Inaliti ye-Zoledronic Acid

-Delile

• Ngaphambi kokuthola umjovo we-zoledronic acid,
• I-Zoledronic acid ingadala imiphumela emibi. Tshela udokotela wakho uma ngabe enye yalezi zimpawu, noma lezo ezisohlwini lwezigaba ze-INDLELA noma ZOKUQAPHA, zinzima noma zingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Zoledronic acid (Reclast) isetshenziselwa ukuvimbela noma ukwelapha i-osteoporosis (isimo lapho amathambo eba mncane futhi abuthakathaka futhi aphuke kalula) kwabesifazane asebedlule esikhathini ('ushintsho lwempilo,' ukuphela kwezikhathi ezijwayelekile zokuya esikhathini). I-Zoledronic acid (Reclast) isetshenziselwa ukwelapha i-osteoporosis emadodeni, nokuvikela noma ukwelapha i-osteoporosis emadodeni nakwabesifazane abathatha i-glucocorticoids (uhlobo lwemithi ye-corticosteroid engadala i-osteoporosis). I-Zoledronic acid (Reclast) nayo isetshenziselwa ukwelapha isifo sePaget samathambo (isimo lapho amathambo ethambe khona futhi ebuthakathaka futhi engahle akhubazeke, abuhlungu, noma aphuke kalula). I-Zoledronic acid (iZometa) isetshenziselwa ukwelapha amazinga aphezulu e-calcium egazini angabangelwa izinhlobo ezithile zomdlavuza. I-Zoledronic acid (iZometa) iyasetshenziswa kanye nomdlavuza womdlavuza ukwelapha ukulimala kwamathambo okubangelwa i-myeloma eminingi [umdlavuza oqala kumaseli e-plasma (amangqamuzana amhlophe egazi akhiqiza izinto ezidingekayo ukulwa nokutheleleka)] noma ngomdlavuza oqale kwenye ingxenye umzimba kodwa usabalele emathanjeni. I-Zoledronic acid (iZometa) akuyona i-chemotherapy yomdlavuza, futhi ngeke inciphise noma imise ukusabalala komdlavuza. Kodwa-ke, ingasetshenziselwa ukwelapha isifo samathambo ezigulini ezinomdlavuza. I-Zoledronic acid isekilasini lemithi ebizwa ngama-bisphosphonates. Isebenza ngokunciphisa ukuwohloka kwamathambo, ukukhulisa ukuminyana kwethambo (ukushuba), nokunciphisa inani le-calcium ekhishwe emathanjeni iye egazini.

I-Zoledronic acid iza njengesisombululo (uketshezi) ukujova emthanjeni okungenani imizuzu eyi-15. Imvamisa ijojowe ngumhlinzeki wezokunakekelwa kwempilo ehhovisi likadokotela, esibhedlela, noma emtholampilo. Lapho umjovo we-zoledronic acid usetshenziselwa ukwelapha amazinga aphezulu egazi e-calcium adalwa ngumdlavuza uvame ukunikezwa njengomthamo owodwa. Umthamo wesibili unganikezwa okungenani izinsuku eziyi-7 ngemuva komthamo wokuqala uma i-calcium yegazi ingehli emazingeni ajwayelekile noma ingahlali emazingeni ajwayelekile. Lapho umjovo we-zoledronic acid usetshenziselwa ukwelapha ukulimala kwethambo okubangelwe yi-myeloma noma umdlavuza osusabalele emathanjeni, kuvame ukunikezwa kanye emavikini ama-3 kuye kwayi-4. Lapho umjovo we-zoledronic acid usetshenziselwa ukwelapha i-osteoporosis kwabesifazane asebedlule esikhathini, noma emadodeni, noma ukwelapha noma ukuvimbela i-osteoporosis kubantu abathatha i-glucocorticoids, kuvame ukunikezwa kanye ngonyaka. Lapho i-zoledronic acid isetshenziselwa ukuvimbela i-osteoporosis kwabesifazane asebeke bayeka ukuya esikhathini, imvamisa inikezwa kanye njalo eminyakeni emibili. Lapho i-zoledronic acid isetshenziselwa ukwelapha isifo sePaget samathambo, imvamisa inikezwa njengomthamo owodwa, kepha imithamo eyengeziwe inganikezwa ngemuva kwesikhathi esithile sidlulile.

