Ama-antibody e-monoclonal: ayini nokuthi kungani esiza ukwelapha izifo

-Delile

• Izibonelo zama-antibody monoclonal
• 1. I-Trastuzumab
• 2. IDenosumab
• 3. Obinutuzumab
• 4. Ustequinumab
• 5. IPertuzumab
• Ungawathatha Kanjani ama-antibody we-Monoclonal

Ama-antibody eMonoclonal angamaprotheni asetshenziswa amasosha omzimba ukukhomba nokunciphisa imizimba yangaphandle, okungaba ngamagciwane, amagciwane noma amaseli wesimila. Lawa maprotheni acacile, njengoba abona okubhekiswe kukho, okubizwa ngokuthi i-antigen, okuzoba khona kumaseli angaphandle komzimba. Qonda ukuthi amasosha omzimba asebenza kanjani.

Ama-antibody e-monoclonal, njenge-denosumab, i-obinutuzumab noma i-ustequinumab, ngokwesibonelo, akhiqizwa elabhorethri, imvamisa ifana nalawo atholakala emzimbeni womuntu, azosiza umzimba ukulwa nezifo ezithile. Ngakho-ke, ngokuya nge-anti-monoclonal antibody esetshenzisiwe, la makhambi angasetshenziswa ukwelapha ezinye izifo ezinkulu ezifana ne-osteoporosis, leukemia, plaque psoriasis noma ezinye izinhlobo zomdlavuza, njengomdlavuza webele noma wethambo, ngokwesibonelo.

Izibonelo zama-antibody monoclonal

Ezinye izibonelo zama-antibody monoclonal zifaka:

1. I-Trastuzumab

Le anti-monoclonal antibody, emakethwa njenge-Herceptin, yathuthukiswa ngobunjiniyela, futhi ihlasela ngqo iprotheni ekhona kubantu abanomdlavuza othile webele nowesisu. Ngakho-ke, leli khambi likhonjisiwe ekwelapheni umdlavuza webele kusenesikhathi noma nge-metastasis nomdlavuza wesisu esiteji esithuthukile.

2. IDenosumab

Imakethwa njengeProlia noma iXgeva, inokwakheka kwayo i-anti monoclonal IgG2 antibody, ephazamisa ukusebenza kweprotheni ethile eyenza amathambo aqine, anciphise amathuba wokwephuka. Ngakho-ke, iDenosumab ikhonjisiwe ekwelashweni kokulahleka kwamathambo, i-osteoporosis, umdlavuza wamathambo noma umdlavuza kusigaba esithuthukile ngamathambo we-metastases (osabalalele emathanjeni).

3. Obinutuzumab

Eyaziwa futhi ngokuthengisa njengeGazyva, inama-antibodies ayo ekubunjweni kwayo abona futhi abophele ngqo kwiprotheni ye-CD20, etholakala ebusweni bamangqamuzana amhlophe egazi noma ama-lymphocyte B. Iyakwazi ukumisa ukukhula okungavamile kwamaseli amhlophe egazi abangela lesi sifo.

4. Ustequinumab

Leli khambi lingahle laziwe ngokuhweba njenge-Stelara futhi lakhiwa yi-IgG1 monoclonal antibody yomuntu, evimbela amaprotheni athile anesibopho sokubangela i-psoriasis. Ngakho-ke, leli thuluzi likhonjisiwe ekwelapheni i-plaque psoriasis.

5. IPertuzumab

Eyaziwa nangokuthi iPerjeta, yakhiwa ngama-antibody monoclonal abophezela kwi-human epidermal factor factor 2 receptor, etholakala kwamanye amangqamuzana omdlavuza, anciphisa noma amise ukukhula kwawo. Ngakho-ke, iPerjeta ikhonjisiwe ekwelapheni umdlavuza webele.

Ungawathatha Kanjani ama-antibody we-Monoclonal

Imithi eneMonoclonal Antibodies kufanele ithathwe kuphela ngaphansi kweseluleko sezokwelapha, njengoba uhlobo lwe-antibody oluzosetshenziswa kanye namanani anconywayo ancike enkingeni ezokwelashwa nobukhali bayo.

Ezimweni eziningi, la makhambi asetshenziswa ekwelapheni umdlavuza, njengoba engamakhambi aphikisayo aqhamuke nezifo okumele asetshenziswe ngokwemiyalo ethile enikezwe udokotela futhi edinga ukwelashwa ezibhedlela noma emitholampilo.