I-Ajovy (fremanezumab-vfrm)

-Delile

• Yini i-Ajovy?
• Uhlobo olusha lomuthi
• Ukusebenza ngempumelelo
• I-Ajovy generic
• U-Ajovy usebenzisa
• I-Ajovy yezinhlungu zekhanda ze-migraine
• Ukuphumelela kwekhanda le-migraine
• Imiphumela emibi ye-Ajovy
• Imiphumela emibi ejwayelekile
• Imiphumela emibi kakhulu
• Ukusabela okweqile
• Imiphumela emibi yesikhathi eside
• Ezinye izindlela ze-Ajovy
• Abaphikisi be-CGRP
• Ajovy vs. ezinye izidakamizwa
• I-Ajovy vs. Aimovig
• Ajovy vs. Emgality
• I-Ajovy vs. Botox
• Izindleko ze-Ajovy
• Usizo lwezezimali
• Isilinganiso se-Ajovy
• Amafomu wezidakamizwa namandla
• Isilinganiso sokuvimbela ikhanda lekhanda le-migraine
• Kuthiwani uma ngiphuthelwa umthamo?
• Ngabe kuzodingeka ngisebenzise lesi sidakamizwa isikhathi eside?
• Ungayithatha kanjani i-Ajovy
• Ungayijova kanjani
• Isikhathi
• Ukuthatha i-Ajovy ngokudla
• Isebenza kanjani i-Ajovy
• Kuthatha isikhathi esingakanani ukusebenza?
• Ajovy notshwala
• Ukusebenzisana kwe-Ajovy
• Ajovy nokukhulelwa
• Ajovy nokuncelisa
• Imibuzo ejwayelekile nge-Ajovy
• Ngabe i-Ajovy ingasetshenziselwa ukwelapha i-migraine headache?
• Uhluke kanjani u-Ajovy kwezinye izidakamizwa ze-migraine?
• Ingabe u-Ajovy welapha ikhanda elibuhlungu?
• Uma ngithatha i-Ajovy, ngingayeka ukuthatha eminye imithi yami yokuvikela?
• Ukweqisa ngokweqile kwe-Ajovy
• Izimpawu zokudlula ngokweqile
• Okufanele ukwenze uma kwenzeka ukweqisa ngokweqile
• Izexwayiso zika-Ajovy
• Ukuphela kwesikhathi kuka-Ajovy

Yini i-Ajovy?

I-Ajovy umuthi kadokotela osetshenziswayo ukuvimbela ukuphathwa yikhanda kubantu abadala. Kuza njengesirinji ekhethiwe. Ungazijova u-Ajovy, noma uthole imijovo ye-Ajovy evela kumhlinzeki wezokunakekelwa kwempilo ehhovisi likadokotela wakho. I-Ajovy ingajovwa njalo ngenyanga noma ngekota (kanye njalo ezinyangeni ezintathu).

I-Ajovy iqukethe i-fremanezumab yezidakamizwa, eyi-antibody monoclonal. I-antibody ye-monoclonal uhlobo lomuthi owenziwe kusuka kumaseli omzimba omzimba. Isebenza ngokuvimbela amanye amaprotheni omzimba wakho ekusebenzeni. I-Ajovy ingasetshenziselwa ukuvimbela kokubili i-episodic ne-chronic migraine headaches.

Uhlobo olusha lomuthi

I-Ajovy iyingxenye yesigaba esisha semithi eyaziwa ngokuthi i-calcitonin peptide ehlobene nezakhi zofuzo (CGRP). Le mithi iyimithi yokuqala eyenzelwe ukuvimbela ukuphathwa yikhanda le-migraine.

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kwagunyaza i-Ajovy ngoSepthemba 2018. I-Ajovy kwakungumuthi wesibili esigabeni sabaphikisi be-CGRP esivunyelwe yi-FDA ukusiza ukuvimbela ukuphathwa yikhanda elibuhlungu.

Kukhona nezinye izimbangi ezimbili ze-CGRP ezitholakalayo. Le mithi ibizwa nge-Emgality (galcanezumab) ne-Aimovig (erenumab). Kunomphikisi wesine we-CGRP obizwa nge-eptinezumab naye ofundwayo. Kulindeleke ukuthi ivunyelwe yi-FDA ngokuzayo.

Ukusebenza ngempumelelo

Ukuze ufunde ngokusebenza kwe-Ajovy, bheka isigaba esithi "Ajovy uses" ngezansi.

I-Ajovy generic

I-Ajovy itholakala kuphela njengomuthi wegama lomkhiqizo. Okwamanje ayitholakali ngendlela ejwayelekile.

I-Ajovy iqukethe i-fremanezumab yezidakamizwa, ebizwa nangokuthi i-fremanezumab-vfrm. Isizathu sokuthi "-vfrm" sivela ekugcineni kwegama ukukhombisa ukuthi umuthi uhlukile emithini efanayo engadalwa ngokuzayo. Amanye ama-antibody monoclonal aqanjwa ngendlela efanayo.

U-Ajovy usebenzisa

Ukuphathwa Kwezokudla Nezidakamizwa e-U.S. Kuvumela imishanguzo kadokotela efana ne-Ajovy ukwelapha noma ukuvimbela izimo ezithile.

I-Ajovy yezinhlungu zekhanda ze-migraine

I-FDA ivume i-Ajovy ukusiza ukuvimbela ukuphathwa yikhanda kubantu abadala. Lezi zinhlungu zekhanda zinzima. Futhi ziyizimpawu eziyinhloko ze-migraine, okuyisimo sezinzwa. Ukuzwela ukukhanya nomsindo, isicanucanu, ukuhlanza, nokukhuluma kabi ngezinye zezimpawu ezingenzeka ngekhanda le-migraine.

I-Ajovy ivunyelwe ukuvikela kokubili okungapheli kwekhanda le-migraine kanye ne-episodic migraine headaches. I-International Headache Society ithi abantu abane-episodic migraine headaches babhekana nezinsuku ezingaphansi kwezingu-15 ze-migraine noma izinsuku zekhanda inyanga ngayinye. Abantu abanezinhlungu ezingapheli ze-migraine, ngakolunye uhlangothi, babhekana nezinsuku ze-15 noma ngaphezulu zekhanda inyanga ngayinye okungenani izinyanga ze-3. Futhi okungenani i-8 yalezi zinsuku yizinsuku ze-migraine.

Ukuphumelela kwekhanda le-migraine

U-Ajovy utholakale esebenza ngempumelelo ekuvikeleni ukuphathwa yikhanda elibuhlungu. Ngemininingwane yokuthi u-Ajovy usebenze kanjani ezifundweni zomtholampilo, bheka imininingwane enquma izidakamizwa.

I-American Headache Society incoma ukusetshenziswa kwe-Ajovy ukuvimbela i-migraine ikhanda kubantu abadala abangakwazi ukunciphisa inani labo lezinsuku ze-migraine ngokwanele ngeminye imithi. Iphinde incoma i-Ajovy kubantu abangakwazi ukuthatha eminye imishanguzo yokuvikela i-migraine ngenxa yemiphumela emibi noma ukuxhumana kwezidakamizwa.

