Isifo sokushintsha okuncane

Isifo sokushintshwa okuncane ukuphazamiseka kwezinso okungaholela kwi-nephrotic syndrome. I-Nephrotic syndrome yiqembu lezimpawu ezibandakanya amaprotheni emchameni, amazinga aphansi wamaprotheni egazini, amazinga aphezulu e-cholesterol, amazinga aphezulu e-triglyceride nokuvuvukala.

Inso ngalinye lenziwe ngamayunithi angaphezu kwesigidi abizwa ngama-nephrons, ahlunga igazi akhiqize nomchamo.

Esikhathini esincane sokushintsha kwesifo, kukhona ukulimala kwe-glomeruli. Le yimithambo yegazi emincane ngaphakathi kwe-nephron lapho kuhluzwa khona igazi ukwenza umchamo nokususwa kwemfucuza. Lesi sifo sithola igama laso ngoba lo monakalo awubonakali ngaphansi kwesibonakhulu esijwayelekile. Ingabonakala kuphela ngaphansi kwesibonakhulu esinamandla kakhulu esibizwa nge-electron microscope.

Isifo sokushintsha okuncane imbangela ejwayelekile kakhulu ye-nephrotic syndrome ezinganeni. Kuyabonakala nakubantu abadala abane-nephrotic syndrome, kepha akuvamile.

Isizathu asaziwa, kepha isifo singenzeka ngemuva noma sihlobane no:

• Ukusabela okweqile
• Ukusetshenziswa kwama-NSAID
• Izimila
• Ukugonywa (umkhuhlane kanye ne-pneumococcal, yize kungavamile)
• Ukutheleleka ngegciwane

Kungaba nezimpawu ze-nephrotic syndrome, kufaka phakathi:

• Ukubukeka kwegwebu lomchamo
• Ukudla okungekuhle
• Ukuvuvukala (ikakhulukazi eduze kwamehlo, izinyawo, namaqakala, nasesiswini)
• Ukuzuza kwesisindo (kusuka ekugcineni okunamanzi)

Isifo sokushintsha okuncane asinciphisi inani lomchamo okhiqizwayo. Kuyaqabukela kudlulela ekuhlulekeni kwezinso.

Umhlinzeki wezokunakekelwa kwempilo kungenzeka angakwazi ukubona noma yiziphi izimpawu zesifo, ngaphandle kokuvuvukala. Ukuhlolwa kwegazi nomchamo kuveza izimpawu zesifo i-nephrotic, kufaka phakathi:

• I-cholesterol ephezulu
• Izinga eliphakeme lamaprotheni emchameni
• Amazinga aphansi e-albhamuin egazini

Ukuhlolwa kwezinso nokuhlolwa kwezicubu nge-microscope ye-electron kungakhombisa izimpawu zesifo esincane sokushintsha.

Imithi ebizwa ngokuthi i-corticosteroids ingelapha isifo esincane sokushintsha ezinganeni eziningi. Ezinye izingane zingadinga ukuhlala kuma-steroids ukugcina lesi sifo singabuyi.

I-Steroids iyasebenza kubantu abadala, kodwa kancane ezinganeni. Abantu abadala bangaphindelela kaningi futhi bathembele kuma-steroids.

Uma i-steroids ingasebenzi, umhlinzeki kungenzeka aphakamise eminye imithi.

Ukuvuvukala kungaphathwa nge:

• Imithi ye-ACE inhibitor
• Ukulawulwa kwengcindezi yegazi
• I-diuretics (amaphilisi wamanzi)

Ungatshelwa nokuthi wehlise inani likasawoti ekudleni kwakho.

Izingane zivame ukuphendula kangcono kuma-corticosteroids kunabantu abadala. Izingane zivame ukuphendula kungakapheli inyanga yokuqala.

Ukubuyela emuva kungenzeka. Isimo singathuthuka ngemuva kokwelashwa kwesikhathi eside ngama-corticosteroids nemithi ecindezela amasosha omzimba (ama-immunosuppressants).

Shayela umhlinzeki wakho uma:

• Uba nezimpawu zesifo sokushintsha okuncane
• Unalesi sifo futhi izimpawu zakho ziba zimbi kakhulu
• Uba nezimpawu ezintsha, kufaka phakathi imiphumela emibi evela emithini esetshenziselwa ukwelapha lesi sifo

Ushintsho oluncane lwe-nephrotic syndrome; Isifo se-Nil; I-lipoid nephrosis; Idiopathic nephrotic syndrome yobuntwana

• I-Glomerulus nephron

I-Appel GB, uRadhakrishnan J, D'Agati VD. Isifo se-glomerular sesibili. Ku: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, ama-eds. IBrenner neRector's The Kidney. Umhla ka-11. IPhiladelphia, PA: Elsevier; 2020: isahluko 32.

Isifo i-Erkan E. Nephrotic syndrome. Ku: Kliegman RM, St Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Incwadi kaNelson Yezingane. Umhlaka 21. IPhiladelphia, PA: Elsevier; 2020: isahluko 545.