Pralsetinib

-Delile

• Ngaphambi kokuthatha i-pralsetinib,
• I-Pralsetinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwezindlela ezithile, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Pralsetinib isetshenziselwa ukwelapha uhlobo oluthile lomdlavuza wamaphaphu ongelona amaseli amancane (i-NSCLC) kubantu abadala oselusabalalele kwezinye izingxenye zomzimba. Ibuye isetshenziselwe ukwelapha uhlobo oluthile lomdlavuza wegilo kubantu abadala nasezinganeni ezineminyaka engu-12 ubudala nangaphezulu oluya ngokuya luba lubi noma olusabalale lwaya kwezinye izingxenye zomzimba. I-Pralsetinib isetshenziselwa ukwelapha uhlobo oluthile lomdlavuza we-thyroid kubantu abadala nasezinganeni ezineminyaka engu-12 ubudala nangaphezulu oluya lubi kakhulu noma olusabalale lwaya kwezinye izingxenye zomzimba futhi alukwazi ukwelashwa nge-iodine enemisebe. I-Pralsetinib isekilasini lemithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo sento ethile eyenzeka ngokwemvelo engadingeka ukusiza amangqamuzana omdlavuza ukuba ande.

I-Pralsetinib iza njengephilisi elizothathwa ngomlomo. Imvamisa kuthathwa kanye nsuku zonke esiswini esingenalutho, okungenani amahora ama-2 ngaphambi futhi okungenani ihora eli-1 ngemuva kokudla. Thatha i-pralsetinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-pralsetinib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Uma uhlanza ngemuva kokuthatha i-pralsetinib, ungathathi omunye umthamo. Qhubeka nesimiso sakho sokulinganisa okuvamile.

