Ambrisentan

-Delile

• Ngaphambi kokuthatha i-ambrisentan,
• I-Ambrisentan ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

Ungathathi ama-ambrisentan uma ukhulelwe noma uhlela ukukhulelwa. I-Ambrisentan ingalimaza umbungu. Uma ungowesifazane futhi ukwazi ukukhulelwa, akufanele uqale ukuthatha i-ambrisentan kuze kube ukuhlolwa kokukhulelwa kubonise ukuthi awukhulelwe. Kufanele usebenzise izindlela ezimbili ezinokwethenjelwa zokulawulwa kokubeletha ngenkathi welashwa ngalo muthi nangenyanga e-1 ngemuva kokuyeka ukwelashwa. Musa ukuya ocansini olungaphephile. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Shayela udokotela wakho ngokushesha uma uphuthelwa ukuya esikhathini noma ucabanga ukuthi ungakhulelwa ngenkathi uthatha i-ambrisentan.

Ngenxa yobungozi bokukhubazeka kokuzalwa, i-ambrisentan itholakala kwabesifazane kuphela ngohlelo olukhethekile lokusabalalisa olukhawulelwe. Kuhlelwe uhlelo olubizwa nge-Ambrisentan REMS (Risk Evaluation and Mitigation Strategy) ukuqinisekisa ukuthi isiguli sesifazane sinezivivinyo ezifanele zelebhu ngaphambi nangesikhathi sithola i-ambrisentan. Abesifazane bangathola ama-ambrisentan kuphela uma bebhalisiwe nalolu hlelo. Udokotela wakho kufanele akubhalise kulolu hlelo. Ungathola kuphela umuthi ekhemisi elibamba iqhaza ohlelweni. Buza udokotela wakho uma unemibuzo mayelana nokuhlanganyela kulolu hlelo noma ukuthi ungayithola kanjani imithi yakho.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ngesikhathi sokwelashwa kwakho ne-ambrisentan.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-ambrisentan futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo.Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokuthatha i-ambrisentan.

I-Ambrisentan isetshenziswa yodwa noma ihlanganiswe ne-tadalafil (Adcirca, Cialis) ukwelapha umfutho wegazi ophakeme wamaphaphu (PAH, umfutho wegazi ophakeme ezitsheni ezihambisa igazi emaphashini). I-Ambrisentan ingathuthukisa ikhono lokuzivocavoca futhi yehlise ukwanda kwezimpawu kubantu abane-PAH. U-Ambrisentan usesigabeni semithi ebizwa nge-endothelin receptor antagonists. Isebenza ngokumisa isenzo se-endothelin, into yemvelo ebangela ukuthi imithambo yegazi inciphise futhi ivimbele ukugeleza kwegazi okujwayelekile kubantu abane-PAH.

I-Ambrisentan iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa nokudla noma ngaphandle kokudla kanye ngosuku. Thatha ama-ambrisentan ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha ama-ambrisentan njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Udokotela wakho angakuqala ngomthamo ophansi we-ambrisentan futhi akhuphule kancane umthamo wakho.

I-Ambrisentan ilawula izimpawu ze-PAH kepha ayiyelaphi. Qhubeka nokuthatha i-ambrisentan noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-ambrisentan ngaphandle kokukhuluma nodokotela wakho. Uma ngokungazelelwe uyeka ukuthatha i-ambrisentan, isimo sakho singase sibe sibi kakhulu.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-ambrisentan,

• Tshela udokotela wakho kanye nosokhemisi uma une-allergies ku-ambrisentan, noma imiphi eminye imithi, noma yiziphi izithako ezibhebheni ze-ambrisentan. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyasho uma uthatha i-cyclosporine (Gengraf, Neoral, Sandimmune). Udokotela wakho angadinga ukushintsha umthamo wemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma une-idiopathic pulmonary fibrosis (isibazi samaphaphu ngesizathu esingaziwa). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-ambrisentan.
• Tshela udokotela wakho uma uke waba ne-anemia (inani eliphansi kunokujwayelekile lamaseli abomvu egazi) noma isifo sesibindi.
• tshela udokotela wakho uma uncelisa. Musa ukuncelisa uma uthatha i-ambrisentan.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Ambrisentan ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuqhuma
• isikhumba esiphaphathekile
• ukushaya kwenhliziyo okusheshayo
• ikhanda

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuvuvukala kobuso, umphimbo, ulimi, izindebe, amehlo, izandla, izinyawo, amaqakala noma imilenze engezansi
• ukushaqeka
• ubunzima bokugwinya noma ukuphefumula
• ukuqubuka
• ukuzuza kwesisindo okungavamile
• ukukhathala ngokweqile
• ukulahlekelwa isifiso sokudla
• ukungabi namandla
• isicanucanu
• ukuhlanza
• ubuhlungu endaweni ephezulu yesisu
• ukuphuzi kwesikhumba noma kwamehlo
• izimpawu ezinjengomkhuhlane
• ukulunywa
• umchamo onombala omnyama

Amanye amadoda aphuza umuthi ofana ne-ambrisentan athuthukise isibalo sesidoda esingaphansi kwesivamile (inani lamaseli okuzala abesilisa); umphumela ongathinta amandla abo okuzala ingane. Khuluma nodokotela wakho ngezingozi zokuthatha i-ambrisentan uma ungathanda ukuba nezingane ngokuzayo.

I-Ambrisentan ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ikhanda
• ukuqhuma
• isiyezi
• isicanucanu
• ukuminyana kwamakhala

Ungavumeli omunye umuntu ukuthi athathe imithi yakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Letairis^®