I-Ademetionine

-Delile

• Yini eyenziwa yi-ademetionine?
• Yini imiphumela emibi ye-ademetionine?
• Ilawulwa kanjani i-ademetionine?
• Ziyini izinzuzo ze-ademetionine?
• Ziyini izingozi ze-ademetionine?
• Isiguli sikulungiselela kanjani ukuthatha i-ademetionine?
• Iyini imiphumela ye-ademetionine?

Yini i-ademetionine?

I-Ademetionine uhlobo lwe-amino acid methionine. Kubizwa nangokuthi i-S-adenosylmethionine, noma i-SAMe.

Imvamisa, umzimba womuntu wenza yonke i-ademetionine ewudingayo ukuze ube nempilo enhle. Kodwa-ke, amazinga aphansi e-methionine, folate, noma i-vitamin B-12 angadala ukwehla kwamazinga e-ademetionine. Njengoba le khemikhali ingekho ekudleni, inguqulo yokwenziwa kwesinye isikhathi isetshenziselwa ukulinganisa amazinga emzimbeni.

I-Ademetionine ithengiswa njengesengezo sokudla e-United States. EYurophu, isetshenziswa njengomuthi kadokotela.

Yini eyenziwa yi-ademetionine?

I-SAMe ibamba iqhaza kumasosha omzimba, igcina ulwelwesi lweseli, futhi isiza ukukhiqiza nokudiliza amakhemikhali obuchopho, njenge-serotonin, i-melatonin, ne-dopamine.

Ucwaningo olwengeziwe kepha olungaqondakali luphakamisa ukuthi futhi lungasiza ekwelapheni izimpawu ze:

• ukudana
• ukuqina kwesibindi
• i-hepatitis yegciwane engapheli
• i-jaundice lapho ukhulelwe
• Isifo sikaGilbert
• i-fibromyalgia
• izinkinga zemizwa ezihlobene nengculazi
• I-cholestasis (ivinjiwe i-bile isuka esibindini iye esinyeni)

Yini imiphumela emibi ye-ademetionine?

I-Ademetionine iphephile kubantu abadala abaningi. Kodwa-ke, kwesinye isikhathi kungadala imiphumela emibi elandelayo:

• igesi
• ukuqunjelwa
• isifo sohudo
• ukuhlanza
• umlomo owomile
• ikhanda
• ukuqwasha okuncane
• i-anorexia
• ukujuluka
• isiyezi
• uvalo
• ukuqubuka kwesikhumba
• isifo se-serotonin

Iziguli ezinokudangala zingazizwa zikhathazekile. Isisu esithukuthele singenzeka futhi lapho iziguli ziqala ukuthatha lesi sengezo. Ukuqala ngamanani amancane nokusebenza kuze kufike kumthamo ogcwele kungasiza umzimba ukuthi ulungise.

Iziguli eziphikisana ne-ademetionine zingaba nezimpawu zokuphendula kwe-anaphylactic. Lezi zimpawu zifaka:

• ukuqhuma noma ukubomvu isikhumba
• ukushaya kwenhliziyo
• isiyezi
• isicanucanu

Ilawulwa kanjani i-ademetionine?

I-Ademetionine yenziwa ngomlomo nangomjovo. IMayo Clinic ibika ukuthi imithamo yomlomo elandelayo isebenze kwabanye abantu abadala abanezimo ezilandelayo:

• i-osteoarthritis: ama-milligram angama-600 kuye kwayi-1,200 (mg) kumthamo owodwa kuya kwemithathu ohlukanisiwe nsuku zonke
• cholestasis: kufika ku-1,600 mg nsuku zonke
• ukudangala: 800 kuya ku-1,600 mg nsuku zonke
• i-fibromyalgia: 400 mg ithathwa kabili nsuku zonke
• isifo sesibindi: 600 kuya ku-1,200 mg nsuku zonke

Umthamo ogcwele we-ademetionine uvame ukuba ngama-400 mg, uthathwa kathathu noma kane ngosuku.

I-Ademetionine ayithathwa njengephephile ezinganeni.

Ziyini izinzuzo ze-ademetionine?

