Inaliti yeVincristine

-Delile

• Ngaphambi kokuthola i-vincristine,
• IVincristine ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka:

IVincristine kufanele inikezwe emthanjeni kuphela. Kodwa-ke, ingahle ivuze izicubu eziseduze ezibangele ukucasuka okukhulu noma ukulimala. Udokotela wakho noma umhlengikazi uzoqapha indawo yakho yokuphatha ngale ndlela. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ubuhlungu, ukulunywa, ubomvu, ukuvuvukala, amabhamuza, noma izilonda endaweni lapho umjovo wafakwa khona.

UVincristine kufanele anikezwe kuphela ngaphansi kokuqondisa kukadokotela onolwazi ekusetshenzisweni kwemithi yokwelapha ngamakhemikhali.

I-Vincristine isetshenziswa ngokuhlangana nezinye izidakamizwa ze-chemotherapy ukwelapha izinhlobo ezithile ze-leukemia (umdlavuza wamaseli amhlophe egazi), kufaka phakathi i-acute myeloid leukemia (AML, ANLL) kanye ne-acute lymphoblastic leukemia (ALL), i-Hodgkin's lymphoma (isifo sikaHodgkin), futhi hhayi -Hodgkin's lymphoma (izinhlobo zomdlavuza eziqala ngohlobo lwamaseli amhlophe egazi ngokuvamile alwa nokutheleleka). IVincristine isetshenziswa futhi ngokuhlangana nezinye izidakamizwa zamakhemikhali ukwelapha isimila seWilms (uhlobo lomdlavuza wezinso owenzeka ezinganeni), i-neuroblastoma (umdlavuza oqala kumaseli ezinzwa futhi uvele ikakhulukazi ezinganeni), kanye ne-rhabdomyosarcoma (umdlavuza owakha imisipha ezinganeni). UVincristine usesigabeni semithi ebizwa nge-vinca alkaloids. Isebenza ngokunciphisa noma ukumisa ukukhula kwamangqamuzana omdlavuza emzimbeni wakho.

UVincristine uza njengesisombululo (uketshezi) sokujova ngomjovo (emthanjeni) ngudokotela noma umhlengikazi esikhungweni sezokwelapha. Imvamisa inikezwa kanye ngesonto. Ubude bokwelashwa buxhomeke ezinhlotsheni zemithi oyiphuzayo, ukuthi umzimba wakho uphendula kahle kangakanani kuyo, nohlobo lomdlavuza onawo.

Udokotela wakho angadinga ukubambezela ukwelashwa kwakho noma ushintshe umthamo wakho uma uhlangabezana nemiphumela ethile emibi. Kubalulekile ukuthi utshele udokotela wakho ukuthi uzizwa kanjani ngenkathi welashwa ngomjovo we-vincristine.

Udokotela wakho angakutshela ukuthi uthathe i-stool softener noma i-laxative ukusiza ukuvimbela ukuqunjelwa ngenkathi welashwa ngomjovo we-vincristine.

