Inaliti ye-Certolizumab

-Delile

• Umjovo we-Certolizumab usetshenziselwa ukuqeda izimpawu zokuphazamiseka komzimba (izimo lapho amasosha omzimba ehlasela khona izingxenye ezinempilo zomzimba futhi abangele ubuhlungu, ukuvuvukala, nomonakalo) kubandakanya okulandelayo:
• Ngaphambi kokusebenzisa umjovo we-certolizumab,
• Umjovo we-Certolizumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha noma uthole usizo oluphuthumayo lwezokwelapha:

Umjovo we-Certolizumab unganciphisa ikhono lakho lokulwa nokutheleleka futhi wandise ubungozi bokuthi uthole ukutheleleka okungathi sína noma okusongela ukuphila okubandakanya ukutheleleka okunzima kwe-fungal, bacterial, kanye ne-virus okungasabalala emzimbeni. Lezi zifo zingadinga ukwelashwa esibhedlela futhi zingadala nokufa. Tshela udokotela wakho uma uvame ukuthola noma yiluphi uhlobo lokutheleleka noma uma une noma ucabanga ukuthi ungahle ube nolunye uhlobo lokutheleleka manje. Lokhu kufaka ukutheleleka okuncane (njengokusikeka okuvulekile noma izilonda), izifo ezifika zidlule (njengezilonda ezibandayo), kanye nezifo ezingamahlalakhona ezingapheli. Tshela nodokotela wakho uma uke waba nesifo sikashukela noma i-hepatitis B (ukutheleleka ngegciwane okuthinta isibindi), igciwane lesandulela-ngculazi (i-HIV), nanoma yisiphi isimo esithinta amasosha akho omzimba, futhi uma uhlala noma owake wahlala kuwo izindawo ezinjengezigodi zase-Ohio naseMississippi River lapho ukutheleleka okunzima kwefungal kuvame kakhulu. Buza udokotela wakho uma ungazi ukuthi ngabe lezi zifo zivamile yini endaweni yangakini. Tshela udokotela wakho uma uthatha imishanguzo eyehlisa umsebenzi amasosha omzimba afana ne-abatacept (Orencia), adalimumab (Humira), anakinra (Kineret), etanercept (Enbrel), golimumab (Simponi), infliximab (Remicade), methotrexate ( Otrexup, Rasuvo, Trexall), natalizumab (Tysabri), rituximab (Rituxan), steroids including dexamethasone, methylprednisolone (Medrol), prednisolone (Prelone), ne-prednisone (Rayos), ne-tocilizumab (Actemra).

Udokotela wakho uzokuqapha ngezibonakaliso zokutheleleka ngesikhathi nangemva kokwelashwa kwakho. Uma unezinye zalezi zimpawu ezilandelayo ngaphambi kokuba uqale ukwelashwa kwakho noma uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi noma ngemuva nje kokwelapha kwakho, shayela udokotela wakho ngokushesha: umphimbo obuhlungu; ukukhwehlela; ukukhwehlela amafinyila anegazi; imfiva; ubuhlungu besisu; isifo sohudo; izimpawu ezinjengomkhuhlane; ukusikeka noma izilonda; ukuncipha komzimba; ubuthakathaka; ukujuluka; ukuphefumula kanzima; ukuchama okunzima, okuvamile, noma okubuhlungu; noma ezinye izimpawu zokutheleleka.