Qiniseka ukuthi uphuza okungenani izingilazi ezimbili zamanzi noma olunye uketshezi kungakapheli amahora ambalwa ngaphambi kokuba uthole i-zoledronic acid.

Udokotela wakho angakunika noma ancome isengezo se-calcium kanye ne-multivitamin equkethe i-vitamin D ongayithatha ngesikhathi sokwelashwa kwakho. Kufanele uthathe lezi zithasiselo nsuku zonke njengoba uqondiswe ngudokotela wakho. Tshela udokotela wakho uma kunesizathu sokuthi ngeke ukwazi ukuthatha lezi zithasiselo ngesikhathi sokwelashwa kwakho.

Ungathola ukusabela ezinsukwini ezimbalwa zokuqala ngemuva kokuthola umthamo womjovo we-zoledronic acid. Izimpawu zalokhu kusabela zingabandakanya izimpawu ezinjengomkhuhlane, umkhuhlane, ikhanda elibuhlungu, ukugodola, nethambo, ubuhlungu bamalunga noma besisipha. Lezi zimpawu zingaqala ezinsukwini ezi-3 zokuqala ngemuva kokuthola umjovo we-zoledronic acid injection futhi ingahlala izinsuku ezi-3 kuye kwezi-14. Udokotela wakho angakutshela ukuthi uthathe isiphunguli sokunciphisa izinhlungu esingabhalwanga phansi / ukunciphisa umkhuhlane ngemuva kokuthola umjovo we-zoledronic acid ukuvimbela noma ukwelapha lezi zimpawu.

Uma uthola umjovo we-zoledronic acid ukuvimbela noma ukwelapha i-osteoporosis, kufanele uqhubeke nokuthola umuthi njengoba kuhlelwe noma ngabe uzizwa uphilile. Kufanele ukhulume nodokotela wakho ngezikhathi ezithile mayelana nokuthi ngabe usadinga ukwelashwa ngalo muthi.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa ngomjovo we-zoledronic acid futhi isikhathi ngasinye lapho uthola umthamo. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi} ukuthola uMhlahlandlela Wezokwelapha.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-zoledronic acid,

