I-Esketamine Nasal Spray

-Delile

• Ngaphambi kokusebenzisa i-esketamine nasal spray,
• I-Esketamine nasal spray ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

Ukusebenzisa i-esketamine nasal spray kungadala ukuthamba, ukuquleka, isiyezi, ukukhathazeka, umuzwa wokujikeleza, noma ukuzwa unqamukile emzimbeni wakho, imicabango, imizwa, isikhala nesikhathi. Uzosebenzisa isifutho samakhala se-esketamine uwedwa esikhungweni sezokwelapha, kepha udokotela wakho uzokuqapha ngaphambi, ngesikhathi, futhi okungenani amahora amabili ngemuva kokwelapha kwakho. Uzodinga ukuhlela ukuthi umnakekeli noma ilungu lomndeni likushayele ekhaya ngemuva kokusebenzisa i-esketamine. Ngemuva kokusebenzisa i-esketamine nasal spray, ungashayeli imoto, sebenzisa imishini, noma wenze noma yini lapho udinga khona ukuqapha ngokuphelele kuze kube usuku olulandelayo ngemuva kokulala kahle ebusuku. Tshela udokotela wakho ngokushesha uma ukhathele ngokweqile, uquleka, ubuhlungu besifuba, ukuphefumula okuncane, ikhanda elibuhlungu ngokuzumayo, ukushintsha kombono, ukuthuthumela okungalawuleki kwengxenye ethile yomzimba, noma ukuquleka.

I-Esketamine ingahle yenze umkhuba. Tshela udokotela wakho uma wena noma omunye emndenini wakho uphuza noma uke waphuza utshwala obuningi, usebenzisa noma uke wasebenzisa izidakamizwa zasemgwaqweni, noma usebenzise ngokweqile imithi kadokotela.

Inani elincane lezingane, intsha, kanye nabantu abadala abasebasha (abangafika eminyakeni engama-24 ubudala) abathathe imishanguzo yokulwa nengcindezi (’mood elevators’) phakathi nezifundo zokwelashwa baba nokuzibulala (becabanga ngokuzilimaza noma ukuzibulala noma ukuhlela noma ukuzama ukwenza njalo). Izingane, intsha, kanye nabantu abadala abasebancane abathatha imishanguzo yokulwisana nokucindezelwa ukwelapha ukudangala noma ezinye izifo zengqondo bangase babe sethubeni lokuzibulala kunezingane, intsha kanye nabantu abadala abangawasebenzisi ama-anti-depressants ukwelapha lezi zimo. Kodwa-ke, ochwepheshe abaqiniseki ngokuthi le ngozi ingakanani nokuthi kufanele icatshangelwe kangakanani ekunqumeni ukuthi ingane noma osemusha kufanele yini athathe i-anti-depressant. Izingane kufanele hhayi sebenzisa i-esketamine.

Kufanele wazi ukuthi impilo yakho yengqondo ingashintsha ngezindlela ezingalindelekile lapho usebenzisa i-esketamine noma amanye ama-anti-depressants noma ngabe ungumuntu omdala ongaphezu kweminyaka engama-24. Ungazibulala, ikakhulukazi ekuqaleni kokwelashwa kwakho futhi noma nini lapho kushintshwa umthamo wakho. Wena, umndeni wakho, noma umnakekeli wakho kufanele ushayele udokotela wakho ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo: ukucindezeleka okusha noma okuya kuba kubi; ukucabanga ngokuzilimaza noma ukuzibulala, noma ukuhlela noma ukuzama ukwenza kanjalo; ukukhathazeka ngokweqile; ukuyaluza; ukwethuka; ubunzima bokulala noma ukulala; isimilo esinolaka; ukucasuka; ukwenza ngaphandle kokucabanga; ukungahlaliseki okukhulu; nokuhlanya okungajwayelekile. Qiniseka ukuthi umndeni wakho noma umnakekeli wakho uyazi ukuthi yiziphi izimpawu ezingaba zimbi kakhulu ukuze bakwazi ukubiza udokotela uma ungakwazi ukuzifunela ukwelashwa wedwa.

Ngenxa yezingozi zalo muthi, i-esketamine itholakala kuphela ngohlelo olukhethekile lokusabalalisa olukhawulelwe. Uhlelo olubizwa ngeSpravato Risk Evaluation and Mitigation Strategies (REMS) programme. Wena, udokotela wakho, kanye nekhemisi lakho kumele nibhalise ohlelweni lweSpravato REMS ngaphambi kokuthola lo muthi. Uzosebenzisa i-esketamine nasal spray endaweni yezokwelapha ngaphansi kokubhekwa udokotela noma omunye uchwepheshe wezokunakekelwa kwempilo.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzohlola umfutho wegazi wakho ngaphambi nangaphansi kwamahora ama-2 ngemuva kokusebenzisa i-esketamine isikhathi ngasinye.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-esketamine futhi isikhathi ngasinye lapho ugcwalisa khona incwadi kadokotela. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

I-Esketamine nasal spray isetshenziswa kanye nenye i-anti-depressant, ethathwe ngomlomo, ukuphatha ukucindezelwa okungazweli ekwelashweni (i-TRD; ukudangala okungathuthuki ngokwelashwa) kubantu abadala. Ibuye isetshenziswe kanye nenye i-anti-depressant, ethathwe ngomlomo, ukwelapha izimpawu ezicindezelayo kubantu abadala abane-disorder depress disorder (MDD) kanye nemicabango yokuzibulala noma izenzo. U-Esketamine usesigabeni semithi ebizwa ngabaphikisi be-NMDA receptor. Isebenza ngokushintsha ukusebenza kwezinto ezithile zemvelo ebuchosheni.

