9 inhibitors amasha futhi anedatha yokuphepha yesikhathi eside.

Futhi, ama-PCSK9 inhibitors abiza kakhulu uma kuqhathaniswa nama-statins.

Ama-PCSK9 inhibitors anikezwa ngomjovo kuphela. Kukhona ama-PCSK9 Inhibitors amabili kuphela atholakalayo namuhla e-United States: Okubalulekile (alirocumab) neRepatha (evolocumab).

Lapho kunqunywa

I-American College of Cardiology incoma ukuthi wena nodokotela wakho nicabange nge-PCSK9 inhibitor kuphela uma:

• uthathwa njengengozi enkulu yenkinga yenhliziyo nemithambo yegazi futhi i-cholesterol yakho ayilawulwa ngama-statins noma ezinye izidakamizwa ezehlisa i-cholesterol
• unesimo sezakhi zofuzo esibizwa ngokuthi i-familial hypercholesterolemia, okubandakanya amazinga aphezulu ngokweqile e-cholesterol

Kwelinye lalawa macala, ama-PCSK9 inhibitors ngokuvamile anqunywa ngemuva kwezinhlobo ezimbili zemithi ezingakusizanga ukwehlisa amazinga akho e-cholesterol. Isibonelo, udokotela wakho angaqala anikeze isitatimende. Uma lokho kungehlisi amazinga akho e-cholesterol ngokwanele, udokotela wakho angaphakamisa i-ezetimibe (i-Zetia) noma izidakamizwa ezibizwa ngokuthi izinhlaka ze-bile acid. Izibonelo zalawa zifaka phakathi i-cholestyramine (i-Locholest), i-colesevelam (i-Welchol), noma i-colestipol (i-Colestid).

Uma amazinga akho e-cholesterol asephakeme kakhulu ngemuva kwalolu hlobo lwesibili lwemithi, udokotela wakho angaphakamisa i-PCSK9 inhibitor.

Basebenza kanjani

Ama-PCSK9 inhibitors angasetshenziswa ngokungeziwe noma esikhundleni sezitembu. Le mithi isebenza ngokuhlukile. Ama-PCSK9 inhibitors akhomba iprotheni esibindini okuthiwa yi-proprotein convertase subtilisin kexin 9, noma i-PCSK9. Ngokunciphisa inani le-PCSK9 emzimbeni wakho, ama-PCSK9 inhibitors avumela umzimba wakho ukuthi ususe i-cholesterol ngokuyimpumelelo.

Okuqhamuka uma udla imishanguzo

Ama-Statins kanye ne-PCSK9 inhibitors ngalinye lingadala imiphumela emibi futhi emibi kakhulu, futhi imiphumela yehlukile phakathi kwemithi.

Ukusebenza ngempumelelo

Izitatimende zikhonjisiwe ukwehlisa i-cholesterol kubantu abaningi. Zisetshenziswe kusukela ngeminyaka yama-1980 futhi imiphumela yazo ifundwe ezinkulungwaneni zabantu abathatha ama-statin ukuvimbela isifo senhliziyo nokushaywa unhlangothi.

Ngokuphambene nalokho, ama-PCSK9 inhibitors asanda kuvunywa, ngakho-ke idatha yokuphepha yesikhathi eside ayiyinhle. Noma kunjalo ama-PCSK9 inhibitors asebenza kakhulu kwabanye abantu.Ucwaningo oluthile lubonise ukuthi i-alirocumab inciphise amazinga e-cholesterol ngamaphesenti angama-61. Kuphinde kwanciphisa amathuba ezehlakalo zenhliziyo nemithambo yegazi njengokuhlaselwa yisifo senhliziyo nokushaywa unhlangothi. Olunye ucwaningo luthole imiphumela efanayo ne-evolocumab.

Izindleko

Izitatimende zitholakala ngegama lomkhiqizo namafomu ejwayelekile. Ama-generic ngokuvamile abiza ngaphansi kwezinguqulo zomkhiqizo, ngakho-ke izitatimende zingabiza kakhulu.

Ama-PCSK9 inhibitors amasha, ngakho-ke awanazo izinhlobo ezijwayelekile okwamanje. Ngalesi sizathu, ayabiza kakhulu kunama-statins. Izindleko ze-PCSK9 inhibitors zingaba ngaphezu kwe- $ 14,000 ngonyaka. Ngaphezu kwalokho, ukuze le ndleko ikhokhelwe umshwalense wakho, kufanele uwele kwesinye sezigaba ezimbili ezinconyelwe ukusebenzisa ama-PCSK9 inhibitors. Uma ungalingani kwesinye salezo zigaba, kungenzeka ukhokhele i-PCSK9 inhibitor ngokwakho.

Khuluma nodokotela wakho

Ama-Statins kanye ne-PCSK9 inhibitors yizinketho ezibalulekile zezidakamizwa ekwelapheni amazinga aphezulu e-cholesterol. Ngenkathi zombili izinhlobo zezidakamizwa zisiza amazinga aphansi e-cholesterol, kukhona umehluko omkhulu. Ithebula elingezansi lichaza lo mehluko shazi.

Khuluma nodokotela wakho

Uma une-cholesterol ephezulu futhi ucabanga ukuthi enye yalezi zinhlobo zemithi kungenzeka ikulungele, isinyathelo sakho sokuqala kufanele kube ukukhuluma nodokotela wakho. Bangakutshela kabanzi ngalezi zidakamizwa nezinye izindlela zokwelashwa. Eminye imibuzo ongayidingida nodokotela wakho kungenzeka:

• Ingabe imithi isinyathelo esilandelayo kimi ekuphatheni i-cholesterol yami ephezulu?
• Ngabe ngihlangabezana nezindlela ezimbili zabantu abangabelwa ama-PCSK9 inhibitors?
• Ingabe kufanele ngikhulume nodokotela we-lipid?
• Ingabe kufanele ngiqale uhlelo lokuzivocavoca ukusiza ukuphatha i-cholesterol yami?
• Ungangidlulisela kuchwepheshe wezokudla obhalisiwe ukuze angisize ngilawule indlela engidla ngayo?