I-Axitinib

-Delile

• Ngaphambi kokuthatha i-axitinib,
• I-Axitinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole usizo oluphuthumayo lwezokwelapha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Axitinib isetshenziswa yodwa ukwelapha i-renal cell carcinoma (RCC, uhlobo lomdlavuza oluqala kumaseli ezinso) kubantu abangazange belashwe ngempumelelo ngomunye umuthi. I-Axitinib isetshenziswa ngokuhlangana ne-avelumab (Bavencio) noma i-pembrolizumab (Keytruda) ukwelapha i-renal cell carcinoma esezingeni eliphakeme. I-Axitinib isekilasini lemithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo sephrotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunciphisa noma ukumisa ukusabalala kwamangqamuzana omdlavuza.

I-Axitinib iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa ngokudla noma ngaphandle kokudla kabili ngosuku. Thatha i-axitinib ngasikhathi sinye nsuku zonke, cishe ngamahora ayi-12 uhlukene. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-axitinib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi ngengilazi yamanzi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Uma uhlanza ngemuva kokuthatha i-axitinib, ungathathi omunye umthamo. Qhubeka nesimiso sakho sokulinganisa okuvamile.

Udokotela wakho angakuqala ngomthamo ophansi we-axitinib futhi akhuphule kancane umthamo wakho, hhayi ngaphezu kwesisodwa njalo emavikini amabili. Lokhu kuya ngokuthi umuthi usebenza kanjani kuwe nakunoma imiphi imiphumela emibi ongayithola. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Qhubeka uthathe i-axitinib noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-axitinib ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-axitinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-axitinib, noma imuphi omunye umuthi, noma iziphi izithako kumaphilisi e-axitinib. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: bosentan (Tracleer); carbamazepine (Carbatrol, Epitol, Tegretol); i-clarithromycin (i-Biaxin, ku-Prevpac); itraconazole (Sporanox); ketoconazole (Nizoral); imithi yokwelapha i-HIV / AID kubandakanya i-atazanavir (Reyataz), efavirenz (Sustiva, e-Atripla), etravirine (Intelence), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), kanye ne-saquinavir (Invirase); i-modafinil (i-Provigil); nafcillin; nefazodone; i-phenobarbital; i-phenytoin (iDilantin, Phenytek); i-rifabutin (i-Mycobutin); i-rifampin (iRifamate, iRifater); i-rifapentine (Priftin); imithi ye-steroid efana ne-dexamethasone (i-Decadron); i-telithromycin (Ketek); kanye ne-voriconazole (Vfend). Eminye imishanguzo eminingi ingaxhumana ne-axitinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi yimiphi imikhiqizo yamakhambi oyithathayo, ikakhulukazi iSt John's wort.
• utshele udokotela wakho uma unesilonda esingapholi, noma ngabe unezinkinga zokopha noma wake waba nazo; amahlule egazi; umfutho wegazi ophakeme; isifo senhliziyo; isifo sikashukela; amazinga aphezulu e-cholesterol; ukopha esiswini noma emathunjini; umdlavuza wobuchopho; i-embolism ye-pulmonary (ihlule legazi emaphashini akho); isifo sohlangothi noma i-ministroke (TIA); noma inhliziyo; isibindi; noma isifo segilo.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uma uhlela ukuba nobaba wengane. Uma ungowesifazane, kuzofanele uthathe ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa futhi usebenzise izilawuli zokubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nangesonto eli-1 ngemuva komthamo wakho wokugcina. Uma ungowesilisa, wena nomlingani wakho wesifazane kufanele nisebenzise ukulawulwa kokubeletha ngesikhathi sokwelashwa kwenu nangesonto eli-1 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-axitinib, shayela udokotela wakho. I-Axitinib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngesikhathi sokwelashwa kwakho nge-axitinib nangamasonto ama-2 ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala kwabesilisa nabesifazane. Khuluma nodokotela wakho ngezingozi zokuthatha i-axitinib.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-axitinib. Udokotela wakho uzokutshela ukuthi uyeke ukuthatha i-axitinib okungenani izinsuku ezimbili ngaphambi kokuhlinzwa kwakho nokuthi kuzokuphepha nini ukuqala ukuthatha i-axitinib futhi ngemuva kokuhlinzwa kwakho.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa umthamo we-axitinib, weqa lowo umthamo uthathe umthamo wakho olandelayo ngesikhathi esijwayelekile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Axitinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• ukuncipha kwesifiso sokudla noma ikhono lokunambitha izinto
• ukuncipha komzimba
• isicanucanu
• ukuhlanza
• ukuqunjelwa
• ukukhathala
• ubuthakathaka
• shintsha ngomsindo wezwi lakho
• ububomvu, ubuhlungu, ukuba ndikindiki, ukuhayiza, noma ukulunywa noma ukuxebuka kwesikhumba ezandleni nasezinyaweni zakho
• ukukhwehlela
• ubuhlungu obuhlangene noma besisipha
• izilonda zomlomo
• ubuhlungu besisu
• inhliziyo ishise
• ikhanda
• isiyezi
• ukuqubuka
• ukulunywa
• isikhumba esomile
• ukuzwa kushisa noma kubanda
• isikhumba esiphaphathekile
• ukushaya kwenhliziyo okusheshayo
• ukulahleka kwezinwele
• kukhala ezindlebeni
• ukoma
• ama-hemorrhoids
• isilonda noma ukusika okungapholi

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole usizo oluphuthumayo lwezokwelapha:

• ubuhlungu obukhulu besisu
• ukuphelelwa umoya
• ukuvuvukala ezandleni noma ezinyaweni
• ukopha okungajwayelekile noma ukulinyazwa
• indle emnyama neyokulinda
• igazi elibomvu endle
• ukuhlanza okunegazi
• izinto zokuhlanza ezibukeka njengezizathu zekhofi
• ubuhlungu besifuba noma ingcindezi
• ubuhlungu ezingalweni, emhlane, entanyeni, noma emhlathini
• ukuvuvukala, ubumnene, imfudumalo, noma ubomvu bomlenze
• ukuphazamiseka okungazelelwe noma ubuthakathaka bobuso, ingalo, noma umlenze (ikakhulukazi ohlangothini olulodwa lomzimba)
• ukudideka okungazelelwe, ukukhathazeka ukukhuluma noma ukuqonda
• inkathazo engazelelwe yokubona kwelinye noma kuwo womabili amehlo
• ukuhamba ngokuzumayo, isiyezi, ukulahlekelwa ibhalansi noma ukuxhumanisa
• ikhanda elibuhlungu ngokuzumayo ngaphandle kwesizathu esaziwayo
• ukudlikiza
• ukulahleka kombono

I-Axitinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• isiyezi
• isithuthwane
• ekhwehlela igazi

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-axitinib. Udokotela wakho uzophinde ahlole umfutho wegazi lakho njalo ngesikhathi sokwelashwa kwakho nge-axitinib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Inlyta^®