Imiphumela emibi ye-Ajovy

I-Ajovy ingadala imiphumela emibi noma emibi. Uhlu olulandelayo luqukethe eminye yemiphumela emibi engaba khona ngenkathi uthatha i-Ajovy. Lolu hlu alufaki yonke imiphumela emibi engaba khona.

Ukuthola eminye imininingwane ngemiphumela engemihle ye-Ajovy, noma amathiphu wokuthi ungabhekana kanjani nemiphumela emibi ekhathazayo, khuluma nodokotela wakho noma usokhemisi.

Imiphumela emibi ejwayelekile

Imiphumela emibi ejwayelekile ye-Ajovy ukusabela kwendawo yokujova. Lokhu kungafaka imiphumela elandelayo esizeni lapho ufaka khona umuthi:

• ububomvu
• ukulunywa
• ubuhlungu
• ububele

Ukuphendula kwesayithi lokujova ngokuvamile akunzima noma akuhlali isikhathi eside. Eminingi yale miphumela emibi inganyamalala ezinsukwini ezimbalwa noma emasontweni ambalwa. Khuluma nodokotela wakho noma usokhemisi uma imiphumela yakho emibi inzima kakhulu noma ingapheli.

Imiphumela emibi kakhulu

Akuvamile ukuba nemiphumela emibi kakhulu evela ku-Ajovy, kodwa kungenzeka. Umphumela omkhulu obucayi we-Ajovy ukusabela okweqile komzimba kumuthi. Bona ngezansi ukuthola imininingwane.

Ukusabela okweqile

Njengezidakamizwa eziningi, abanye abantu bangathola ukusabela okweqile ngemuva kokuthatha i-Ajovy. Izimpawu zokuphendula okuncane kokungezwani komzimba zingafaka:

• ukulunywa
• ukuqubuka kwesikhumba
• ukuqhuma (ukufudumala nokubomvu esikhunjeni sakho)

Ukusabela okweqile komzimba ku-Ajovy akuvamile. Izimpawu ezingenzeka zokuphendula okweqile zihlanganisa:

• ukuvuvukala kolimi lwakho, umlomo, noma umphimbo
• i-angioedema (ukuvuvukala ngaphansi kwesikhumba sakho, imvamisa ezinkalweni zakho, izindebe, izandla, noma izinyawo)
• inkinga yokuphefumula

Uma unesifo esibi kakhulu ku-Ajovy, shayela udokotela wakho ngokushesha. Uma izimpawu zakho zizwa zisongela impilo noma uma ucabanga ukuthi unezimo eziphuthumayo zezokwelapha, shayela ku-911.

Imiphumela emibi yesikhathi eside

I-Ajovy ngumuthi osanda kuvunywa esigabeni esisha semithi. Ngenxa yalokhu, kuncane kakhulu ucwaningo lwesikhathi eside mayelana nokuphepha kuka-Ajovy, futhi kuncane okwaziwayo ngemiphumela yalo yesikhathi eside. Ucwaningo lomtholampilo olude kunazo zonke (i-PS30) lwase-Ajovy luthathe unyaka owodwa, futhi abantu abakucwaningo abayibikanga imiphumela emibi kakhulu.

Ukuphendula kwesayithi lokujova kwaba umthelela ohlangothini ovame kakhulu obikwe ocwaningweni lonyaka wonke. Abantu babike imiphumela elandelayo endaweni lapho umjovo wanikezwa khona:

• ubuhlungu
• ububomvu
• ukopha
• ukulunywa
• isikhumba esinamaqhuqhuva noma esikhuphukile

Ezinye izindlela ze-Ajovy

Kuneminye imishanguzo etholakalayo engasiza ukuvimbela ukuphathwa yikhanda elibuhlungu. Abanye bangakulungela kangcono kuwe kunabanye. Uma ungathanda ukuthola enye indlela ye-Ajovy, khuluma nodokotela wakho. Bangakusiza ukuthi ufunde ngeminye imithi engakulungela.

Nazi ezinye izibonelo zezinye izidakamizwa ezivunyelwe yi-FDA ukusiza ukuvimbela ikhanda le-migraine:

• i-beta-blocker propranolol (Inderal, Inderal LA)
• i-neurotoxin onabotulinumtoxinA (Botox)
• imishanguzo ethile yokuthatha, njenge-divalproex sodium (Depakote) noma i-topiramate (i-Topamax, iTrokendi XR)
• abanye abaphikisi be-peptide ehlobene nohlobo lwe-calcitonin (CGRP): i-erenumab-aooe (Aimovig) ne-galcanezumab-gnlm (Emgality)

Nazi ezinye izibonelo zezinye izidakamizwa ezingasetshenziswa ngaphandle kwelebula lokuvikela ikhanda lekhanda le-migraine:

• imithi ethile yokubanjwa, njenge-valproate sodium
• ama-anti-depressants athile, njenge-amitriptyline noma i-venlafaxine (i-Effexor XR)
• ama-beta-blocker athile, afana ne-metoprolol (Lopressor, Toprol XL) noma i-atenolol (Tenormin)

Abaphikisi be-CGRP

I-Ajovy wuhlobo olusha lomuthi obizwa ngokuthi yi-calcitonin peptide-related-peptide (CGRP) antagonist. Ku-2018, i-FDA ivume i-Ajovy ukuvimbela ukuphathwa ikhanda kwe-migraine, kanye nabanye abaphikisi be-CGRP: i-Emgality ne-Aimovig. Umuthi wesine (eptinezumab) kulindeleke ukuthi uvunyelwe kungekudala.

Basebenza kanjani

Abaphikisi abathathu be-CGRP abakhona njengamanje basebenza ngezindlela ezihlukile ukusiza ukuvimbela ikhanda le-migraine.

I-CGRP yiprotheni emzimbeni wakho. Kuxhunyaniswe ne-vasodilation (ukunwetshwa kwemithambo yegazi) nokuvuvukala ebuchosheni, okungaholela ebuhlungwini bekhanda elibuhlungu. Ukwenza le miphumela ebuchosheni, i-CGRP idinga ukubopha (ukunamathisela) kuma-receptors ayo. Ama-Receptor angama-molecule asezindongeni zamaseli akho obuchopho.

I-Ajovy ne-Emgality isebenza ngokunamathela ku-CGRP. Lokhu kuvimbela i-CGRP ukuthi inamathisele kuma-receptors ayo. I-Aimovig, ngakolunye uhlangothi, isebenza ngokunamathisela kuma-receptors ngokwawo. Lokhu kugcina i-CGRP inganamathiseli kubo.

Ngokuvimbela i-CGRP ukuthi inamathisele kwi-receptor yayo, le mithi emithathu isiza ukuvimbela i-vasodilation nokuvuvukala. Ngenxa yalokho, bangasiza ekuvikeleni ikhanda le-migraine.

