Sofosbuvir

-Delile

• Ngaphambi kokuthatha i-sofosbuvir,
• I-Sofosbuvir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

Kungenzeka ukuthi usungenwe yi-hepatitis B (igciwane elithelela isibindi futhi lingadala ukulimala kwesibindi) kepha ungabi nazimpawu zesifo. Kulokhu, ukuthatha i-sofosbuvir kungandisa ubungozi bokuthi uzoba nezimpawu futhi ukutheleleka kwakho kuzoba kubi kakhulu noma kusongele impilo. Tshela udokotela wakho uma ngabe uke waba nokutheleleka ngegciwane le-hepatitis B. Udokotela wakho uzokuyalela ukuhlolwa kwegazi ukuze abone ukuthi uke waba nokutheleleka kwesifo sikashukela B. Udokotela wakho uzokuhlola futhi nangezimpawu zokutheleleka kwesifo sokusha kwesibindi kohlobo B ngesikhathi nangezinyanga ezimbalwa ngemuva kokwelashwa kwakho. Uma kunesidingo, udokotela wakho angakunika imithi yokwelapha lesi sifo ngaphambi nangesikhathi sokwelashwa kwakho nge-sofosbuvir. Uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi noma ngemuva kokwelashwa kwakho, shayela udokotela wakho ngokushesha: ukukhathala ngokweqile, ukuphuzi kwesikhumba noma kwamehlo, ukulahlekelwa isifiso sokudla, isicanucanu, ukuhlanza, indle ephaphathekile, ubuhlungu besisu, noma umchamo omnyama.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho angalawula izivivinyo ezithile ngaphambi, ngesikhathi, nangemva kokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-sofosbuvir.

Khuluma nodokotela wakho ngobungozi (s) bokuthatha i-sofosbuvir.

I-Sofosbuvir isetshenziswa kanye ne-ribavirin (i-Copegus, i-Rebetol, i-Ribasphere, neminye) kwesinye isikhathi omunye umuthi (i-peginterferon alfa [Pegasys]) ukwelapha izinhlobo ezithile zesifo sokusha kwesibindi kohlobo C (okutheleleka okuqhubekayo kwegciwane okulimaza isibindi) kubantu abadala. I-Sofosbuvir nayo iyasetshenziswa kanye ne-ribavirin ukwelapha izinhlobo ezithile ze-hepatitis C engapheli (ukutheleleka ngegciwane okuqhubekayo okulimaza isibindi) ezinganeni ezineminyaka emithathu ubudala nangaphezulu. I-Sofosbuvir isekilasini lemithi elwa namagciwane ebizwa nge-nucleotide polymerase inhibitors. Isebenza ngokunciphisa inani le-virus ye-hepatitis C (HCV) emzimbeni. I-Sofosbuvir kungenzeka ingavimbeli ukusakazeka kwesifo sokusha kwesibindi kohlobo C kwabanye abantu.

ISofosbuvir iza njengethebhulethi namaphilisi okuzothathwa ngomlomo. Imvamisa kuthathwa nokudla noma ngaphandle kokudla kanye ngosuku. Thatha i-sofosbuvir ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-sofosbuvir njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Ama-pellets weSofosbuvir angagwinywa (ngaphandle kokuhlafunwa) noma angathathwa nokudla. Ukulungiselela umthamo wamaphilisi we-sofosbuvir ngokudla, fafaza lonke iphakethe lamaphilisi kokukodwa noma ngaphezulu kwezipuni zokubanda okubandayo noma ekamelweni lokudla okungekho i-asidi okufana ne-pudding, isiraphu yoshokholethi, amazambane acubuziwe, noma u-ayisikhilimu. Thatha yonke ingxube kungakapheli imizuzu engama-30 ufafaze ama-pellets ekudleni. Ukugwema ukunambitheka okumunyu, musa ukuhlafuna ama-pellets.

