Ukwelapha ama-Multiple Sclerosis Flare-Ups ngama-Steroids

-Delile

• Multiple sclerosis steroids
• I-Solumedrol
• Prednisone
• I-Decadron
• Ingabe kuyasebenza?
• Ukusetshenziswa kwama-steroid kwemiphumela emibi ye-MS
• Imiphumela yesikhashana
• Imiphumela yesikhathi eside
• Ukuhamba kancane
• Ukudla okudlela endlini

I-steroids isetshenziswa kanjani ukuphatha i-MS

Uma une-multiple sclerosis (MS), udokotela wakho angakunikeza ama-corticosteroids ukwelapha iziqephu zomsebenzi wezifo obizwa ngokuthi yi-exacerbations. Lezi ziqephu zezimpawu ezintsha noma ezibuyayo zaziwa nangokuthi ukuhlaselwa, ukuqhuma, noma ukubuyela emuva.

Ama-steroid enzelwe ukunciphisa ukuhlaselwa ukuze ubuyele emzileni ngokushesha.

Akudingekile ukwelapha konke ukubuyela emuva kwe-MS nge-steroids, noma kunjalo. Le mithi ngokuvamile ibekelwe ukubuyela emuva okukhulu okuphazamisa amandla akho okusebenza. Ezinye izibonelo zalokhu ubuthakathaka obukhulu, izingqinamba zokulinganisela, noma ukuphazamiseka kombono.

Imithi yokwelapha i-steroid inamandla futhi ingadala imiphumela emibi eyehluka kuye ngomuntu. Ukwelashwa nge-Intravenous (IV) steroid kungabiza futhi kube nzima.

Ubuhle nobubi be-steroids ye-MS kumele bukalwe ngamunye futhi bungashintsha phakathi nesikhathi sesifo.

Qhubeka ufunde ukuze ufunde kabanzi ngama-steroids e-MS kanye nezinzuzo zawo ezingaba khona kanye nemiphumela engemihle.

Multiple sclerosis steroids

Uhlobo lwe-steroids olusetshenziselwa i-MS lubizwa ngokuthi yi-glucocorticoids. Le mithi ilingisa umphumela wamahomoni akhiqizwa ngumzimba wakho ngokwemvelo.

Basebenza ngokuvala isithiyo esingalungile segazi nobuchopho, esisiza ukumisa amaseli wokuvuvukala ekuthutheleleni kohlelo oluphakathi lwezinzwa. Lokhu kusiza ukucindezela ukuvuvukala nokunciphisa izimpawu ze-MS.

Ama-steroids aphezulu kakhulu ahanjiswa ngemithambo yegazi kanye ngosuku izinsuku ezintathu kuya kwezinhlanu. Lokhu kufanele kwenziwe emtholampilo noma esibhedlela, imvamisa kwenzelwa abagulayo. Uma unenkinga enkulu yezempilo, kungadingeka ukwelashwa esibhedlela.

Ukwelashwa kwe-IV kwesinye isikhathi kulandelwa inkambo ye-steroids yomlomo isonto elilodwa noma amabili, lapho umthamo wehla kancane. Kwezinye izimo, ama-steroids omlomo athathwa isikhathi esingangesonto eliyisithupha.

Akukho mkhawulo ojwayelekile noma uhlobo lokwelashwa kwe-steroid lwe-MS. Udokotela wakho uzobheka ubunzima bezimpawu zakho futhi kungenzeka afune ukuqala ngomthamo ophansi kakhulu ongaba khona.

Okulandelayo ngamanye ama-steroids asetshenziselwa ukwelapha ukubuyela emuva kwe-MS.

I-Solumedrol

I-Solumedrol, i-steroid esetshenziswa kakhulu ukwelapha i-MS, yigama lomkhiqizo le-methylprednisolone. Inamandla impela futhi ijwayele ukusetshenziselwa ukubuyela emuva okukhulu.

Izilinganiso zokulinganisa ezijwayelekile zisuka kuma-milligram angama-500 kuye kwayi-1000 ngosuku. Uma unesisindo esincane somzimba, umthamo ongaphansi kwesikali ungabekezeleleka.

