I-glomerulosclerosis engxenyeni eqondile

I-Focal segmental glomerulosclerosis izicubu ezibomvu kuphiko lokuhlunga izinso. Lesi sakhiwo sibizwa ngokuthi i-glomerulus. I-glomeruli isebenza njengezihlungi ezisiza umzimba ukuthi ulahle izinto eziyingozi. Inso ngalinye linezinkulungwane zama-glomeruli.

"Ukugxila" kusho ukuthi amanye ama-glomeruli aba nezibazi. Ezinye zihlala zijwayelekile. "Okwehlukanisiwe" kusho ukuthi kuphela ingxenye yelungu elilodwa le-glomerulus elimele.

Imbangela ye-focal segmental glomerulosclerosis ivame ukungaziwa.

Lesi simo sithinta izingane kanye nabantu abadala. Kwenzeka kaninginingi emadodeni nakubafana. Kuvame kakhulu kubantu base-Afrika baseMelika. I-Focal segmental glomerulosclerosis ibangela ikota yazo zonke izimo ze-nephrotic syndrome.

Izimbangela ezaziwayo zifaka:

• Izidakamizwa ezifana ne-heroin, i-bisphosphonates, i-anabolic steroids
• Ukutheleleka
• Izinkinga zofuzo
• Ukukhuluphala ngokweqile
• I-Reflux nephropathy (isimo lapho umchamo ugelezela khona emuva usuka esinyeni uye ezinso)
• Isifo se-Sickle cell
• Eminye imithi

Izimpawu zingafaka:

• Umchamo we-foam (kusuka emaprotheni amaningi ngokweqile)
• Ukudla okungekuhle
• Ukuvuvukala, okubizwa nge-edema ejwayelekile, kusuka kuketshezi olugcinwe emzimbeni
• Ukuzuza kwesisindo

Umhlinzeki wezokunakekelwa kwempilo uzokwenza ukuhlolwa komzimba. Lokhu kuhlolwa kungakhombisa ukuvuvukala kwezicubu (i-edema) nomfutho wegazi ophezulu. Izimpawu zokuhluleka kwezinso (izinso) noketshezi oluningi kungavela njengoba isimo siba sibi kakhulu.

Ukuhlolwa kungafaka:

• Ukucubungula izinso
• Ukuhlolwa kokusebenza kwezinso (igazi nomchamo)
• Ukuhlolwa komchamo
• I-microscopy yomchamo
• Amaprotheni omchamo

Ukwelashwa kungafaka:

• Imithi yokwehlisa impendulo yomzimba yokuvuvukala.
• Imithi yokwehlisa umfutho wegazi. Eminye yale mithi isiza nokwehlisa inani lamaprotheni achitheka emchameni.
• Imithi yokuqeda uketshezi oluningi (isisu noma "iphilisi lamanzi").
• Ukudla okuphansi kwe-sodium ukunciphisa ukuvuvukala nokwehlisa umfutho wegazi.

Umgomo wokwelashwa ukulawula izimpawu ze-nephrotic syndrome nokuvimbela ukwehluleka kwezinso okungamahlalakhona. Lezi zindlela zokwelashwa zingabandakanya:

• Ama-antibiotic ukulawula izifo
• Ukuvinjelwa kwamanzi
• Ukudla okunamafutha amancane
• Ukudla okuphansi noma okulinganiselayo kwamaprotheni
• Izithako ze-Vitamin D
• I-Dialysis
• Ukufakelwa kwezinso

Ingxenye enkulu yabantu abane-glomerulosclerosis egxile noma engxenyeni ethile bayoba nokuhluleka kwezinso okungamahlalakhona.

Izinkinga zingafaka:

• Ukwehluleka kwezinso okungamahlalakhona
• Isifo sezinso sokugcina
• Ukutheleleka
• Ukungondleki
• I-Nephrotic syndrome

Shayela umhlinzeki wakho uma uba nezimpawu zalesi simo, ikakhulukazi uma kukhona:

• Imfiva
• Ubuhlungu ngokuchama
• Ukwehla kokukhishwa komchamo

Akukho ukuvimbela okwaziwayo.

Ingxenye yeglomerulosclerosis; I-Focal sclerosis ene-hyalinosis

• Uhlelo lwesilisa lomchamo

I-Appel GB, D'Agati VD. Izimbangela eziyinhloko nezesibili (ezingezona ezofuzo) ze-glomerulosclerosis egxile futhi engxenyeni ethile. Ku: Feehally J, Floege J, Tonelli M, Johnson RJ, abahleli. I-Nephrology Yomtholampilo Ephelele. Umhlaka 6. IPhiladelphia, PA: Elsevier; 2019: isahluko 18.

I-Appel GB, i-Radhakrishnan J. Izifo ze-Glomerular nama-syndromes we-nephrotic. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil.Umhla ka-25. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 121.

IPendergraft WF, uNachman PH, uJennette JC, uFalk RJ. Isifo esiyisisekelo se-glomerular. Ku: Skorecki K, Taal MW, Chertow GM, Marsden PA, Yu ASL, ama-eds. IBrenner neRector's The Kidney. Umhlaka 10. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 32.