Umhlahlandlela Wakho We-Anti-Androgens

-Delile

• Zisetshenziswa kanjani?
• Kwabesifazane
• Kwabesifazane abangama-transgender nabantu abangabhalisi
• Okwabesilisa
• Yiziphi ezinye ezivamile?
• I-Flutamide
• I-Spironolactone
• ICyproterone
• Iyini imiphumela emibi?
• Okubalulekile

Yini ama-anti-androgens?

Ama-Androgens ngama-hormone alawula ukuthuthukiswa kwezici zobulili. Imvamisa, abantu abazalwa ngezici zobulili besilisa banamazinga aphezulu ama-androgens. Abantu abazalwa ngezici zesifazane banamazinga aphansi ama-androgens. Esikhundleni salokho, banamazinga aphezulu ama-estrogens.

Izidakamizwa ze-anti-androgen zisebenza ngokuvimba imiphumela ye-androgens, efana ne-testosterone. Benza lokhu ngokubopha amaprotheni abizwa ngama-androgen receptors. Babopha kulawa ma-receptors ukuze ama-androgens angakwazi.

Kunezinhlobo eziningi zama-anti-androgens. Imvamisa zithathwa ngeminye imithi noma ngezikhathi ezithile zokuhlinzwa.

Zisetshenziswa kanjani?

Ama-anti-androgens anokusebenzisa okuningi, kusukela ekuphatheni umdlavuza wendlala yesinye kuya ekwehliseni izinwele zobuso ezingadingeki.

Kwabesifazane

Bonke abesifazane ngokwemvelo bakhiqiza inani elincane lama-androgens. Kodwa-ke, abanye besifazane bakhiqiza ngaphezu kwabanye.

Isibonelo, abesifazane abane-polycystic ovary syndrome (i-PCOS) banamazinga aphezulu we-androgen.Lokhu kungadala ukukhula ngokweqile kwezinwele, izinduna nezinkinga zokuvuthwa. Ama-anti-androgens angasiza ekunciphiseni lezi zimpawu kwabesifazane abane-PCOS.

Ezinye izimo ezibanga amazinga aphezulu we-androgens kwabesifazane afaka:

• i-adrenal hyperplasia
• izimila zesibeletho
• izimila zezindlala ze-adrenal

Ama-anti-androgens angasiza ukuphatha lezi zimo futhi avimbele izinkinga ezibangelwa amazinga aphezulu e-androgen kwabesifazane. Lezi zinkinga zifaka:

• isifo sikashukela
• cholesterol ephezulu
• umfutho wegazi ophakeme
• Isifo senhliziyo

Kwabesifazane abangama-transgender nabantu abangabhalisi

Kubantu abaguqukayo, ama-anti-androgens angasiza ukuvimba eminye yemiphumela yokuhlunga ye-testosterone. Banganciphisa ezinye izici zobudoda, njenge:

• impandla yomuntu wesilisa
• ukukhula kwezinwele ebusweni
• ukuvinjelwa ekuseni

Ama-anti-androgens asebenza kakhulu kwabesifazane be-transgender uma bethathwe nge-estrogen, i-hormone yabesifazane eyinhloko. Ngaphezu kokubangela ukuthuthukiswa kwezici zomzimba zesifazane, ezifana namabele, i-estrogen futhi yehlisa ngokungaqondile amazinga e-testosterone. Ukuthatha ama-anti-androgens nge-estrogen kungasiza kuzo zombili ukucindezela izici zobudoda futhi kuthuthukise ezabesifazane.

Kubantu abakhomba njengokungajwayelekile, ukuthatha ama-anti-androgens kukodwa kungasiza ekunciphiseni izici zomzimba wesilisa.

Okwabesilisa

I-Androgens ivuselela umdlavuza weseli endleleni. Ukwehlisa amazinga e-androgen, noma ukuvimbela ama-androgens ukuthi afinyelele kumaseli omdlavuza, kungasiza ukwehlisa umdlavuza. Kungabuye kunciphise izicubu ezikhona.

