I-testosterone

Ukuhlolwa kwe-testosterone kukala inani le-hormone yowesilisa, i-testosterone, egazini. Kokubili abesilisa nabesifazane bakhiqiza le hormone.

Ukuhlolwa okuchazwe kule ndatshana kukala inani eliphelele le-testosterone egazini. Iningi le-testosterone egazini liboshelwe kuphrotheni elibizwa nge-sex hormone binding globulin (SHBG). Okunye ukuhlolwa kwegazi kungalinganisa i-testosterone "yamahhala". Kodwa-ke, lolu hlobo lokuhlola kaningi alunembile kakhulu.

Isampuli segazi sithathwa emthanjeni. Isikhathi esihle sokuthathwa kwesampula yegazi siphakathi kuka-7 ekuseni no-10 ekuseni. Isampula lesibili livame ukudingeka ukuqinisekisa umphumela ongaphansi kwalowo obekulindelekile.

Umhlinzeki wezokunakekelwa kwempilo angakweluleka ukuthi uyeke ukuthatha imishanguzo engathinta ukuhlolwa.

Ungase uzwe ukubhoboza noma ukuluma okuncane lapho inaliti ifakwa. Kungase kube khona ukuthwebula okuthile ngemuva kwalokho.

Lokhu kuhlolwa kungenziwa uma unezimpawu zokukhiqizwa okungavamile kwe-hormone yabesilisa (androgen).

Kwabesilisa, amasende akhiqiza iningi le-testosterone emzimbeni. Amazinga avame ukubhekwa ukuze ahlole izimpawu ze-testosterone engavamile njenge:

• Ukuthomba kokuqala noma sekwephuzile (kubafana)
• Ukungabi nenzalo, ukungasebenzi kahle kwe-erectile, izinga eliphansi lentshisekelo yezocansi, ukuncipha kwamathambo (emadodeni)

Kwabesifazane, amaqanda akhiqiza kakhulu i-testosterone. Izindlala ze-adrenal nazo zingakhiqiza amanye ama-androgens amaningi aguqulwa abe yi-testosterone. Izinga livame ukubhekwa ukuhlola izimpawu zamazinga aphezulu we-testosterone, njenge:

• Izinduna, isikhumba esinamafutha
• Shintsha ngezwi
• Ukwehla kobukhulu besifuba
• Ukukhula kwezinwele okweqile (izinwele ezimnyama, ezimangele endaweni yamadevu, intshebe, ukubamba eceleni, isifuba, izinqe, amathanga angaphakathi)
• Usayizi owandisiwe we-clitoris
• Izikhathi zokuya esikhathini ezingajwayelekile noma ezingekho
• Impandla yamadoda noma ukuncipha kwezinwele

Izilinganiso ezijwayelekile zalezi zivivinyo:

• Owesilisa: ama-nanograms angama-300 kuye kwangama-1 000 nge-deciliter ngayinye (ng / dL) noma ama-nanomoles ayi-10 kuye kwangama-35 ngelitha
• Owesifazane: 15 kuya ku-70 ng / dL noma u-0.5 kuye ku-2.4 nmol / L

Izibonelo ezingenhla yizilinganiso ezijwayelekile zemiphumela yalezi zivivinyo. Ububanzi bamanani ajwayelekile bungahluka kancane phakathi kwamalabhorethri ahlukene. Amanye amalebhu asebenzisa izilinganiso ezahlukahlukene noma avivinye izinhlobo ezihlukile. Khuluma nomhlinzeki wakho mayelana nencazelo yemiphumela yakho ethile yokuhlolwa.

Izimo ezithile zempilo, imithi, noma ukulimala kungaholela ku-testosterone ephansi. Izinga le-testosterone nalo lehla ngokwemvelo ngokukhula. I-testosterone ephansi ingathinta ukushayela ucansi, imizwa, nobukhulu bemisipha emadodeni.

Ukwehla kwe-testosterone ephelele kungabangelwa:

• Ukugula okungalapheki
• Indlala ye-pituitary ayikhiqizi inani elijwayelekile lamanye noma lawo wonke amahomoni ayo
• Inkinga ngezindawo zobuchopho ezilawula ama-hormone (hypothalamus)
• Umsebenzi we-thyroid ophansi
• Ukuthomba okulibazisekile
• Izifo zamasende (ukuhlukumezeka, umdlavuza, ukutheleleka, amasosha omzimba, ukugcwala kwensimbi)
• Isimila seBenign samaseli we-pituitary akhiqiza kakhulu i-hormone prolactin
• Amafutha omzimba amaningi kakhulu (ukukhuluphala)
• Izinkinga zokulala (ukuvimbela ukuphefumula kokulala)
  
• Ukucindezeleka okungapheli okuvela ekuzivocavoca ngokweqile (i-overtraining syndrome)
  

Ukukhuphuka kwenani le-testosterone kungenzeka kungenxa yokuthi:

• Ukumelana nokwenziwa kwamahomoni wesilisa (ukumelana ne-androgen)
• Isimila sama-ovari
• Umdlavuza wamasende
• I-hyperplasia yokuzalwa ye-adrenal
• Ukuthatha imithi noma izidakamizwa ezandisa izinga le-testosterone (kufaka phakathi ezinye izithasiselo)

I-serum testosterone

Rey RA, Josso N. Ukuxilongwa nokwelashwa kokuphazamiseka kokuthuthuka kwezocansi. Ku: Jameson JL, De Groot LJ, de Kretser DM, et al, abahleli. I-Endocrinology: Eyabantu Abadala Neyengane. Umhla wesi-7. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 119.

URosenfield RL, uBarnes RB, u-Ehrmann DA. I-Hyperandrogenism, i-hirsutism, ne-polycystic ovary syndrome. Ku: Jameson JL, De Groot LJ, de Kretser DM, et al, abahleli. I-Endocrinology: Eyabantu Abadala Neyengane. Umhla wesi-7. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 133.

I-Swerdloff RS, i-Wang C. I-testis ne-hypogonadism yabesilisa, ukungabi nenzalo, kanye nokungasebenzi kahle kwezocansi. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 221.