Umjovo we-Letermovir

-Delile

• Ngaphambi kokusebenzisa umjovo weletermovir,
• Umjovo weLetermovir ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu shayela udokotela wakho ngokushesha:

Umjovo weLetermovir usetshenziselwa ukuvikela ukutheleleka kanye nesifo se-cytomegalovirus (CMV) kubantu abathile abathole ukufakelwa i-hematopoietic stem-cell transplant (HSCT; inqubo efaka umongo wethambo onesifo ngomnkantsha onempilo) futhi basengozini enkulu yokuthola i-CMV ukutheleleka. ILetermovir isekilasini lemithi ebizwa ngama-antivirals. Isebenza ngokubambezela ukukhula kwe-CMV.

Umjovo weLetermovir uza njengoketshezi oluzohlanjululwa futhi lunikezwe ngemithambo (emthanjeni). Imvamisa ijovwa kancane esikhathini sehora eli-1. Imvamisa inikezwa kanye ngosuku uma nje ungeke ukwazi ukuthatha amaphilisi e-letermovir ngomlomo.

Ungathola umjovo we-letermovir esibhedlela, noma unganikeza umuthi ekhaya. Uma uzothola umjovo weletermovir ekhaya, umhlinzeki wakho wezokunakekelwa kwezempilo uzokukhombisa ukuthi uwusebenzisa kanjani umuthi. Qiniseka ukuthi uyaziqonda lezi zinkomba, bese ubuza umhlinzeki wakho wezokunakekelwa kwezempilo uma unemibuzo.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokusebenzisa umjovo weletermovir,

• Tshela udokotela kanye nosokhemisi wakho uma unegciwane ku-letermovir, noma imiphi eminye imithi, noma iziphi izithako zomjovo we-letermovir. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma uthatha ama-ergot alkaloids afana ne-ergotamine (Ergomar, eCafergot, Migergot) kanye ne-dihydroergotamine (iDHE 45, Migranal), ne-pimozide (Orap). Udokotela wakho mhlawumbe uzokutshela ukuthi ungayithathi le mithi uma usebenzisa umjovo we-letermovir. Tshela nodokotela wakho uma uthatha i-cyclosporine kanye ne-simvastatin noma i-pitavastatin. Udokotela wakho mhlawumbe uzokutshela ukuthi ungayithathi le nhlanganisela yemithi ngeletermovir.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: amiodarone (Nexterone, Pacerone); i-cyclosporine (Gengraf, Neoral, Sandimmune); fentanyl (Actiq, Duragesic, Subsys, abanye); i-glyburide (i-Diabeta, i-Glynase); I-HMG-CoA reductase inhibitors efana ne-atorvastatin (Lipitor, eCaduet), fluvastatin (Lescol), lovastatin (Altoprev), pitavastatin (Livalo, Zypitamag), pravastatin (Pravachol), rosuvastatin (Crestor), ne-simvastatin (Flolipid, I-Vytorin); i-omeprazole (Prilosec, eYosprala, eZegerid); i-pantoprazole (Protonix); i-phenytoin (iDilantin, Phenytek); i-rifampin (Rifadin, Rimactane, eRfater, eRifamate); i-sirolimus (i-Rapamune); i-quinidine (ku-Nuedexta); i-repaglinide (Prandin); i-rosiglitazone (i-Avandia); tacrolimus (Astagraf, Envarsus, Prograf); i-voriconazole (Vfend); kanye ne-warfarin (Coumadin, Jantoven). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana nomjovo we-letermovir, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• tshela udokotela wakho uma uke waba nesifo sezinso noma sesibindi.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi usebenzisa umjovo weletermovir, shayela udokotela wakho.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi usebenzisa umjovo we-letermovir.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Umjovo weLetermovir ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• isifo sohudo
• ubuhlungu besisu
• ukuvuvukala kwezingalo noma imilenze yakho
• ikhanda
• ukukhathala ngokweqile

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu shayela udokotela wakho ngokushesha:

• ukushaya kwenhliziyo okusheshayo noma okungajwayelekile; ukuzizwa ubuthakathaka noma unesiyezi, ukuphefumula kanzima, ubuhlungu besifuba

Umjovo weLetermovir ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho anga-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-letermovir.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Prevymis^®