Siponimod

-Delile

• Ngaphambi kokuthatha i-siponimod,
• I-Siponimod ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Siponimod isetshenziselwa ukuvimbela iziqephu zezimpawu futhi yehlise ukwanda kokukhubazeka kubantu abadala abanezinhlobo zokubuyiselwa emuva (izifo zesifo lapho izimpawu ziqhuma khona ngezikhathi ezithile) ze-multiple sclerosis (MS; isifo lapho izinzwa zingasebenzi kahle futhi abantu bangabhekana nobuthakathaka, ukuba ndikindiki, ukulahleka kokuhlangana kwemisipha, nezinkinga ngombono, ukukhuluma, nokulawula isinye). I-Siponimod isekilasini lemithi ebizwa nge-sphingosine l-phosphate receptor modulators. Isebenza ngokunciphisa isenzo samaseli omzimba angadala ukulimala kwezinzwa.

I-Siponimod iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa kanye ngosuku noma ngaphandle kokudla. Thatha i-siponimod ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-siponimod njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Udokotela wakho kungenzeka akuqale ngomthamo ophansi we-siponimod futhi akhuphule kancane umthamo wakho ezinsukwini zokuqala ezi-4 noma ezi-5,

I-Siponimod ingadala ukuthi ukushaya kwenhliziyo kwehle, ikakhulukazi phakathi namahora ayisithupha okuqala ngemuva kokuthatha umthamo wakho wokuqala. Uzothola i-electrocardiogram (ECG; isivivinyo esiqopha umsebenzi kagesi wenhliziyo) ngaphambi kokuthatha umthamo wakho wokuqala futhi namahora ayisithupha ngemuva kokuthatha umthamo. Uzothatha umthamo wakho wokuqala we-siponimod ehhovisi likadokotela wakho noma kwenye indawo yezokwelapha. Uzodinga ukuhlala esikhungweni sezokwelapha okungenani amahora angu-6 ngemuva kokudla umuthi ukuze ubhekwe. Ungadinga ukuhlala esikhungweni sezokwelapha isikhathi esingaphezu kwamahora ayisithupha noma ubusuku bonke uma unemibandela ethile noma uthatha imishanguzo ethize ekhulisa ubungozi bokuthi ukushaya kwenhliziyo yakho kuzokwehla noma uma ukushaya kwenhliziyo yakho kuhamba kancane kunokulindelekile noma kuqhubeka ukwehla ngemuva kwe-6 yokuqala amahora. Kungase kudingeke nokuthi uhlale esikhungweni sezokwelapha okungenani amahora angu-6 ngemuva kokuthatha umthamo wakho wesibili uma ukushaya kwenhliziyo yakho kwehla kakhulu lapho uthatha umthamo wakho wokuqala. Tshela udokotela wakho uma uba nesiyezi, ukhathala, ubuhlungu besifuba, noma ukushaya kwenhliziyo okuhamba kancane noma okungajwayelekile nganoma yisiphi isikhathi lapho welashwa.

I-Siponimod ingasiza ekulawuleni i-multiple sclerosis kepha ngeke iyelaphe. Ungayeki ukuthatha i-siponimod ngaphandle kokukhuluma nodokotela wakho. Uma ungathathi i-siponimod usuku olungu-1 noma ngaphezulu phakathi nezinsuku zokuqala ezine noma ezi-5 zokwelashwa noma izinsuku ezingama-4 noma ngaphezulu ngemuva kwesonto lokuqala lokwelashwa, khuluma nodokotela wakho ngaphambi kokuba uqale ukukuthatha futhi. Ungahle uthole ukushaya kwenhliziyo okwehlisiwe lapho uqala ukuthatha i-siponimod futhi, ngakho-ke kuzodingeka uqale kabusha umuthi ngamanani aphansi ehhovisi likadokotela wakho futhi ukhuphule kancane umthamo ngaphezu kwezinsuku ezi-4 noma ezi-5.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-siponimod futhi isikhathi ngasinye ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-siponimod,