Icala ngecala

Leli shadi liqhathanisa eminye imininingwane nge-Aimovig, Ajovy, ne-Emgality. Le mithi yiziphikisi ezintathu ze-CGRP ezivunyelwe okwamanje ukusiza ukuvimbela ukuphathwa ikhanda kwe-migraine. (Ukuze ufunde kabanzi ngokuthi i-Ajovy iqhathaniswa kanjani nale mithi, bheka isigaba se- "Ajovy vs. other drug" ngezansi.)

Amanani angahluka ngokuya ngendawo okuyo, ikhemisi elisetshenzisiwe, ukumbozwa komshuwalense wakho, nezinhlelo zosizo zabakhiqizi.

Ajovy vs. ezinye izidakamizwa

Ungase uzibuze ukuthi i-Ajovy iqhathanisa kanjani neminye imithi enqunyelwe ukusetshenziswa okufanayo. Ngezansi ukuqhathanisa phakathi kuka-Ajovy nemithi eminingana.

I-Ajovy vs. Aimovig

I-Ajovy iqukethe i-fremanezumab yezidakamizwa, eyi-antibody monoclonal. I-Aimovig iqukethe i-erenumab, nayo eyi-anti-monoclonal antibody. Ama-antibody e-monoclonal yizidakamizwa ezenziwe ngamaseli omzimba omzimba. Bamisa ukusebenza kwamaprotheni athile emzimbeni wakho.

U-Ajovy no-Aimovig basebenza ngezindlela ezihluke kancane. Kodwa-ke, bobabili bayamisa ukusebenza kweprotheni ebizwa nge-calcitonin peptide ehlobene nohlobo (CGRP). I-CGRP ibangela i-vasodilation (ukunwetshwa kwemithambo yegazi) nokuvuvukala ebuchosheni. Le miphumela ingaholela ekhanda le-migraine.

Ngokuvimba i-CGRP, i-Ajovy ne-Aimovig kusiza ukuvimbela ukuphefumula nokuvuvukala. Lokhu kungasiza ekuvimbeleni i-migraine ikhanda.

Isebenzisa

U-Ajovy no-Aimovig bobabili bavunyelwe yi-FDA ukuvimbela i-migraine ikhanda kubantu abadala.

Amafomu nokuphathwa

Izidakamizwa i-Ajovy ne-Aimovig zombili ziza ngendlela yomjovo onikezwa ngaphansi kwesikhumba sakho (ngaphansi kwesikhumba). Ungazijova ngokwakho izidakamizwa ekhaya. Yomibili le mithi ingazijolela yona ezindaweni ezintathu: ingaphambili lamathanga akho, emuva kwengalo yakho ephezulu, noma isisu sakho.

I-Ajovy iza ngesirinji efakwe ngomthamo owodwa. I-Ajovy inganikezwa njengomjovo owodwa we-225 mg kanye ngenyanga. Ngenye indlela, inganikezwa njengemijovo emithathu ka-675 mg enikezwa njalo ngekota (kanye njalo ezinyangeni ezintathu).

I-Aimovig iza ngesimo se-autoinjector esigcwaliswe ngomthamo owodwa. Imvamisa inikezwa njengomjovo we-70-mg kanye ngenyanga. Kepha umthamo wenyanga we-140-mg ungahle ube ngcono kwabanye abantu.

Imiphumela emibi kanye nezingozi

U-Ajovy no-Aimovig basebenza ngezindlela ezifanayo ngakho-ke babanga imiphumela emibi efanayo. Zibanga nemiphumela emibi eyehlukene.

Imiphumela emibi ejwayelekile

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi ejwayelekile engenzeka nge-Ajovy, ne-Aimovig, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

• Kungenzeka nge-Ajovy:
  • akukho nemiphumela engejwayelekile eyehlukile
• Kungenzeka nge-Aimovig:
  • ukuqunjelwa
  • amajaqamba noma ama-spasms
  • izifo eziphezulu zokuphefumula ezifana nokutheleleka okuvamile komkhuhlane noma kwesono
  • izimpawu ezinjengomkhuhlane
  • ukuhlungu obusemhlane
• Kungenzeka ngamabili u-Ajovy no-Aimovig:
  • ukuphendula kwesiza somjovo njengobuhlungu, ukulunywa, noma ukubomvu

Imiphumela emibi kakhulu

Umphumela oyisisekelo oyinhloko we-Ajovy ne-Aimovig ukusabela okweqile okunzima. Ukusabela okunjalo akuvamile, kodwa kungenzeka. (Ngeminye imininingwane, bheka “Ukusabela okweqile” kusigaba “Semiphumela emibi ye-Ajovy” ngenhla).

Ukusabela komzimba

Ekuvivinyweni komtholampilo kuzo zombili izidakamizwa, iphesenti elincane labantu lithole ukuphendula komzimba. Lokhu kuphendula kwabangela ukuthi imizimba yabo yakhe amasosha omzimba alwa no-Ajovy noma i-Aimovig.

Ama-antibody amaphrotheni asemasosheni omzimba ahlasela izinto zangaphandle emzimbeni wakho. Umzimba wakho ungakha amasosha omzimba kunoma yiluphi udaba lwangaphandle. Lokhu kufaka ama-antibody monoclonal. Uma umzimba wakho udala amasosha omzimba ku-Ajovy noma ku-Aimovig, umuthi kungenzeka ungabe usakusebenzela. Kodwa khumbula ukuthi ngenxa yokuthi u-Ajovy no-Aimovig bavunyelwa ngonyaka we-2018, kusesekuseni kakhulu ukuthi ungazi ukuthi uvame kangakanani lo mphumela nokuthi ungathinta kanjani abantu ukuthi bayisebenzisa kanjani le mithi ngokuzayo.

Ukusebenza ngempumelelo

Le mithi ayikaze iqhathaniswe ngqo esivivinyweni somtholampilo. Kodwa-ke, ucwaningo luthole ukuthi u-Ajovy no-Aimovig basebenza kahle ekuvikeleni kokubili ukuphathwa yikhanda elibuhlungu kanye nelingapheli.

Ngaphezu kwalokho, imihlahlandlela yokwelashwa kwe-migraine incoma noma yisiphi isidakamizwa njengenketho kubantu abathile. Lokhu kufaka phakathi abantu abangakwazanga ukunciphisa izinsuku zabo zenyanga ze-migraine ngokwanele neminye imithi. Bafaka nabantu abangakwazi ukubekezelela eminye imithi ngenxa yemiphumela emibi noma ukuhlangana kwezidakamizwa.

Izindleko

Izindleko ze-Ajovy noma i-Aimovig zingahluka ngokuya ngohlelo lwakho lokwelashwa. Ukuqhathanisa amanani ale mithi, hlola i-GoodRx.com. Inani langempela ozolikhokhela noma iyiphi yalezi zidakamizwa lizoya ngohlelo lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

Ajovy vs. Emgality

I-Ajovy iqukethe i-fremanezumab, eyi-anti-monoclonal antibody. Ubungqayizivele buqukethe i-galcanezumab, nayo eyi-anti-monoclonal antibody. I-anti-monoclonal antibody uhlobo lomuthi owenziwe ngamaseli omzimba. Imisa ukusebenza kwamaprotheni athile emzimbeni wakho.