I-Ademetionine iyasebenza ekuqedeni ubuhlungu be-osteoarthritis. Izinzuzo ze-ademetionine ekwelapheni ezinye izimo aziqinisekile. Obunye ubufakazi busikisela ukuthi bungasiza ekwelapheni:

• ukudana
• ukunakekelwa kokushoda kokungasebenzi kahle (ADHD) kubantu abadala
• cholestasis kuzo zombili iziguli ezikhulelwe nezingakhulelwe
• i-fibromyalgia
• isifo sesibindi

I-Ademitionine isetshenziselwa ukwelapha ezinye izimo eziningi, noma ngabe bukhona ubufakazi obanele bokunquma ukuthi ingabe buyasiza kulezi zimo. Izimo lapho kwesinye isikhathi kusetshenziswa i-ademitionine zifaka:

• i-premenstrual syndrome (i-PMS)

• Isifo senhliziyo
• ikhanda le-migraine
• ukulimala komgogodla
• isithuthwane
• i-multiple sclerosis

Ziyini izingozi ze-ademetionine?

Xhumana nomhlinzeki wezokunakekelwa kwempilo ngaphambi kokuthatha noma yimiphi imithi, kufaka phakathi amakhambi nezithako.

I-Ademetionine ithathwa njengephephile kubantu abadala abaningi. Kodwa-ke, zingazenza zibe zimbi izimpawu ezigulini ezinokuphazamiseka okuthile, njenge-bipolar disorder noma isifo sikaParkinson. Abesifazane abakhulelwe noma abancelisayo akufanele bathathe i-ademetionine.

Njengoba ithinta isimiso sezinzwa esiyinhloko, i-ademetionine ingaphazamisa ukuhlinzwa. Ukusetshenziswa kwayo kufanele kumiswe okungenani amasonto amabili ngaphambi kokuhlinzwa.

I-Ademetionine ihlangana ne-serotonin, ikhemikhali ebuchosheni bakho. Uma ihlanganiswe nemithi ethinta i-serotonin, i-ademetionine ingakhuphula ubungozi be-serotonin syndrome. Lesi yisimo esingahle sibangelwe yi-serotonin eningi kakhulu. Imiphumela emibi ingafaka izinkinga zenhliziyo, ukuqhaqhazela nokukhathazeka.

I-Ademetionine akufanele ithathwe ngemithi elandelayo:

• i-dextromethorphan (isithako esisebenzayo emithini eminingi yokukhwehlela engaphezulu kwe-the-counter)
• izidakamizwa zokulwa nengcindezi
  • i-fluoxetine
  • paroxetine
  • umabhebhana
  • amithole
  • clomipramine
  • imipramine
• i-monoamine oxidase inhibitors (MAOIs)
  • phenzi
  • umagazine
  • i-meperidine (Demerol)
  • pentazocine
  • bhabha

I-Ademetionine akufanele ithathwe ngamakhambi nezithako ezengeza amazinga e-serotonin. Lokhu kufaka phakathi:

• levodopa
• I-baby babyrose yaseHawaii
• I-tryptophan
• Isibungu iSt

I-Ademetionine akufanele ithathwe ngemithi yesifo sikashukela ngoba ingakhuphula imiphumela yale mithi. Lokhu kungakhuphula ubungozi boshukela ophansi wegazi, noma i-hypoglycemia.

Isiguli sikulungiselela kanjani ukuthatha i-ademetionine?

Imiphumela emibi yesisu neyokugaya ukudla ingenzeka uma uqala ngomthamo onconywe ngokuphelele. Ukuqala ngemithamo emincane kuze kwehle imiphumela engemihle kungasiza umzimba ukuthi ulungise.

Iyini imiphumela ye-ademetionine?

I-Ademetionine iyasiza ekuqedeni ubuhlungu be-osteoarthritis. Kubukeka kusebenza kahle njengezidakamizwa ezingezona ukuvuvukala (ama-NSAID) ekwelapheni lesi simo, ngokusho kweMayo Clinic. Kodwa-ke, abukho ubufakazi obanele ekusetshenzisweni kwe-ademetionine yokudangala, i-fibromyalgia, ne-cholestasis yesibindi. Imininingwane eminingi iyadingeka ukuncoma ukusetshenziswa kwayo ekwelapheni lezi zimo.