Inaliti ye-Adalimumab

-Delile

• Umjovo we-Adalimumab usetshenziswa wedwa noma neminye imishanguzo yokuqeda izimpawu zezifo ezithile ezizimele (izimo lapho amasosha omzimba ahlasela khona izingxenye ezinempilo zomzimba futhi abangele ubuhlungu, ukuvuvukala nokulimala) kubandakanya okulandelayo:
• Ngaphambi kokusebenzisa umjovo we-adalimumab,
• Umjovo we-Adalimumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukunakekelwa okuphuthumayo:

Ukusebenzisa umjovo we-adalimumab kunganciphisa ikhono lakho lokulwa nokutheleleka futhi kwandise ithuba lokuthi uzoba nokutheleleka okungathi sína, kufaka phakathi ukutheleleka okunzima kwe-fungal, bacterial kanye ne-virus okungasakazeka emzimbeni. Lezi zifo zingadinga ukwelashwa esibhedlela futhi zingadala nokufa. Tshela udokotela wakho uma uvame ukuthola noma yiluphi uhlobo lokutheleleka noma uma une noma ucabanga ukuthi ungahle ube nolunye uhlobo lokutheleleka manje. Lokhu kufaka ukutheleleka okuncane (njengokusikeka okuvulekile noma izilonda), izifo ezifikayo (ezifana nezilonda ezibandayo) noma izifo ezingamahlalakhona ezingapheli. Phinda utshele udokotela wakho uma ngabe uke waba nanoma yisiphi isimo esithinta amasosha akho omzimba noma uma uhlala noma owake wahlala ezindaweni ezinjengezigodi zemifula i-Ohio noma iMississippi lapho ukutheleleka okunzima kwefungal kuvame kakhulu. Buza udokotela wakho uma ungazi ukuthi ngabe lezi zifo zivame kakhulu endaweni yangakini. Tshela udokotela wakho uma uthatha imishanguzo eyehlisa ukusebenza kohlelo lomzimba njengokulandelayo: abatacept (Orencia), anakinra (Kineret), certolizumab (Cimzia), etanercept (Enbrel), golimumab (Simponi), infliximab (Remicade) , methotrexate (Otrexup, Rasuvo, Trexall), rituximab (Rituxan), noma ama-steroids afana ne-dexamethasone, methylprednisolone (Medrol), i-prednisone (i-Rayos), noma i-prednisolone (i-Prelone).

Udokotela wakho uzokuqapha ngezibonakaliso zokutheleleka ngesikhathi nangemva kokwelashwa kwakho. Uma unezinye zalezi zimpawu ezilandelayo ngaphambi kokuba uqale ukwelashwa kwakho noma uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi noma ngemuva nje kokwelapha kwakho, shayela udokotela wakho ngokushesha: ubuthakathaka; ukujuluka; Umphimbo obuhlungu; ukukhwehlela; ukukhwehlela amafinyila anegazi; imfiva; ukuncipha komzimba; ukukhathala ngokweqile; isifo sohudo; ubuhlungu besisu; isikhumba esifudumele, esibomvu, noma esibuhlungu; ukuchama okubuhlungu, okunzima, noma okuvamile; noma ezinye izimpawu zokutheleleka.

Kungenzeka ukuthi usungenwe yisifo sofuba (i-TB; ukutheleleka okungathi sína kwamaphaphu) noma i-hepatitis B (igciwane elithinta isibindi) kodwa ungabi nazimpawu zesifo. Kulokhu, umjovo we-adalimumab ungandisa ubungozi bokuthi ukutheleleka kwakho kuzoba kubi kakhulu futhi uzoba nezimpawu. Udokotela wakho uzokwenza ukuhlolwa kwesikhumba ukuze abone ukuthi unesifo se-TB esingasebenzi yini futhi anga-oda ukuhlolwa kwegazi ukubona ukuthi unesifo se-hepatitis B esingasebenzi yini. Uma kunesidingo, udokotela wakho angakunika imithi yokwelapha lesi sifo ngaphambi kokuba uqale ukwelashwa kwakho nge-adalimumab. Tshela udokotela wakho uma uke waba ne-TB noma wake waba nayo, uma wake wahlala noma wavakashela izwe lapho i-TB ijwayelekile khona, noma uma wake waba seduze komuntu one-TB noma owake waba nayo. Uma unezinye zalezi zimpawu ze-TB ezilandelayo, noma uma uba nalezi zimpawu phakathi nokwelashwa kwakho, shayela udokotela wakho ngokushesha: ukukhwehlela, ukwehla kwesisindo, ukulahleka kwethoni yemisipha, umkhuhlane noma ukujuluka ebusuku. Phinda ushayele udokotela wakho ngokushesha uma unanoma iyiphi yalezi zimpawu zesifo sokusha kwesibindi kohlobo B noma uma uba nanoma yiziphi zalezi zimpawu ngesikhathi noma ngemuva kokwelashwa kwakho: ukukhathala ngokweqile, ukuphuzi kwesikhumba noma kwamehlo, ukulahlekelwa isifiso sokudla, isicanucanu noma ukuhlanza, izinhlungu zemisipha, umchamo omnyama, ukuhamba kwamathumbu anombala wobumba, umkhuhlane, amakhaza, ubuhlungu besisu, noma ukuqubuka.

