Ukuhlolwa kwe-BCR ABL Genetic

-Delile

• Luyini uvivinyo lwe-BCR-ABL?
• Kusetshenziselwa ini?
• Kungani ngidinga ukuhlolwa kofuzo kwe-BCR-ABL?
• Kwenzekani ngesikhathi sokuhlolwa kofuzo kwe-BCR-ABL?
• Ngabe kukhona engizodinga ukukwenza ukulungiselela isivivinyo?
• Ingabe zikhona izingozi esivivinyweni?
• Isho ukuthini imiphumela?
• Ngabe kukhona okunye engidinga ukukwazi mayelana nokuhlolwa kofuzo kwe-BCR-ABL?
• Izinkomba

Luyini uvivinyo lwe-BCR-ABL?

Ukuhlolwa kofuzo kwe-BCR-ABL kubheka ukuguquka kwezakhi zofuzo (ushintsho) kwi-chromosome ethile.

Ama-Chromosomes ayizingxenye zamaseli akho aqukethe izakhi zofuzo zakho. Izakhi zofuzo ziyingxenye ye-DNA edluliselwe isuka kumama nobaba wakho. Ziphethe imininingwane enquma izici zakho ezihlukile, njengokuphakama nombala wamehlo.

Ngokuvamile abantu banama-chromosomes angama-46, ahlukaniswe ngamabili angama-23, esitokisini ngasinye. Elinye lama-chromosomes ngalinye livela kunina, kanti elinye iqembu livela kuyihlo.

I-BCR-ABL inguquko eyakhiwa yinhlanganisela yezakhi zofuzo ezimbili, ezaziwa nge-BCR ne-ABL. Kwesinye isikhathi kubizwa ngofuzo lokuxuba.

• Uhlobo lwe-BCR luvame ukuba kwinombolo ye-chromosome 22.
• Uhlobo lwe-ABL luvame ukuba yinombolo ye-chromosome 9.
• Ukuguqulwa kwe-BCR-ABL kwenzeka lapho izingcezu zezakhi zofuzo ze-BCR ne-ABL ziphuka futhi zishintsha izindawo.
• Ukuguqulwa kuvela ku-chromosome 22, lapho ucezu lwe-chromosome 9 luzihlanganise khona.
• I-chromosome eshintshiwe engu-22 ibizwa nge-chromosome yaseFiladelphia ngoba idolobha lapho abacwaningi baqala ukulithola khona.
• Uhlobo lwe-BCR-ABL akulona uhlobo lokuguqula olutholwa ngabazali bakho. Luhlobo lwenguquko ye-somatic, okusho ukuthi awuzalwanga nayo. Uyithola kamuva empilweni.

Uhlobo lwe-BCR-ABL luvela ezigulini ezinezinhlobo ezithile ze-leukemia, umdlavuza wamnkantsha wamathambo namaseli amhlophe egazi. I-BCR-ABL itholakala cishe kuzo zonke iziguli ezinohlobo lwe-leukemia okuthiwa i-chronic myeloid leukemia (CML). Elinye igama le-CML alipheli i-myelogenous i-leukemia. Womabili la magama asho isifo esifanayo.

Uhlobo lwe-BCR-ABL luyatholakala nakwezinye iziguli ezinohlobo lwe-acute lymphoblastic leukemia (ALL) futhi kuyaqabukela ezigulini ezine-acute myelogenous leukemia (AML).

Imithi ethile yomdlavuza isebenza ngempumelelo ekwelapheni iziguli ze-leukemia ngokushintshwa kofuzo kwe-BCR-ABL. Le mithi futhi inemiphumela emibi embalwa kunezinye izindlela zokwelapha umdlavuza. Imithi efanayo ayisebenzi ekwelapheni izinhlobo ezahlukene ze-leukemia noma eminye imidlavuza.

Amanye amagama: Ukuhlanganiswa kwe-BCR-ABL1, BCR-ABL1, chromosome yaseFiladelphia

Kusetshenziselwa ini?