Udokotela wakho anganciphisa umthamo wakho noma ayeke ukwelashwa kwakho okwesikhashana noma unomphela uma uhlangabezana nemiphumela ethile emibi. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho nge-pralsetinib.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-pralsetinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-pralsetinib, noma imuphi omunye umuthi, noma iziphi izithako kuma-pralsetinib capsules. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: imishanguzo yokubulala amagciwane efaka i-itraconazole (i-Onmel, i-Sporanox) ne-ketoconazole; i-clarithromycin (ku-Biaxin); imishanguzo ethile ye-HIV efana ne-efavirenz (Sustiva, e-Atripla, Symfi), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, e Kaletra, Viekira Pak), kanye ne-saquinavir (Invirase); oxcarbazepine (Oxtellar XR, Trileptal); i-phenobarbital; i-phenytoin (iDilantin, Phenytek); iPioglitazone (Actos, e-Oseni, eDuetact); i-rifabutin (i-Mycobutin); kanye ne-rifampin (Rifadin, Rimactane, eRifater). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• utshele udokotela wakho uma uke waba nezinkinga zamaphaphu noma zokuphefumula ngaphandle komdlavuza wamaphaphu, izinkinga zokopha, umfutho wegazi ophakeme noma isifo sesibindi.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uma uhlela ukuba nobaba wengane. I-Pralsetinib ingahle iphazamise isenzo semithi yokuvimbela inzalo yamahomoni (amaphilisi okulawula ukubeletha, amabala, izindandatho, okufakelwayo, noma imijovo), ngakho-ke akufanele usebenzise lokhu njengendlela yakho kuphela yokulawula ukubeletha ngenkathi welashwa. Kufanele usebenzise ukulawulwa kokuzalwa okungenayo i-hormonal njengendlela yokuvimbela (idivaysi evimbela isidoda ukuba singene esibelethweni njengekhondomu noma i-diaphragm). Buza udokotela wakho ukuthi akusize ukhethe indlela yokulawula ukubeletha ezokusebenzela. Uma ungowesifazane, kuzodingeka ukuthi uhlolwe ukukhulelwa ngaphambi kokuqala ukwelashwa, futhi kufanele usebenzise ukulawulwa kokuzalwa okungewona okwamahomoni ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho kanye namasonto ama-2 ngemuva komthamo wakho wokugcina. Uma ungowesilisa futhi umlingani wakho angakhulelwa, kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nangesonto eli-1 ngemuva komthamo wakho wokugcina. Kufanele wazi ukuthi lo muthi unganciphisa ukuzala kwabesilisa nabesifazane; noma kunjalo, akufanele ucabange ukuthi awukwazi ukukhulelwa noma ukuthi awukwazi ukukhulelisa omunye umuntu. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-pralsetinib, shayela udokotela wakho. I-Pralsetinib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa noma uhlela ukuncelisa. Akufanele uncelise ngenkathi uthatha i-pralsetinib kanye neviki elilodwa ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala kwabesilisa nabesifazane. Khuluma nodokotela wakho ngezingozi zokuthatha i-pralsetinib.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-pralsetinib. Udokotela wakho angakutshela ukuthi ungathathi i-pralsetinib izinsuku ezi-5 ngaphambi kokuhlinzwa kwakho futhi uzokutshela ukuthi uqale nini ukuthatha umuthi futhi.
• kufanele wazi ukuthi umfutho wegazi wakho unganda ngesikhathi sokwelashwa kwakho nge-pralsetinib. Udokotela wakho uzoqapha ukucindezelwa kwegazi lakho ngokucophelela, futhi angakunikeza nemithi yokwelapha umfutho wegazi ophakeme uma ikhula.
• kufanele wazi ukuthi ungathola i-tumor lysis syndrome (i-TLS; isimo esibangelwa ukuwohloka okusheshayo kwamangqamuzana omdlavuza angadala ukwehluleka kwezinso nezinye izinkinga) ngenkathi welashwa nge-pralsetinib. Ukusiza ukunciphisa ingozi yokuthola i-TLS, udokotela wakho angakucela ukuthi uphuze amanzi ngaphambi nangesikhathi sokwelashwa kwakho, futhi isikhathi ngasinye lapho umthamo wakho wanda. Ngaphezu kwalokho, udokotela wakho uzokunika umuthi okufanele uwuthathe ngaphambi kokuqala nangesikhathi sokwelashwa kwakho ukusiza ukuvimbela lo mphumela ohlangothini. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo ze-TLS, shayela udokotela wakho ngokushesha: umkhuhlane, ukugodola, isicanucanu, ukuhlanza, ukudideka, ukuphefumula okuncane, ukuqubuka, ukushaya kwenhliziyo okungajwayelekile, umchamo omnyama noma onamafu, ukukhathala okungavamile, noma ubuhlungu bemisipha noma obuhlangene.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngosuku olufanayo ngokushesha uma uwukhumbula. Ngemuva kwalokho, qhubeka neshejuli yakho ejwayelekile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Pralsetinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuqunjelwa
• isifo sohudo
• umlomo owomile
• ubuhlungu bemisipha noma bethambo
• ukuvuvukala kwezandla, amaqakala, noma izinyawo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwezindlela ezithile, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukudideka, ukuphathwa ikhanda, ukuphefumula kanzima, isiyezi, noma ubuhlungu besifuba
• umkhuhlane, ukuphefumula okuncane, noma ukukhwehlela
• isikhumba esiphaphathekile, ukukhathala, noma ukuphefumula okuncane
• ukuphuzi kwesikhumba noma kwamehlo, umchamo onombala omnyama, ukopha noma ukulimaza kalula kunokujwayelekile, ukulahlekelwa isifiso sokudla, amandla anciphile, noma ubuhlungu ohlangothini lwesokunene sendawo yesisu
• indle emnyama neyokulinda
• igazi elibomvu endle
• ukuhlanza okunegazi
• izinto zokuhlanza ezibukeka njengezizathu zekhofi
• ekhwehlela igazi
• ukopha okungajwayelekile noma ukulinyazwa
• ukopha okungavamile kwesitho sangasese sowesifazane
• ukuphuma kwamakhala kaningi
• ukozela, ukudideka, ukuphathwa ikhanda, noma ukukhuluma kanzima

I-Pralsetinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda ukuhlolwa kwelebhu ngaphambi kokwelashwa kwakho ukuthola ukuthi umdlavuza wakho ungelashwa nge-pralsetinib. Udokotela wakho uzophinde a-ode izivivinyo ezithile zelebhu ngaphambi, ngesikhathi, nangemva kokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-pralsetinib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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