I-Angiokeratoma

-Delile

• Yiziphi izinhlobo ezahlukahlukene?
• Ziyini izimpawu?
• Yini ebangela i-angiokeratoma?
• I-angiokeratoma itholakala kanjani?
• Ilashwa kanjani?
• Uyini umbono wabantu abane-angiokeratoma?

Yini i-angiokeratoma?

I-Angiokeratoma yisimo lapho kuvela khona amabala amancane, amnyama esikhunjeni. Zingavela noma kuphi emzimbeni wakho. Lezi zilonda zenzeka lapho imithambo yegazi emincane ebizwa ngokuthi ama-capillaries ivuleka, noma yanda, eduze kwesikhumba sakho.

Ama-angiokeratomas angazizwa emangele ekuthinteni. Zivame ukuvela ngamaqoqo esikhunjeni azungeze:

• umthondo
• isikhumba
• ingquza
• labia majora

Bangaphanjaniswa nokuqubuka, umdlavuza wesikhumba, noma isimo esifana nezinsumpa zangasese noma i-herpes. Isikhathi esiningi, ama-angiokeratomas awanabungozi futhi awadingi ukwelashwa.

Ama-angiokeratomas kwesinye isikhathi angaba wuphawu lwesimo esiyimbangela, njengesifo sofuzo esingajwayelekile esaziwa ngeFabry disease (FD). Ungadinga ukubona udokotela ukuze uthole ukwelashwa ukuvimbela izinkinga.

Yiziphi izinhlobo ezahlukahlukene?

Izinhlobo ze-angiokeratoma zifaka:

• I-angiokeratoma eyedwa. Lezi zivame ukuvela zodwa. Zivame ukutholakala ezingalweni nasemilenzeni yakho. Azinabungozi.
• I-Angiokeratoma yeFordyce. Lokhu kuvela esikhunjeni sesikhumba noma sangasese. Zitholakala kakhulu kwi-scrotum ngamaqoqo amakhulu. Lolu hlobo lungakhula esithweni sangasese sabesifazane abakhulelwe. Azinabungozi, kepha zijwayele ukuphuma igazi uma ziklwebhekile.
• I-Angiokeratoma kaMibelli. Lokhu kubangelwa imithambo yegazi evulekile esondele kakhulu ku-epidermis, noma ungqimba oluphezulu lwesikhumba sakho. Azinabungozi. Lolu hlobo luvame ukuqina futhi lukhuni ngokuhamba kwesikhathi kunqubo eyaziwa njenge-hyperkeratosis.
• I-Angiokeratoma circumscriptum. Leli ifomu elivelele kakhulu elivela ngamaqoqo emilenzeni yakho noma esifubeni. Ungazalwa unalolu hlobo. Kuvame ukubonakala morph ekubukekeni ngokuhamba kwesikhathi, kube mnyama noma ukuthatha ubujamo obuhlukile.
• I-Angiokeratoma corporis diffusum. Lolu hlobo luyisibonakaliso se-FD. Kungenzeka nezinye izifo ze-lysosomal, ezithinta ukuthi amaseli asebenza kanjani. Lezi zimo azivamile futhi zinezinye izimpawu ezibonakalayo, njengokushisa izandla nezinyawo noma izinkinga zokubona. Lawa ma-angiokeratomas ajwayelekile kakhulu emzimbeni ongezansi. Zingavela noma yikuphi kusuka phansi kwesifuba sakho kuya emathangeni akho aphezulu.

Ziyini izimpawu?

Ukuma ngqo, ubukhulu, nombala kuyahlukahluka. Ungaba nezimpawu ezengeziwe uma unesimo esihambisanayo, njenge-FD.

Ngokuvamile, ama-angiokeratomas abonisa lezi zimpawu ezilandelayo:

• avele njengamabhampa amancane naphakathi nendawo kusuka ku-1 millimeter (mm) kuye ku-5 mm noma kumaphethini ajwayelekile, afana nensumpa
• banesimo esifana nedome
• uzizwe ujiyile noma ulukhuni ebusweni
• ziveze zodwa noma ngamaqoqo ambalwa kuphela acishe abe yikhulu
• anemibala emnyama, kufaka phakathi okubomvu, okuluhlaza okwesibhakabhaka, onsomi, noma omnyama

Ama-angiokeratomas aqhamuka nje athanda ukuba bomvu ngombala. Amachashazi abesesikhumbeni sakho isikhashana avame ukuba mnyama.

Ama-Angiokeratomas ku-scrotum nawo angavela kanye nokubomvu endaweni enkulu yesikhwama. Ama-angiokeratomas ku-scrotum noma i-vulva nawo angopha kalula uma uklwebekile kunalawo akwezinye izingxenye zomzimba wakho.