Kungenzeka ukuthi usungenwe yisifo sofuba (i-TB; ukutheleleka okungathi sína kwamaphaphu) noma i-hepatitis B (igciwane elithinta isibindi) kodwa ungabi nazimpawu zesifo. Kulokhu, ukusebenzisa umjovo we-certolizumab kungenza ukutheleleka kwakho kube kubi kakhulu futhi kukwenze ube nezimpawu. Udokotela wakho uzokwenza ukuhlolwa kwesikhumba ukuze abone ukuthi unesifo se-TB esingasebenzi yini futhi anga-oda ukuhlolwa kwegazi ukubona ukuthi unesifo se-hepatitis B esingasebenzi yini. Uma kunesidingo, udokotela wakho uzokunika imithi yokwelapha lesi sifo ngaphambi kokuqala ukusebenzisa i-certolizumab. Tshela udokotela wakho uma uke waba ne-TB noma wake waba nayo, uma wake wahlala noma wavakashela izwe lapho i-TB ijwayelekile khona, noma uma wake waba seduze komuntu one-TB. Uma unezinye zalezi zimpawu ze-TB ezilandelayo, noma uma uba nalezi zimpawu ngesikhathi sokwelashwa kwakho, shayela udokotela wakho ngokushesha: ukukhwehlela, ukwehla kwesisindo, ukulahleka kwethoni lezicubu, noma umkhuhlane. Phinda ushayele udokotela wakho ngokushesha uma unanoma iyiphi yalezi zimpawu zesifo sokusha kwesibindi kohlobo B noma uma uba nanoma yiziphi zalezi zimpawu ngesikhathi noma ngemuva kokwelashwa kwakho: ukukhathala ngokweqile, ukuphuzi kwesikhumba noma kwamehlo, ukulahlekelwa isifiso sokudla, isicanucanu noma ukuhlanza, izinhlungu zemisipha, umchamo omnyama, ukuhamba kwamathumbu anombala wobumba, umkhuhlane, amakhaza, ubuhlungu besisu, noma ukuqubuka.

Ezinye izingane nentsha ethola imishanguzo efana nomjovo we-certolizumab yaba nomdlavuza onzima noma osongela ukuphila kubandakanya i-lymphoma (umdlavuza oqala kumaseli alwa nokutheleleka). Izingane nentsha akufanele zivame ukuthola umjovo we-certolizumab, kepha kwezinye izimo, udokotela anganquma ukuthi umjovo we-certolizumab umuthi ongcono kakhulu wokwelapha isimo sengane. Uma umjovo we-certolizumab unikezwe ingane yakho, kufanele ukhulume nodokotela wengane yakho ngobungozi nezinzuzo zokusebenzisa lo muthi. Uma ingane yakho iba nalezi zimpawu phakathi nokwelashwa kwayo, shayela udokotela wayo ngokushesha: ukuncipha kwesisindo okungachazeki; izindlala ezivuvukile entanyeni, ngaphansi kwekhwapha, noma emgodini; noma ukulimaza okulula noma ukopha.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa ngomjovo we-certolizumab futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokusebenzisa umjovo we-certolizumab.

Umjovo we-Certolizumab usetshenziselwa ukuqeda izimpawu zokuphazamiseka komzimba (izimo lapho amasosha omzimba ehlasela khona izingxenye ezinempilo zomzimba futhi abangele ubuhlungu, ukuvuvukala, nomonakalo) kubandakanya okulandelayo:

• Isifo sikaCrohn (isimo lapho umzimba uhlasela ulwelwesi lomgudu wokugaya ukudla, ubangele ubuhlungu, isifo sohudo, ukwehla kwesisindo nomkhuhlane) okungazange kuthuthuke lapho welashwa ngeminye imithi,
• i-rheumatoid arthritis (isimo lapho umzimba uhlasela khona amalunga awo, ubangele ubuhlungu, ukuvuvukala nokulahlekelwa ngumsebenzi),
• i-psoriatic arthritis (isimo esidala ubuhlungu bamalunga nokuvuvukala nezikali esikhunjeni),
• i-ankylosing spondylitis esebenzayo (isimo lapho umzimba uhlasela khona amalunga omgogodla nezinye izindawo ezibangela ubuhlungu, ukuvuvukala nokulimala ngokuhlanganyela) nezinguquko ezibonwe ku-X-ray,
• i-axial spondyloarthritis engasebenziyo nge-radiographic (isimo lapho umzimba uhlasela khona amalunga omgogodla nezinye izindawo okubangela ubuhlungu nezimpawu zokuvuvukala), kepha ngaphandle kwezinguquko ezibonakala ku-X-ray,
• i-plaque psoriasis (isifo sesikhumba lapho kuvela khona amabala abomvu, anezikhala ezindaweni ezithile zomzimba) kubantu abangahlomula ngemithi noma nge-phototherapy (ukwelashwa okubandakanya ukuveza isikhumba ekukhanyeni kwe-ultraviolet).