Qhubeka nokuthatha i-sofosbuvir noma ngabe uzizwa uphilile. I-Sofosbuvir kumele ithathwe ihlanganiswe ne-peginterferon alfa ne-ribavirin noma ihlanganiswe ne-ribavirin iyodwa. Uma i-sofosbuvir ithathwa ihlanganiswe ne-peginterferon alfa ne-ribavirin, ijwayele ukuthathwa amasonto ayi-12. Uma i-sofosbuvir ithathwa ihlanganiswe ne-ribavirin iyodwa, imvamisa iphuzwa amasonto ayi-12 noma angama-24. Uma unomdlavuza wesibindi futhi ulinde ukufakelwa kwesibindi, uzothatha i-sofosbuvir ne-ribavirin kuze kube amasonto angama-48 noma uze ube nokufakelwa kwesibindi. Ubude bokwelashwa kwakho buxhomeke esimeni sakho, ukuthi uphendula kahle kanjani emithini, nokuthi ngabe unemiphumela emibi kakhulu yini. Ungayeki ukuthatha i-sofosbuvir, i-peginterferon alfa, noma i-ribavirin, ngaphandle kokuthi utshelwe ngudokotela wakho ukuthi wenze njalo.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-sofosbuvir,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-sofosbuvir, noma imuphi omunye umuthi, noma iziphi izithako kumathebulethi e-sofosbuvir noma amaphilisi. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: amiodarone (Nexterone, Pacerone); imithi ethile yomdlavuza; imithi yesifo sikashukela; imithi ethile yokuquleka efana ne-carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), oxcarbazepine (Trileptal), phenobarbital, noma phenytoin (Dilantin, Phenytek); imithi ethile ecindezela amasosha omzimba; i-rifabutin (i-Mycobutin); i-rifampin (iRifadin, iRimactane, eRifamate, eRifater); i-rifapentine (Priftin); i-tipranavir (Aptivus) ne-ritonavir (i-Norvir); kanye ne-warfarin (Coumadin, Jantoven). Udokotela wakho angakutshela ukuthi ungathathi i-sofosbuvir uma uthatha eyodwa noma ngaphezulu yale mithi noma ukukuqapha ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-sofosbuvir, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort. Akufanele uthathe i-wort yaseSt. John ngesikhathi sokwelashwa kwakho nge-sofosbuvir.
• utshele udokotela wakho ukuthi ngabe uke wafakelwa isibindi noma ngabe uke waba negciwane lesandulela ngculaza noma i-HIV noma wake waba nalo noma yiluphi uhlobo, noma yiluphi uhlobo lwesifo sesibindi ngaphandle kwesifo sokusha kwesibindi kohlobo C, isifo sezinso, noma olwe-dialysis.
• Tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma kungenzeka ukhulelwe. Uma ungowesilisa, tshela udokotela wakho uma umlingani wakho ekhulelwe, ehlela ukukhulelwa, noma angakhulelwa. I-Sofosbuvir kumele ithathwe nge-ribavirin engalimaza umbungu kakhulu. Kufanele usebenzise izindlela ezimbili zokuvimbela inzalo ukuvimbela ukukhulelwa kuwe noma kumlingani wakho ngenkathi welashwa ngale mithi nangezinyanga eziyisithupha ngemuva kokwelashwa kwakho. Khuluma nodokotela wakho mayelana nokuthi yiziphi izindlela okufanele uzisebenzise; Izindlela zokuvimbela inzalo zamahomoni (amaphilisi okulawula ukubeletha, iziqeshana, izimila, izindandatho, noma imijovo) kungenzeka zingasebenzi kahle kwabesifazane abathatha le mithi. Wena noma umlingani wakho kufanele nihlolelwe ukukhulelwa ngaphambi kokwelashwa, njalo ngenyanga ngesikhathi sokwelashwa, futhi izinyanga eziyisithupha emva kokwelashwa kwakho. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha le mithi noma kungakapheli izinyanga eziyisithupha ukwelashwa kwakho, shayela udokotela wakho ngokushesha.
• tshela udokotela wakho uma uncelisa.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma ukhumbula umthamo ongabanjwanga ngosuku obekufanele uwuthathe, thatha isilinganiso esilahlekile ngokushesha nje lapho usikhumbula ngalolo suku. Kodwa-ke, uma ungawukhumbuli umthamo ophuthelwe kuze kube usuku olulandelayo, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi imithamo emibili ngosuku olufanayo.

I-Sofosbuvir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• ikhanda
• ubuhlungu bemisipha
• ubunzima bokulala noma ukulala
• ukucasuka
• ukulunywa
• ukuqubuka

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• isikhumba esiphaphathekile
• isiyezi
• ukuphelelwa umoya
• ubuthakathaka
• umphimbo obuhlungu, umkhuhlane, amakhaza nezinye izimpawu zokutheleleka
• ukuqubuka, ngamabhamuza noma ngaphandle kwawo
• ukuvuvukala kobuso, umphimbo, ulimi, izindebe, amehlo, izandla, izinyawo, amaqakala noma imilenze engezansi
• ukushaqeka
• ubunzima bokugwinya noma ukuphefumula

I-Sofosbuvir ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Sovaldi^®