Atazanavir

-Delile

• Ngaphambi kokuthatha i-atazanavir,
• I-Atazanavir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Uma uba nokuqubuka okukhulu nganoma iyiphi yalezi zimpawu ezilandelayo, yeka ukuthatha i-atazanavir bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Atazanavir isetshenziswa kanye neminye imishanguzo, efana ne-ritonavir (Norvir), ukwelapha ukutheleleka ngegciwane lesandulela ngculazi (i-HIV) kubantu abadala nasezinganeni okungenani ezinezinyanga ezintathu ubudala futhi inesisindo okungenani esingu-22 lb (10 kg). I-Atazanavir isekilasini lemithi ebizwa ngama-protease inhibitors. Isebenza ngokunciphisa inani le-HIV egazini. Yize i-atazanavir ingayelaphi i-HIV, ingahle inciphise amathuba okuba ne-immunodeficiency syndrome (i-AIDS) kanye nezifo ezihlobene ne-HIV ezinjengezifo ezibucayi noma umdlavuza. Ukuthatha le mithi kanye nokwenza ucansi oluphephile nokwenza ezinye izinguquko endleleni yokuphila kunganciphisa ingozi yokudlulisela igciwane le-HIV kwabanye abantu.

I-Atazanavir iza njenge-capsule nanjengempuphu engayithatha ngomlomo. I-capsule kanye ne-powder kuvame ukuthathwa kanye ngosuku ngokudla noma nge-snack. Thatha i-atazanavir ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-atazanavir njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Uzothatha eminye imithi ye-HIV ngenkathi uthatha i-atazanavir. Udokotela wakho uzokutshela ukuthi ngabe le mithi kufanele iphuzwe ngasikhathi sinye ne-atazanavir, noma amahora ambalwa ngaphambi noma ngemuva kokuthatha i-atazanavir. Landela lolu hlelo ngokucophelela, bese ubuza udokotela noma usokhemisi wakho uma unemibuzo mayelana nezikhathi okufanele uthathe ngayo imithi yakho.

I-Atazanavir powder kumele ithathwe nge-ritonavir (Norvir). Ungathathi i-atazanavir powder ngaphandle kwe-ritonavir (Norvir).

Gwinya wonke amaphilisi; ungazihlukanisi, uzihlafune, noma uzivule. Uma ungakwazi ukugwinya amaphilisi, tshela udokotela noma usokhemisi.

I-Atazanavir powder ingangezwa ekudleni okufana ne-appleauce noma iyogathi, noma iziphuzo ezinjengamanzi, ubisi, noma ubisi lwebele lwabantwana. Hlanganisa kahle, bese uthatha yonke ingxube ngokushesha ukuze uthathe umthamo ophelele. Uma uxutshwe namanzi, yidla isidlo noma isidlo ngokushesha ngemuva kokuthatha ingxube yempuphu. Ezinganeni (ezindala kunezinyanga ezintathu ubudala) ezingakwazi ukuphuza enkomishini, impuphu ingaxubaniswa nefomula yezinsana bese inikezwa ngesirinji yomlomo; unganikeli usana ngengxube esebhodleleni lengane. Uma ingxube ingathathwa ngokushesha kufanele igcinwe ekamelweni lokushisa futhi ithathwe kungakapheli ihora elilodwa. Funda ngokucophelela imiyalelo yomkhiqizi echaza ukuthi ungaxuba kanjani futhi uthathe umthamo we-atazanavir. Qiniseka ukuthi ubuza usokhemisi noma udokotela wakho uma unanoma yimiphi imibuzo mayelana nokuthi ungawuhlanganisa kanjani noma uwuthathe kanjani lo muthi.

Khuluma nodokotela ngalokho okufanele ukwenze uma ingane yakho ihlanza, ikhafula, noma ithatha kuphela ingxenye yesilinganiso se-atazanavir.