• Tshela udokotela kanye nosokhemisi wakho uma kukhona okweqile ku-siponimod noma imuphi omunye umuthi, noma yiziphi izithako ezikumaphilisi e-siponimod. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: alemtuzumab (Campath, Lemtrada); i-amiodarone (i-Nexterone, i-Pacerone); ama-beta-blocker anjenge-atenolol (Tenormin, in Tenoretic), carteolol, labetalol (Trandate), metoprolol (Lopressor, Toprol-XL, eDutoprol, eLopressor HCT), nadolol (Corgard, eCorzide), nebivolol (Bystolic, eByvalson ), propranolol (Inderal LA, Innopran XL), kanye ne-timolol; carbamazepine (Carbatrol, Equetro, Tegretol, abanye); i-digoxin (i-Lanoxin); i-diltiazem (Cardizem, Cartia, Tiazac, abanye); efavirenz (Sustiva, e-Atripla, eSymfi); i-fluconazole (iDiflucan); ivabradine (Corlanor); i-modafinil (i-Provigil); procainamide; i-quinidine (ku-Nuedexta); i-rifampin (Rifadin, Rimactane, eRifamate, abanye); i-sotalol (iBetapace, iSorine, iSotylize); kanye ne-verapamil (Calan, Verelan, eTarka). Tshela nodokotela ukuthi ngabe uphuza noma iyiphi yale mithi elandelayo, noma uma uke wayisebenzisa esikhathini esedlule: i-corticosteroids efana ne-dexamethasone, methylprednisolone (Medrol), ne-prednisone (i-Rayos); imithi yomdlavuza; nemithi yokwenziwa buthaka noma yokulawula amasosha omzimba njenge-glatiramer acetate (Copaxone, Glatopa) ne-interferon beta (Betaseron, Extavia, Plegridy). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-siponimod, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• Tshela udokotela wakho uma uke waba nanoma iyiphi yalezi zimo ezinyangeni eziyisithupha ezedlule: isifo senhliziyo, i-angina (ubuhlungu besifuba), isifo sohlangothi noma ukushaywa unhlangothi, noma ukwehluleka kwenhliziyo. Phinda utshele udokotela wakho uma unesigqi senhliziyo esingajwayelekile. Udokotela wakho angakutshela ukuthi ungathathi i-siponimod.
• utshele udokotela wakho uma wake waquleka, wahlaselwa yisifo senhliziyo, isifo sohlangothi noma isifo sohlangothi; uma njengamanje unemfiva noma ezinye izimpawu zokutheleleka noma uma unesifo esifika sidlule noma esingapheli; futhi uma uke waba nesifo sikashukela noma wake waba naso; ukulala ubuthongo (isimo lapho uyeka kafushane ukuphefumula kaningi ebusuku) noma ezinye izinkinga zokuphefumula; umfutho wegazi ophakeme; uveitis (ukuvuvukala kweso) noma ezinye izinkinga zamehlo; ukushaya kwenhliziyo okuhamba kancane; umdlavuza wesikhumba, noma isifo senhliziyo noma sesibindi. Phinda utshele udokotela wakho uma usanda kuthola umuthi wokugoma.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa, noma uncelisa. Kufanele usebenzise ukulawulwa kokubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho futhi okungenani izinsuku eziyi-10 ngemuva komthamo wakho wokugcina. Uma ukhulelwa ngenkathi uthatha i-siponimod noma zingakapheli izinsuku eziyi-10 ngemuva komthamo wakho wokugcina, shayela udokotela wakho.
• awunawo umuthi wokugoma isonto eli-1 ngaphambi kokuba uqale ukwelashwa kwakho nge-siponimod, ngesikhathi sokwelashwa kwakho, noma inyanga engu-1 ngemuva komthamo wakho wokugcina ngaphandle kokukhuluma nodokotela wakho. Khuluma nodokotela wakho ngemigomo ongayidinga ukuyithola ngaphambi kokuqala ukwelashwa kwakho nge-siponimod.
• Tshela udokotela wakho uma ungakaze ube nochoko futhi awutholanga umuthi wokugomela ubungu. Udokotela wakho angayalela ukuhlolwa kwegazi ukuze abone ukuthi ngabe uchayekile yini ekubhekaneni nenkukhu. Ungahle udinge ukuthola umuthi wokugomela ubungu bese ulinda inyanga e-1 ngaphambi kokuqala ukwelashwa kwakho nge-siponimod.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekusondele isikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese ushayela udokotela wakho ngaphambi kokuthatha umthamo olandelayo. Ungadinga ukubhekwa njengoba uqala kabusha imishanguzo yakho ngomthamo ophansi futhi njengoba umthamo wenyuka kancane kancane ngaphezu kwezinsuku ezi-4 noma ezi-5. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Siponimod ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ubuthakathaka
• ubuhlungu ezingalweni, emilenzeni, ezandleni, noma ezinyaweni
• isifo sohudo
• ikhanda