I-Ajovy ne-Emgality bobabili bayamisa umsebenzi we-peptide ehlobene nohlobo lwe-calcitonin (CGRP). I-CGRP yiprotheni emzimbeni wakho. Kubanga i-vasodilation (ukunwetshwa kwemithambo yegazi) nokuvuvukala ebuchosheni, okungaholela ekhanda le-migraine.

Ngokumisa i-CGRP ekusebenzeni, i-Ajovy ne-Emgality zisiza ukuvimbela i-vasodilation nokuvuvukala ebuchosheni. Lokhu kungasiza ekuvimbeleni ikhanda le-migraine.

Isebenzisa

I-Ajovy ne-Emgality zombili zivunyelwe yi-FDA ukuvimbela i-migraine ikhanda kubantu abadala.

Amafomu nokuphathwa

I-Ajovy iza ngesirinji efakwe ngomthamo owodwa. Ubunzima buza ngendlela yesirinji noma ipeni eligcwaliswe ngomthamo owodwa.

Yomibili le mithi ijojowe ngaphansi kwesikhumba sakho (ngaphansi kwesikhumba). Ungakwazi ukujova u-Ajovy no-Emgality ekhaya.

I-Ajovy ingazilimaza usebenzisa eyodwa yamashejuli amabili ahlukene. Inganikezwa njengomjovo owodwa we-225 mg kanye ngenyanga, noma imijovo emithathu ehlukene (yenani eliphelele lama-675 mg) kanye njalo ezinyangeni ezintathu. Udokotela wakho uzokukhetha uhlelo olufanele.

Ukuqina kunikezwa njengomjovo owodwa we-120 mg, kanye ngenyanga. (Umthamo wenyanga yokuqala ungumthamo wemijovo emibili ofinyelela ku-240 mg.)

Kokubili i-Ajovy ne-Emgality ingafakwa ezindaweni ezintathu ezingaba khona: ngaphambili kwamathanga akho, emuva kwezingalo zakho ezingaphezulu, noma esiswini sakho. Ngaphezu kwalokho, i-Emgality ingafakwa ezinqeni zakho.

Imiphumela emibi kanye nezingozi

I-Ajovy ne-Emgality ziyizidakamizwa ezifanayo kakhulu futhi zidala imiphumela emibi efanayo nembi kakhulu.

Imiphumela emibi ejwayelekile

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi ejwayelekile engenzeka nge-Ajovy, nge-Emgality, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

• Kungenzeka nge-Ajovy:
  • akukho nemiphumela engejwayelekile eyehlukile
• Kungenzeka nge-Emgality:
  • ukuhlungu obusemhlane
  • ukutheleleka komgudu wokuphefumula
  • Umphimbo obuhlungu
  • ukutheleleka kwesono
• Kungenzeka ngamabili i-Ajovy ne-Emgality:
  • ukuphendula kwesiza somjovo njengobuhlungu, ukulunywa, noma ukubomvu

Imiphumela emibi kakhulu

Ukusabela okweqile komzimba kungumphumela omkhulu obucayi we-Ajovy ne-Emgality. Akuvamile ukuba nokusabela okunjalo, kodwa kungenzeka. (Ngeminye imininingwane, bheka “Ukusabela okweqile” kusigaba “Semiphumela emibi ye-Ajovy” ngenhla).

Ukusabela komzimba

Ezivivinyweni ezihlukene zomtholampilo zemithi i-Ajovy ne-Emgality, iphesenti elincane labantu lithole ukuphendula komzimba. Lokhu kusabela kwamasosha omzimba kubangele ukuthi imizimba yabo yakhe amasosha omzimba alwa nezidakamizwa.

Ama-antibody amaprotheni omzimba wakho ahlasela izinto zangaphandle emzimbeni wakho. Umzimba wakho ungakha amasosha omzimba kunoma iyiphi into yangaphandle. Lokhu kufaka ama-antibody monoclonal anjenge-Ajovy ne-Emgality.

Uma umzimba wakho udala amasosha omzimba ku-Ajovy noma Emgality, lowo muthi kungenzeka ungabe usakusebenzela.

Kodwa-ke, kuseseduze kakhulu ukwazi ukuthi lo mphumela ungavama kangakanani ngoba i-Ajovy ne-Emgality yamukelwa ngonyaka we-2018. Futhi kusheshe kakhulu ukwazi ukuthi kungathinta kanjani ukuthi abantu bayisebenzisa kanjani le mithi emibili ngokuzayo.

Ukusebenza ngempumelelo

Le mithi ayikaze iqhathaniswe ngqo esivivinyweni somtholampilo. Kodwa-ke, ucwaningo luthole ukuthi i-Ajovy ne-Emgality zisebenza ngempumelelo ekuvikeleni zombili izinhlungu ze-migraine ezingapheli nezingapheli.

Ngaphezu kwalokho, zombili i-Ajovy ne-Emgality zinconyelwa imihlahlandlela yokwelashwa yabantu abangakwazi ukuthatha eminye imishanguzo ngenxa yemiphumela emibi noma ukuxhumana kwezidakamizwa. Ziyanconywa futhi kubantu abangakwazi ukunciphisa inani labo lezinyanga zonke le-migraine ekhanda ngokwanele nezinye izidakamizwa.

Izindleko

Izindleko ze-Ajovy noma ze-Emgality zingahluka ngokuya ngohlelo lwakho lokwelashwa. Ukuqhathanisa amanani ale mithi, hlola i-GoodRx.com. Inani langempela ozolikhokhela noma iyiphi yalezi zidakamizwa lizoya ngohlelo lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

I-Ajovy vs. Botox

I-Ajovy iqukethe i-fremanezumab, eyi-anti-monoclonal antibody. I-anti-monoclonal antibody uhlobo lomuthi owenziwe ngamaseli omzimba. I-Ajovy isiza ukuvimbela ukuphathwa ikhanda elibuhlungu ngokumisa ukusebenza kwamaprotheni athile adala ama-migraines.

Isithako esiyinhloko sezidakamizwa eBotox yi-onabotulinumtoxinA. Lesi sidakamizwa siyingxenye yesigaba semithi eyaziwa ngokuthi ama-neurotoxin. IBotox isebenza ngokukhubaza okwesikhashana imisipha efakwe kuyo. Lo mphumela emisipheni ugcina amasiginali ezinhlungu ukuthi angavulwa. Kucatshangwa ukuthi lesi senzo sisiza ukuvimbela ikhanda le-migraine ngaphambi kokuba liqale.

Isebenzisa

I-FDA ivume i-Ajovy ukuvimbela ikhanda elingapheli noma le-episodic migraine kubantu abadala.