• Tshela udokotela kanye nosokhemisi wakho uma une-aleji ku-zoledronic acid noma yimuphi omunye umuthi, noma yisiphi isithako somjovo we-zoledronic acid. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• kufanele wazi ukuthi umjovo we-zoledronic acid uyatholakala ngaphansi kwegama lomkhiqizo iZometa neReclast. Kufanele uphathwe kuphela ngomunye wale mikhiqizo ngasikhathi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: ama-antibiotic e-aminoglycoside afana ne-amikacin (Amikin), i-gentamicin (i-Garamycin), i-kanamycin (i-Kantrex), i-neomycin (i-Neo-Rx, i-Neo-Fradin), i-paromomycin (i-Humatin), i-streptomycin, ne-tobramycin (i-Tobi , Nebcin); i-aspirin nezinye izidakamizwa ezingezona ukuvuvukala (ama-NSAID) njenge-ibuprofen (Advil, Motrin) ne-naproxen (Aleve, Naprosyn); imithi yomdlavuza yamakhemikhali; i-digoxin (iLanoxin, eDigitek); isisu (‘amaphilisi amanzi’) njenge-bumetanide (Bumex), i-ethacrynic acid (i-Edecrin), ne-furosemide (i-Lasix); kanye ne-steroids yomlomo efana ne-dexamethasone (i-Decadron, i-Dexone), i-methylprednisolone (i-Medrol), ne-prednisone (i-Deltasone). Eminye imithi eminingi ingaxhumana ne-zoledronic acid, ngakho-ke tshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma uke waba nesifo sezinso noma unomlomo owomile, umchamo omnyama, ukwehla kokujuluka, isikhumba esomile, nezinye izimpawu zokoma noma osanda kuba nohudo, ukuhlanza, imfiva, ukutheleleka, ukujuluka okweqile, noma behlulekile ukuphuza uketshezi olwanele. Udokotela wakho uzokulinda kuze kube yilapho ungasenamanzi ngaphambi kokukunika umjovo we-zoledronic acid noma uma unezinhlobo ezithile zesifo sezinso kungenzeka ukuthi angakunikezi le ndlela yokwelashwa. Phinda utshele udokotela wakho uma wake waba nezinga eliphansi le-calcium egazini lakho. Udokotela wakho mhlawumbe uzohlola izinga le-calcium egazini lakho ngaphambi kokuba uqale ukwelashwa futhi kungenzeka anganikeli lo muthi uma izinga liphansi kakhulu.
• tshela udokotela wakho uma welashwe nge-zoledronic acid noma amanye ama-bisphosphonates (Actonel, Actonel + Ca, Aredia, Boniva, Didronel, Fosamax, Fosamax + D, Reclast, Skelid, neZometa) esikhathini esedlule; uma uke wahlinzwa endlaleni yakho ye-parathyroid (indlala encane entanyeni) noma indlala yegilo noma ukuhlinzwa ukuze ususe izingxenye zamathumbu akho amancane; futhi uma uke wahluleka noma wake wahluleka yinhliziyo (isimo lapho inhliziyo ingakwazi ukumpompa igazi elanele kwezinye izingxenye zomzimba); i-anemia (isimo lapho amangqamuzana abomvu egazi engakwazi ukuletha umoya-mpilo owenele kwezinye izingxenye zomzimba); noma isiphi isimo esivimba igazi lakho ekunqandeni ngokujwayelekile; amazinga aphansi we-calcium, i-magnesium, noma i-potassium egazini lakho; noma isiphi isimo esivimbela umzimba wakho ekutholeni izakhamzimba ekudleni; noma izinkinga ngomlomo wakho, ngamazinyo, noma ngezinsini; ukutheleleka, ikakhulukazi emlonyeni wakho; isifuba somoya noma ukuphefumula, ikakhulukazi uma kwenziwa kubi ngokuthatha i-aspirin; noma isifo se-parathyroid noma sesibindi.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Kufanele usebenzise indlela ethembekile yokulawula ukubeletha ukuvimbela ukukhulelwa ngenkathi uthola i-zoledronic acid. Uma ukhulelwa ngenkathi uthola i-zoledronic acid, shayela udokotela wakho. I-Zoledronic acid ingalimaza umbungu. Khuluma nodokotela wakho uma uhlela ukukhulelwa nganoma yisiphi isikhathi ngokuzayo ngoba i-zoledronic acid ingahlala emzimbeni wakho iminyaka ngemuva kokuyeka ukuyithola.
• kufanele wazi ukuthi umjovo we-zoledronic acid ungadala ubuhlungu obukhulu bethambo, imisipha, noma amalunga. Ungaqala ukuzwa lobu buhlungu kungakapheli izinsuku noma izinyanga ezimbalwa ngemuva kokuthola umjovo we-zoledronic acid. Yize lolu hlobo lobuhlungu lungaqala ngemuva kokuthi uthole umjovo we-zoledronic acid isikhashana, kubalulekile ukuthi wena nodokotela wakho nazi ukuthi kungabangelwa yi-zoledronic acid. Shayela udokotela wakho ngokushesha uma uzwa ubuhlungu obukhulu noma kunini ngesikhathi sokwelashwa kwakho ngomjovo we-zoledronic acid. Udokotela wakho angayeka ukukunika umjovo we-zoledronic acid futhi ubuhlungu bakho bungaphela ngemuva kokuyeka ukwelashwa ngalo muthi.
• kufanele wazi ukuthi i-zoledronic acid ingadala i-osteonecrosis yomhlathi (i-ONJ, isimo esibi sethambo lomhlathi), ikakhulukazi uma uhlinzwa noma ukwelashwa ngenkathi usebenzisa umuthi. Udokotela wamazinyo kufanele ahlole amazinyo akho futhi enze noma yiziphi izindlela zokwelashwa ezidingekayo, kufaka phakathi ukuhlanza, ngaphambi kokuba uqale ukusebenzisa i-zoledronic acid. Qiniseka ukuthi uxubha amazinyo futhi uhlanza umlomo wakho kahle ngenkathi usebenzisa i-zoledronic acid. Khuluma nodokotela wakho ngaphambi kokuthola noma yikuphi ukwelashwa kwamazinyo ngenkathi usebenzisa le mithi.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa isikhathi sokuthola i-zoledronic acid infusion, shayela udokotela wakho ngokushesha okukhulu.