I-Atazanavir iyasiza ukulawula ukutheleleka nge-HIV, kepha ayiyelaphi. Qhubeka uthathe i-atazanavir noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-atazanavir ngaphandle kokukhuluma nodokotela wakho. Lapho ukunikezwa kwakho kwe-atazanavir kuqala ukwehla, thola okuningi kudokotela wakho noma kukhemisi. Uma uyeka ukuthatha i-atazanavir noma ukweqa imithamo, isimo sakho singaba nzima ukwelashwa.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli. Funda lolu lwazi ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo.

I-Atazanavir kwesinye isikhathi isetshenziselwa ukuvikela ukutheleleka kubasebenzi bezokunakekelwa kwezempilo noma kwabanye abantu abachayeke ngengozi ku-HIV. Khuluma nodokotela wakho ngezingozi zokusebenzisa lo muthi ngesimo sakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-atazanavir,

• Tshela udokotela kanye nosokhemisi wakho uma unegciwane ku-atazanavir, noma imiphi eminye imithi, noma iziphi izithako ezikuma-capsule we-atazanavir noma i-powder. Udokotela wakho angakutshela ukuthi ungathathi i-atazanavir. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• utshele udokotela wakho uma uthatha noma yimiphi imithi elandelayo noma imikhiqizo yemithi: i-alfuzosin (i-Uroxatral); i-cisapride (i-Propulsid; ayitholakali e-US); i-elbasvir ne-grazoprevir (iZepatier); i-ergot alkaloids efana ne-dihydroergotamine (i-DHE 45, i-Migranal), i-ergonovine, i-ergotamine (i-Ergomar, eCafergot, eMigergot), noma i-methylergonovine (Methergine); i-glecaprevir ne-pibrentasvir (iMavyret); indinavir (Crixivan); i-irinotecan (iCamptosar); i-lovastatin (Altoprev); i-lurasidone (Latuda); i-midazolam ngomlomo; i-nevirapine (i-Viramune), i-pimozide (i-Orap); i-rifampin (Rimactane, Rifadin, eRifater, eRifamate); i-sildenafil (uphawu lwe-Revatio kuphela olusetshenziselwa isifo samaphaphu); simvastatin (iZocor, eVytorin); ISt John's wort; kanye ne-triazolam (Halcion). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-atazanavir uma uphuza eyodwa noma ngaphezulu yale mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, imikhiqizo yamakhambi, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha.Qiniseka ukuthi usho noma ikuphi kokulandelayo: ama-anticoagulants (’ama-thinner egazi’) njenge-warfarin (i-Coumadin, i-Jantoven); ama-antidepressants (’mood elevators’) njenge-amitriptyline, desipramine (Norpramin), doxepin (Silenor, Zonalon), imipramine (Tofranil, Surmontil), protriptyline (Vivactil), trazodone, ne-trimipramine (Surmontil); ezinye izinto zokuvikela ezifana ne-itraconazole (i-Onmel, i-Sporanox), i-ketoconazole (i-Extina, i-Nizoral, i-Xolegel), ne-voriconazole (i-Vfend); i-bepridil (i-Vascor) (ayitholakali e-US); ama-beta blocker afana ne-labetalol (Trandate), nadolol (Corgard, eCorzide), kanye nepropranolol (Hemangeol, Inderal, Innopran XL, e-Inderide); i-boceprevir (ayisatholakali e-U.S .; eVictrelis); i-bosentan (iTracleer); i-buprenorphine (iBuprenex, iButrans, eBunavail, eSuboxone, eZubsolv); ama-calcium channel blocker afana ne-diltiazem (Cardizem, Cartia, Tiazac, abanye), felodipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab, Procardia), kanye ne-verapamil (Calan, Verelan, eTarka, abanye); imishanguzo ethile yokwehlisa i-cholesterol (ama-statins) afana ne-atorvastatin (Lipitor, eCaduet), ne-rosuvastatin (Crestor); i-clarithromycin (i-Biaxin, ku-Prevpac); i-colchicine (Colcrys, Mitigare); i-digoxin (i-Lanoxin); i-fluticasone (i-Flonase, i-Flovent, e-Advair); imishanguzo yokushaya kwenhliziyo okungajwayelekile njenge-amiodarone (Cordarone, Nexterone, Pacerone), lidocaine (Octocaine, Xylocaine), ne-quinidine (eNuedexta); imithi evimbela amasosha omzimba njenge-cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), ne-tacrolimus (Astagraf, Prograf); eminye imishanguzo ye-HIV noma i-AIDS kubandakanya i-efavirenz (Sustiva, e-Atripla), ritonavir (Norvir, eKaletra, eViekira Pak), saquinavir (Invirase), kanye ne-tenofovir (Viread, e-Atripla, eStribild, eTruvada, eminye); i-midazolam ngomjovo; i-paclitaxel (i-Abraxane, i-Taxol); amanye ama-phosphodiesterase inhibitors (PDE-5 inhibitors) asetshenziselwa ukungasebenzi kahle kwe-erectile njenge-sildenafil (Viagra), tadalafil (Cialis), ne-vardenafil (i-Levitra, i-Staxyn); i-repaglinide (Prandin, ePrandimet); i-quetiapine (iSeroquel); i-rifabutin (i-Mycobutin); i-salmeterol (iSerevent, e-Advair); i-sofosbuvir, i-velpatasvir, ne-voxilaprevir (i-Sovaldi, i-Epclusa, i-Vosevi); kanye ne-tadalafil (Adcirca, Cialis). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-atazanavir, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• uma uthatha ama-antacids, amaphilisi we-didanosine abambezeleka ukukhipha (i-Videx EC), noma omunye umuthi ophikisiwe njenge-buffered aspirin (iBufferin), thatha i-atazanavir amahora amabili ngaphambi noma ihora eli-1 ngemuva kokuthatha umuthi. Buza udokotela noma usokhemisi wakho uma ungaqiniseki ukuthi ikhona yini imishanguzo oyisebenzisayo ehlukunyeziwe.
• Tshela udokotela wakho uma uthatha umuthi we-indigestion, isilungulela, noma izilonda ezifana ne-cimetidine, esomeprazole (Nexium, eVimovo), i-famotidine (Pepcid, e-Duexis), i-lansoprazole (Prevacid, e-Prevpac), i-nizatidine (i-Axid), i-omeprazole (Prilosec, eZegerid), pantoprazole (Protonix), rabeprazole (AcipHex), noma ranitidine (Zantac). Udokotela wakho angakutshela ukuthi ungayithathi imishanguzo noma uthathe umthamo omncane womuthi. Uma uzoqhubeka nokuthatha umuthi, udokotela wakho uzokutshela ukuthi kufanele usinike isikhathi esingakanani phakathi kokuthatha umuthi nokuthatha i-atazanavir.
• Tshela udokotela wakho uma ngabe uke waba nokushaya kwenhliziyo okungajwayelekile, isifo sikashukela noma ushukela ophakeme wegazi, i-hemophilia (isimo lapho igazi lingagcwali ngokwejwayelekile) noma esinye isifo sokopha, i-hepatitis (isifo segciwane lesibindi) noma esinye isifo sesibindi, izinso noma isifo senhliziyo.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uma ukhulelwa ngenkathi uthatha i-atazanavir, shayela udokotela wakho. Akufanele uncelise ibele uma utheleleke nge-HIV futhi uthatha i-atazanavir.
• kufanele wazi ukuthi i-atazanavir inganciphisa ukusebenza kahle kokuvimbela inzalo ngamahomoni (amaphilisi okulawula ukubeletha, amabala, izindandatho, okufakelwa kanye nemijovo). Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela ngenkathi uthatha i-atazanavir.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-atazanavir.
• kufanele wazi ukuthi ungathola i-hyperglycemia (iyanda kushukela wakho wegazi) ngenkathi uthatha lo muthi, noma ngabe awunaso vele isifo sikashukela. Tshela udokotela wakho ngokushesha uma unezinye zalezi zimpawu ezilandelayo ngenkathi uthatha i-atazanavir: ukoma ngokweqile, ukuchama kaningi, ukulamba ngokweqile, ukungaboni kahle, noma ubuthakathaka. Kubaluleke kakhulu ukubiza udokotela wakho ngokushesha uma unezinye zalezi zimpawu, ngoba ushukela wegazi ongelashwa ungadala isimo esibi esibizwa nge-ketoacidosis. I-Ketoacidosis ingasongela impilo uma ingelashwa kusenesikhathi. Izimpawu ze-ketoacidosis zifaka phakathi: umlomo owomile, isicanucanu nokuhlanza, ukuphefumula okuncane, ukuphefumula okunuka izithelo, nokuncipha kokwazi.
• kufanele wazi ukuthi ngenkathi uthatha i-atazanavir amafutha akho omzimba angakhuphuka noma ahambele ezindaweni ezahlukahlukene zomzimba wakho njengasemuva kwentamo yakho namahlombe aphezulu ('buffalo hump'), isisu, namabele. Ungalahlekelwa amafutha ezingalweni, emilenzeni, ebusweni nasezinqeni. Khuluma nodokotela wakho uma ubona noma yiziphi zalezi zinguquko emafutheni omzimba wakho.
• uma une-phenylketonuria (i-PKU, isimo esizuzwe njengefa lapho kufanele kudliwe ukudla okhethekile ukuvimbela ukubola kwengqondo), kufanele wazi ukuthi i-atazanavir powder powder iswidi ne-aspartame eyakha i-phenylalanine.
• kufanele wazi ukuthi ngenkathi uthatha imishanguzo yokwelapha ukutheleleka nge-HIV, amasosha omzimba wakho angaqina futhi aqale ukulwa nezinye izifo ezazivele zisemzimbeni wakho. Lokhu kungadala ukuthi ube nezimpawu zalezo zifo. Uma unezimpawu ezintsha noma eziya ziba zimbi noma kunini ngesikhathi sokwelashwa kwakho ne-atazanavir, qiniseka ukuthi utshela udokotela wakho.