I-Solumedrol ifakwa ngemithambo ngaphakathi esikhungweni sokumnika noma esibhedlela. Ukumnika ngakunye kuhlala cishe ihora, kepha lokhu kungahluka. Ngesikhathi sokumnika, ungahle ubone ukunambitheka kwensimbi emlonyeni wakho, kepha kungokwesikhashana.

Ngokuya ngokuthi uphendula kanjani, ungadinga ukumnika nsuku zonke ukusuka ezinsukwini ezintathu kuya kweziyisikhombisa.

Prednisone

I-Orn prednisone iyatholakala ngaphansi kwamagama ezimpawu ezinjengeDeltasone, Intensol, iRayos, neSterapred. Lo muthi ungasetshenziswa esikhundleni se-IV steroids, ikakhulukazi uma ubuyela emuva kancane.

I-Prednisone nayo isetshenziselwa ukukusiza wehle ngemuva kokuthola i-IV steroids, imvamisa isonto elilodwa noma amabili. Isibonelo, ungathatha ama-milligram angama-60 ngosuku izinsuku ezine, ama-milligram angama-40 ngosuku izinsuku ezine, bese kuba ama-milligram angama-20 ngosuku izinsuku ezine.

I-Decadron

I-decadron yigama lomkhiqizo le-dexamethasone yomlomo. Ukuthatha umthamo wansuku zonke wama-30 milligram (mg) ngesonto kuboniswe ukuthi kuyasebenza ekwelapheni ukubuyela emuva kwe-MS.

Lokhu kungalandelwa ngu-4-12 mg njalo ezinsukwini ezithile kuze kube yinyanga. Udokotela wakho uzokunquma isilinganiso sokuqala esifanele.

Ingabe kuyasebenza?

Kubalulekile ukuqaphela ukuthi ama-corticosteroids akulindelekile ukuthi ahlinzeke ngezinzuzo zesikhathi eside noma aguqule inkambo ye-MS.

Kunobufakazi bokuthi zingakusiza ukuthi ululame ekubuyeleni emuva ngokushesha. Kungathatha izinsuku ezimbalwa ukuzwa izimpawu zakho ze-MS zithuthuka.

Kepha njengoba i-MS ihluka kakhulu komunye umuntu, kanjalo nokwelashwa kwama-steroid kwenza. Akunakwenzeka ukubikezela ukuthi kuzokusiza kangakanani ukuthi uthole kabusha noma kuzothatha isikhathi esingakanani.

Ucwaningo oluncane oluncane luye lwasikisela ukuthi imithamo eqhathaniswa ye-corticosteroids yomlomo ingasetshenziswa esikhundleni se-high-dose IV methylprednisolone.

U-2017 uphethe ngokuthi i-methylprednisolone yomlomo ayiphansi kune-IV methylprednisolone, futhi ibekezelelwa ngokulinganayo futhi iphephile.

Njengoba i-steroids yomlomo ilula kakhulu futhi ibiza kancane, ingaba yindlela enhle yokwelashwa kwe-IV, ikakhulukazi uma ukumnika kuyinkinga kuwe.

Buza udokotela wakho ukuthi ngabe ama-steroids omlomo angakhetha kahle kuwe.

Ukusetshenziswa kwama-steroid kwemiphumela emibi ye-MS

Ukusetshenziswa ngezikhathi ezithile kwe-high-dose corticosteroids kuvame ukubekezelelwa kahle. Kepha banemiphumela engemihle. Ezinye uzozizwa ngokushesha. Eminye ingabangelwa ukwelashwa okuphindaphindiwe noma kwesikhathi eside.

Imiphumela yesikhashana

Ngenkathi uthatha ama-steroids, ungahle uhlangane namandla esikhashana angenza kube nzima ukulala noma nokuhlala uphumule. Kungadala nezinguquko zemizwelo nokuziphatha. Ungase uzizwe unethemba elikhulu noma ungacabangi ngenkathi uku-steroids.

Ngokubambisana, le miphumela emibi ingakwenza ufune ukubhekana namaphrojekthi amakhulu noma uthathe imithwalo yemfanelo engaphezulu kunalokho okufanele ukwenze.