I-Vincristine kwesinye isikhathi isetshenziselwa ukwelapha izinhlobo ezithile zamathumba obuchopho, izinhlobo ezithile zomdlavuza wamaphaphu, i-myeloma eminingi (uhlobo lomdlavuza womnkantsha wamathambo), i-lymphocytic leukemia engapheli (CLL; uhlobo lomdlavuza wamaseli amhlophe egazi), amaKaposi's I-sarcoma (uhlobo lomdlavuza oludala izicubu ezingavamile ukuba zikhule ezingxenyeni ezihlukene zomzimba) ezihlobene ne-immunodeficiency syndrome (i-AIDS), i-Ewings sarcoma (uhlobo lomdlavuza emathanjeni noma emisipheni), kanye nezicubu zomzimba ezikhulelwe (uhlobo lwesimila) eyakheka ngaphakathi kwesibeletho sowesifazane ngenkathi ekhulelwe). I-Vincristine kwesinye isikhathi isetshenziselwa ukwelapha i-thrombotic thrombocytopenic purpura (TPP; isifo segazi esibangela ukuthi amahlule egazi akhe emithanjeni yegazi emincane emzimbeni). Khuluma nodokotela wakho ngezingozi zokusebenzisa lo muthi ngesimo sakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola i-vincristine,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-vincristine, noma imiphi eminye imithi, noma yiziphi izithako zomjovo we-vincristine. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: aprepitant (Emend); carbamazepine (Tegretol); ezinye izinto zokuvikela ezifana ne-itraconazole (Sporanox), i-ketoconazole (i-Nizoral), i-voriconazole (i-Vfend), ne-posaconazole (i-Noxafil); i-clarithromycin (i-Biaxin, ku-Prevpac); i-darifenacin (i-Enablex); i-dexamethasone (i-Decadron); i-fesoterodine (Toviaz); I-HIV protease inhibitors kufaka phakathi i-atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, eKaletra), ne-saquinavir (Invirase); nefazodone; i-oxybutynin (Ditropan, Ditropan XL, Oxytrol); i-phenobarbital; i-phenytoin (iDilantin); i-rifabutin (i-Mycobutin); i-rifampin (i-Rifadin, i-Rimactane); i-rifapentine (Priftin); i-solifenacin (i-Vesicare); i-telithromycin (Ketek); i-trospium (iSanctura); noma i-tolterodine (iDetrol, iDetrol LA). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• utshele udokotela wakho uma uke waba nesifo esithinta izinzwa zakho noma wake waba naso. Udokotela wakho angahle angafuni ukuthi uthole umjovo we-vincristine.
• Tshela udokotela wakho uma uthola noma wake waba nemithi yokwelashwa ngemisebe (i-x-ray), uma unesifo, noma uma uke waba nesifo samaphaphu noma sesibindi.
• kufanele wazi ukuthi i-vincristine ingaphazamisa umjikelezo ojwayelekile wokuya esikhathini (isikhathi) kwabesifazane futhi ingamisa okwesikhashana noma unomphela ukukhiqizwa kwesidoda emadodeni. Tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma ukuncelisa. Akufanele ukhulelwe noma uncelise ngenkathi uthola umjovo we-vincristine. Uma ukhulelwa ngenkathi uthola umjovo we-vincristine, shayela udokotela wakho. UVincristine angalimaza umbungu.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

IVincristine ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• izilonda emlonyeni nasemphinjeni
• ukulahlekelwa isifiso sokudla noma isisindo
• ubuhlungu besisu
• isifo sohudo
• ikhanda
• ukulahleka kwezinwele

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• isifuba
• ukuqubuka
• ukulunywa
• ukuphefumula kanzima noma ukugwinya
• ukuqunjelwa
• ukwanda noma ukwehla kokuchama
• ukuvuvukala kobuso, izingalo, izandla, izinyawo, amaqakala noma imilenze engezansi
• ukopha okungajwayelekile noma ukulinyazwa
• ukukhathala okungajwayelekile noma ubuthakathaka
• ubuhlungu, ukuba ndikindiki, ukushiswa, noma ukuhayiza ezandleni noma ezinyaweni
• ukuhamba kanzima noma ukuhamba ungagxilile
• ubuhlungu bemisipha noma bamalunga
• izinguquko ezingazelele embonweni, kufaka phakathi ukulahleka kombono
• ukulahlekelwa ukuzwa
• isiyezi
• ukulahleka kwekhono lokuhambisa imisipha nokuzwa ingxenye yomzimba
• ukudina noma ukulahlekelwa yikhono lokukhulumela phezulu
• isithuthwane
• ubuhlungu bomhlathi
• umkhuhlane, umphimbo obuhlungu, amakhaza, noma ezinye izimpawu zokutheleleka

UVincristine angandisa ubungozi bokuthi uzoba neminye imidlavuza. Khuluma nodokotela wakho ngezingozi zokuthola umjovo we-vincristine.

IVincristine ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka:

• isithuthwane
• ukuqunjelwa okukhulu
• ubuhlungu besisu
• ukopha okungajwayelekile noma ukulinyazwa

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-vincristine.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Oncovin^®¶
• UVincasar^® I-PFS
• UVincrex^®¶

• I-Leurocristine Sulfate
• I-LCR
• I-VCR

^¶ Lo mkhiqizo onophawu alusekho emakethe. Ezinye izindlela ezijwayelekile zingatholakala.