IBotox ivunyelwe ukuvimbela ikhanda elingapheliyo le-migraine kubantu abadala. IBotox nayo ivunyelwe ukwelapha izimo eziningi, kufaka phakathi:

• ukuqina kwemisipha
• isinye esisebenza ngokweqile
• ukujuluka okweqile
• i-dystonia yomlomo wesibeletho (intamo esontekile ebuhlungu)
• ukuqhuma kwejwabu leso

Amafomu nokuphathwa

I-Ajovy iza njengesirinji ekhethiwe yedosi elilodwa. Unikezwa njengomjovo ngaphansi kwesikhumba sakho (ongaphansi kwesikhumba) ongazinikeza wona ekhaya, noma umhlinzeki wezokunakekelwa kwezempilo akunikeza ehhovisi likadokotela wakho.

I-Ajovy inganikezwa kwelinye lamashejuli amabili ahlukene: umjovo owodwa ongu-225-mg kanye ngenyanga, noma imijovo emithathu ehlukene (ingu-675 mg) kanye njalo ezinyangeni ezintathu. Udokotela wakho uzokukhetha uhlelo olufanele.

I-Ajovy ingajovwa ezindaweni ezintathu ezingaba khona: ngaphambili kwamathanga akho, emuva kwezingalo zakho ezingaphezulu, noma esiswini sakho.

IBotox nayo inikezwa njengomjovo, kodwa njalo inikezwa ehhovisi likadokotela. Ijojowe emsipheni (emsipheni), imvamisa njalo emavikini ayi-12.

Amasayithi lapho i-Botox ijwayelwe khona afaka ebunzini lakho, ngenhla nangaseduze kwezindlebe zakho, eduze koboya bezinwele phansi entanyeni yakho, nangemuva kwentamo namahlombe akho. Ekuvakasheni ngakunye, udokotela wakho uvamise ukukunikeza imijovo emincane engama-31 kulezi zindawo.

Imiphumela emibi kanye nezingozi

I-Ajovy neBotox zombili zisetshenziselwa ukuvimbela ukuphathwa yikhanda elibuhlungu, kodwa zisebenza ngezindlela ezingafani emzimbeni. Ngakho-ke, zinemiphumela emibi efanayo, futhi eminye yehlukile.

Imiphumela emibi ejwayelekile

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi engaba khona ne-Ajovy, neBotox, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

• Kungenzeka nge-Ajovy:
  • nemiphumela engemihle embalwa ejwayelekile
• Kungenzeka ngeBotox:
  • izimpawu ezinjengomkhuhlane
  • ikhanda noma ukuqina kwekhanda elibuhlungu
  • ijwabu leso ligobekile
  • ukukhubazeka kwemisipha ebusweni
  • ubuhlungu bentamo
  • ukuqina kwemisipha
  • ubuhlungu bemisipha nobuthakathaka
• Kungenzeka ngamabili i-Ajovy neBotox:
  • ukuphendula kwesiza somjovo

Imiphumela emibi kakhulu

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi engaba khona ne-Ajovy, ne-Xultophy, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

• Kungenzeka nge-Ajovy:
  • nemiphumela engemihle embalwa eyingqayizivele
• Kungenzeka ngeBotox:
  • ukusabalala kokukhubazeka emisipha eseduzane *
  • Inkinga yokugwinya nokuphefumula
  • ukutheleleka okungathi sína
• Kungenzeka ngamabili i-Ajovy neBotox:
  • ukusabela okweqile komzimba

I-Botox inesixwayiso esibhokisi esivela ku-FDA ngokusabalala kokukhubazeka kuya emisipha eseduze kulandela ukujova. Isexwayiso esibhakeleni yisixwayiso esiqine kakhulu esidingwa yi-FDA. Kwazisa odokotela neziguli ngemiphumela yezidakamizwa engaba yingozi.

Ukusebenza ngempumelelo

Ukuqaqanjelwa yikhanda elingapheli yisimo kuphela okusetshenziselwa ukusivimbela bobabili u-Ajovy noBotox.

Imihlahlandlela yokwelashwa incoma u-Ajovy njengenketho engenzeka kubantu abangakwazi ukwehlisa inani labo lekhanda le-migraine ngokwanele neminye imithi. I-Ajovy nayo inconyelwa abantu abangakwazi ukubekezelela ezinye izidakamizwa ngenxa yemiphumela yazo emibi noma ukuhlangana kwezidakamizwa.

I-American Academy of Neurology incoma iBotox njengenketho yokwelashwa kubantu abanezinhlungu ezingamahlalakhona ezingapheli.

Ucwaningo lwezemitholampilo aluqhathanisanga ngqo ukusebenza kwe-Ajovy neBotox. Kepha izifundo ezihlukile zikhombise ukuthi u-Ajovy noBotox basebenze ngempumelelo ekusizeni ukuvimbela ikhanda elingapheliyo le-migraine.

Izindleko

Izindleko ze-Ajovy noma i-Botox zingahluka ngokuya ngohlelo lwakho lokwelashwa. Ukuqhathanisa amanani ale mithi, hlola i-GoodRx.com. Inani langempela ozolikhokhela noma iyiphi yalezi zidakamizwa lizoya ngohlelo lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

Izindleko ze-Ajovy

Njengayo yonke imithi, amanani we-Ajovy angahluka.

Izindleko zakho zangempela zizoxhomeka kumshwalense wakho, indawo okuyo nasekhemisi oyisebenzisayo.

Usizo lwezezimali

Uma udinga uxhaso lwezezimali ukukhokhela i-Ajovy, usizo luyatholakala.

Abakwa-Teva Pharmaceuticals, abakhiqizi be-Ajovy, banesithembiso sokonga esingakusiza ukuthi ukhokhe imali encane nge-Ajovy. Ukuthola eminye imininingwane nokuthola ukuthi ufanelekile yini, vakashela iwebhusayithi yohlelo.

Isilinganiso se-Ajovy

Imininingwane elandelayo ichaza imithamo ejwayelekile ye-Ajovy. Kodwa-ke, qiniseka ukuthatha isilinganiso udokotela wakho akubekela sona. Udokotela wakho uzokunquma uhlelo oluhle kakhulu lokulandelwa kwakho.

Amafomu wezidakamizwa namandla

U-Ajovy uza ngesirinji ekhethwe ngomthamo owodwa. Isirinji ngayinye iqukethe i-225 mg ye-fremanezumab ku-1.5 mL yesisombululo.

I-Ajovy inikezwa njengomjovo ngaphansi kwesikhumba sakho (ngaphansi kwesikhumba). Ungazijova ngokwakho umuthi ekhaya, noma umhlinzeki wezokunakekelwa kwezempilo angakunika umjovo ehhovisi likadokotela wakho.

Isilinganiso sokuvimbela ikhanda lekhanda le-migraine

Kunezinhlelo ezimbili zokuncoma zomthamo:

• umjovo owodwa ongaphansi kuka-225-mg onikezwa njalo ngenyanga, noma
• imijovo emithathu engaphansi kwengu-225-mg enikezwe ndawonye (eyodwa emva kwenye) kanye njalo ezinyangeni ezintathu

Wena nodokotela wakho nizonquma uhlelo oluhle kakhulu lokulandelwa kwakho, ngokuya ngokuncamelayo nokuphila kwakho.

Kuthiwani uma ngiphuthelwa umthamo?

