Lomitapide

-Delile

• Ngaphambi kokuthatha i-lomitapide,
• I-Lomitapide ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, yeka ukuthatha i-lomitapide bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

ILomitapide ingadala umonakalo omkhulu esibindini. Tshela udokotela wakho uma uke waba nesifo sesibindi noma wake waba nezinkinga zesibindi ngenkathi uthatha eminye imithi.Udokotela wakho angakutshela ukuthi ungathathi i-lomitapide. Tshela udokotela wakho uma uphuza utshwala. Ukuphuza utshwala kungandisa ingozi yokuthi uzoba nezinkinga zesibindi. Ungaphuzi isiphuzo esidakayo esingaphezu kwesisodwa ngosuku ngenkathi uthatha i-lomitapide. Tshela udokotela wakho kanye nosokhemisi uma uthatha i-acetaminophen (Tylenol, abanye), amiodarone (Cordarone), doxycycline (Doryx, Vibramycin, others), isotretinoin (Accutane), methotrexate (Rheumatrex), minocycline (Dynacin, Minocin), tamoxifif) ), noma i-tetracycline (Sumycin). Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo nganoma yisiphi isikhathi ngesikhathi sokwelashwa kwakho, yeka ukuthatha i-lomitapide bese ushayela udokotela wakho ngokushesha: ukukhathala ngokweqile, ukungabi namandla, ubuthakathaka, isicanucanu noma ukuhlanza okuya kuba kubi kakhulu noma kungapheli, kubuhlungu kwesokudla phezulu ingxenye yesisu, ukungathandi ukudla, ukuphuzi kwesikhumba noma kwamehlo, umkhuhlane, noma izimpawu ezifana nomkhuhlane. Udokotela wakho angadinga ukushintsha umthamo noma ayeke noma abambezele ukwelashwa kwakho uma uhlangabezana nezinkinga zesibindi.

Uhlelo olubizwa ngeJuxtapid REMS^® ivunyelwe yi-Food and Drug Administration (FDA) ngenxa yokuthi kungenzeka ukulimala kwesibindi okuhambisana nokusetshenziswa kwe-lomitapide. Bonke abantu abanikezwe i-lomitapide kumele babe nemithi yokudonswa kukadokotela obhaliswe neJuxtapid REMS^®, futhi ugcwaliswe ngudokotela ekhemisi elibhaliswe neJuxtapid REMS^® ukuze uthole lo muthi.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-lomitapide.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-lomitapide futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

I-Lomitapide isetshenziswa kanye nezinguquko ekudleni (ukuvinjelwa kwe-cholesterol kanye nokudla okunamafutha) nezinye izindlela zokwelapha ukunciphisa inani le-cholesterol esezingeni eliphansi ye-lipoprotein (LDL) ('cholesterol embi'), i-cholesterol ephelele, nezinye izinto ezinamafutha egazini ezine-hypercholesterolemia yomndeni e-homozygous (HoFH; isimo esizuzwe njengefa lapho i-cholesterol ingenakususwa emzimbeni ngokujwayelekile). I-Lomitapide akufanele isetshenziselwe ukwehlisa amazinga e-cholesterol kubantu abangenayo i-HoFH. ILomitapide isekilasini lemithi ebizwa ngemithi yokwehlisa i-cholesterol. Isebenza ngokunciphisa ukukhiqizwa kwe-cholesterol emzimbeni ukwehlisa inani le-cholesterol engakha ezindongeni zemithambo futhi ivimbele ukugeleza kwegazi liye enhliziyweni, ebuchosheni nakwezinye izingxenye zomzimba.

Ukuqoqeka kwe-cholesterol namafutha eceleni kwezindonga zemithambo (inqubo eyaziwa ngokuthi i-atherosclerosis) kunciphisa ukugeleza kwegazi, ngakho-ke, ukunikezwa komoya-mpilo enhliziyweni yakho, ebuchosheni nakwezinye izingxenye zomzimba wakho. Ukwehlisa izinga legazi lakho le-cholesterol namafutha kungasiza ekuvikeleni isifo senhliziyo, i-angina (ubuhlungu besifuba), imivimbo nokuhlaselwa yinhliziyo.

ILomitapide iza njengephilisi elizothathwa ngomlomo. Kuvame ukuthathwa kanye ngosuku. I-Lomitapide kufanele ithathwe ngaphandle kokudla esiswini esingenalutho, okungenani amahora amabili ngemuva kokudla kwakho kwakusihlwa. Phuza ingilazi egcwele yamanzi ngomthamo ngamunye we-lomitapide.

Thatha lomitapide ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha lomitapide njengoba nje kuyalelwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune, ungawaqedi noma uwaqede.

Uzodinga ukuthatha isithasiselo samavithamini ngenkathi welashwa nge-lomitapide Qiniseka ukuthi ulandela izincomo ezenziwe ngudokotela wakho ngokucophelela.