Ezinye izingane, intsha, nabantu abadala abathole umjovo we-adalimumab noma imishanguzo efanayo baba nomdlavuza onzima noma osongela ukuphila kubandakanya i-lymphoma (umdlavuza oqala kumaseli alwa nokutheleleka). Abanye besilisa abadala nabancane abathathe i-adalimumab noma imishanguzo efanayo baba ne-hepatosplenic T-cell lymphoma (HSTCL), uhlobo lomdlavuza olubi kakhulu oluvame ukubulala esikhathini esifushane. Iningi labantu abathuthukise i-HSTCL babelashelwa isifo sikaCrohn (isimo lapho umzimba uhlasela ulwelwesi lwendlela yokugaya, kubangela ubuhlungu, isifo sohudo, ukuncipha komzimba nomkhuhlane) noma i-ulcerative colitis. ulwelwesi lwekholoni [amathumbu amakhulu] ne-rectum) nge-adalimumab noma umuthi ofanayo kanye nomunye umuthi obizwa nge-azathioprine (Imuran) noma u-6-mercaptopurine (Purinethol). Tshela udokotela wengane yakho uma ingane yakho yake yaba nohlobo oluthile lomdlavuza. Uma ingane yakho iba nalezi zimpawu phakathi nokwelashwa kwayo, shayela udokotela wayo ngokushesha: ubuhlungu besisu; imfiva; ukuncipha kwesisindo okungaqondakali; izindlala ezivuvukile entanyeni, ngaphansi kwekhwapha, noma emgodini; noma ukulimaza okulula noma ukopha. Khuluma nodokotela wengane yakho ngezingozi zokufaka umjovo we-adalimumab enganeni yakho.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa ngomjovo we-adalimumab futhi isikhathi ngasinye lapho uthola umuthi. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokusebenzisa umjovo we-adalimumab.

Umjovo we-Adalimumab usetshenziswa wedwa noma neminye imishanguzo yokuqeda izimpawu zezifo ezithile ezizimele (izimo lapho amasosha omzimba ahlasela khona izingxenye ezinempilo zomzimba futhi abangele ubuhlungu, ukuvuvukala nokulimala) kubandakanya okulandelayo:

• isifo samathambo (isimo lapho umzimba uhlasela khona amalunga awo, ubangele ubuhlungu, ukuvuvukala, nokulahlekelwa ngumsebenzi) kubantu abadala,
• i-juvenile idiopathic arthritis (i-JIA; isimo esithinta izingane lapho umzimba uhlasela khona amalunga omzimba, ubangele ubuhlungu, ukuvuvukala, ukuphelelwa umsebenzi, nokubambezeleka kokukhula nentuthuko) ezinganeni ezineminyaka emibili ubudala nangaphezulu,
• Isifo sikaCrohn (isimo lapho umzimba uhlasela ulwelwesi lomgudu wokugaya ukudla, ubangele ubuhlungu, isifo sohudo, ukuncipha komzimba nomkhuhlane) ongakathuthuki lapho welashwa ngeminye imithi kubantu abadala nezingane ezineminyaka engu-6 nangaphezulu,
• i-ulcerative colitis (isimo esidala ukuvuvukala nezilonda emgqeni wekholoni [amathumbu amakhulu] ne-rectum) lapho eminye imithi nokwelashwa kungasizanga noma kungabekezeleleki kubantu abadala nasezinganeni ezineminyaka engu-5 nangaphezulu,
• i-ankylosing spondylitis (isimo lapho umzimba uhlasela khona amalunga omgogodla nezinye izindawo okubangela ubuhlungu nokulimala ngokuhlanganyela) kubantu abadala,
• i-psoriatic arthritis (isimo esidala ubuhlungu bamalunga nokuvuvukala nezikali esikhumbeni) kubantu abadala,
• i-hidradenitis suppurativa (isifo sesikhumba esidala amaqhuqhuva anjengezinduna emakhwapheni, emgodini nasendaweni yangasese) kubantu abadala nezingane ezineminyaka engu-12 nangaphezulu,
• I-uveitis (ukuvuvukala nokuvuvukala kwezindawo ezahlukahlukene zeso) kubantu abadala nezingane ezineminyaka engu-2 nangaphezulu,
• i-plaque psoriasis engapheli (isifo sesikhumba lapho kwakhiwa khona amabala abomvu, anezikhala ezindaweni ezithile zomzimba) kubantu abadala.

