IGlucagonoma

IGlucagonoma iyisigaxa esingavamile kakhulu samangqamuzana esiqhingini samanyikwe, okuholela ekweqiseni kwe-hormone yeglucagon egazini.

IGlucagonoma imvamisa inomdlavuza (iyingozi). Umdlavuza uvame ukusabalala futhi ube mubi kakhulu.

Lo mdlavuza uthinta amaseli esiqhingini samanyikwe. Ngenxa yalokhu, amaseli we-islet akhiqiza i-hormone glucagon eningi kakhulu.

Imbangela ayaziwa. Izici zofuzo zidlala indima kwezinye izimo. Umlando womndeni we-syndrome multiple endocrine neoplasia type I (MEN I) uyingozi.

Izimpawu ze-glucagonoma zingafaka noma yikuphi okulandelayo:

• Ukungabekezelelani kwe-glucose (umzimba unenkinga yokwephula ushukela)
• Ushukela wegazi ophakeme (i-hyperglycemia)
• Uhudo
• Ukoma ngokweqile (ngenxa kashukela ophakeme wegazi)
• Ukuchama njalo (ngenxa yeshukela ephezulu yegazi)
• Ukwanda kwesifiso
• Kuvuvukala umlomo nolimi
• Ukuchama ebusuku (ebusuku)
• Ukuqhuma kwesikhumba ebusweni, esiswini, ezinqeni, noma ezinyaweni ezifika futhi zidlule, futhi zihambe zenyuka
• Ukwehla kwesisindo

Ezimweni eziningi, umdlavuza usuvele usakazekele esibindi lapho utholakala.

Umhlinzeki wezokunakekelwa kwempilo uzokwenza ukuhlolwa ngokomzimba abuze ngomlando nezimpawu zakho zezokwelapha.

Ukuhlolwa okungenziwa kufaka phakathi:

• I-CT scan yesisu
• Izinga leGlucagon egazini
• Izinga le-glucose egazini

Ukuhlinzwa ukususa isisu kuvame ukunconywa. Isimila ngokuvamile asiphenduli ekwelashweni ngamakhemikhali.

Unganciphisa ukucindezela kokugula ngokujoyina iqembu lokusekela umdlavuza. Ukwabelana nabanye abanokuhlangenwe nakho okuvamile nezinkinga kungakusiza ungazizwa uwedwa.

Cishe ama-60% ala mathumba anomdlavuza. Kujwayelekile ukuthi lo mdlavuza usabalalele esibindini. Balinganiselwa ku-20% kuphela abantu abangalashwa ngokuhlinzwa.

Uma isimila sisezinhlakeni kuphela futhi ukuhlinzwa kusikhipha kuphumelela, abantu banesilinganiso seminyaka emihlanu sokusinda sama-85%.

Umdlavuza ungadlulela esibindini. Izinga likashukela egazini eliphakeme lingadala izinkinga nge-metabolism kanye nokulimala kwezicubu.

Shayela umhlinzeki wakho uma ubona izimpawu ze-glucagonoma.

AMADODA I - glucagonoma

• Izindlala ze-Endocrine

Iwebhusayithi yeNational Cancer Institute. Ukwelashwa kwe-Pancreatic neuroendocrine tumors (islet cell tumors) (PDQ) - inguqulo yezempilo. www.cancer.gov/types/pancreatic/hp/pnet-treatment-pdq. Kubuyekezwe uFebhuwari 8, 2018. Kufinyelelwe ngoNovemba 12, 2018.

USchneider DF, Mazeh H, Lubner SJ, Jaume JC, Chen H. Cancer wohlelo lwe-endocrine. Ku: Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE, abahleli. I-Abeloff’s Clinical Oncology. Umhlaka 5. IPhiladelphia, PA: Elsevier Saunders; 2014: isahluko 71.

UVella A. Amahomoni emathunjini namathumbu we-endocrine gut. Ku: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, abahleli. Incwadi kaWilliams ye-Endocrinology. Umhlaka 13. IPhiladelphia, PA: Elsevier; 2016: isahluko 38.