Uma ukhohlwa noma uphuthelwa umthamo, lawula umthamo ngokushesha nje lapho ukhumbula.Ngemuva kwalokho, qhubeka neshejuli ejwayelekile enconyiwe.

Isibonelo, uma usohlelweni lwanyanga zonke, hlela umthamo olandelayo amasonto amane ngemuva kokwenza umthamo wakho wokwenza izimonyo. Uma usohlelweni lwamakota onke, lawula umthamo olandelayo amasonto ayi-12 ngemuva kethamo lakho lokwenza izimonyo.

Ngabe kuzodingeka ngisebenzise lesi sidakamizwa isikhathi eside?

Uma wena nodokotela wakho nibona ukuthi i-Ajovy iphephile futhi iyasebenza kuwe, ungasebenzisa lesi sidakamizwa isikhathi eside ukuvimbela ukuphathwa yikhanda elibuhlungu.

Ungayithatha kanjani i-Ajovy

I-Ajovy ngumjovo onikezwa ngaphansi kwesikhumba (ngaphansi kwesikhumba) kanye ngenyanga noma kanye njalo ezinyangeni ezintathu. Ungazenzela umjovo ngokwakho ekhaya, noma umhlinzeki wezokunakekelwa kwezempilo akunike imijovo ehhovisi likadokotela wakho. Isikhathi sokuqala lapho uthola khona udokotela we-Ajovy, umhlinzeki wakho wezokunakekelwa kwempilo angachaza ukuthi ungawujova kanjani umuthi ngokwakho.

I-Ajovy iza njengomthamo owodwa, isirinji ekhethiwe eyi-225-mg. Isirinji ngayinye iqukethe umthamo owodwa kuphela futhi yenzelwe ukuthi isetshenziswe kanye bese ilahlwa.

Ngezansi kunemininingwane yokuthi ungasisebenzisa kanjani isirinji ekhethiwe. Ngeminye imininingwane, ividiyo, nezithombe zemiyalo yomjovo, bheka iwebhusayithi yomkhiqizi.

Ungayijova kanjani

Udokotela wakho uzokunika ama-225 mg kanye ngenyanga, noma u-675 mg kanye ezinyangeni ezintathu (ngekota). Uma unqunywe u-225 mg njalo ngenyanga, uzozinika umjovo owodwa. Uma unqunyelwe ama-675 mg njalo ngekota, uzozinika imijovo emithathu ehlukene ngokulandelana.

Ilungiselela ukujova

• Imizuzu engamashumi amathathu ngaphambi kokujova umuthi, susa isirinji esiqandisini. Lokhu kuvumela ukuthi umuthi ufudumale futhi ufike ekamelweni lokushisa. Gcina ikepisi esirinji uze ulungele ukusebenzisa isipetu. (I-Ajovy ingagcinwa ekamelweni lokushisa kuze kufinyelele emahoreni angama-24. Uma i-Ajovy igcinwa ngaphandle kwesiqandisisi amahora angama-24 ngaphandle kokusetshenziswa, ungayifaki esiqandisini. Yilahle esitsheni sakho esibukhali.)
• Ungazami ukufudumeza isirinji ngokushesha ngokuyihambisa ngemicrowave noma ngokuhambisa amanzi ashisayo phezu kwaso. Futhi, unganyakazisi isirinji. Ukwenza lezi zinto kungenza i-Ajovy iphephe kakhulu futhi isebenze kahle.
• Uma ukhipha isipetu emaphaketheni aso, qiniseka ukuthi usivikela ekukhanyeni.
• Ngenkathi ulinde isirinji ukufudumala kuze kufike ekamelweni lokushisa, thola i-gauze noma ibhola likakotini, ukusula utshwala, kanye nesitsha sakho sokulahla esibukhali. Futhi, qiniseka ukuthi unenani elifanele lamasirinji womthamo wakho onqunyiwe.
• Bheka isirinji ukuze uqiniseke ukuthi umuthi awunamafu noma uphelelwe isikhathi. Uketshezi kufanele lucace kuphuzi kancane. Kulungile uma kunamabhamuza. Kodwa uma uketshezi lumbala noma kunamafu, noma uma kunezicucu ezincane eziqinile kulo, ungalusebenzisi. Futhi uma kukhona ukuqhekeka noma ukuvuza kusirinji, ungayisebenzisi. Uma kudingeka, xhumana nodokotela wakho mayelana nokuthola okusha.
• Sebenzisa insipho namanzi ukugeza izandla zakho, bese ukhetha indawo yomjovo wakho. Ungafaka ngaphansi kwesikhumba sakho kulezi zindawo ezintathu:
• ngaphambili kwamathanga akho (okungenani amasentimitha amabili ngaphezulu kwedolo lakho noma amasentimitha amabili ngaphansi kwe-groin yakho)
• ngemuva kwezingalo zakho ezingaphezulu
• isisu sakho (okungenani amasentimitha amabili kude nenkinobho yesisu sakho)
• Uma ufuna ukujova umuthi ngemuva kwengalo yakho, othile angadinga ukukujova ngomuthi.
• Sebenzisa ukusula utshwala ukuhlanza indawo yomjovo oyikhethile. Qiniseka ukuthi utshwala bome ngokuphelele ngaphambi kokujova umuthi.
• Uma uzinika imijovo emithathu, ungaziniki imijovo endaweni efanayo. Futhi ungalokothi ujove ezindaweni ezilimele, ezibomvu, ezibaziweyo, ezidwebiwe, noma okunzima ukuthinta.

Ukujova i-Ajovy isirinji egcwalisiwe

1. Thatha ikepisi lenaliti kusipontsho ulilahle kudoti.
2. Nciphisa ngobumnene okungenani intshi eyodwa yesikhumba ofisa ukujova.
3. Faka inaliti esikhunjeni esicwilisiwe engxenyeni yama-degree angama-45 kuya kwangu-90.
4. Lapho inaliti isifakwe ngokuphelele, sebenzisa isithupha sakho ukusunduza kancane i-plunger lapho izofika khona.
5. Ngemuva kokujova u-Ajovy, donsela inaliti ngaphandle kwesikhumba bese ukhulula isibambo sesikhumba. Ukuze ugweme ukunamathela kuwe, ungaphindi inaliti.
6. Cindezela ngobumnene ibhola likakotini noma i-gauze kusayithi lokujova imizuzwana embalwa. Ungayihlikihli indawo.
7. Phonsa isirinji nenaliti esetshenzisiwe esitsheni sakho sokulahla ngokushesha.

Isikhathi

I-Ajovy kufanele ithathwe kanye ngenyanga noma kanye ezinyangeni ezintathu (njalo ngekota), kuya ngokuthi udokotela wakho ukunquma ini. Ingathathwa nganoma yisiphi isikhathi sosuku.

Uma uphuthelwa umthamo, thatha i-Ajovy ngokushesha okukhulu lapho ukhumbula khona. Umthamo olandelayo kufanele ube yinyanga eyodwa noma izinyanga ezintathu ngemuva kokuthatha lowo, kuya ngesheduli yakho yokuncoma. Ithuluzi lesikhumbuzo semithi lingakusiza ukuthi ukhumbule ukuthatha i-Ajovy ngesikhathi esifanele.