Umjovo we-Adalimumab usesigabeni semithi ebizwa nge-tumor necrosis factor (TNF) inhibitors. Isebenza ngokuvimba isenzo se-TNF, into esemzimbeni ebangela ukuvuvukala.

Umjovo we-Adalimumab uza njengesisombululo (uketshezi) ukujova ngomgogodla (ngaphansi kwesikhumba). Udokotela wakho uzokutshela ukuthi usebenzise i-adalimumab kangaki ngokuya ngesimo sakho nobudala bakho. Ukukusiza ukuthi ukhumbule ukujova umjovo we-adalimumab, phawula izinsuku ohlelelwe ukujova ngazo ekhalendeni lakho. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Sebenzisa umjovo we-adalimumab njengoba uqondisiwe. Ungayisebenzisi ngaphezulu noma ngaphansi kwayo noma uyisebenzise kaningi kunokuyalelwa ngudokotela wakho.

Uzothola isilinganiso sakho sokuqala somjovo we-adalimumab ehhovisi likadokotela wakho. Ngemuva kwalokho, ungazifaka umjovo we-adalimumab ngokwakho noma umngane noma isihlobo senze imijovo. Ngaphambi kokusebenzisa umjovo we-adalimumab okokuqala, funda imiyalelo ebhaliwe eza nayo. Buza udokotela wakho noma usokhemisi ukuthi akubonise noma umuntu ozobe ejova umuthi ukuthi ungawujova kanjani.

Umjovo we-Adalimumab uza ngemijovo ekhethiwe kanye nezibaya zokulinganisa. Sebenzisa isirinji noma ipeni ngalinye kanye bese ufaka yonke ikhambi esirinji noma epeni. Noma ngabe kusekhona isixazululo esisele esirinji noma ipeni ngemuva kokujova, musa ukujova futhi. Lahla imijovo nezibaya ezisetshenzisiwe esitsheni esingamelana nokubhoboza. Khuluma nodokotela wakho noma usokhemisi mayelana nokuthi ungasilahla kanjani isitsha esingamelana nokubhoboza.

Uma usebenzisa isirinji oyifakile noma ipeni lomthamo elifakwe esiqandisini, beka isirinji noma ipeni endaweni eyisicaba ngaphandle kokukhipha isigaxa senaliti bese uyivumela ifudumele ekamelweni lokushisa imizuzu eyi-15 kuya kwengama-30 ngaphambi kokuba ulungele ukujova umuthi .Ungazami ukufudumeza umuthi ngokuwufudumeza ngemicrowave, uwubeke emanzini ashisayo, noma ngenye indlela.

Qaphela ukuthi ungalahli noma uchoboze imijovo oyikhethile noma izibaya zokulinganisa. Lawa madivayisi enziwe ngengilazi noma aqukethe ingilazi futhi angahle aphuke uma ewa.

Ungafaka umjovo we-adalimumab noma yikuphi ngaphambili kwamathanga noma esiswini sakho ngaphandle kwenkaba yakho nendawo engamasentimitha ama-5 ukuyizungeza. Ukwehlisa amathuba okuba buhlungu noma okubomvu, sebenzisa isiza esihlukile ngomjovo ngamunye. Nika umjovo ngamunye okungenani iyintshi eli-1 (2.5 amasentimitha) ukusuka endaweni osuvele wayisebenzisa. Gcina uhlu lwezindawo lapho uhlabe khona imijovo ukuze ungaphinde ujove kulezi zindawo. Ungafaki endaweni lapho isikhumba sithambile, silimele, sibomvu, noma siqinile noma lapho unezibazi noma izimpawu zokwelula.

Njalo bheka isisombululo somjovo we-adalimumab ngaphambi kokusijova. Bheka ukuthi usuku lokuphelelwa yisikhathi aludlulanga yini, ukuthi isirinji noma ipeni lomthamo liqukethe inani elifanele loketshezi, nokuthi uketshezi lucacile futhi alunambala. Ungasebenzisi isirinji noma ipeni lokufaka imithamo uma iphelelwe yisikhathi, uma ingenalo inani elifanele liketshezi, noma uma uketshezi lunamafu noma luqukethe ama-flakes.