Umjovo we-Certolizumab usesigabeni semithi ebizwa nge-tumor necrosis factor (TNF) inhibitors. Isebenza ngokuvimba umsebenzi we-TNF, into esemzimbeni ebangela ukuvuvukala.

Umjovo weCertolizumab uza njengempuphu yokuxutshwa namanzi oyinyumba bese ujovwa ngomgogodla (ngaphansi nje kwesikhumba) ngudokotela noma umhlengikazi ehhovisi lezokwelapha nanjengesirinji egcwaliswe ngaphambili ongazijova ngayo wedwa ekhaya. Lapho umjovo we-certolizumab usetshenziselwa ukwelapha isifo sikaCrohn, uvame ukunikezwa njalo emavikini amabili ngemithamo yokuqala emithathu bese njalo njalo emavikini amane inqobo nje uma ukwelashwa kuqhubeka. Lapho umjovo we-certolizumab usetshenziselwa ukwelapha i-rheumatoid arthritis, i-psoriatic arthritis, i-ankylosing spondylitis, noma i-axial spondyloarthritis, imvamisa inikezwa njalo emavikini amabili ngemithamo emithathu yokuqala bese njalo njalo emavikini amabili noma amane uma nje ukwelashwa kuqhubeka. Lapho umjovo we-certolizumab usetshenziselwa ukwelapha i-plaque psoriasis, imvamisa unikezwa njalo emavikini amabili. Uma ujove umjovo we-certolizumab ngokwakho, landela izinkomba ezikulebula lakho kadokotela ngokucophelela. Ungafaki i-certolizumab engaphezulu noma encane kunokuyalelwa ngudokotela wakho.

Uma uzofaka umjovo we-certolizumab uwedwa ekhaya noma unomngane noma isihlobo sikufakela umuthi, cela udokotela wakho ukuthi akubonise noma umuntu ozokujova umuthi ukuthi angawufaka kanjani umjovo. Wena kanye nomuntu ozojova umuthi kufanele futhi ufunde imiyalo ebhaliwe yokusetshenziswa eza nomuthi.

Ngaphambi kokuthi uvule iphakethe eliqukethe imishanguzo yakho, hlola ukuqinisekisa ukuthi iphakethe alidabuki, ukuthi izimpawu ezingabonakali kalula phezulu nangaphansi kwephakeji azilahlekile noma zephuliwe nokuthi usuku lokuphelelwa yisikhathi oluphrintwe kwiphakethe alukaze kudlulile. Ngemuva kokuvula iphakethe, bhekisisa uketshezi olukusipontsho. Okuketshezi kufanele kucace noma kuphuzi ngokukhanyayo futhi akufanele kube nezinhlayiya ezinkulu ezinemibala. Shayela usokhemisi wakho, uma kunezinkinga ngephakethe noma ngesirinji. Musa ukujova umuthi.

Ungajova umjovo we-certolizumab noma kuphi esiswini noma emathangeni akho ngaphandle kwenkaba yakho (inkinobho yesisu) nendawo engama-intshi amabili kuyo. Ungawufaki umuthi esikhumbeni esithambile, esilimele, esibomvu, noma esiqinile, noma esinezibazi noma izimpawu zokwelula. Ungawufaki umuthi endaweni efanayo kaningi. Khetha indawo entsha okungenani i-intshi eyodwa ukusuka endaweni oyisebenzise ngaphambi kokufaka umuthi njalo. Uma udokotela wakho ekutshele ukuthi ujove imijovo emibili ye-certolizumab yedosi ngayinye, khetha indawo ehlukile yomjovo ngamunye.

Ungayisebenzisi imijovo egcwaliswe ngaphambili ye-certolizumab futhi ungaphindi amajojo ngemuva kokuyisebenzisa. Lahla imijovo esetshenzisiwe esitsheni esingamelana nokubhoboza. Buza usokhemisi wakho ukuthi usilahla kanjani isitsha.

