Buza Isazi: Imijovo yesifo sikashukela soHlobo 2

-Delile

• Yimiphi imithi ejojwayo elapha uhlobo lwesifo sikashukela se-2?
• Ingabe ukujova kubangela ukuncipha? Ukuzuza kwesisindo?
• Ngabe umthamo ulingana nowokujova? Ngabe ngiyobe ngiyijova ngokwami ​​imijovo?
• Ingabe ikhona imiphumela engemihle emithini yokujova okufanele ngiyazi?
• Hlobo luni lwezinguquko zokuphila engizodinga ukuzenza ngaphezu kokuqala ukwelashwa?
• Kubiza malini ukujova? Ngabe zivalwa ngaphansi komshwalense?

Yimiphi imithi ejojwayo elapha uhlobo lwesifo sikashukela se-2?

I-Glucagon-like peptide-1 receptor agonists (i-GLP-1 RAs) yimithi yokujova elapha uhlobo lwesifo sikashukela sohlobo lwe-2.

Ngokufana ne-insulin, bajojowe ngaphansi kwesikhumba. Ama-GLP-1 RAs asetshenziswa kakhulu ngokuhlanganyela nezinye izindlela zokwelapha isifo sikashukela.

Njengamanje, kunama-GLP-1 RAs amaningi emakethe ahluka ngokuhlelwa kwesilinganiso nobude besenzo. Kubandakanya:

• i-exenatide (Byetta)
• exenatide - ukukhululwa okwandisiwe (Bydureon)
• dulaglutide (Trulicity)
• semaglutide (Ozempic) - nayo iyatholakala ngefomu lethebulethi (iRybelsus)
• i-liraglutide (i-Victoza)
• i-lixisenatide (i-Adlyxin)

I-Pramlintide (Symlin) kungenye yezidakamizwa ezijojwayo ezivunyelwe ukwelashwa kohlobo lwesifo sikashukela sohlobo 2. Isetshenziswa ngokubambisana nezikhathi zokudla ze-insulin shots. Yize ingasetshenziswa kakhulu, isebenza ngokufana ne-GLP-1 RAs.

Ingabe ukujova kubangela ukuncipha? Ukuzuza kwesisindo?

Ngokungafani ne-insulin nezinye izidakamizwa ezilwa nesifo sikashukela, ukujova akubangeli ukukhuluphala.

Ngenxa yokuthi zinciphisa isifiso sokudla, zingase zibe nomthelela nasekunciphiseni isisindo ebangeni elingamakhilogremu angu-1.5 kuya kwamakhilogremu amathathu. Inani lokwehla kwesisindo lincike ezintweni eziningi, njenge:

• ukudla
• ukuzivocavoca umzimba
• ukusetshenziswa kweminye imithi

Ngenxa yalokhu, ama-GLP-1 RAs alungele kahle abantu abakhuluphele ngokweqile noma abanesisindo. Zivame ukusetshenziselwa ukuhlanganiswa nezinye izidakamizwa noma i-insulin ukunciphisa ukuzuza kwesisindo.

Ngabe umthamo ulingana nowokujova? Ngabe ngiyobe ngiyijova ngokwami ​​imijovo?

Ama-GLP-1 RAs ayatholakala ezibayeni ezigcwalisiwe ozihambisa zona, ngendlela efanayo ne-insulin. Zihluka ngomthamo nobude besenzo.

Okwamanje azikho izivivinyo zokuqhathanisa ezibonisa ukuthi ukukhetha imithi kuyithinta kanjani imiphumela yesiguli yesikhathi eside.

Udokotela wakho uvame ukukuqala ngomthamo ophansi. Lokhu kuzokwandiswa kancane kancane ngokuya ngokubekezelelana nomphumela oyifunayo.

I-Byetta ukuphela kwe-ejenti edinga ukuphathwa kabili ngosuku. Eminye imijovo yansuku zonke noma yamasonto onke.

Ingabe ikhona imiphumela engemihle emithini yokujova okufanele ngiyazi?

Imiphumela emibi yamathumbu, efana nesicanucanu, ukuhlanza, nohudo, yenzeka ezigulini eziningi. I-nausea ingancipha ngokuhamba kwesikhathi noma ngokunciphisa umthamo. Kungenzeka futhi ukuthi kwenzeke kaningi nabenzeli bamasonto onke.