Lezi zimpawu ngokuvamile zingezesikhashana futhi ziqala ukuthuthuka njengoba unciphisa umuthi.

Eminye imiphumela emibi engaba khona ibandakanya:

• induna
• ukuqhuma ebusweni
• ukusabela okweqile
• ukudana
• ukuvuvukala kwezandla nezinyawo (kusuka ekugcineni uketshezi kanye ne-sodium)
• ikhanda
• ukwanda kwesifiso sokudla
• ukwanda kweglucose yegazi
• ukwanda komfutho wegazi
• ukuqwasha
• kwehlisa ukumelana nokutheleleka
• ukunambitheka kwensimbi emlonyeni
• ubuthakathaka bemisipha
• ukucasuka kwesisu noma izilonda

Imiphumela yesikhathi eside

Ukwelashwa kwesikhathi eside kwe-steroid kungahle kuholele emiphumeleni emibi efana nale:

• ngamehlo
• i-glaucoma ebhebhetheka
• isifo sikashukela
• ukukhumuzeka kwamathambo
• ukuzuza kwesisindo

Ukuhamba kancane

Kubalulekile ukulandela ngokucophelela imiyalo kadokotela wakho maqondana nokunciphisa ama-steroids. Uma uyeka ukuzithatha ngokungazelelwe, noma uma wehla ngokushesha okukhulu, ungahle ube nezimpawu zokuhoxa.

I-Prednisone ingathinta ukukhiqizwa kwakho kwe-cortisol, ikakhulukazi uma uyithatha isikhathi esingaphezu kwamasonto ambalwa ngasikhathi. Izimpawu zokuthi ucisha ngokushesha okukhulu zingafaka:

• Ubuhlungu bomzimba
• ubuhlungu obuhlangene
• ukukhathala
• ubumhlophe
• isicanucanu
• ukulahlekelwa isifiso sokudla
• ubuthakathaka

Ukumisa i-Decadron ngokungazelelwe kungaholela ku:

• ukudideka
• ukozela
• ikhanda
• ukulahlekelwa isifiso sokudla
• ukuncipha komzimba
• ubuhlungu bemisipha namalunga
• ukukhipha isikhumba
• isisu esicasulayo nokuhlanza

Ukudla okudlela endlini

AmaCorticosteroids asetshenziselwa ukwelapha izimpawu ezinzima futhi anciphise ubude bokubuyela emuva kwe-MS. Abaselaphi lesi sifo uqobo.

Ngaphandle kwesimo sokulahleka kombono, ukwelashwa kokubuyela emuva kwe-MS akuphuthumi. Kepha kufanele iqalwe ngokushesha okukhulu.

Izinqumo mayelana nezinzuzo nemiphumela emibi yale mithi kumele zenziwe ngazodwana. Izinto okufanele uxoxe ngazo nodokotela zifaka:

• ubunzima bezimpawu zakho nokuthi ukubuyela kwakho emuva kuthinta kanjani amandla akho okwenza imisebenzi yakho yansuku zonke
• ukuthi uhlobo ngalunye lwe-steroid luphathwa kanjani nokuthi uyakwazi yini ukuhambisana nohlobo lwemithi
• imiphumela emibi engaba khona nokuthi ingathinta kanjani ikhono lakho lokusebenza
• noma yiziphi izinkinga ezinkulu ezingaba khona, kufaka phakathi ukuthi ama-steroids angazithinta kanjani ezinye izimo zakho ezifana nesifo sikashukela noma izingqinamba zempilo yengqondo
• noma yikuphi ukuxhumana okungenzeka neminye imithi
• yiziphi izindlela zokwelashwa ze-steroid ezihlanganiswa umshwalense wakho wezokwelapha
• iziphi ezinye izindlela zokwelashwa ezitholakalayo zezimpawu ezithile zokubuyela emuva kwakho

Kungumqondo omuhle ukuba nale ngxoxo ngokuzayo lapho uvakashela udokotela wezinzwa. Ngaleyo ndlela, uzobe usukulungele ukunquma uma kwenzeka ubuyela emuva.