Enzalutamide

-Delile

• Ngaphambi kokuthatha i-enzalutamide,
• I-Enzalutamide ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Enzalutamide isetshenziselwa ukwelapha umdlavuza wendlala yesinye osakaze kwezinye izingxenye zomzimba emadodeni futhi osizwe yimithi ethile yokwelashwa nokuhlinzwa eyehlisa amazinga e-testosterone. Iphinde isetshenziselwe ukwelapha umdlavuza wendlala yabesilisa emadodeni angazange asizwe izindlela ezithile zokwelapha nezokuhlinza ezehlisa amazinga e-testosterone. U-Enzalutamide usesigabeni semithi ebizwa nge-androgen receptor inhibitors. Isebenza ngokuvimba imiphumela ye-androgen (i-hormone yokuzala yowesilisa) ukunqanda ukukhula nokusabalala kwamangqamuzana omdlavuza.

I-Enzalutamide iza njengethebhulethi noma iphilisi elizothathwa ngomlomo. Imvamisa kuthathwa nokudla noma ngaphandle kokudla kanye ngosuku. Thatha i-enzalutamide ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-enzalutamide njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi noma amaphilisi; musa ukuchoboza, ukuhlafuna, ukwahlukanisa, ukuncibilikisa, noma ukuwavula.

Udokotela wakho angakutshela ukuthi uyeke ukuthatha i-enzalutamide isikhashana noma wehlise umthamo wakho uma uba nemiphumela emibi ngesikhathi sokwelashwa kwakho. Qiniseka ukuthi ukhuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngenkathi welashwa nge-enzalutamide.

Uma udokotela wakho enikeze omunye umuthi njenge-degarelix (Firmagon), i-goserelin (i-Zoladex), i-histrelin (i-Supprelin LA, i-Vantas), i-leuprolide (i-Eligard, i-Lupron, e-Lupaneta Pack), noma i-triptorelin (Trelstar, i-Triptodur) yokwelapha umdlavuza wakho wendlala yesinye , kuzodingeka uqhubeke nokuthola lo muthi ngenkathi welashwa nge-enzalutamide.

Qhubeka uthathe i-enzalutamide noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-enzalutamide ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-enzalutamide,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-enzalutamide, noma imiphi eminye imithi, noma iziphi izithako ezikumaphilisi we-enzalutamide noma amaphilisi. Buza usokhemisi wakho noma hlola imininingwane yomkhiqizi ngesiguli ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela noma engabhaliswanga, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: ama-anticoagulants ('ama-blood thinner') afana ne-warfarin (Coumadin, Jantoven), carbamazepine (Carbatrol, Equetro, Tegretol, abanye), clopidogrel (Plavix), cyclosporine (Gengraf, Neoral, Sandimmune), dihydroergotamine (DHE 45, Migranal), ergotamine (eMigergot, eCafergot), fentanyl (Actiq, Duragesic, Fentora, Subsys, abanye), gemfibrozil (Lopid), itraconazole (Onmel, Sporanox), omeprazole (Prilose) , phenytoin (Dilantin, Phenytek), pimozide (Orap), quinidine (eNuedexta), rifabutin (Mycobutin, in Talicia), rifampin (Rimactane, eRifamate, eRifater), rifapentine (Priftin), sirolimus (Rapamune) (Prograf). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingaxhumana ne-enzalutamide, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho ukuthi uke waquleka noma wake wahlaselwa yini, ukulimala ebuchosheni, isimila ebuchosheni, i-arteriovenous malformation (ukuxhumana okungajwayelekile phakathi kwemithambo nemithambo ebuchosheni eyenzeka ngaphambi kokuzalwa futhi kungadala ukopha ebuchosheni), amathambo aphukile, i-osteoporosis (isimo lapho amathambo eba mncane futhi abe buthakathaka futhi aphuke kalula), isifo sikashukela, amazinga aphezulu e-cholesterol, umfutho wegazi ophakeme, isifo senhliziyo, noma abe nesifo sohlangothi noma i-ministroke.
• kufanele wazi ukuthi i-enzalutamide iyi- kuphela ukuze isetshenziswe emadodeni. Abesifazane akufanele bathathe le mithi, ikakhulukazi uma bekhulelwe noma bengakhulelwa noma bencelisa. Abesifazane, ikakhulukazi labo abangakhulelwa noma abangakhulelwa akufanele bathinte amaphilisi e-enzalutamide. Uma ithathwa ngabesifazane abakhulelwe, i-enzalutamide ingalimaza umbungu. Uma owesifazane okhulelwe ethatha i-enzalutamide, kufanele abize udokotela wakhe ngokushesha.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala emadodeni. Kodwa-ke, akufanele ucabange ukuthi umlingani wakho wesifazane akakwazi ukukhulelwa. Uma umlingani wakho ekhulelwe, kufanele usebenzise ikhondomu noma nini lapho uya ocansini ngesikhathi sokwelashwa kwakho ne-enzalutamide nezinyanga ezintathu ngemuva komthamo wakho wokugcina. Uma umlingani wakho engakhulelwe kepha engakhulelwa, kufanele usebenzise ukulawulwa kokubeletha okusebenzayo noma nini lapho uya ocansini ngesikhathi sokwelashwa kwakho nezinyanga ezi-3 ngemuva komthamo wakho wokugcina.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-enzalutamide.
• kufanele wazi ukuthi i-enzalutamide ingadala ukuquleka. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma ungakhumbuli kuze kube usuku olulandelayo, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa okujwayelekile. Ungathathi umthamo ongaphezu kowodwa ngosuku olulodwa futhi ungathathi umthamo ophindwe kabili ukwenzela owulahlekile.

I-Enzalutamide ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ubuthakathaka
• ukukhathala
• ubuhlungu obuhlangene
• ubuthakathaka bemisipha noma ukuqina
• ukuncipha komzimba
• ukulahlekelwa isifiso sokudla
• ikhanda
• isiyezi
• ukushisa, ukuba ndikindiki, noma ukuncinza ezingalweni, ezandleni noma ezinyaweni
• ukuncipha komuzwa wokuthinta noma ikhono lokuzwa imizwa
• ukushisa okushisayo
• ubunzima bokulala noma ukulala
• ukukhathazeka
• ubunzima bokukhumbula, ukucabanga, noma ukunaka
• isifo sohudo
• ukuqunjelwa
• ukulunywa
• isikhumba esomile
• ukuphuma kwamakhala
• ukuchama kaningi
• izinguquko zokunambitheka

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• isithuthwane
• ikhanda; ukudideka; noma izinguquko zombono
• ukuvuvukala kobuso, ulimi, izindebe, umphimbo, izingalo, imilenze, izandla noma izinyawo
• umkhuhlane, ukukhwehlela, umphimbo obuhlungu, noma ezinye izimpawu zokutheleleka
• ubuhlungu besifuba
• ukuphelelwa umoya
• ubuhlungu emuva, imisipha, kanye / noma imilenze
• ukuba ndikindiki noma ukuncinza ezinqeni noma emilenzeni
• ubunzima bokulawula ukuchama noma ukuhamba kwamathumbu
• ukuphefumula kanzima
• ukuwa
• amathambo aphukile noma ukuphuka
• ukubona izinto ezingekho (ukubona izinto noma ukuzwa amazwi angekho)
• ukukhuliswa kwamabele emadodeni
• umchamo obomvana noma obomvu

I-Enzalutamide ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• isithuthwane

Gcina wonke ama-aphoyintimenti nodokotela wakho.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Xtandi^®