Inaliti ye-Dupilumab

-Delile

• Ngaphambi kokusebenzisa umjovo we-dupilumab,
• Umjovo we-Dupilumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Uma uhlangabezana nenye yalezi zimpawu, yeka ukusebenzisa umjovo we-dupilumab bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Umjovo we-Dupilumab usetshenziselwa ukwelapha izimpawu ze-eczema (i-atopic dermatitis; isifo sesikhumba esibangela ukuthi isikhumba somile futhi silume futhi kwesinye isikhathi sikhule sibe nokuqubuka okubomvu, okunesikhumba) kubantu abadala nezingane ezineminyaka engu-6 nangaphezulu abangakwazi ukusebenzisa eminye imithi yabo isimo noma i-eczema yakhe engaphendulanga kweminye imithi. Iyasetshenziswa kanye neminye imishanguzo yokuvikela ukuphefumula, ukuphelelwa umoya, ukukhwehlela, nokuqina kwesifuba ngenxa yezinhlobo ezithile zesifuba somoya kubantu abadala nezingane ezineminyaka eyi-12 nangaphezulu izimpawu zazo ezingalawulwa neminye imithi. Umjovo we-Dupilumab uyasetshenziswa kanye neminye imithi yokwelapha i-rhinosinusitis engapheli nge-nasal polyposis (ikhala eliqhubekayo, ukuvuvukala kwesinusi kanye / noma ukuminyana kwempumulo, ngaphandle kokuncipha komuzwa wephunga noma ubuhlungu nokucindezela ebusweni) kubantu abadala abanezimpawu ayilawulwa ngeminye imithi. Umjovo we-Dupilumab usesigabeni semithi ebizwa ngama-antibody monoclonal. Isebenza ngokumisa isenzo sezinto ezithile emzimbeni ezibangela izimpawu ze-eczema.

Umjovo we-Dupilumab uza njengesirinji ekhethiwe kanye nepeni eligcwalisiwe ukujova ngaphansi kwesikhumba). Ekwelapheni i-eczema kubantu abadala, imvamisa inikezwa njengemijovo emibili yomthamo wokuqala, ilandelwe umjovo owodwa njalo emavikini amabili. Ekwelapheni i-eczema ezinganeni ezineminyaka engama-6 kuya kwengu-17 ubudala, imvamisa inikezwa njengemijovo emibili yomthamo wokuqala, ilandelwe umjovo owodwa njalo emavikini amabili kuya kwamane kuye ngesisindo sengane. Ekwelapheni i-asthma kubantu abadala nezingane ezineminyaka eyi-12 nangaphezulu, imvamisa inikezwa njengemijovo emibili yomthamo wokuqala, ilandelwe umjovo owodwa njalo emavikini amabili. Ekwelapheni i-rhinosinusitis engapheli ne-nasal polyposis kubantu abadala, imvamisa inikezwa njengomjovo owodwa njalo emavikini amabili. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Sebenzisa umjovo we-dupilumab njengoba uqondisiwe. Ungayifaki ngaphezulu noma ngaphansi kwayo noma uyijoje kaningi kunokuyalelwa ngudokotela wakho.

Uma usebenzisa i-dupilumab futhi une-asthma, qhubeka uphuze noma usebenzise yonke eminye imishanguzo udokotela ayinikeze ukwelapha i-asthma yakho. Ungayeki ukuthatha noma imuphi umuthi wakho noma ushintshe imithamo yanoma imuphi umuthi wakho ngaphandle kokuthi udokotela wakho akutshele ukuthi kufanele. Umjovo we-Dupilumab usiza ukuvimbela ukuhlaselwa yisifuba somoya kepha ngeke kumise ukuhlaselwa yi-asthma osekuqalile. Ungasebenzisi umjovo we-dupilumab ngesikhathi sokuhlaselwa yisifuba somoya. Udokotela wakho uzonikeza i-inhaler ezosetshenziswa ngesikhathi sokuhlaselwa yisifuba somoya.

Ungathola umthamo wakho wokuqala womjovo we-dupilumab ehhovisi likadokotela wakho. Ngemuva kwalokho, udokotela wakho angakuvumela noma umnakekeli enze imijovo ekhaya. Ngaphambi kokusebenzisa umjovo we-dupilumab ngokwakho okokuqala, funda imininingwane yomkhiqizi yesiguli esiza nomuthi. Cela udokotela wakho noma usokhemisi ukuthi akubonise noma umuntu ozokunikeza umuthi ukuthi ungawujova kanjani.

Sebenzisa isipetu ngasinye nepeni kanye kuphela. Lahla imijovo nezibaya ezisetshenzisiwe esitsheni esingamelana nokubhoboza. Khuluma nodokotela wakho noma usokhemisi mayelana nokuthi ungasilahla kanjani isitsha esingamelana nokubhoboza.