Umjovo we-Adalimumab ungasiza ukulawula isimo sakho kepha ngeke uselaphe. Qhubeka nokusebenzisa umjovo we-adalimumab noma ngabe uzizwa uphilile. Ungayeki ukusebenzisa umjovo we-adalimumab ngaphandle kokukhuluma nodokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokusebenzisa umjovo we-adalimumab,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-adalimumab injection, noma imiphi eminye imithi, noma yiziphi izithako zomjovo we-adalimumab. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako. Uma uzosebenzisa isirinji ekhethiwe, phinda utshele udokotela wakho uma wena noma umuntu ozokusiza ukujova umjovo we-adalimumab uyaliwa ne-latex noma i-rubber.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imishanguzo ebhalwe esigabeni ESIBALULEKILE SEXWAYISO nanoma yikuphi okulandelayo: i-cyclosporine (Gengraf, Neoral, Sandimmune), theophylline (Elixophyllin, Theo 24, Theochron), noma warfarin (Coumadin, Jantoven). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• ngaphezu kwezimo ezishiwo esigabeni SOKUXWAYISA OKUBALULEKILE, tshela udokotela wakho uma uke waba noma waba nezindimbane noma ukunkeneneza kunoma iyiphi ingxenye yomzimba wakho, noma yisiphi isifo esithinta isimiso sakho sezinzwa, njenge-multiple sclerosis (isifo lapho izinzwa azisebenzi kahle zibangela ubuthakathaka, ukuba ndikindiki, ukulahleka kokuxhumanisa kwemisipha nezinkinga ngombono, ukukhuluma, nokulawula isinye), i-Guillain-Barré syndrome (ubuthakathaka, ukuncinza, nokukhubazeka okungenzeka ngenxa yokulimala okungazelelwe kwezinzwa), noma i-optic neuritis (ukuvuvukala yezinzwa ezithumela imiyalezo isuka esweni iye ebuchosheni); noma yiluphi uhlobo lomdlavuza, isifo sikashukela, ukwehluleka kwenhliziyo, noma isifo senhliziyo. Uma une-psoriasis, tshela udokotela wakho ukuthi ngabe welashwe ngemithi elula.
• Tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa Uma ukhulelwa ngenkathi usebenzisa umjovo we-adalimumab, shayela udokotela wakho.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi usebenzisa umjovo we-adalimumab.
• ungenayo imigomo ngaphandle kokukhuluma nodokotela wakho. Uma ingane yakho izothola umjovo we-adalimumab, qiniseka ukuthi ingane yakho ithole yonke isibhamu esidingekayo ezinganeni ezineminyaka yakhe ngaphambi kokuba iqale ukwelashwa ngomjovo we-adalimumab.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Jova umthamo ophuthelwe ngokushesha nje lapho uwukhumbula. Bese ujove umthamo olandelayo osukwini lwakho oluhleliwe njalo. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungasebenzisi umthamo ophindwe kabili ukwenza okulahlekile.

Umjovo we-Adalimumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ububomvu, ukulunywa, ukulinyazwa, ubuhlungu, noma ukuvuvukala endaweni owafaka kuyo umjovo we-adalimumab
• isicanucanu
• ikhanda
• ukuhlungu obusemhlane

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukunakekelwa okuphuthumayo:

• ukuba ndikindiki noma ukuhayiza
• izinkinga ngombono
• ubuthakathaka emilenzeni
• ubuhlungu besifuba
• ukuphelelwa umoya
• ukuqubuka, ikakhulukazi ukuqubuka ezihlathini noma ezingalweni ezizwela ukukhanya kwelanga
• ubuhlungu obusha obuhlangene
• isifuba
• ukulunywa
• ukuvuvukala kobuso, izinyawo, amaqakala, noma imilenze engezansi
• ukuphefumula kanzima noma ukugwinya
• umkhuhlane, umphimbo obuhlungu, amakhaza nezinye izimpawu zokutheleleka
• ukulimaza noma ukopha okungavamile
• isikhumba esiphaphathekile
• isiyezi
• okubomvu, amabala anezikhala noma amaqhuqhuva agcwaliswa ubomvu esikhunjeni

Abantu abadala abathola umjovo we-adalimumab kungenzeka babe nomdlavuza wesikhumba, i-lymphoma, nezinye izinhlobo zomdlavuza kunabantu abangawutholi umjovo we-adalimumab. Khuluma nodokotela wakho ngezingozi zokuthola lo muthi.

Umjovo we-Adalimumab ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi usebenzisa lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Yigcine esiqandisini bese uyivikela ekukhanyeni. Umjovo we-Adalimumab ungagcinwa nasekamelweni lokushisa (kuze kufike ku-77 ° F [25 ° C]) kuze kube yizinsuku eziyi-14 futhi uvikeleke ekukhanyeni. Uma umjovo we-adalimumab ugcinwa ekamelweni lokushisa izinsuku ezingaphezu kwezingu-14 futhi ungasetshenziswanga, kufanele ulahlwe. Ungayifaki iqhwa. Lahla noma imuphi umuthi okhandisiwe.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ngaphambi, ngesikhathi, nangemva kokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-adalimumab.

Ungavumeli omunye umuntu asebenzise imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Humira^® Ukujova