Ezigabeni zayo zokuqala, amangqamuzana omdlavuza wendlala yesinye ancike kuma-androgens ukondla ukukhula kwawo. Ama-anti-androgens asebenza ngokuvimba ama-androgens ekubambeni kuya kuma-androgen receptors kumaseli womdlavuza wesinye. Lokhu kulambisa amangqamuzana omdlavuza we-androgens awadingayo ukuze akhule.

Kodwa-ke, ama-anti-androgens awayeki ukukhiqizwa kwe-androgen. Zivame ukusetshenziselwa ukuhlanganiswa nezinye izindlela zokwelapha, njengokuhlinza ngokuhlinzwa noma ngamakhemikhali. Lezi zinhlanganisela zibizwa nangokuthi:

• ukuvaleka kwe-androgen okuhlangene
• ukuqedela ukuvinjelwa kwe-androgen
• ukuvinjelwa okuphelele kwe-androgen

Yiziphi ezinye ezivamile?

Kunama-anti-androgens amaningi atholakalayo, ngalinye linokusetshenziswa okuhlukile okwehlukile. Nakhu ukubuka okunye okuvame kakhulu.

I-Flutamide

I-Flutamide uhlobo lwe-anti-androgen olusetshenziswa neminye imithi yokwelapha izinhlobo ezithile zomdlavuza wesinye. I-Flutamide ibophezela kuma-androgen receptors kumaseli womdlavuza wendlala yesinye, evimba ama-androgens ekuboshweni kuma-receptors. Lokhu kuvimbela ama-androgens ekukhuthazeni ukukhula komdlavuza wesibeletho.

I-Spironolactone

I-Spironolactone (Aldactone) uhlobo lwe-anti-androgen esetshenziselwe ukwelapha induna ye-hormonal nezinwele zomzimba ezeqile. Ukuguquka kwabantu kungakuthatha ukunciphisa izici zobudoda. Yize kunobufakazi obuncane bokuxhasa ukusetshenziswa kwayo, futhi buyisela yona impandla yephethini yabesifazane.

ICyproterone

ICyproterone ibingenye yama-anti-androgens okuqala. Kungenxa yeminye imithi yokwelapha abesifazane abane-PCOS. Kubuye kuboniswe kumazinga we-testosterone nokukhiqizwa kwamafutha abangela izinduna.

Ingasetshenziswa futhi ukunciphisa izici zobudoda kwabesifazane be-transgender. Kodwa-ke, ngenxa yemiphumela yaso emibi, ngokuvamile ayithandwa.

Iyini imiphumela emibi?

Ama-anti-androgens angakhiqiza imiphumela eminingi engemihle, ngokuya ngomthamo nohlobo oluthathayo.

Eminye imiphumela emibi engaba khona ifaka phakathi:

• ukushayela ucansi okuphansi
• ingozi eyengeziwe yokudangala
• ama-enzyme wesibindi aphakeme
• kunciphile izinwele nobuso bomzimba
• ingozi ephezulu yokukhubazeka kokuzalwa uma ithathwa ngesikhathi sokukhulelwa
• i-hepatitis
• ukulimala kwesibindi
• ukungasebenzi kahle kwe-erectile
• isifo sohudo
• isisa sebele
• ukushisa okushisayo
• ukungahambi kahle esikhathini
• ukuqubuka kwesikhumba
• anti-androgen resistance, okusho ukuthi umuthi uyeka ukusebenza

Udokotela wakho angakusiza ukhethe i-anti-androgen efaneleke kangcono izidingo zakho futhi iza nemiphumela emibi kakhulu.

Okubalulekile

Ama-anti-androgens anokusebenzisa okuningi kwabesilisa, abesifazane, nabantu ekushintsheni kobulili, bebodwa futhi ngokuhlangana neminye imishanguzo nokwelashwa. Kodwa-ke, ama-anti-androgens yizidakamizwa ezinamandla ezingadala imiphumela emibi ethile. Sebenza nodokotela wakho ukukala izinzuzo nezingozi zokuthatha ama-anti-androgens.