Voriconazole

-Delile

• Ngaphambi kokuthatha i-voriconazole,
• IVoriconazole ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini Lwezinyathelo Ezikhethekile, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Voriconazole isetshenziswa kubantu abadala nasezinganeni ezineminyaka emi-2 nangaphezulu ukwelapha izifo ezibucayi ezifana ne-aspergillosis (isifo esikhunta esiqala emaphashini futhi sisakazeke egazini kwezinye izitho), i-esophageal candidiasis (imvubelo (uhlobo lwe ukhunta] ukutheleleka okungadala ukubamba okumhlophe emlonyeni nasemphinjeni), kanye ne-candidemia (ukutheleleka kwefungal egazini). Ibuye isetshenziselwe ukwelapha ezinye izifo zokukhunta lapho eminye imithi ingeke izisebenzele iziguli ezithile. IVoriconazole isekilasini lemithi yokwelapha ebizwa ngokuthi ama-triazoles. Isebenza ngokunciphisa ukukhula kwesikhunta esidala ukutheleleka.

IVoriconazole iza njengethebhulethi nokumiswa (uketshezi) ukuthatha ngomlomo. Imvamisa kuthathwa njalo emahoreni ayi-12 esiswini esingenalutho, okungenani ihora eli-1 ngaphambi noma ihora eli-1 ngemuva kokudla. Ukukusiza ukuthi ukhumbule ukuthatha i-voriconazole, yithathe ngezikhathi ezifanayo nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-voriconazole njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Uma uthatha ukumiswa kwe-voriconazole, gubha ibhodlela elivaliwe cishe imizuzwana eyi-10 ngaphambi kokusetshenziswa ngakunye ukuxuba umuthi ngokulinganayo. Musa ukuxuba ukumiswa neminye imithi, amanzi, noma olunye uketshezi. Njalo sebenzisa okokulinganisa okuza nemithi yakho. Ungahle ungatholi inani elifanele lemithi uma usebenzisa isipuni sasekhaya ukukala umthamo wakho.

Ekuqaleni kokwelashwa kwakho, ungathola i-voriconazole ngomjovo we-intravenous (ube semthanjeni). Lapho uqala ukuthatha i-voriconazole ngomlomo, udokotela wakho angakuqala ngomthamo ophansi futhi akhuphule umthamo wakho uma isimo sakho singathuthuki. Udokotela wakho futhi anganciphisa umthamo wakho uma uhlangabezana nemiphumela emibi evela ku-voriconazole.

Ubude bokwelashwa kwakho buxhomeke empilweni yakho ejwayelekile, uhlobo lokutheleleka onalo, nokuthi uphendula kahle kanjani emithini. Qhubeka uthathe i-voriconazole noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-voriconazole ngaphandle kokukhuluma nodokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-voriconazole,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-voriconazole, eminye imishanguzo efana ne-fluconazole (Diflucan), i-itraconazole (i-Onmel, i-Sporanox), noma i-ketoconazole (i-Nizoral); noma imiphi eminye imithi, i-lactose, noma ezinye izithako kumathebulethi e-voriconazole nokumiswa. Buza usokhemisi wakho ukuthola uhlu lwezithako kumathebulethi e-voriconazole nokumiswa.
• ungathathi i-voriconazole uma uthatha noma iyiphi yale mithi elandelayo: i-carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); i-cisapride (i-Propulsid); i-efavirenz (iSustiva, e-Atripla); imishanguzo yohlobo lwe-ergot efana ne-dihydroergotamine (i-DHE 45, i-Migranal), i-ergoloid mesylates (i-Hydergine), i-ergotamine (i-Ergomar, eCafergot, eMigergot), ne-methylergonovine (Methergine); ivabradine (Corlanor); naloxegol (Monvatik); i-phenobarbital; ipimozide (i-Orap); i-quinidine (ku-Nuedexta); i-rifabutin (i-Mycobutin); i-rifampin (iRifadin, iRimactane, eRifamate, eRifater); i-ritonavir (iNorvir, eKaletra); i-sirolimus (i-Rapamune); ISt John's wort; i-tolvaptan (Jynarque, Samsca); kanye ne-venetoclax (Venclexta).
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokunganikezwa imishanguzo, amavithamini, nezithako zokudla okunomsoco okwenzayo. Qiniseka ukuthi usho noma ikuphi kokulandelayo: ama-anticoagulants (’ama-thinner egazi’) njenge-warfarin (i-Coumadin, i-Jantoven); ama-benzodiazepines afana ne-alprazolam (i-Niravam, i-Xanax), i-midazolam, ne-triazolam (i-Halcion); ama-calcium channel blocker anjenge-amlodipine (Norvasc, e-Amturnide, eTekamlo), felodipine (Plendil), isradipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab, Procardia), nimodipine (Nymalize), ne-nisoldipine (Sular); imithi yokwehlisa i-cholesterol (ama-statins) njenge-atorvastatin (Lipitor, eCaduet, eLiptruzet), i-fluvastatin (Lescol), i-lovastatin (i-Altoprev, ku-Advicor), i-pravastatin (i-Pravachol), ne-simvastatin (i-Zocor, e-Simcor, e-Vytorin); i-cyclosporine (Gengraf, Neoral, Sandimmune); everolimus (Afinitor, Zortress); i-fentanyl (Abstral, Actiq, Fentora, Lazanda, Subsys); imithi yesifo sikashukela efana ne-glipizide (Glucotrol), i-glyburide (i-Diabeta, i-Glynase,, e-Glucovance), ne-tolbutamide; imishanguzo ye-HIV efana ne-delavirdine (Rescriptor), i-nelfinavir (i-Viracept), i-nevirapine (i-Viramune), ne-saquinavir (i-Invirase); i-methadone (i-Dolophine, i-Methadose); izidakamizwa ezingezona ukuvuvukala (i-diclofenac, ibuprofen), izivimbelinzalo zomlomo; i-oxycodone (i-Oxecta, i-Oxycontin, ku-Oxycet, ePercocet, ePercodan, eRoxicet, eXartemis); i-phenytoin (iDilantin, Phenytek); ama-proton-pump inhibitors afana ne-esomeprazole (Nexium, eVimovo), lansoprazole (Prevacid), omeprazole (Prilosec, e-Prevpac), pantoprazole (Protonix), ne-rabeprazole (AcipHex); i-tacrolimus (i-Astagraf, Prograf); vinblastine; no-vincristine. Eminye imishanguzo eminingi ingaxhumana ne-voriconazole, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma uke waphathwa ngemithi yokwelashwa ngamakhemikhali yomdlavuza, futhi uma uke waba nesikhathi sokuphela se-QT (inkinga engavamile yenhliziyo engadala ukushaya kwenhliziyo okungajwayelekile, ukuquleka, noma ukufa okungazelelwe), noma uma owake waba nokushaya kwenhliziyo okuhamba kancane noma okungajwayelekile, amazinga aphansi egazi e-potassium, i-magnesium, noma i-calcium, i-cardiomyopathy (isisindo senhliziyo esikhulisiwe noma esijiyile esivimba inhliziyo ukuthi ingashayi igazi ngokujwayelekile), umdlavuza wamaseli egazi, ukungabekezelelani kwe-galactose noma i-glucose-galactose malabsorption ( izimo ezizuzwe njengefa lapho umzimba ungakwazi ukubekezelela i-lactose); noma isiphi isimo esikwenza kube nzima kuwe ukugaya i-sucrose (ushukela wetafula) noma i-lactose (etholakala obisini nasemikhiqizweni yobisi), noma isifo sesibindi noma sezinso.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Akufanele ukhulelwe ngenkathi uthatha i-voriconazole. Kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nge-voriconazole. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma ukhulelwa ngenkathi uthatha i-voriconazole, shayela udokotela wakho ngokushesha. IVoriconazole ingalimaza umbungu.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-voriconazole.
• kufanele wazi ukuthi i-voriconazole ingadala ukungaboni kahle noma ezinye izinkinga ngokubona kwakho futhi ingenza amehlo akho azwele ekukhanyeni okukhanyayo. Ungashayeli imoto ebusuku ngenkathi uthatha i-voriconazole. Ungashayeli imoto emini noma usebenzise imishini uma unezinkinga ngombono wakho ngenkathi uthatha lo muthi.
• hlela ukugwema ukuvezwa yilanga ngokungadingekile noma isikhathi eside futhi ugqoke izingubo zokuzivikela, izibuko zelanga, nesikhumba selanga. IVoriconazole ingenza isikhumba sakho sizwele ekukhanyeni kwelanga.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

