Selumetinib

-Delile

• Ngaphambi kokuthatha i-selumetinib,
• I-Selumetinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Selumetinib isetshenziselwa ukwelapha uhlobo lwe-neurofibromatosis 1 (NF1; ukuphazamiseka kwesistimu yezinzwa okubangela ukuthi izicubu zikhule ezinzwa) ezinganeni ezineminyaka engu-2 ubudala nangaphezulu ezine-plexiform neurofibromas (PN; izicubu ezithambile) ezingenakususwa ngokuphelele ngokuhlinzwa. USelumetinib usesigabeni semithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba ukusebenza kweprotheni engavamile ekhombisa ukuthi izicubu zikhula. Lokhu kusiza ukumisa noma ukunciphisa ukukhula kwesimila.

ISelumetinib iza njengephilisi elizothathwa ngomlomo. Imvamisa kuthathwa kabili ngosuku esiswini esingenalutho. Ungadli noma yikuphi ukudla amahora amabili ngaphambi noma ihora elingu-1 ngemuva komthamo ngamunye. Thatha i-selumetinib ngasikhathi sinye nsuku zonke, cishe ngamahora ayi-12. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-selumetinib njengoba kushiwo. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi ngamanzi; ungazivuli, uzihlafune noma uzichoboze.

Uma uhlanza ngemuva kokuthatha i-selumetinib, ungathathi omunye umthamo. Qhubeka nesimiso sakho sokulinganisa okuvamile.

Udokotela wakho anganciphisa umthamo wakho noma ayeke ukwelashwa kwakho okwesikhashana noma unomphela uma uhlangabezana nemiphumela ethile emibi. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho nge-selumetinib.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-selumetinib,

• Tshela udokotela wakho kanye nosokhemisi uma une-aleji ye-selumetinib, noma imiphi eminye imishanguzo, noma ezinye izithako kuma-selumetinib capsules. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: ama-anticoagulants (’ama-thinner egazi’) njenge-warfarin (i-Coumadin, i-Jantoven); ama-antifungals afana ne-fluconazole (Diflucan), i-itraconazole (i-Sporanox), i-ketoconazole (i-Nizoral), ne-voriconazole (i-Vfend); i-aprepitant (Hlela); i-clarithromycin (i-Biaxin, ku-Prevpac); i-clopidogrel (i-Plavix); i-corticosteroids efana ne-betamethasone (i-Celestone), i-budesonide (i-Entocort), i-cortisone (i-Cortone), i-dexamethasone (i-Decadron, i-Dexpak, i-Dexasone, abanye), i-hydrocortisone (i-Cortef, i-Hydrocortone), i-methylprednisolone (i-Medrol, i-Meprolone, abanye), i-prednisolone (i-Prelisolone (i-Prelisolone) ), ne-prednisone (iRayos); i-diltiazem (Cardizem, Dilacor, Tiazac, abanye); i-erythromycin (E.E.S., E-Mycin, Erythrocin); imishanguzo ethile ye-HIV kubandakanya i-indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, eKaletra), kanye ne-saquinavir (Fortovase, Invirase); idelalisib (iZydelig); nefazodone; i-phenobarbital; i-rifabutin (i-Mycobutin); i-rifampin (iRifadin, iRimactane, eRifamate, eRifater); i-verapamil (Calan, Covera); kanye no-vitamin E. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• tshela udokotela wakho uma uke waba nezinkinga zokubona, ubunzima bokugwinya, noma isifo senhliziyo noma sesibindi.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uma uhlela ukuba ngubaba wengane. Uma ungowesifazane, kuzodingeka uthathe ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa futhi usebenzise izilawuli zokubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho futhi okungenani isonto elilodwa ngemuva komthamo wakho wokugcina. Uma ungowesilisa, wena nomlingani wakho kufanele nisebenzise ukulawulwa kokubeletha ngesikhathi sokwelashwa nge-selumetinib nangesonto eli-1 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-selumetinib, shayela udokotela wakho ngokushesha. I-Selumetinib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele ngenkathi uthatha i-selumetinib kanye neviki elilodwa ngemuva komthamo wokugcina.

Gwema ukudla isithelo samagilebhisi noma ukuphuza ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma kungaphakathi kwamahora angu-6 womthamo olandelayo, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Selumetinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuhlanza
• ukuqunjelwa
• ubuhlungu besisu
• isicanucanu
• isikhumba esomile
• ikhanda
• izilonda zomlomo
• ukulunywa
• ububomvu obuzungeze izinzipho
• ukuphuma kwamakhala
• ukukhathala
• ukulahlekelwa isifiso sokudla
• ukulahleka kwezinwele noma ukushintsha kombala wezinwele

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• imfiva
• ukopha okungavamile
• isikhumba esiphaphathekile noma ukukhathala
• ukungaboni kahle; ukulahleka kombono; amabala amnyama embonweni wakho; noma ezinye izinguquko zombono
• isifo sohudo
• ukuqubuka, amabhamuza esikhumba noma ukuxebuka
• ubuhlungu bemisipha, ubuhlungu, noma ubuthakathaka; noma umchamo omnyama
• ukukhwehlela noma ukuphefumula; ukuphelelwa umoya; ukuvuvukala kwamaqakala nezinyawo; noma ukukhathala ngokweqile

I-Selumetinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Ungayikhiphi i-desiccant (iphakethe elincane elifakwe nama-capsule ukumunca umswakama) ebhodleleni lakho.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina konke ukubonana nodokotela wakho, udokotela wamehlo, kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu, kufaka phakathi izivivinyo zamehlo, ngaphambi, ngesikhathi, nangemva kokwelashwa kwakho ukuhlola impendulo yomzimba wakho ku-selumetinib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UKoselugo^®