Ukuthatha i-Ajovy ngokudla

I-Ajovy ingathathwa nokudla noma ngaphandle.

Isebenza kanjani i-Ajovy

I-Ajovy yi-antibody eyodwa. Lolu hlobo lomuthi luyiprotheni ekhethekile yesistimu yomzimba eyenziwe elebhu. U-Ajovy usebenza ngokumisa ukusebenza kweprotheni ebizwa nge-peptide ehlobene nohlobo lwe-calcitonin (CGRP). I-CGRP ibandakanyeka ku-vasodilation (ukunwetshwa kwemithambo yegazi) nokuvuvukala ebuchosheni bakho.

I-CGRP ikholelwa ukuthi idlala indima ebalulekile ekubangeleni ikhanda le-migraine. Eqinisweni, lapho abantu beqala ukuthola ikhanda le-migraine, banamazinga aphezulu we-CGRP egazini labo. U-Ajovy usiza ukugcina ikhanda lekhanda le-migraine liqale ngokumisa umsebenzi we-CGRP.

Imithi eminingi ikhomba (yenza) amakhemikhali amaningi noma izingxenye zamaseli emzimbeni wakho. Kepha i-Ajovy namanye ama-antibody monoclonal akhomba into eyodwa kuphela emzimbeni. Ngenxa yalokhu, kungahle kube nokuxhumana okumbalwa kwezidakamizwa nemiphumela engemihle nge-Ajovy. Lokhu kungakwenza kube ukukhetha okuhle kubantu abangakwazi ukuthatha ezinye izidakamizwa ngenxa yemiphumela emibi noma ukuxhumana kwezidakamizwa.

I-Ajovy futhi ingahle ibe yisinqumo esihle kubantu abazame ezinye izidakamizwa, kepha izidakamizwa azenzanga ngokwanele ukunciphisa inani lezinsuku ze-migraine.

Kuthatha isikhathi esingakanani ukusebenza?

Kungathatha amasonto ambalwa nganoma yiluphi ushintsho lwe-migraine u-Ajovy abangela ukuthi lubonakale. Futhi kungathatha izinyanga ezimbalwa ukuthi u-Ajovy asebenze ngokugcwele.

Imiphumela yezifundo zokwelashwa ikhombise ukuthi abantu abaningi abathathe u-Ajovy babhekana nezinsuku ezimbalwa ze-migraine kungakapheli inyanga eyodwa bethathe umthamo wabo wokuqala. Ezinyangeni ezimbalwa, inani lezinsuku ze-migraine liqhubeke nokwehla kwabantu abasesifundweni.

Ajovy notshwala

Akukho ukuxhumana phakathi kuka-Ajovy notshwala.

Kodwa-ke, kwabanye abantu, ukuphuza utshwala ngenkathi uthatha i-Ajovy kungahle kubonakale kwenza umuthi ungasebenzi kahle. Lokhu kungenxa yokuthi utshwala buyimbangela ye-migraine kubantu abaningi, futhi ngisho notshwala obuncane bungadala ikhanda le-migraine kubo.

Uma uthola ukuthi utshwala budala ikhanda elibuhlungu kakhulu noma elibuhlungu njalo, kufanele ugweme iziphuzo eziqukethe utshwala.

Ukusebenzisana kwe-Ajovy

U-Ajovy akakhonjiswanga ukuthi uhlangana neminye imithi. Kodwa-ke, kusabalulekile ukukhuluma nodokotela wakho noma usokhemisi nganoma imiphi imishanguzo kadokotela, amavithamini, izithasiselo, nemithi oyithenga ngaphambi kokuyiqala i-Ajovy.

Ajovy nokukhulelwa

Akwaziwa ukuthi i-Ajovy iphephile ukusetshenziswa ngesikhathi sokukhulelwa. Ngenkathi i-Ajovy inikezwa abesifazane abakhulelwe ezifundweni zezilwane, abukho ubungozi obukhonjisiwe ekukhulelweni. Kepha imiphumela yezifundo zezilwane ayihlali ibikezela ukuthi umuthi ungabathinta kanjani abantu.

Uma ukhulelwe noma ucabanga ngokukhulelwa, khuluma nodokotela wakho. Bangasiza ukuthola ukuthi i-Ajovy iyindlela enhle ongayikhetha ngayo. Kungase kudingeke ukuthi ulinde ukusebenzisa i-Ajovy uze ungabe usakhulelwa.

Ajovy nokuncelisa

Akukaziwa ukuthi u-Ajovy uyadlula yini ebisini lomuntu lwebele. Ngakho-ke, akucaci ukuthi i-Ajovy iphephile yini ukusebenzisa ngenkathi uncelisa.

Uma ucabanga ukuthola ukwelashwa kwe-Ajovy ngenkathi uncelisa, khuluma nodokotela wakho ngezinzuzo nezingozi ezingaba khona. Uma uqala ukuthatha i-Ajovy, kungadingeka ukuthi uyeke ukuncelisa.

Imibuzo ejwayelekile nge-Ajovy

Nazi izimpendulo zemibuzo ebuzwa njalo nge-Ajovy.

Ngabe i-Ajovy ingasetshenziselwa ukwelapha i-migraine headache?

Cha, i-Ajovy ayilona ukwelashwa kwekhanda le-migraine. I-Ajovy isiza ukuvimbela ukuphathwa yikhanda ngaphambi kokuba iqale.

Uhluke kanjani u-Ajovy kwezinye izidakamizwa ze-migraine?

I-Ajovy yehlukile kunezinye izidakamizwa eziningi ze-migraine ngoba ingenye yemithi yokuqala eyenzelwe ukusiza ukuvimbela ikhanda le-migraine. I-Ajovy iyingxenye yesigaba esisha semithi ebizwa nge-calcitonin peptide ehlobene nohlobo (CGRP).

Iningi leminye imishanguzo esetshenziselwa ukuvimbela ukuphathwa yikhanda ye-migraine yenzelwe izinhloso ezahlukahlukene, njengokulapha ukuquleka, ukudangala, noma umfutho wegazi ophakeme. Eziningi zalezi zidakamizwa zisetshenziselwa i-off-label ukusiza ukuvimbela ikhanda le-migraine.

I-Ajovy ibuye yehluke kuneminye imithi eminingi ye-migraine ngokuthi ijojowe kanye ngenyanga noma kanye njalo ezinyangeni ezintathu. Iningi leminye imishanguzo esetshenziselwa ukuvimbela ukuphathwa yikhanda elibuhlungu liza njengamaphilisi odinga ukuwaphuza kanye ngosuku.

Omunye umuthi ongasetshenziswa yiBotox. IBotox nayo ingumjovo, kodwa uyithola kanye njalo ezinyangeni ezintathu ehhovisi likadokotela wakho. Ungazijova u-Ajovy wena ekhaya noma umhlinzeki wezokunakekelwa kwezempilo akunikeze umjovo ehhovisi likadokotela wakho.