Ukuhlolwa kwe-BCR-ABL kuvame ukusetshenziselwa ukuxilonga noma ukukhipha i-myeloid leukemia (CML) noma uhlobo oluthile lwe-acute lymphoblastic leukemia (ALL) olubizwa nge-Ph-positive ALL. I-Ph-positive isho ukuthi kutholakale i-chromosome yaseFiladelphia. Ukuhlola akusetshenziswanga ukuthola ezinye izinhlobo ze-leukemia.

Isivivinyo singasetshenziswa futhi uku:

• Bona ukuthi ukwelashwa komdlavuza kuyasebenza yini.
• Bheka ukuthi isiguli sesimelane nokwelashwa okuthile yini. Lokho kusho ukuthi ukwelashwa obekukade kusebenza akusasebenzi.

Kungani ngidinga ukuhlolwa kofuzo kwe-BCR-ABL?

Ungadinga ukuhlolwa kwe-BCR-ABL uma unezimpawu zesifo esingalapheki se-myeloid leukemia (CML) noma i-Ph-positive acute lymphoblastic leukemia (BONKE). Lokhu kufaka phakathi:

• Ukukhathala
• Imfiva
• Ukwehla kwesisindo
• Ukujuluka ebusuku (ukujuluka ngokweqile ngenkathi ulele)
• Ubuhlungu obuhlangene noma bethambo

Abanye abantu abane-CML noma i-Ph-positive BONKE abanazo izimpawu, noma izimpawu eziphansi kakhulu, ikakhulukazi ezigabeni zokuqala zesifo. Ngakho-ke umhlinzeki wakho wezokunakekelwa kwempilo anga-oda lokhu kuhlolwa uma ukubalwa okuphelele kwegazi noma okunye ukuhlolwa kwegazi kukhombisa imiphumela ebingajwayelekile. Kufanele futhi wazise umhlinzeki wakho uma unezimpawu ezikukhathazayo. I-CML ne-Ph-positive ZONKE kulula ukuzelapha uma zitholwe kusenesikhathi.

Ungase futhi udinge lokhu kuhlolwa uma ngabe manje welashelwa i-CML noma i-Ph-positive YONKE. Ukuhlolwa kungasiza umhlinzeki wakho ukuthi abone ukuthi ukwelashwa kwakho kuyasebenza yini.

Kwenzekani ngesikhathi sokuhlolwa kofuzo kwe-BCR-ABL?

Ukuhlolwa kwe-BCR-ABL kuvame ukuhlolwa kwegazi noma inqubo ebizwa ngokuthi ukufisa umnkantsha kanye ne-biopsy.

Uma uthola ukuhlolwa kwegazi, uchwepheshe wezokunakekelwa kwempilo uzothatha isampuli yegazi emthanjeni osengalweni yakho, esebenzisa inaliti encane. Ngemuva kokuthi kufakwe inaliti, kuzoqoqwa inani elincane legazi kufakwe ithubhu yokuhlola noma isitsha. Ungase uzizwe uluma kancane lapho inaliti ingena noma iphuma. Lokhu ngokuvamile kuthatha imizuzu engaphansi kwemihlanu.

Uma uthola isifiso somnkantsha kanye ne-biopsy, inqubo yakho ingafaka lezi zinyathelo ezilandelayo:

• Uzolala ngohlangothi noma esiswini sakho, kuya ngokuthi yiliphi ithambo elizosetshenziselwa ukuhlolwa. Iningi lokuhlolwa komnkantsha wamathambo lithathwa ethangeni lesinqe.
• Umzimba wakho uzombozwa ngendwangu, ukuze kubonakale kuphela indawo ezungeze indawo yokuhlola.
• Isiza sizohlanzwa ngesibulali magciwane.
• Uzothola umjovo wesixazululo esikindayo. Kungaluma.
• Lapho indawo isikindiki, umhlinzeki wezempilo uzothatha isampula. Uzodinga ukuqamba amanga unganyakazi ngesikhathi sokuhlolwa.
  • Ngokulangazelela umnkantsha wethambo, ovame ukwenziwa kuqala, umhlinzeki wezokunakekelwa kwempilo uzofaka inaliti ngethambo akhiphe uketshezi lomnkantsha kanye namaseli. Ungabuzwa ubuhlungu obubukhali kodwa obufushane lapho kufakwa inaliti.
  • Nge-biopsy yomnkantsha wamathambo, umhlinzeki wezokunakekelwa kwempilo uzosebenzisa ithuluzi elikhethekile elizisontela ethanjeni ukukhipha isampula lezicubu zomnkantsha. Ungazizwa unengcindezi ethile kusayithi ngenkathi kuthathwa isampula.
• Kuthatha cishe imizuzu eyi-10 ukwenza zombili izivivinyo.
• Ngemuva kokuhlolwa, umhlinzeki wezokunakekelwa kwempilo uzomboza isiza ngebhandishi.
• Hlela ukuthi othile akuhambise ekhaya, ngoba unganikezwa umuthi wokuthambisa ngaphambi kokuhlolwa, okungakwenza ukozele.

Ngabe kukhona engizodinga ukukwenza ukulungiselela isivivinyo?

Imvamisa awudingi amalungiselelo akhethekile wokuhlolwa kwegazi noma umnkantsha.

Ingabe zikhona izingozi esivivinyweni?

Kunengozi encane kakhulu yokuhlolwa kwegazi. Ungaba nobuhlungu obuncane noma ukulimaza lapho kufakwe khona inaliti, kepha izimpawu eziningi ziyaphela ngokushesha.

Ngemuva kokuhlolwa komnkantsha wamathambo, ungazizwa uqine noma ubuhlungu endaweni okujojelwa kuyo. Lokhu kuvame ukuphela ezinsukwini ezimbalwa. Umhlinzeki wakho wezokunakekelwa kwempilo angancoma noma anikeze umuthi wokuqeda izinhlungu ukusiza.

Isho ukuthini imiphumela?

Uma imiphumela yakho ikhombisa ukuthi unesakhi sofuzo se-BCR-ABL, kanye nenani elingajwayelekile lamaseli amhlophe egazi, cishe uzotholakala ukuthi une-myeloid leukemia (CML) engapheli noma i-Ph-positive, acute lymphoblastic leukemia (ALL).

Uma okwamanje welashelwa i-CML noma i-Ph-positive YONKE, imiphumela yakho ingakhombisa:

• Inani le-BCR-ABL egazini lakho noma umnkantsha wethambo liyanda. Lokhu kungasho ukuthi ukwelashwa kwakho akusebenzi futhi / noma usumelana nokwelashwa okuthile.
• Inani le-BCR-ABL egazini lakho noma umnkantsha liyancipha. Lokhu kungasho ukuthi ukwelashwa kwakho kuyasebenza.
• Inani le-BCR-ABL egazini lakho noma emnkantsheni wethambo alikhuphukile noma lehle. Lokhu kungasho ukuthi isifo sakho sizinzile.

Uma unemibuzo ngemiphumela yakho, khuluma nomhlinzeki wakho wezokunakekelwa kwempilo.

Funda kabanzi mayelana nokuhlolwa kwelabhorethri, ububanzi bezinkomba, nemiphumela yokuqonda.

Ngabe kukhona okunye engidinga ukukwazi mayelana nokuhlolwa kofuzo kwe-BCR-ABL?

Ukwelashwa kwe-myeloid leukemia (CML) ne-Ph-positive, acute lymphoblastic leukemia (ALL) kuphumelele ezigulini ezinalezi zinhlobo ze-leukemia. Kubalulekile ukubona umhlinzeki wakho wokunakekelwa kwezempilo njalo ukuze uqiniseke ukuthi ukwelashwa kwakho kuyaqhubeka nokusebenza. Uma umelana nokwelashwa, umhlinzeki wakho angancoma ezinye izinhlobo zokwelashwa komdlavuza.

Izinkomba

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Imininingwane ekulesi siza akufanele isetshenziswe esikhundleni sezokunakekelwa kwezokwelapha noma iseluleko. Xhumana nomhlinzeki wezempilo uma unemibuzo ngempilo yakho.