I-Ribociclib

-Delile

• Ngaphambi kokuthatha i-ribociclib,
• I-Ribociclib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

I-Ribociclib isetshenziswa ngokuhlangana nomunye umuthi ukwelapha uhlobo oluthile lwe-hormone receptor – positive (kuya ngama-hormone afana ne-estrogen ukukhula) umdlavuza webele osezingeni eliphezulu noma osabalale wahambela kwezinye izingxenye zomzimba kwabesifazane abangakaze babhekane nokunqamuka kokuya esikhathini. yokuphila; ukuphela kwezikhathi zokuya esikhathini njalo ngenyanga) nakulabo abasondelene noma asebevele babhekana nokunqamuka kokuya esikhathini. I-Ribociclib isetshenziswa futhi ngokuhlangana ne-fulvestrant (Faslodex) ukwelapha uhlobo oluthile lomdlavuza webele osezingeni eliphakeme we-hormone receptor noma osabalele kwezinye izingxenye zomzimba njengokwelashwa kokuqala noma kubantu abangazange belashwe ngempumelelo ngezinye izindlela zokwelapha kwabesifazane asebevele babhekana nokunqamuka kokuya esikhathini. I-Ribociclib isekilasini lemithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo sephrotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunciphisa noma ukumisa ukusabalala kwamangqamuzana omdlavuza.

I-Ribociclib iza njengethebhulethi ukuthatha ngomlomo. Imvamisa kuthathwa noma ngaphandle kokudla kanye nsuku zonke ekuseni ngezinsuku zokuqala ezingama-21 zomjikelezo wezinsuku ezingama-28. Thatha i-ribociclib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-ribociclib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze. Ungaphuzi amaphilisi aphukile noma achotshoziwe.

Uma uhlanza ngemuva kokuthatha i-ribociclib, ungathathi omunye umthamo. Qhubeka nesimiso sakho sokulinganisa okuvamile.

Udokotela wakho anganciphisa umthamo wakho we-ribociclib noma ayeke unomphela noma okwesikhashana ukwelashwa kwakho. Lokhu kuncike ekutheni umuthi usebenza kanjani kuwe kanye nemiphumela emibi oyitholayo. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho nge-ribociclib.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-ribociclib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-ribociclib, noma imiphi eminye imithi, noma iziphi izithako ezibhebheni ze-ribociclib. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: amiodarone (Nexterone, Pacerone); ama-antibiotic athile afana ne-clarithromycin (i-Biaxin, e-Prevpac), i-erythromycin (i-E.E.S., i-Ery-tab, i-Eryped), ne-moxifloxacin (i-Avelox); imishanguzo ethize yokubulala izinhlungu efana ne-itraconazole (i-Onmel, i-Sporanox), i-ketoconazole (i-Nizoral), i-posaconazole (i-Noxafil), ne-voriconazole (i-Vfend); i-bepridil (ayisatholakali e-U.S.); i-boceprevir (i-Victrelis, ayisatholakali e-U.S.); i-chloroquine (Aralen); i-conivaptan; i-cyclosporine (Gengraf, Neoral, Sandimmune); i-dihydroergotamine (i-DHH 45, i-Migranal); i-disopyramide (iNorpace); i-ergotamine (i-Ergomar, eCafergot, eMigergot); everolimus (Afinitor, Zortress); i-fentanyl (Abstral, Actiq, Fentora, Onsolis); i-halofantrine (i-Halfan; ayisatholakali e-U.S.); i-haloperidol (iHaldol); imishanguzo ethile yegciwane lengculazi (i-HIV) efana ne-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), lopinavir (eKaletra), nelfinavir (Viracept), ritonavir (Norvir, eKaletra), kanye ne-saquinavir (Invirase); imithi ethile yokuquleka efana ne-carbamazepine (Carbatrol, Equetro, Teril, others) ne-phenytoin (Dilantin, Phenytek); i-methadone (i-Dolophine, i-Methadose); nefazodone; i-ondansetron (emthanjeni); ipimozide (i-Orap); procainamide; i-quinidine (ku-Nuedexta); i-rifampin (Rimactane, Rifadin, eRifamate, eRifater); i-sirolimus (i-Rapamune); i-sotalol (iBetapace, iSotylize); i-tacrolimus (i-Envarsus XR, i-Prograf), ne-tamoxifen (i-Soltamox). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.Eminye imishanguzo eminingi ingaxhumana ne-ribociclib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• utshele udokotela wakho ukuthi yimiphi imikhiqizo yamakhambi oyithathayo, ikakhulukazi iSt John's Wort.
• tshela udokotela wakho uma ngabe uke wahlaselwa yinhliziyo muva nje; noma uke waba nokushaya kwenhliziyo okuhamba kancane; isikhathi se-QT eside (inkinga yenhliziyo engajwayelekile engadala ukushaya kwenhliziyo okungajwayelekile, ukuquleka, noma ukufa ngokuzuma); amazinga angajwayelekile we-potassium, i-calcium, i-phosphorus, noma i-magnesium egazini lakho; ukwehluleka kwenhliziyo; noma isibindi, izinso, noma isifo senhliziyo.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uzodinga ukwenza ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa. Sebenzisa indlela ethembekile yokulawula ukubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho kanye namaviki amathathu ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma ukhulelwa ngenkathi uthatha i-ribociclib, shayela udokotela wakho ngokushesha. I-Ribociclib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa noma uhlela ukuncelisa. Akufanele uncelise ngenkathi uthatha i-ribociclib futhi okungenani amasonto amathathu ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala emadodeni. Khuluma nodokotela wakho ngezingozi zokuthatha i-ribociclib.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-ribociclib.

Ungadli isithelo samagilebhisi noma uphuze izithelo zomvini ngenkathi uthatha lo muthi.

Yeqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa esivamile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Ribociclib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• ukuqunjelwa
• ubuhlungu besisu
• ikhanda
• ukulahleka kwezinwele
• ukuhlungu obusemhlane
• ukulunywa
• izilonda zomlomo
• ukuvuvukala kwezandla, izinyawo, amaqakala, noma imilenze engezansi
• ubunzima bokulala noma ukulala

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• umkhuhlane, umphimbo obuhlungu, amakhaza, noma ezinye izimpawu zokutheleleka
• ukuqubuka
• ukushwabana noma ukuxebuka kwesikhumba
• ukushisa noma ukushisa kwezindebe, amehlo, noma umlomo
• ukushaya kwenhliziyo okusheshayo, okungajwayelekile, noma okushaya ngamandla
• ukuphefumula kanzima noma ukuphefumula okuncane; ukukhwehlela nge-mucus noma ngaphandle kwayo; noma ubuhlungu besifuba
• isiyezi
• ukuquleka
• ukuphuzi kwesikhumba noma kwamehlo
• umchamo omnyama noma onsundu (ombala wetiye)
• ukukhathala
• ukulahlekelwa isifiso sokudla
• ubuhlungu ohlangothini olungaphezulu kwesokudla sesisu
• isicanucanu
• ukuhlanza
• ukopha noma ukulimaza kalula kunokujwayelekile

I-Ribociclib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-ribociclib. Udokotela wakho angaphinde ahlele i-electrocardiogram (ECG; ukuhlolwa okulinganisa umsebenzi kagesi enhliziyweni) ngaphambi nangesikhathi sokwelashwa kwakho.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Kisqali^®

• Kisqali^® Femera^® (njengomkhiqizo ohlanganisiwe oqukethe i-Letrazole ne-Ribociclib)