I-Esketamine iza njengesisombululo (uketshezi) ukufafaza emakhaleni. Ukuphathwa kwengcindezelo engazweli ekwelashweni, kuvamise ukufuthwa emakhaleni kabili ngeviki phakathi namasonto ayisithupha kuya kwelesine, kanye ngesonto phakathi kwamasonto 5-8, bese kuthi kanye ngesonto noma kanye njalo emavikini amabili phakathi kweviki 9 nangaphezulu. Ukwelashwa kwezimpawu zokudangala kubantu abadala abanenkinga enkulu yokudangala nemicabango yokuzibulala noma izenzo, kuvamise ukufuthwa emakhaleni kabili ngesonto kuze kube amasonto amane. I-Esketamine kumele isetshenziswe esikhungweni sezokwelapha.

Ungadli okungenani amahora ama-2 noma uphuze iziphuzo okungenani imizuzu engama-30 ngaphambi kokusebenzisa i-esketamine nasal spray.

Idivayisi ngayinye yokufafaza amakhala ihlinzeka izifutho ezi-2 (isifutho esisodwa sekhala ngalinye). Amachashazi amabili aluhlaza kudivayisi akutshela ukuthi isifutho samakhala sigcwele, ichashazi elilodwa eliluhlaza likutshela ukuthi kusetshenziswe isifutho esisodwa, futhi awekho amachashazi aluhlaza akhombisa ukuthi kusetshenziswe umthamo ophelele wezifutho ezi-2.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokusebenzisa i-esketamine nasal spray,

• Tshela udokotela kanye nosokhemisi wakho uma uxabana ne-esketamine, i-ketamine, noma yimiphi eminye imithi, noma iziphi izithako ezise-esketamine nasal spray. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: ama-amphetamine, imishanguzo yokukhathazeka, i-armodafinil (i-Nuvigil), i-MAO inhibitors efana ne-phenelzine (Nardil), i-procarbazine (i-Matulane), i-tranylcypromine (i-Parnate), ne-selegiline (i-Eldepryl, i-Emsam, i-Zelapar); eminye imishanguzo yokugula ngengqondo, i-methylphenidate (i-Aptension, i-Jornay, i-Metadate, abanye), i-modafanil, i-opioid (narcotic) imithi yezinhlungu, imishanguzo yokuxhuzula, imishanguzo, amaphilisi okulala, kanye ne-tranquilizers. Tshela udokotela wakho uma usanda kuthatha noma iyiphi yale mithi.
• uma usebenzisa i-nasal corticosteroid efana ne-ciclesonide (i-Alvesco, i-Omnaris, i-Zetonna) ne-mometasone (i-Asmanex) noma i-decongestant yamakhala efana ne-oxymetazoline (Afrin) ne-phenylephrine (i-Neosynephrine), yisebenzise okungenani ihora elilodwa ngaphambi kokusebenzisa i-esketamine nasal spray.
• utshele udokotela wakho uma unesifo semithambo yegazi ebuchosheni, esifubeni, endaweni yesisu, ezingalweni noma emilenzeni; ube ne-arteriovenous malformation (ukuxhumana okungavamile phakathi kwemithambo yakho nemithambo yegazi); noma ube nomlando wokopha ebuchosheni bakho. Udokotela wakho mhlawumbe uzokutshela ukuthi ungasebenzisi i-esketamine nasal spray.
• utshele udokotela wakho uma wake wahlaselwa isifo sohlangothi, isifo senhliziyo, ukulimala ebuchosheni, noma esinye isimo esidala ukukhuphuka kwengcindezi yobuchopho. Tshela udokotela wakho uma ubona, uzizwa, noma uzwa izinto ezingekho; noma ukholwe ezintweni ezingelona iqiniso. Futhi, tshela udokotela wakho uma uke waba nesifo se-valve senhliziyo, ukwehluleka kwenhliziyo, umfutho wegazi ophakeme (umfutho wegazi ophakeme), ukushaya kwenhliziyo okuhamba kancane noma okungajwayelekile, ukuphefumula okuncane, ubuhlungu besifuba, noma isifo sesibindi noma senhliziyo.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uma ukhulelwa ngenkathi usebenzisa i-esketamine nasal spray, shayela udokotela wakho ngokushesha. I-Esketamine nasal spray ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele ngenkathi usebenzisa i-esketamine nasal spray.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi usebenzisa i-esketamine nasal spray.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa yisikhathi sokwelashwa xhumana nodokotela wakho khona manjalo ukuhlela i-aphoyintimenti. Uma uphuthelwa ukwelashwa futhi ukucindezeleka kwakho kuba kubi kakhulu, udokotela wakho kungadingeka ukuthi ashintshe umthamo noma uhlelo lwakho lokwelashwa.

I-Esketamine nasal spray ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuchama njalo, okuphuthumayo, okushisayo, noma okubuhlungu
• ukuqunjelwa
• isifo sohudo
• umlomo owomile
• isicanucanu
• ukuhlanza
• ubunzima bokucabanga noma ukuzizwa udakiwe
• ikhanda
• ukunambitheka okungavamile noma kwensimbi emlonyeni
• Ukungaphatheki kahle kwamakhala
• ukucasuka komphimbo
• ukujuluka okwandayo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi izimpawu ezibhalwe ku-ISEXWAYISO ESIBALULEKILE, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo.

I-Esketamine nasal spray ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi usebenzisa lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Spravato^®