I-entiginib

-Delile

• Ngaphambi kokuthatha i-entrectinib,
• I-Entrectinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Entrectinib isetshenziselwa ukwelapha uhlobo oluthile lomdlavuza wamaphaphu wamangqamuzana ongewona omncane kubantu abadala (i-NSCLC) kubantu abadala abasakaze kwezinye izingxenye zomzimba. Ibuye isetshenziselwe ukwelapha izinhlobo ezithile zezimila eziqinile kubantu abadala nasezinganeni ezineminyaka engu-12 ubudala nangaphezulu ezingakwazi ukwelashwa ngokuhlinzwa noma ezisabalalele kwezinye izingxenye zomzimba futhi eziye zaba zimbi kakhulu ngemuva kokwelashwa ngeminye imithi ye-chemotherapy. I-Entrectinib isekilasini lemithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba ukusebenza kweprotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukumisa noma ukubambezela ukusabalala kwamangqamuzana omdlavuza.

I-Entrectinib iza njengephilisi elizothathwa ngomlomo. Imvamisa kuthathwa noma ngaphandle kokudla kanye ngosuku. Thatha i-entrectinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-entrectinib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungazivuli, uzihlafune noma uzichoboze.

Uma uhlanza ngokushesha ngemuva kokuthatha i-entrectinib, thatha omunye umthamo ngokushesha ngangokunokwenzeka.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-entrectinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-entrectinib, noma imuphi omunye umuthi, noma iziphi izithako kuma-capsule e-entrectinib. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukusho okulandelayo: i-aprepitant (Emend), imishanguzo ethile yokubulala izinhlungu efana ne-fluconazole (i-Diflucan), i-itraconazole (i-Omel, i-Sporanox), noma i-ketoconazole; imithi ethile ye-arrhythmias efana ne-amiodarone (Nexterone, Pacerone), i-procainamide, i-quinidine (eNuedexta), ne-sotalol (i-Betapace, i-Sorine, i-Sotylize); i-azithromycin (iZithromax); i-clarithromycin (i-Biaxin, ku-Prevpac); i-diltiazem (Cardizem, Tiazac, abanye); i-erythromycin (E.E.S., Erythrocin, abanye); enzalutamide (Xtandi); imishanguzo ethile ye-HIV efana ne-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, e Kaletra, abanye), noma i-saquinavir (Invirase); i-lithium (i-Lithobid); i-modafinil (i-Provigil); nefazodone; oxcarbazepine (Trileptal); i-phenobarbital; i-phenytoin (iDilantin, Phenytek); i-pioglitazone (Actos, e-Actoplus, i-Duetact, e-Oseni); i-rifabutin (i-Mycobutin); i-rifampin (iRifadin, iRimactane, eRifater); i-steroids yomlomo efana ne-dexamethasone, i-methylprednisolone (i-Medrol), ne-prednisone (i-Rayos); kanye ne-verapamil (Calan). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingaphinde ihlanganyele ne-entrectinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• utshele udokotela wakho ukuthi yimiphi imikhiqizo yamakhambi oyithathayo, ikakhulukazi iSt John's Wort.
• Tshela udokotela wakho uma uke waba nesimo sesimiso sezinzwa, isikhathi eside se-QT (inkinga yenhliziyo engajwayelekile engadala ukushaya kwenhliziyo okungajwayelekile, ukuquleka, noma ukufa okungazelelwe), ukushaya kwenhliziyo okuhamba kancane noma okungajwayelekile, isifo senhliziyo, ukuhluleka kwenhliziyo, noma isifo senhliziyo noma sesibindi.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uma uhlela ukuba ngubaba wengane. Uma ungowesifazane, kuzodingeka uthathe ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa futhi usebenzise izilawuli zokubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho futhi okungenani amasonto ama-5 ngemuva komthamo wakho wokugcina. Uma ungowesilisa, wena nomlingani wakho kufanele nisebenzise ukulawulwa kokubeletha ngesikhathi sokwelashwa nge-entrectinib nezinyanga ezintathu ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-entrectinib, shayela udokotela wakho ngokushesha. I-Entrectinib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngenkathi uthatha i-entrectinib nezinsuku ezingu-7 ngemuva komthamo wokugcina.
• kufanele wazi ukuthi i-entrectinib ingadala isiyezi noma ukudideka. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Uma uphuthelwa ngumthamo ngaphansi kwamahora ayi-12, thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula bese uthatha umthamo olandelayo ngesikhathi esihleliwe. Kodwa-ke, uma uphuthelwa umthamo ngaphezu kwamahora we-12, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Entrectinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukukhathala
• ukuqunjelwa
• isifo sohudo
• izinguquko zokunambitheka
• ikhanda
• ukukhwehlela, umkhuhlane, noma ezinye izimpawu zokutheleleka
• ubuhlungu bemisipha noma bamalunga
• ukuhlungu obusemhlane
• izinguquko zesisindo
• ukuqubuka
• ubunzima bokuwa noma ukulala

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ubunzima ngokufunda, inkumbulo, ukunakwa, noma ukuxazulula izinkinga
• ukuguquka kwemizwelo njengokukhathazeka, ukudangala, ukudideka, noma ukukhathazeka
• ubuhlungu bamathambo noma ubunzima bokuhamba
• izinkinga zombono noma ushintsho kumbono
• ubuhlungu obuhlangene, ukuqina, ubomvu, noma ukuvuvukala
• ubuhlungu engxenyeni engaphezulu kwesokudla yesisu, ukuphuzi kwesikhumba noma kwamehlo, ukulahlekelwa isifiso sokudla, noma ukopha noma ukulimaza kalula
• ukuphelelwa umoya; ubunzima bokuphefumula lapho ulele; noma ukuvuvukala kwezingalo, imilenze, izandla, noma izinyawo

I-Entrectinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzokuyalela ukuhlolwa kwelebhu ngaphambi kokuba uqale ukwelashwa kwakho ukuze ubone ukuthi umdlavuza wakho ungelashwa nge-entrectinib. Udokotela wakho angalawula izivivinyo ezithile zelebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-entrectinib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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