I-Diroximel Fumarate

-Delile

• Ngaphambi kokuthatha i-diroximel fumarate,
• I-Diroximel fumarate ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Diroximel fumarate isetshenziselwa ukwelapha abantu abadala abanezinhlobo ezahlukahlukene ze-multiple sclerosis (MS; isifo lapho izinzwa zingasebenzi kahle futhi abantu bangathola ubuthakathaka, ukuba ndikindiki, ukulahleka kokuhlangana kwemisipha, nezinkinga ngombono, ukukhuluma, nokulawula isinye) kufaka phakathi:

• i-syndrome ehlukanisiwe nomtholampilo (i-CIS; iziqephu zezimpawu zemizwa ezihlala okungenani amahora angama-24),
• amafomu wokubuyisela emuva (inkambo yesifo lapho izimpawu zivela khona ngezikhathi ezithile), noma
• amafomu wesibili aqhubekayo (inkambo yesifo lapho ukubuyela emuva kwenzeka kaningi).

I-Diroximel fumarate isekilasini lemithi ebizwa nge-Nrf2 activators. Isebenza ngokunciphisa ukuvuvukala nokuvimbela ukulimala kwezinzwa okungadala izimpawu ze-multiple sclerosis.

I-Diroximel fumarate iza njengokukhishwa okubambezelekile (kukhipha umuthi emathunjini ukuvimbela ukonakala kwemithi ngesisu acid) iphilisi elizothathwa ngomlomo. Imvamisa iphuzwa kabili ngosuku. Thatha i-diroximel fumarate cishe ngezikhathi ezifanayo nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-diroximel fumarate njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

I-Diroximel fumarate ingathathwa ngokudla noma ngaphandle kokudla. Kodwa-ke, ungayithathi ngesidlo esinamafutha amaningi, esinama-khalori amaningi noma isinongo; isidlo noma isidlo esincane kumele sibe namakhalori angaphansi kwama-700 kanye nama-gram angaphansi kwama-30 amafutha.

Ungaphuzi iziphuzo ezidakayo ngasikhathi sinye uthatha i-diroximel fumarate.

Gwinya wonke amaphilisi okukhishwa okulibazisekile; ungawahlukanisi, ungawahlafune, uwaphule noma uwafafaze.

Ungathatha i-aspirin eboshwe nge-non-enteric (325 mg noma ngaphansi) imizuzu engama-30 ngaphambi kokuthatha i-diroximel fumarate ukunciphisa amathuba okugobhoza (ukubomvu kobuso) ngesikhathi sokwelashwa kwakho.

Udokotela wakho mhlawumbe uzokuqala ngomthamo ophansi we-diroximel fumarate futhi akhuphule umthamo wakho ngemuva kwezinsuku eziyi-7.

I-Diroximel fumarate ingasiza ekulawuleni i-multiple sclerosis, kepha ngeke iyelaphe. Qhubeka uthathe i-diroximel fumarate noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-diroximel fumarate ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-diroximel fumarate,

• Tshela udokotela wakho kanye nosokhemisi uma une-allergies ku-diroximel fumarate, dimethyl fumarate (Tecfidera), noma imuphi omunye umuthi, noma iziphi izithako kuma-diroximel fumarate amaphilisi okukhipha okulibazisekile. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• utshele udokotela wakho uma uthatha i-dimethyl fumarate (Tecfidera). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-diroximel fumarate uma uthatha lo muthi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma unesifo, kufaka phakathi izifo ezifika zidlule kanye nezifo ezingapheli ezingapheli, noma uma unesibalo esincane segazi elimhlophe noma isifo sesibindi noma sezinso.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-diroximel fumarate, shayela udokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Diroximel fumarate ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• imfudumalo, ubomvu, ukulunywa, noma ukushiswa kwesikhumba
• ubuhlungu besisu
• isifo sohudo
• isicanucanu
• ukuhlanza
• isilungulela

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuphefumula kanzima noma ukugwinya
• isifuba
• ukuqubuka
• ukuvuvukala kobuso, umphimbo, ulimi, izindebe, amehlo, izandla, izinyawo, amaqakala noma imilenze engezansi
• ubuthakathaka ohlangothini olulodwa lomzimba, ukungabi namandla ezingalweni noma emilenzeni, izinkinga zombono, izinguquko ekucabangeni nasekukhumbuleni, ukudideka, noma izinguquko zobuntu
• ukukhathala, ukulahlekelwa isifiso sokudla, ubuhlungu ohlangothini lwesokunene sesisu sakho, umchamo omnyama, noma ukuphuzi kwesikhumba noma kwamehlo

I-Diroximel fumarate ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Udokotela wakho anga-oda ukuhlolwa kwegazi ngaphambi kokuba uqale ukwelashwa kwakho futhi anga-oda izivivinyo ezithile zebhu ngesikhathi sokwelashwa kwakho ukuze uhlole impendulo yomzimba wakho ku-diroximel fumarate.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Ubuningi^®