Ama-endocrine neoplasia amaningi (AMADODA) I

Uhlobo lwe-endocrine neoplasia (MEN) uhlobo I luyisifo lapho eyodwa noma eziningi zezindlala ze-endocrine zisebenza ngokweqile noma zakha isimila. Idluliselwa emindenini.

Izindlala ze-Endocrine ezivame ukubandakanyeka zifaka:

• Amapancreas
• I-Parathyroid
• I-pituitary

AMADODA Mina ngidalwa ukukhubazeka kofuzo oluphethe ikhodi yeprotheyini ebizwa nge-menin. Isimo senza ukuthi izicubu zezindlala ezahlukahlukene zivele kumuntu ofanayo, kodwa hhayi ngasikhathi sinye.

Lesi sifo singavela nganoma yisiphi isikhathi, futhi sithinta abesilisa nabesifazane ngokulinganayo. Umlando womndeni walesi sifo uphakamisa ubungozi bakho.

Izimpawu ziyahlukahluka kuye ngomuntu, futhi kuya ngokuthi iyiphi indlala ebandakanyekayo. Zingafaka:

• Ubuhlungu besisu
• Ukukhathazeka
• Okumnyama, izitulo zokubambezeleka
• Ukuzwa okuqhakazile ngemuva kokudla
• Ukushisa, ukuqaqamba, noma indlala ukungakhululeki esiswini esingenhla noma esifubeni esingezansi esikhululwe ngama-antacids, ubisi, noma ukudla
• Ukwehla kwezintshisekelo zocansi
• Ukukhathala
• Ubuhlungu bekhanda
• Ukungabi nesikhathi sokuya esikhathini (kwabesifazane)
• Ukuphelelwa isifiso sokudla
• Ukulahlekelwa izinwele noma izinwele ebusweni (emadodeni)
• Izinguquko zengqondo noma ukudideka
• Ubuhlungu bemisipha
• Isicanucanu nokuhlanza
• Ukuzwela emakhazeni
• Ukwehla kwesisindo ngokungenhloso
• Izinkinga zombono
• Ubuthakathaka

Umhlinzeki wezokunakekelwa kwempilo uzokwenza ukuhlolwa ngokomzimba abuze imibuzo ngomlando nezimpawu zakho zezokwelapha. Ukuhlolwa okulandelayo kungenziwa:

• Izinga le-cortisol yegazi
• I-CT scan yesisu
• I-CT scan yekhanda
• Ukuzila ushukela wegazi
• Ukuhlolwa kofuzo
• Ukuhlolwa kwe-insulin
• I-MRI yesisu
• I-MRI yekhanda
• I-serum adrenocorticotropic hormone
• I-calcium yeserum
• I-serum follicle evuselela i-hormone
• I-serum gastrin
• I-Serum glucagon
• I-serum luteinizing hormone
• I-serum hormone ye-parathyroid
• I-serum prolactin
• I-Serum thyroid ekhuthaza i-hormone
• I-Ultrasound yentamo

Ukuhlinzwa ukususa indlala egulayo imvamisa kuyindlela yokwelashwa oyithandayo. Umuthi obizwa nge-bromocriptine ungasetshenziswa esikhundleni sokuhlinzwa kwezicubu zomthambo ezikhipha i-hormone prolactin.

Izindlala ze-parathyroid, ezilawula ukukhiqizwa kwe-calcium, zingasuswa. Kodwa-ke, kunzima emzimbeni ukulawula amazinga e-calcium ngaphandle kwalezi zindlala, ngakho-ke ukususwa ngokuphelele kwe-parathyroid akwenziwa kuqala ezimweni eziningi.

Imithi iyatholakala ukunciphisa ukukhiqizwa okweqile kwesisu esiswini okubangelwa ezinye izicubu (gastrinomas), nokunciphisa ubungozi bezilonda.

Ukwelashwa okufaka esikhundleni seHormone kunikezwa lapho kukhishwa zonke izindlala noma kungakhiqizi ama-hormone anele.

Izicubu zepituitary kanye neparathyroid ngokuvamile azinomdlavuza (benign), kepha ezinye izimila ze-pancreatic zingaba nomdlavuza (zibulale) bese zisakazekela esibindini. Lokhu kunganciphisa isikhathi sokuphila.

Izimpawu zesifo se-peptic ulcer, ushukela ophansi wegazi, i-calcium eyeqile egazini, kanye nokungasebenzi kahle kwepituitary kuvame ukuphendula kahle ekwelashweni okufanele.

Amathumba angaqhubeka abuye. Izimpawu nezinkinga zixhomeke ekutheni yiziphi izindlala ezihilelekile. Ukuhlolwa njalo ngumhlinzeki wakho kubalulekile.

Shayela umhlinzeki wakho uma ubona izimpawu ze-MEN I noma unomlando womndeni walesi simo.

Kunconywa ukuhlola izihlobo eziseduze zabantu abathintekayo ngalesi sifo.

Isifo se-Wermer; AMADODA I

• Izindlala ze-Endocrine

Iwebhusayithi ye-National Comprehensive Cancer Network. Imihlahlandlela yokusebenza kwemitholampilo ku-oncology (imihlahlandlela ye-NCCN): izicubu ze-neuroendocrine. Inguqulo 1.2019. www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdf. Kubuyekezwe ngoMashi 5, 2019. Kufinyelelwe ngoMashi 8, 2020.

UNewey PJ, uThakker RV. Ama-neoplasia amaningi we-endocrine. Ku: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, abahleli. Incwadi kaWilliams ye-Endocrinology. Umhlaka 14. IPhiladelphia, PA: Elsevier; 2020: isahluko 42.

UNieman LK, uSpiegel AM. Ukuphazamiseka kwePolyglandular. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 218.

I-Thakker RV. Uhlobo lwe-endocrine neoplasia eminingi 1. Ku: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. I-Endocrinology: Eyabantu Abadala Neyengane. Umhla wesi-7. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 148.