Uma unesimo esinjenge-FD esenza ukuthi ama-angiokeratomas avele, ezinye izimpawu ongazithola zifaka:

• i-acroparesthesias, noma ubuhlungu ezandleni nasezinyaweni zakho
• i-tinnitus, noma umsindo wokukhala ezindlebeni zakho
• i-corneal opacity, noma ifu embonweni wakho
• i-hypohidrosis, noma ukungakwazi ukujuluka kahle
• ubuhlungu esiswini sakho nasemathunjini
• ukuzwa isifiso sokuzikhulula ngemuva kokudla

Yini ebangela i-angiokeratoma?

Ama-angiokeratomas abangelwa ukwanda kwemithambo yegazi eseduze kwesikhumba. Ama-angiokeratomas abodwa kungenzeka adalwe ukulimala okwenzeke phambilini endaweni lapho avela khona.

I-FD idluliselwa emindenini, futhi ingadala ama-angiokeratomas. Cishe umuntu oyedwa kwabesilisa abangama-40,000 kuya ku-60,000 abane-FD, ngokusho komnyango wezofuzo we-U.S. National Library of Medicine.

Ngaphandle kokuhlangana kwabo ne-FD nezinye izimo ze-lysosomal, akucaci njalo ukuthi yini imbangela eyisisekelo yama-angiokeratomas. Izimbangela ezingaba khona zifaka:

• umfutho wegazi ophezulu, noma umfutho wegazi ophezulu emithanjeni eseduze kwesikhumba
• unesimo esithinta imithambo yegazi yendawo, njenge-inguinal hernia, ama-hemorrhoids, noma i-varicocele (lapho imithambo yesikhumba ikhula)

I-angiokeratoma itholakala kanjani?

Ama-angiokeratomas ngokuvamile awanabungozi. Awudingi njalo ukubona udokotela ukuthola ukuxilongwa.

Kepha uma ubona ezinye izimpawu, njengokuphuma njalo kwegazi noma izimpawu ze-FD, bheka udokotela wakho khona manjalo ukuthola ukuxilongwa nokwelashwa. Ungase futhi ufune ukubona udokotela wakho uma usola ukuthi indawo ebukeka njenge-angiokeratoma ingaba nomdlavuza.

Udokotela wakho uzothatha isampula lezicubu ze-angiokeratoma ukuyithola. Lokhu kwaziwa njenge-biopsy. Phakathi nale nqubo, udokotela wakho angakhipha, noma asike i-angiokeratoma esikhumbeni sakho ukuze ayisuse ukuze ihlaziywe. Lokhu kungabandakanya udokotela wakho usebenzisa i-scalpel ukususa i-angiokeratoma kusuka kusisekelo sayo ngaphansi kwesikhumba.

Udokotela wakho futhi angancoma ukuhlolwa kofuzo lwe-GLA ukubona ukuthi unayo yini i-FD. I-FD ibangelwa ukuguquka kwezakhi zofuzo kule geni.

Ilashwa kanjani?

Ama-angiokeratomas ngokuvamile awadingi ukwelashwa uma ungekho ebuhlungwini noma ebuhlungwini. Ungahle ufune zisuswe uma zivame ukopha noma ngenxa yezizathu zezimonyo.Kulokhu, kunezinketho zokwelashwa eziningana ezitholakalayo:

• I-Electrodessication kanye ne-curettage (i-ED & C). Udokotela wakho undizisa indawo ezungeze ama-angiokeratomas nge-anesthesia yendawo, bese usebenzisa i-cautery kagesi namathuluzi ukuklwebha amabala nokususa izicubu.
• Ukususwa kwe-Laser. Udokotela wakho usebenzisa ama-lasers, njenge-pulsed dae laser, ukubhubhisa imithambo yegazi eseluliwe edala ama-angiokeratomas.
• I-Cryotherapy. Udokotela wakho ubamba ama-angiokeratomas nezicubu ezizungezile futhi awasuse.

Ukwelashwa kwe-FD kungafaka imithi, efana nale:

• I-Agalsidase beta (i-Fabrazyme). Uzothola imijovo ejwayelekile yeFabrazyme yokusiza umzimba wakho ekwehliseni amafutha omakhalekhukhwini athe xaxa akhiwe ngenxa yokulahlekelwa yi-enzyme ebangelwe yizinguquko ze-GLA.
• I-Neurontin (Gabapentin) noma i-carbamazepine (Tegretol). Le mithi ingelapha ubuhlungu bezandla nezinyawo.

Udokotela wakho futhi angancoma ukuthi ubone ongoti bezimpawu zenhliziyo, izinso, noma uhlelo lwezinzwa ze-FD, futhi.

Uyini umbono wabantu abane-angiokeratoma?

Ama-angiokeratomas akuvamile ukuthi abangele ukukhathazeka. Bona udokotela wakho uma ubona noma yikuphi ukopha noma ukulimala kuma-angiokeratomas, noma uma usola ukuthi kunesimo esingaphansi esikubangela ukungaphatheki kahle noma ubuhlungu.