Eminye imibiko ixhumanisa i-acute pancreatitis ne-GLP-1 RAs, kodwa ayikho imininingwane eyanele yokuthola ubudlelwano obucacile bokubangela. Ucwaningo luhlolisise eminye imiphumela emibi engaba khona kumanyikwe, njengomdlavuza wepancreatic, kepha abukho ubufakazi obanele.

Amanye ama-GLP-1 RAs angadala ukusabela kwesikhumba kwasendaweni yokujova. Abanye abantu abasebenzisa i-exenatide (Bydureon, Byetta) babike lo mphumela wecala.

I-Hypoglycemia ayivamile ukuvela nge-GLP-1 RAs lapho isetshenziswa yodwa. Kodwa-ke, ukubangeza ekwelashweni okususelwa ku-insulin kungakhuphula ubungozi.

Ezifundweni zamagundane, kube nokwanda kwezicubu ze-thyroid ze-medullary. Umphumela ofanayo awukatholakali kubantu.

Hlobo luni lwezinguquko zokuphila engizodinga ukuzenza ngaphezu kokuqala ukwelashwa?

Izinguquko zokuphila kwabantu abanesifo sikashukela sohlobo 2 zingaqukatha:

• ukulungisa ukudla
• ukwehlisa amaphesenti ama-5 kuye kwayi-10 esisindo somzimba, kulabo abanesisindo esiningi noma ukukhuluphala ngokweqile
• ukuzivocavoca njalo imizuzu eyi-150 ngeviki
• ukuzihlola ngokwakho ushukela wegazi
• ukunciphisa umkhawulo wotshwala esiphuzweni esisodwa ngosuku kwabesifazane abadala neziphuzo ezimbili ngosuku kwabesilisa abadala
• ukungabhemi noma ukuyeka ukubhema

Indlela yesifo sikashukela isetshenziswa kakhulu ekunikezeni ukuholwa okuyisisekelo kokuhlela ukudla nangosizo lwayo olubukwayo.

Ukubona ingcweti yokudla ebhalisiwe kungakusiza nokukuholela ekudleni okunempilo. Isazi sokudla singancoma uhlelo lokudla okunomuntu ngamunye olubangela izici zakho ezithile kanye nokuncamelayo.

Ngokuvamile, ukunciphisa ukudla kwakho kwe-carbohydrate kuyadingeka ukuthuthukisa ukuphathwa koshukela wegazi.

Khetha ama-carbs angama:

• ubukhulu bezakhi
• ifayibha ephezulu
• kusetshenzwe kancane

Shintsha iziphuzo ezinoshukela ngamanzi.

Ngokwengeziwe, ukudla ukudla okunothe ngamafutha e-monounsaturated ne-polyunsaturated kungahle kuthuthukise imetabolism metabolism kanye nengozi ephansi yenhliziyo.

Kubiza malini ukujova? Ngabe zivalwa ngaphansi komshwalense?

Ama-injection we-GLP-1 RA nama-pramlintide (Symlin) abizayo. Azikho izinketho ezijwayelekile ezitholakalayo okwamanje. Amanani entengo aphakathi nendawo ahamba kanjena:

• Ngaphandle: $ 840
• I-Dulaglutide: $ 911
• I-Semaglutide: $ 927
• I-Liraglutide: $ 1,106
• ILixisenatide: $ 744
• I-Pramlintide: $ 2,623

Lokhu kumbozwe yizinhlelo eziningi zomshuwalense. kepha imihlahlandlela yenqubomgomo, ukukhishwa, izidingo zokwelashwa kwesinyathelo, kanye nokugunyazwa kwangaphambili kuhluka kakhulu.

Kubalulekile ukujwayela imininingwane yohlelo lwakho lwemithi kadokotela.

UDkt Maria S. Prelipcean ungudokotela onguchwepheshe be-endocrinology nesifo sikashukela. Njengamanje usebenza eSouthview Medical Group eBirmingham, e-Alabama. UDkt Prelipcean uphothule eCarol Davila Medical School eBucharest, eRomania. Uqede ukuqeqeshwa kwakhe kwezokwelapha kwangaphakathi e-University of Illinois naseNorthwestern University eChicago nokuqeqeshwa kwakhe kwe-endocrinology e-University of Alabama eBirmingham. UDkt Prelipcean ubizwe kaningi njengoBirmingham Top Doctor futhi enguMuntu we-American College of Endocrinology. Ngesikhathi sakhe sokuphumula, uyakujabulela ukufunda, ukuhamba, nokuchitha isikhathi nomndeni wakhe.