Umjovo we-Certolizumab ungasiza ukulawula izimpawu zakho, kepha ngeke uselaphe isimo sakho. Ungayeki ukusebenzisa umjovo we-certolizumab ngaphandle kokukhuluma nodokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokusebenzisa umjovo we-certolizumab,

• Tshela udokotela kanye nosokhemisi wakho uma une-aleji kumjovo we-certolizumab; noma imuphi omunye umuthi, i-latex noma i-raber, noma yiziphi izithako zomjovo we-certolizumab. Buza usokhemisi wakho noma hlola umhlahlandlela wemithi ukuthola uhlu lwezithako. Uma uzosebenzisa isirinji ekhethiwe, tshela udokotela wakho uma wena noma umuntu ozojova umuthi unalesi sifo ku-latex.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imithi efakwe kuhlu esigabeni ESIBALULEKILE SESEXWAYISO. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma uke waba nesifo esithinta isistimu yakho yezinzwa, njenge-multiple sclerosis (MS; isifo lapho izinzwa zingasebenzi kahle zibangela ubuthakathaka, ukuba ndikindiki, ukulahleka kokuhlangana kwemisipha nezinkinga ngombono, inkulumo , kanye nesilawuli sesinye) I-Guillain-Barré syndrome (ubuthakathaka, ukuluma, kanye nokukhubazeka okungenzeka ngenxa yokulimala okungazelelwe kwemizwa) noma i-optic neuritis (ukuvuvukala kwemizwa ethumela imiyalezo isuka esweni iye ebuchosheni); ukuba ndikindiki, ukushiswa, noma ukuncinza kunoma iyiphi ingxenye yomzimba wakho; ukuquleka; ukwehluleka kwenhliziyo; noma yiluphi uhlobo lomdlavuza; noma izinkinga zokopha noma izifo ezithinta igazi lakho.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi usebenzisa umjovo we-certolizumab, shayela udokotela wakho.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi usebenzisa umjovo we-certolizumab.
• ungenayo imigomo ngaphandle kokukhuluma nodokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Jova umthamo ophuthelwe ngokushesha nje lapho uwukhumbula. Uma sekusondele isikhathi somthamo wakho olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Musa ukujova umthamo ophindwe kabili ukwenzela okulahlekile.

Umjovo we-Certolizumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ububomvu, ukulunywa, ubuhlungu, noma ukuvuvukala endaweni yomjovo
• ikhanda
• ukuhlungu obusemhlane

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha noma uthole usizo oluphuthumayo lwezokwelapha:

• ukuvuvukala kobuso, umphimbo, ulimi, izindebe, amehlo, izandla, izinyawo, amaqakala noma imilenze engezansi
• ukushaqeka
• ukuphelelwa umoya
• ubunzima bokugwinya noma ukuphefumula
• ubuhlungu besifuba
• ukuzuza kwesisindo ngokungazelelwe
• isifuba
• ukushisa okushisayo
• isiyezi noma ukuquleka
• ukuqubuka, ikakhulukazi ezihlathini noma ezingalweni eziba nzima elangeni
• ukulimaza noma ukopha okungavamile
• isikhumba esiphaphathekile
• isikhumba esiqhumayo
• ukukhathala ngokweqile
• ukuba ndikindiki noma ukuhayiza
• izinkinga ngombono
• ubuthakathaka ezandleni noma emilenzeni
• ubuhlungu obuhlangene
• ukulahlekelwa isifiso sokudla
• amabala abomvu ama-scaly kanye / noma amaqhubu agcwele ubomvu esikhunjeni

Abantu abadala abathola umjovo we-certolizumab kungenzeka babe nomdlavuza wesikhumba, i-lymphoma, nezinye izinhlobo zomdlavuza kunabantu abangawutholi umjovo we-certolizumab. Khuluma nodokotela wakho ngezingozi zokuthola lo muthi.

Umjovo we-Certolizumab ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi usebenzisa lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina izingqayi kanye nemijovo ekhethiwe kwikhathoni yoqobo efike ngayo ukuzivikela ekukhanyeni nasekufinyelelekeni kwezingane. Gcina umjovo we-certolizumab esiqandisini futhi ungafrizi.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho kumjovo we-certolizumab.

Ngaphambi kokwenza noma yiluphi uvivinyo lwelabhoratri, tshela udokotela wakho nabasebenzi belebhuthi ukuthi usebenzisa umjovo we-certolizumab.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Cimzia^®