I-Zoledronic acid ingadala imiphumela emibi. Tshela udokotela wakho uma ngabe enye yalezi zimpawu, noma lezo ezisohlwini lwezigaba ze-INDLELA noma ZOKUQAPHA, zinzima noma zingapheli:

• ukulunywa, ububomvu, ubuhlungu, noma ukuvuvukala endaweni lapho uthole khona umjovo wakho
• amehlo abomvu, avuvukile, alumayo noma anezinyembezi noma ukuvuvukala ezungeze amehlo
• ukuqunjelwa
• isicanucanu
• ukuhlanza
• isifo sohudo
• ubuhlungu besisu
• ukulahlekelwa isifiso sokudla
• ukuncipha komzimba
• isilungulela
• izilonda zomlomo
• ukukhathazeka ngokweqile
• ukuyaluza
• ukudana
• ubunzima bokulala noma ukulala
• umkhuhlane, amakhaza, ukukhwehlela, nezinye izimpawu zokutheleleka
• amabala amhlophe emlonyeni
• ukuvuvukala, ububomvu, ukucasuka, ukushisa, noma ukulunywa kwesitho sangasese sowesifazane
• ukukhishwa kwesitho sangasese sowesifazane esimhlophe
• ukuba ndikindiki noma ukuncinza emlonyeni noma eminweni noma ezinzwaneni
• ukulahleka kwezinwele

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha:

• ukuqubuka
• isifuba
• ukulunywa
• ukuvuvukala kwamehlo, ubuso, izindebe, ulimi, umphimbo, izandla, izingalo, izinyawo, amaqakala noma imilenze engezansi
• ukushaqeka
• ukuphefumula kanzima noma ukugwinya
• ubuhlungu besifuba esingenhla
• ukushaya kwenhliziyo okungajwayelekile
• ukuphazamiseka kwemisipha, ukudikiza, noma amajaqamba
• ukulimaza noma ukopha okungavamile
• izinsini ezibuhlungu noma ezivuvukele
• ukukhululeka kwamazinyo
• ukuba ndikindiki noma ukuzwa okusindayo emhlathini
• ubuhlungu emlonyeni noma emhlathini ongapholi

I-Zoledronic acid ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Ukwelashwa ngemithi ye-bisphosphonate efana nomjovo we-zoledronic acid we-osteoporosis kungakhuphula ubungozi bokuthi uzophula amathambo akho ethanga. Ungazizwa ubuthuntu, ubuhlungu obuhlungu okhalweni lwakho, emgodini, noma emathangeni amasonto ambalwa noma izinyanga ngaphambi kokuphuka kwamathambo, futhi ungathola ukuthi elilodwa noma womabili amathambo akho ethanga aphukile yize ungazange uwe okunye ukuhlukumezeka. Akujwayelekile ukuthi ithambo lamathanga liphuke kubantu abaphilile, kepha abantu abane-osteoporosis bangaliphula leli thambo noma bengatholi umjovo we-zoledronic acid. Khuluma nodokotela wakho ngezingozi zokuthola umjovo we-zoledronic acid.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Udokotela wakho uzogcina lo muthi ehhovisi lakhe akunikeze uma kudingeka.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• imfiva
• ubuthakathaka
• ukuqina okungazelelwe kwemisipha noma amajaqamba emisipha
• ukushesha, ukushaya ngamandla, noma ukushaya kwenhliziyo okungajwayelekile
• isiyezi
• ukunyakaza kwamehlo okungalawuleki
• ukubona kabili
• ukudana
• ukuhamba kanzima
• ukuzamazama okungalawuleki kwengxenye yomzimba wakho
• isithuthwane
• ukudideka
• ukuphelelwa umoya
• ubuhlungu, ukuvutha, ukuba ndikindiki noma ukuhayiza ezandleni noma ezinyaweni
• kunzima ukukhuluma
• ubunzima bokugwinya
• ukuncipha kokuchama

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-zoledronic acid.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Ukuvuselelwa^®
• Zometa^®