Khuluma nodokotela wakho mayelana nokudla isithelo samagilebhisi noma ukuphuza ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Atazanavir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• ubuhlungu besisu
• isifo sohudo
• ikhanda
• ukudana
• imfiva
• ubunzima bokulala noma ukulala
• ubuhlungu bemisipha
• ukuqhuma okuncane
• ukuba ndikindiki, ukushiswa, ubuhlungu, noma ukulunywa izandla noma izinyawo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukushaya kwenhliziyo okungajwayelekile
• isiyezi
• ukuzizwa uphela amandla noma unekhanda elincane
• umbono uyashintsha
• ukuphuzi kwesikhumba noma kwamehlo (ikakhulukazi ezinganeni ezisanda kuzalwa)
• ubuhlungu emhlane wakho noma ohlangothini
• ubuhlungu noma ukushisa ngokuchama
• igazi emchameni
• ukuhlanza
• ukulahlekelwa isifiso sokudla
• ukuvuvukala kwezandla, izinyawo, imilenze, noma amaqakala
• ukuncipha kokuchama
• umchamo onombala omnyama
• ukunyakaza kwamathumbu okukhanyayo
• ukwakhiwa okuhlala isikhathi eside kunamahora ama-4

Uma uba nokuqubuka okukhulu nganoma iyiphi yalezi zimpawu ezilandelayo, yeka ukuthatha i-atazanavir bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukugula okujwayelekile noma izimpawu 'zomkhuhlane'
• imfiva
• ubuhlungu bemisipha noma obuhlangene
• amehlo abomvu noma avuvukile
• amabhamuza noma isikhumba esixobukayo
• izilonda zomlomo
• ukuvuvukala kobuso noma intamo yakho
• isigaxa esibuhlungu, esifudumele, noma esibomvu ngaphansi kwesikhumba sakho

I-Atazanavir ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni noma ephaketheni efikile, ivalwe ngokuqinile, futhi lapho izingane nezilwane ezifuywayo zingafinyeleli khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ukuphuzi kwesikhumba noma kwamehlo

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-atazanavir.

Gcina ukutholakala kwe-atazanavir kusesandleni. Ungalindi uze uphelelwe yimithi yokugcwalisa imishanguzo yakho.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Reyataz^®

• I-Evotaz^® (equkethe i-Atazanavir, Cobicistat)

• I-ATZ