Futhi, i-Ajovy iyi-anti-monoclonal antibody, okuwuhlobo lomuthi owenziwe ngamaseli omzimba. Isibindi asizidilizi lezi zidakamizwa, njengoba senza nangezinye izidakamizwa eziningi ezisetshenziselwa ukuvimbela ukuphathwa yikhanda elibuhlungu. Lokhu kusho ukuthi i-Ajovy namanye ama-antibody monoclonal anokuxhumana okumbalwa kwezidakamizwa kuneminye imithi esiza ukuvimbela ukuphathwa yikhanda elibuhlungu.

Ingabe u-Ajovy welapha ikhanda elibuhlungu?

Cha, u-Ajovy akasizi ekwelapheni ikhanda le-migraine. Njengamanje, azikho izidakamizwa ezitholakalayo ezingelapha amakhanda we-migraine. Izidakamizwa ze-migraine ezitholakalayo zingasiza ekuvikeleni noma ekwelapheni ikhanda le-migraine.

Uma ngithatha i-Ajovy, ngingayeka ukuthatha eminye imithi yami yokuvikela?

Lokho kuya ngokuthi. Impendulo yawo wonke umuntu ku-Ajovy yehlukile. Uma lesi sidakamizwa sinciphisa inani lekhanda lakho le-migraine lize liye enanini elilawulekayo, kungenzeka ukuthi ukwazi ukuyeka ukusebenzisa eminye imithi yokuvikela. Kepha lapho uqala ukuthatha i-Ajovy, udokotela wakho cishe uzokukunikeza kanye nezinye izidakamizwa zokuvimbela.

Ucwaningo lomtholampilo luthole ukuthi i-Ajovy iphephile futhi iyasebenza ukusetshenziswa neminye imishanguzo yokuvikela. Eminye imishanguzo ongayinikwa udokotela wakho nge-Ajovy ifaka i-topiramate (Topamax), i-propranolol (Inderal), kanye nemithi ethile elwa nokucindezeleka. I-Ajovy ingasetshenziswa futhi ne-onabotulinumtoxinA (Botox).

Ngemuva kokuzama i-Ajovy izinyanga ezimbili kuya kwezintathu, udokotela wakho cishe uzokhuluma nawe ukuze abone ukuthi umuthi usebenza kanjani kuwe. Ngaleso sikhathi, nobabili ninganquma ukuthi kufanele niyeke ukuthatha eminye imishanguzo yokuvikela, noma ukuthi kufanele ninciphise isilinganiso senu saleyo mithi.

Ukweqisa ngokweqile kwe-Ajovy

Ukujova imithamo eminingi ye-Ajovy kungakhuphula ubungozi bokuphendulwa kwesiza somjovo. Uma une-allergen noma u-hypersensitive ku-Ajovy, ungaba sengozini yokuphendula okubi kakhulu.

Izimpawu zokudlula ngokweqile

Izimpawu zokudlula ngokweqile zingabandakanya:

• ubuhlungu obukhulu, ukulunywa, noma ubomvu endaweni eseduze nomjovo
• ukuqhuma
• isifuba
• i-angioedema (ukuvuvukala ngaphansi kwesikhumba)
• ukuvuvukala kolimi, umphimbo, noma umlomo
• inkinga yokuphefumula

Okufanele ukwenze uma kwenzeka ukweqisa ngokweqile

Uma ucabanga ukuthi uthathe kakhulu lo muthi, shayela udokotela wakho noma funa ukuholwa yi-American Association of Poison Control Centers ku-800-222-1222 noma ngethuluzi labo eliku-inthanethi. Kepha uma izimpawu zakho zinzima, shayela ku-911 noma uye egumbini lezimo eziphuthumayo eliseduze ngokushesha.

Izexwayiso zika-Ajovy

Ngaphambi kokuthatha u-Ajovy, khuluma nodokotela wakho ngomlando wakho wezempilo. Akufanele uthathe i-Ajovy uma unomlando wokusabela okukhulu kwe-hypersensitivity ku-Ajovy noma ezinye izithako zayo. Ukusabela okukhulu kwe-hypersensitivity kungadala izimpawu ezinjenge:

• ukuqubuka kwesikhumba
• ukulunywa
• inkinga yokuphefumula
• i-angioedema (ukuvuvukala ngaphansi kwesikhumba)
• ukuvuvukala kolimi, umlomo, nomphimbo

Ukuphela kwesikhathi kuka-Ajovy

Lapho u-Ajovy ekhishwa ekhemisi, usokhemisi uzokwengeza usuku lokuphelelwa yisikhathi kwilebula esesitsheni. Lolu suku luvame unyaka owodwa kusukela ngosuku okwakhishwa ngalo umuthi.

Inhloso yezinsuku zokuphelelwa isikhathi ezinjalo ukuqinisekisa ukusebenza komuthi ngalesi sikhathi. Isimo samanje se-Food and Drug Administration (i-FDA) ukugwema ukusebenzisa imishanguzo ephelelwe yisikhathi.

Ukuthi umuthi uhlala ulungile isikhathi eside kangakanani kungancika ezintweni eziningi, kufaka phakathi ukuthi umuthi ugcinwa kanjani futhi kuphi.

Imijovo ye-Ajovy kufanele igcinwe esiqandisini esitsheni sokuqala ukuyivikela ekukhanyeni. Zingagcinwa ngokuphepha esiqandisini izinyanga ezifika kwezingama-24, noma kuze kufike usuku lokuphelelwa yisikhathi ezibalwe esitsheni. Uma usukhishiwe esiqandisini, isirinji ngayinye kufanele isetshenziswe kungakapheli amahora angama-24.

Uma usebenzise umuthi ongasetshenziswanga osudlulile esikhathini sokuphelelwa yisikhathi, khuluma nosokhemisi wakho mayelana nokuthi usengakwazi yini ukuwusebenzisa.

Ukuzikhulula:Izindaba Zokwelapha Namuhla wenze yonke imizamo yokuqinisekisa ukuthi lonke ulwazi luyiqiniso, luphelele futhi lusesikhathini. Kodwa-ke, le ndatshana akufanele isetshenziswe njengokungena esikhundleni solwazi nobungoti bochwepheshe bezokunakekelwa kwezempilo onelayisense. Kufanele uhlale uthintana nodokotela wakho noma omunye uchwepheshe wezokunakekelwa kwempilo ngaphambi kokuthatha noma imuphi umuthi. Imininingwane yezidakamizwa equkethwe lapha ingashintsha futhi ayihloselwe ukumboza konke ukusetshenziswa okungaba khona, izinkomba, izixwayiso, izexwayiso, ukuxhumana kwezidakamizwa, ukungezwani komzimba, noma imiphumela emibi. Ukungabikho kwezixwayiso noma olunye ulwazi lomuthi othile awukhombisi ukuthi inhlanganisela yezidakamizwa noma yezidakamizwa iphephile, iyasebenza, noma ilungele zonke iziguli noma konke ukusetshenziswa okuthile.