Uma usebenzisa isirinji oyifakile noma ipeni eligcwalisiwe elifakwe esiqandisini, beka isirinji endaweni eyisicaba ngaphandle kokukhipha isigaxa senaliti bese usivumela sifudumele ekamelweni lokushisa (imizuzu engama-30 yesirinji ekhethiwe engu-200 mg nemizuzu engama-45 ngo-300 mg isiponji esenziwe ngaphambili noma ipeni eligcwalisiwe) ngaphambi kokuba ulungele ukujova umuthi. Ungazami ukufudumeza umuthi ngokuwufudumeza ngemicrowave, uwubeke emanzini ashisayo, noma ngenye indlela.

Unganyakazisi isirinji noma ipeni eliqukethe i-dupilumab.

Njalo bheka isisombululo se-dupilumab ngaphambi kokusijova. Bheka ukuthi usuku lokuphelelwa yisikhathi aludlulanga nokuthi uketshezi lucacile futhi alunambala noma luphuzi kancane. Uketshezi akufanele luqukethe izinhlayiya ezibonakalayo. Ungasebenzisi isirinji noma ipeni uma iqhekeziwe noma yephukile, uma iphelelwe yisikhathi noma iqandisiwe, noma uma uketshezi luguqubekile noma luqukethe izinhlayiya ezincane.

Ungajova umjovo we-dupilumab noma yikuphi ngaphambili kwamathanga akho (umlenze ongaphezulu) noma isisu (isisu) ngaphandle kwenkaba yakho nendawo engamasentimitha ama-5 ukuyizungeza. Uma umnakekeli ejova umuthi, ingemuva lengalo engaphezulu nayo ingasetshenziswa. Ukwehlisa amathuba okuba buhlungu noma okubomvu, sebenzisa isiza esihlukile ngomjovo ngamunye. Ungafaki endaweni lapho isikhumba sithambile, silimele, sibomvu, noma siqinile noma lapho unezibazi noma izimpawu zokwelula.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokusebenzisa umjovo we-dupilumab,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-dupilumab, noma imiphi eminye imithi, noma iziphi izithako zomjovo we-dupilumab. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: imishanguzo yomlomo noma ehogelwayo ye-corticosteroid efana ne-dexamethasone, methylprednisolone (Medrol), ne-prednisone (i-Rayos). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma uke waba nezinkinga zamehlo noma wake waba nayo, noma uma une-hookworm, i-roundworm, i-whipworm, noma i-threadworm infection (ukutheleleka ngezibungu ezihlala ngaphakathi emzimbeni).Uma uthola i-dupilumab yokwelashwa kwe-atropic dermatitis, tshela udokotela wakho uma nawe unesifo somoya.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi usebenzisa umjovo we-dupilumab, shayela udokotela wakho.
• thintana nodokotela wakho ukuze ubone uma ngabe udinga ukuthola noma yimiphi imigomo. Ungabi nayo imigomo ngesikhathi sokwelashwa kwakho ngaphandle kokukhuluma nodokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa umthamo womjovo we-dupilumab, jovelela umthamo wakho olahlekile ngokushesha nje lapho uwukhumbula bese uqala uhlelo lwakho lokuqala. Kodwa-ke, uma kungaphezu kwezinsuku eziyi-7 ngemuva kethamo lakho elilahlekile, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungasebenzisi umthamo ophindwe kabili ukwenza okulahlekile. Shayela udokotela wakho uma uphuthelwa umthamo futhi unemibuzo mayelana nokuthi wenzeni.

Umjovo we-Dupilumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ububomvu noma ubuhlungu endaweni yomjovo
• ubuhlungu bomphimbo
• izilonda zomlomo noma zomlomo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• izinkinga zamehlo ezintsha noma eziya ziba zimbi, kufaka phakathi ubuhlungu beso, ukungaboni kahle, amehlo (abomvu) noma abomvu, izinkophe ezibomvu noma ezivuvukile, noma izinguquko kumbono
• ukuqubuka, ukuphefumula, umkhuhlane, ubuhlungu besifuba, ukuzwa izikhonkwane nezinaliti, noma ukuba ndikindiki ezingalweni noma emilenzeni

Uma uhlangabezana nenye yalezi zimpawu, yeka ukusebenzisa umjovo we-dupilumab bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuvuvukala kobuso, amajwabu amehlo, ulimi, noma umphimbo
• ama-lymph node avuvukile
• ubunzima bokugwinya noma ukuphefumula
• ukuqina esifubeni noma emphinjeni
• ukulunywa
• ukuqubuka
• isifuba
• ukuquleka, isiyezi, noma ukuzizwa unekhanda elincane
• ubuhlungu obuhlangene
• izigaxa zesikhumba eziyizicaba, eziqinile, ezishisayo, ezibomvu nezibuhlungu
• imfiva

Umjovo we-Dupilumab ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi usebenzisa lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni sokuqala efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina umjovo we-dupilumab esiqandisini noma ekamelweni lokushisa kuze kube yizinsuku eziyi-14. Ungafrizi. Gcina imijovo nezibaya emabhokisini abo okuqala ukuwavikela ekukhanyeni.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho.

Ungavumeli omunye umuntu asebenzise imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Okuphindwe kabili^®