Injection yeBurosumab-twza

-Delile

• Ngaphambi kokusebenzisa umjovo we-burosumab-twza,
• Umjovo weBurosumab-twza ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho:

Umjovo weBurosumab-twza usetshenziselwa ukwelapha i-X-linked hypophosphatemia (XLH; isifo esizuzwe njengefa lapho umzimba ungagcini i-phosphorus futhi okuholela emathanjeni abuthakathaka) kubantu abadala nasezinyangeni ezineminyaka engu-6 nangaphezulu. Ibuye isetshenziselwe ukwelapha i-osteomalacia ebangelwa isimila (isimila esidala ukulahleka kwe-phosphorus emzimbeni eholela emathanjeni abuthakathaka) angenakususwa ngokuhlinzwa kubantu abadala nezingane ezineminyaka engu-2 nangaphezulu, umjovo weBurosumab-twza isigaba semithi esibizwa nge-fibroblast growth factor 23 (FGF23) esivimba amasosha omzimba. Isebenza ngokuvimba ukusebenza kwento ethile yemvelo emzimbeni edala izimpawu ze-XLH.

Umjovo weBurosumab-twza uza njengesisombululo (uketshezi) okufanele ujovwe ngomgogodla (ngaphansi kwesikhumba) ngudokotela noma umhlengikazi. Ekwelapheni i-hypophosphatemia exhunywe ku-X, kuvamise ukujova kanye njalo emavikini amabili ezinganeni ezinezinyanga eziyisithupha kuya kwengu-17 ubudala, kanye kanye njalo emavikini amane kubantu abadala. Ekwelapheni i-osteomalacia ebangelwa isimila, ezinganeni ezineminyaka emi-2 kuya kwengu-17 ubudala, kuvamise ukujova kanye njalo emavikini amabili. Ekwelapheni i-osteomalacia ebangelwa isimila kubantu abadala, kuvamise ukujova njalo emavikini amane futhi njengoba umthamo wanda kungenzeka ujovwe njalo emavikini amabili. Udokotela wakho noma umhlengikazi uzojova umuthi engalweni yakho ephezulu, ethangeni eliphezulu, ezinqeni, noma endaweni yesisu, futhi asebenzise indawo ehlukile yokujova njalo.

Tshela udokotela wakho uma uthatha noma iziphi izithako ze-phosphate noma izithasiselo ezithile zikavithamini D ezifana ne-calcitriol (Rocaltrol) noma i-paricalcitol (i-Zemplar). Kuzodingeka uyeke ukuthatha lawa sonto eli-1 ngaphambi kokuba uqale ukwelashwa.

Udokotela wakho angakhuphula umthamo wakho (hhayi ngaphezu kwesisodwa njalo emavikini amane), noma angeqe umthamo, kuya ngemiphumela yokuhlolwa kwakho kwelebhu.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokusebenzisa umjovo we-burosumab-twza,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-burosumab-twza, noma imuphi omunye umuthi, noma iziphi izithako zomjovo we-burosumab-twza. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• tshela udokotela wakho uma unesifo sezinso. Udokotela wakho angakutshela ukuthi ungasebenzisi umjovo we-burosumab-twza.
• Tshela udokotela wakho uma uke waba nesifo semilenze esingazinzi (i-RLS; isimo esidala ukungakhululeki emilenzeni kanye nesifiso esinamandla sokuhambisa imilenze, ikakhulukazi ebusuku nalapho uhleli noma ulele phansi).
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthola umjovo we-burosumab-twza, shayela udokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa isikhathi sokuthola i-aphoyintimenti, yenza enye i-aphoyintimenti ngokushesha okukhulu.

Umjovo weBurosumab-twza ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• ukuhlanza
• imfiva
• ubuhlungu ezingalweni, emilenzeni, noma emhlane
• ubuhlungu bemisipha
• ukuqunjelwa
• isiyezi

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho:

• ububomvu, ukuqubuka, isifuba, ukulunywa, ukuvuvukala, ubuhlungu, noma ukulinyazwa eduze noma lapho umuthi ubulawe khona
• ukuqubuka noma isifuba
• ukungakhululeki emilenzeni; isifiso esinamandla sokuhambisa imilenze, ikakhulukazi ebusuku nalapho uhleli noma ulele phansi

Umjovo weBurosumab-twza ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho kumjovo we-burosumab-twza.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UCrysvita^®