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• ukushaya kwenhliziyo okuhamba kancane
• umphimbo obuhlungu, ubuhlungu bomzimba, umkhuhlane, ukubanda, ukukhwehlela, nezinye izimpawu zokutheleleka nangesikhathi sokwelashwa futhi kuze kube yinyanga eyodwa ngemuva kokwelashwa kwakho
• ikhanda, ukuqina kwentamo, umkhuhlane, ukuzwela ekukhanyeni, isicanucanu, noma ukudideka ngesikhathi sokwelashwa futhi kuze kube inyanga engu-1 ngemuva kokwelashwa kwakho
• ikhanda elibuhlungu ngokuzumayo, ukudideka, izinguquko kumbono, noma ukuquleka
• ukufiphala, izithunzi, noma indawo engaboni maphakathi nombono wakho; ukuzwela ekukhanyeni; umbala ongavamile kumbono wakho noma ezinye izinkinga zombono
• ubuthakathaka ohlangothini olulodwa lomzimba noma ubuthakathaka bezingalo noma imilenze obuba bucayi ngokuhamba kwesikhathi; izinguquko emcabangweni wakho, ememori, noma ekulinganiseni; ukudideka noma izinguquko zobuntu; noma ukuphelelwa amandla
• ukuphefumula okusha noma okuya kuba kubi kakhulu
• isicanucanu, ukuhlanza, ukungathandi ukudla, ubuhlungu besisu, ukuphuzi kwesikhumba noma kwamehlo, noma umchamo omnyama

I-Siponimod ingandisa ingozi yokuthola umdlavuza wesikhumba. Khuluma nodokotela wakho ngezingozi zokuthatha lo muthi.

Ukwanda okungazelelwe kweziqephu zezimpawu ze-MS nokwanda kokukhubazeka kungenzeka ngemuva kokuyeka ukuthatha i-siponimod. Tshela udokotela wakho uma izimpawu zakho ze-MS ziba zimbi kakhulu ngemuva kokumisa i-siponimod.

I-Siponimod ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina iziqukathi ezingavulwa zalo muthi esiqandisini. Amaphakethe namabhodlela avuliwe angagcinwa ekamelweni lokushisa futhi kude nokushisa nomswakama okweqile (hhayi endlini yangasese) isikhathi esithile. Amaphakethe we-blister avuliwe angagcinwa ekamelweni lokushisa kuze kube yiviki elilodwa ngemuva kokusetshenziswa kokuqala. Amabhodlela avuliwe angagcinwa ekamelweni lokushisa kuze kube inyanga engu-1 ngemuva kokusetshenziswa kokuqala.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ukushaya kwenhliziyo okuphuzile noma okungajwayelekile

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu, izivivinyo zamehlo, futhi aqaphe umfutho wegazi wakho ngaphambi nangesikhathi sokwelashwa kwakho ukuze aqiniseke ukuthi kuphephile ukuthi uqale ukuthatha noma uqhubeke nokuthatha i-siponimod.

Ngaphambi kokwenza noma yiluphi uvivinyo lwelabhoratri, tshela udokotela wakho kanye nabasebenzi be-laboratory ukuthi uthatha i-siponimod.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UMayzent^®