IVoriconazole ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• umbono ongavamile
• kunzima ukubona imibala
• isifo sohudo
• isicanucanu
• ukuhlanza
• ikhanda
• isiyezi
• umlomo owomile
• ukuqhuma

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini Lwezinyathelo Ezikhethekile, shayela udokotela wakho ngokushesha:

• imfiva
• Ukugodola noma ukuqhaqhazela
• ukushaya kwenhliziyo okusheshayo
• ukuphefumula okusheshayo
• ukudideka
• isisu esibuhlungu
• ukukhathala ngokweqile
• ukulimaza noma ukopha okungavamile
• ukulahlekelwa isifiso sokudla
• ukulunywa, umchamo omnyama, ukulahlekelwa isifiso sokudla, ukukhathala, ukuphuzi kwesikhumba noma kwamehlo, ubuhlungu engxenyeni engaphezulu yesisu, isicanucanu, ukuhlanza, noma izimpawu ezifana nemikhuhlane
• ukukhathala; ukungabi namandla; ubuthakathaka; isicanucanu; ukuhlanza; isiyezi; ukuncipha, noma ubuhlungu besisu
• ukukhuluphala; isikhumba esinamafutha phakathi kwamahlombe; ubuso obuyindilinga (ubuso benyanga); ukwenza mnyama kwesikhumba esiswini, emathangeni, emabeleni, nasezingalweni; ukuncipha kwesikhumba; ukulinyazwa; ukukhula ngokweqile kwezinwele; noma ukujuluka
• ukusangana (ukubona izinto noma ukuzwa amazwi angekho)
• ubuhlungu besifuba noma ukuqina
• ukuqubuka
• ukujuluka
• isifuba noma ukuxebuka kwesikhumba
• ukuphefumula kanzima noma ukugwinya
• ukuvuvukala kwezandla, izinyawo, amaqakala, noma imilenze engezansi

IVoriconazole ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina amaphilisi ekamelweni lokushisa kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Gcina ukumiswa ngomlomo okungaxutshiwe esiqandisini, kodwa uma usuxubene ukukugcine ekamelweni lokushisa futhi ungasifaki esiqandisini. Lahla noma yikuphi ukumiswa okungasetshenziswanga ngemuva kwezinsuku eziyi-14.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ukuzwela ekukhanyeni
• abafundi abakhulisiwe (imibuthano emnyama phakathi kwamehlo)
• amehlo avaliwe
• ukumunca amathe
• ukulahlekelwa ibhalansi ngenkathi kuhamba
• ukudana
• ukuphelelwa umoya
• isithuthwane
• isisu esivuvukile
• ukukhathala ngokweqile

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-voriconazole.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho. Uma usenezimpawu zokutheleleka ngemuva kokuqeda i-voriconazole, shayela udokotela wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Vfend^®