Ukukhiqizwa ngokweqile kwama-androgens

Ukukhiqizwa ngokweqile kwe-ovarian kwama-androgens yisimo lapho ama-ovari enza khona i-testosterone eningi kakhulu. Lokhu kuholela ekuthuthukiseni izici zesilisa kowesifazane. Ama-Androgens avela kwezinye izingxenye zomzimba nawo angadala ukuthi izici zesilisa zikhule kwabesifazane.

Kwabesifazane abaphilile, ama-ovari nezindlala ze-adrenal zikhiqiza cishe i-40% kuya ku-50% ye-testosterone yomzimba. Izimila zama-ovari kanye ne-polycystic ovary syndrome (i-PCOS) zombili zingadala ukukhiqizwa kwe-androgen kakhulu.

Isifo seCushing siyinkinga ngendlala ye-pituitary eholela kumanani amaningi we-corticosteroids. ICorticosteroids idala ushintsho lomzimba wesilisa kwabesifazane. Izicubu ezindumbeni ze-adrenal nazo zingadala ukukhiqizwa okuningi kwe-androgens futhi kungaholela kuzimpawu zomzimba wesilisa kwabesifazane.

Izinga eliphakeme lama-androgens kowesifazane angadala:

• Izinduna
• Izinguquko esimweni somzimba sowesifazane
• Nciphisa usayizi webele
• Khulisa ezinweleni zomzimba ngephethini yabesilisa, njengasebusweni, esilevini nasesiswini
• Ukungabi nesikhathi sokuya esikhathini (amenorrhea)
• Isikhumba esinamafutha

Lezi zinguquko kungenzeka futhi:

• Khulisa ngosayizi we-clitoris
• Ukujula kwezwi
• Khulisa isisindo semisipha
• Ukuncipha kwezinwele nokulahleka kwezinwele ngaphambili kwesikhumba ekhanda nhlangothi zombili zekhanda

Umhlinzeki wakho wokunakekelwa kwezempilo uzokwenza ukuhlolwa komzimba. Noma yikuphi ukuhlolwa kwegazi nokucabanga oku-odiwe kuzoya ngezimpawu zakho, kepha kungafaka:

• Ukuhlolwa kwe-17-hydroxyprogesterone
• Ukuhlolwa kwe-ACTH (okungavamile)
• Ukuhlolwa kwegazi le-cholesterol
• Iskena se-CT
• Ukuhlolwa kwegazi le-DHEA
• Ukuhlolwa kweglucose
• Ukuhlolwa kwe-insulin
• I-pelvic ultrasound
• Ukuhlolwa kweprolactin (uma izikhathi zivela kancane noma cha)
• Ukuhlolwa kwe-testosterone (kokubili i-testosterone yamahhala neyengqikithi)
• Ukuhlolwa kwe-TSH (uma kukhona ukulahleka kwezinwele)

Ukwelashwa kuncike enkingeni ebangela ukukhiqizwa okwandayo kwe-androgen. Imithi inganikezwa ukwehlisa ukukhiqizwa kwezinwele kwabesifazane abanezinwele zomzimba ezeqile, noma ukulawula imijikelezo yokuya esikhathini. Kwezinye izimo, ukuhlinzeka kungadingeka ukususa i-ovarian noma i-adrenal tumor.

Impumelelo yokwelashwa incike kwisizathu sokukhiqizwa okweqile kwe-androgen. Uma isimo sibangelwa isimila esivela esibelethweni, ukuhlinzwa ukuze kususwe isimila kungalungisa inkinga. Izicubu eziningi zama-ovari aziwona umdlavuza (benign) futhi ngeke zibuye ngemuva kokuthi zisusiwe.

Ku-polycystic ovary syndrome, lezi zinyathelo ezilandelayo zinganciphisa izimpawu ezibangelwa amazinga aphezulu e-androgen:

• Ukuqapha ngokucophelela
• Ukwehla kwesisindo
• Izinguquko zokudla
• Imithi
• Ukuzivocavoca njalo ngamandla

Ukuzala kanye nezinkinga ngesikhathi sokukhulelwa kungenzeka.

Abesifazane abane-polycystic ovary syndrome bangaba sengozini enkulu yokuthi:

• Isifo sikashukela
• Umfutho wegazi ophezulu
• I-cholesterol ephezulu
• Ukukhuluphala ngokweqile
• Umdlavuza wesibeletho

Abesifazane abane-polycystic ovary syndrome banganciphisa ushintsho lwabo lwezinkinga zesikhathi eside ngokugcina isisindo esijwayelekile ngokudla okunempilo nokuvivinya umzimba njalo.

• Amaqanda akhiqiza ngokweqile
• Ukuthuthukiswa kwezinhlamvu

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IHuddleston HG, Quinn M, Gibson M. Polycystic ovary syndrome kanye ne-hirsutism. Ku: Kliegman RM, St Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Incwadi kaNelson Yezingane. Umhlaka 21. IPhiladelphia, PA: Elsevier; 2020: isahluko 567.

Lobo RA. I-Hyperandrogenism ne-androgen ngokweqile: i-physiology, i-etiology, ukuxilongwa okwehlukile, ukuphathwa. Ku: Lobo RA, Gershenson DM, Lentz GM, Valea FA, eds. I-Gynecology ephelele. Umhla wesi-7. IPhiladelphia, PA: Elsevier; 2017: isahluko 40.

URosenfield RL, uBarnes RB, u-Ehrmann DA. I-Hyperandrogenism, i-hirsutism, ne-polycystic ovary syndrome. Ku: Jameson JL, De Groot LJ, de Kretser DM, et al, abahleli. I-Endocrinology: Eyabantu Abadala Neyengane. Umhla wesi-7. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 133.