Qhubeka nokuthatha lomitapide noma ngabe uzizwa uphilile. Ungayeki ukuthatha lomitapide ngaphandle kokukhuluma nodokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-lomitapide,

• Tshela udokotela kanye nosokhemisi wakho uma uneguliswa i-lomitapide, noma imiphi eminye imithi, noma iziphi izithako ezikuma-capsules omitapide. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma uthatha imishanguzo efana ne-fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), ne-voriconazole (Vfend); i-boceprevir (i-Victrelis); i-aprepitant (Hlela); i-ciprofloxacin (Cipro); i-clarithromycin (i-Biaxin); i-crizotinib (i-Xalkori); i-diltiazem (iCardizem, iDilacor, iTiazac); i-erythromycin (E.E.S., E-Mycin, Erythrocin); I-HIV protease inhibitors efana ne-amprenavir (Agenerase), atazanavir (Reyataz), darunavir (Prezista), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (eKaletra), nelfinavir (Viracept), saquinavir (Invirase), ritirase) eKaletra), i-ritonavir ne-tipranavir (i-Aptivus), ne-teleprevir (i-Incivek); imatinib (Gleevec); nefazodone; i-telithromycin (Ketek); kanye ne-verapamil (Calan, Covera, Isoptin, Verelan). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-lomitapide uma uphuza eyodwa noma ngaphezulu yale mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imithi efakwe kuhlu esigabeni ESIBALULEKILE SESEXWAYISO nakokulandelayo: i-aliskiren (Tekturna); i-alprazolam (Xanax); ambrisentan (Letairis); amiodarone (Cordarone, Pacerone); i-amlodipine (iNorvasc, eCaduet); i-bicalutamide (i-Casodex); i-cilostazol (i-Pletal); imithi ethile yomlomo yesifo sikashukela efana ne-saxagliptin (i-Onglyza eKombiglyze) ne-sitagliptin (Januvia, eJanumet); i-cimetidine (i-Tagament); i-colchicine (ama-Colcrys); dabigatran (Pradaxa); i-digoxin (i-Lanoxin); everolimus (Afinitor, Zortress); i-fexofenadine (Allegra); i-fluoxetine (i-Prozac); i-fluvoxamine (i-Luvox); i-isoniazid (INH, Nydrazid); i-lapatinib (iTykerb); i-maraviroc (i-Selzentry); imithi ecindezela amasosha omzimba njenge-cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune) kanye ne-tacrolimus (Prograf); i-nilotinib (iTasigna); izinto zokuvimbela inzalo ngomlomo (amaphilisi okuvimbela inzalo); eminye imithi yokwehlisa i-cholesterol efana ne-atorvastatin (Lipitor, eCaduet, eLiptruzet), lovastatin (Mevacor), kanye ne-simvastatin (iZocor, eSimcor, eVytorin); pazopanib (Votrient); i-ranitidine (iZantac); i-ranolazine (Ranexa); i-ticagrelor (Brilinta); i-tolvaptan (iSamsca); i-topotecan (iHycamtin); i-warfarin (i-Coumadin); kanye ne-zileuton (Zyflo). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-lomitapide, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi yimiphi imikhiqizo yamakhambi oyithathayo, ikakhulukazi i-ginkgo noma i-goldenseal.
• uma uthatha i-cholestyramine (i-Questran), i-colesevelam (i-WellChol), noma i-colestipol (i-Colestid), yithathe amahora amane ngaphambi noma kumahora ama-4 ngemuva kwe-lomitapide.
• Tshela udokotela wakho uma uke waba nokuhlukumezeka kwe-galactose noma i-glucose-galactose malabsorption (izimo ezizuzwe njengefa lapho umzimba ungakwazi ukubekezelela i-lactose), izinkinga eziqhubekayo zesisu noma zamathumbu, noma amanyikwe noma isifo sezinso.
• Tshela udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uma ungowesifazane ongakhulelwa, kuzodingeka wenze ukuhlolwa kokukhulelwa ngaphambi kokuba uqale ukuthatha i-lomitapide. Uma ungakhulelwa, kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ngenkathi uthatha i-lomitapide. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma ukhulelwa ngenkathi uthatha i-lomitapide, yeka ukuthatha imithi bese ushayela udokotela wakho ngokushesha. ILomitapide ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele ngenkathi uthatha i-lomitapide.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Udokotela wakho uzokutshela ukuthi udle ukudla okunamafutha amancane. Ukudla ukudla okunamafutha amancane kunganciphisa ithuba lokuthi uzoba nezinkinga zesisu kufaka phakathi isicanucanu, ukuhlanza, isisu esibuhlungu, nohudo ngenkathi uthatha lomitapide. Landela zonke izincomo zokudla ezenziwe udokotela wakho noma udokotela osetshenziswayo ngokucophelela.

Yeqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa okujwayelekile ngosuku olulandelayo. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Lomitapide ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• isicanucanu
• ukuhlanza
• ubuhlungu besisu
• ukuqunjelwa
• ukuqunjelwa
• igesi
• isisu esibuhlungu
• ukuncipha komzimba
• ikhanda
• isiyezi
• Umphimbo obuhlungu
• ikhala eligijimayo
• ukuhlungu obusemhlane

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, yeka ukuthatha i-lomitapide bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• isifo sohudo esibi
• ubumhlophe
• kunciphise ukuphuma komchamo

I-Lomitapide ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Juxtapid^®