Izilonda Zesisu Esisemathunjini: Izimpawu, Izimbangela, Nezici Zengozi

-Delile

• Izimpawu
• Izimbangela
• Izici zobungozi
• Ubudala
• Izakhi zofuzo

Izicubu zomzimba emathunjini (GISTs) yizicubu, noma amaqoqo amaseli akhule kakhulu, epheshaneni lesisu (GI). Izimpawu zezimila ze-GIST zifaka:

• indle enegazi
• ubuhlungu noma ukungaphatheki kahle esiswini
• isicanucanu nokuhlanza
• ukuvimbelwa kwamathumbu
• isisindo esiswini ongasizwa
• ukukhathala noma ukuzizwa ukhathele kakhulu
• uzizwe usuthe kakhulu ngemuva kokudla amanani amancane
• ubuhlungu noma ubunzima lapho ugwinya

Ipheshana le-GI uhlelo olubhekele ukugaya nokumunca ukudla nezakhamzimba. Kufaka phakathi umphimbo, isisu, amathumbu amancane nekholoni.

Ama-GIST aqala kumaseli akhethekile ayingxenye yohlelo lokuzimela oluzimele. Lawa maseli atholakala odongeni lwepheshana le-GI, futhi alawula ukunyakaza kwemisipha ukugaya.

Iningi lama-GISTs akha esiswini. Kwesinye isikhathi zakheka emathunjini amancane, kepha ama-GIST akhiwa kukholoni, i-esophagus, ne-rectum ajwayelekile kakhulu. Ama-GIST angaba kubi futhi abe nomdlavuza noma abe nobungozi hhayi umdlavuza.

Izimpawu

Izimpawu zincike kubukhulu besimila nokuthi sitholakala kuphi. Ngenxa yalokhu, zivame ukuhluka ngobukhulu futhi zisuke komunye umuntu ziye komunye. Izimpawu ezinjengobuhlungu besisu, isicanucanu, nokukhathala ziyahlangana nezinye izimo nezifo eziningi.

Uma uhlangabezana nenye yalezi noma ezinye izimpawu ezingavamile, kufanele ukhulume nodokotela wakho. Zizosiza ukuthola imbangela yezimpawu zakho.

Uma unezici zobungozi be-GIST noma esinye isimo esingadala lezi zimpawu, qiniseka ukusho lokho kudokotela wakho.

Izimbangela

Imbangela ngqo yama-GISTs ayaziwa, yize kubonakala sengathi kunokuhlobana nokuguquka kwesimo ekubonisweni kweprotheni ye-KIT. Umdlavuza uqala lapho amangqamuzana eqala ukukhula angalawuleki. Njengoba amangqamuzana eqhubeka nokukhula ngokungalawuleki, ayakha akhe isisindo esibizwa ngokuthi isimila.

Ama-GIST aqala kupheshana le-GI futhi angakhula aye ngaphandle abe izakhiwo noma izitho eziseduze. Zivame ukusabalala esibindini nase-peritoneum (ulwelwesi oluqukethe ulwelwesi lwesisu) kepha kuyaqabukela kuma-lymph node aseduze.

Izici zobungozi

Zimbalwa kuphela izici eziyingozi ezaziwayo zama-GIST:

Ubudala

Iminyaka ejwayelekile kakhulu yokwenza i-GIST iphakathi kuka-50 no-80. Ngenkathi ama-GIST engenzeka kubantu abangaphansi kweminyaka engama-40, ayivelakancane ngokweqile.

Izakhi zofuzo

Iningi lama-GIST lwenzeka ngokungahleliwe futhi alinaso isizathu esicacile. Kodwa-ke, abanye abantu bazalwa benokushintshwa kwezakhi zofuzo okungaholela kuma-GIST.

Ezinye zofuzo nemibandela ehlotshaniswa nama-GIST afaka:

I-Neurofibromatosis 1: Lesi sifo sofuzo, esibizwa nangokuthi i-Von Recklinghausen's disease (i-VRD), sibangelwa ukukhubazeka kwesifo se- NF1 isakhi sofuzo. Isimo singadluliswa sisuka kumzali siye enganeni kodwa asihlali sizuzwa njengefa. Abantu abanalesi simo basengozini eyengeziwe yokuthuthukisa izicubu ezinobungozi emithanjeni besebancane. Lezi zicubu zingadala amabala amnyama esikhunjeni futhi ziqhume emgodini noma ekhwapheni. Lesi simo futhi sandisa ubungozi bokusungula i-GIST.

Umndeni ojwayelekile wamathumbu wesisu isimila syndrome: Lesi sifo sidalwa kakhulu yisakhi se-KIT esingajwayelekile esidluliswa sisuka kumzali siye enganeni. Lesi simo esingajwayelekile sandisa ubungozi bama-GIST. Lawa ma-GIST angakha esemncane kunabantu abaningi. Abantu abanalesi simo bangaba nama-GIST amaningi ngesikhathi sokuphila kwabo.

Ukuguquka kwezakhi zofuzo ku-succinate dehydrogenase (SDH) genes: Abantu abazalwa nokuguquka kwezakhi zofuzo kuhlobo lwe-SDHB kanye ne-SDHC basengozini eyengeziwe yokuthuthukisa ama-GIST. Banobungozi obengeziwe bokuthuthukisa uhlobo lwesimila sezinzwa esibizwa ngokuthi yi-paraganglioma.